WO2008035376A3 - A novel bio-erodible insert for ophthalmic applications and a process for the preparation thereof - Google Patents

A novel bio-erodible insert for ophthalmic applications and a process for the preparation thereof Download PDF

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Publication number
WO2008035376A3
WO2008035376A3 PCT/IN2007/000374 IN2007000374W WO2008035376A3 WO 2008035376 A3 WO2008035376 A3 WO 2008035376A3 IN 2007000374 W IN2007000374 W IN 2007000374W WO 2008035376 A3 WO2008035376 A3 WO 2008035376A3
Authority
WO
WIPO (PCT)
Prior art keywords
insert
preparation
erodible
conditions
bio
Prior art date
Application number
PCT/IN2007/000374
Other languages
French (fr)
Other versions
WO2008035376A2 (en
WO2008035376A4 (en
Inventor
Janumala Hadassah
Praveen Kumar Sehgal
Original Assignee
Council Scient Ind Res
Janumala Hadassah
Praveen Kumar Sehgal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Council Scient Ind Res, Janumala Hadassah, Praveen Kumar Sehgal filed Critical Council Scient Ind Res
Publication of WO2008035376A2 publication Critical patent/WO2008035376A2/en
Publication of WO2008035376A3 publication Critical patent/WO2008035376A3/en
Publication of WO2008035376A4 publication Critical patent/WO2008035376A4/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Abstract

The present invention provides a novel bio-erodible ophthalmic insert a process for the preparation of the said bio-erodible insert. In the said process collagen is treated with organic polar solvents, hydrophilic polymers and therapeutically active substances under controlled conditions. The resulting solution is air dried in a dust free chamber to make collagen film. This film is cut into shape to obtain insert, which is subjected to cross-linking with UV irradiation followed by conventional sterilization. The prepared inserts are very effective for temporary punctal occlusion in various corneal conditions and are very effective to treat dry eye syndrome due to occupational conditions.
PCT/IN2007/000374 2006-09-19 2007-08-30 A novel bio-erodible insert for ophthalmic applications and a process for the preparation thereof WO2008035376A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2064DE2006 2006-09-19
IN2064/DEL/2006 2006-09-19

Publications (3)

Publication Number Publication Date
WO2008035376A2 WO2008035376A2 (en) 2008-03-27
WO2008035376A3 true WO2008035376A3 (en) 2008-11-20
WO2008035376A4 WO2008035376A4 (en) 2009-01-29

Family

ID=39092185

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000374 WO2008035376A2 (en) 2006-09-19 2007-08-30 A novel bio-erodible insert for ophthalmic applications and a process for the preparation thereof

Country Status (1)

Country Link
WO (1) WO2008035376A2 (en)

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ES2700433T3 (en) 2005-12-13 2019-02-15 Incyte Holdings Corp Derivatives of pyrrolo [2,3-d] pyrimidine as inhibitors of Janus kinases
HUE029236T2 (en) 2007-06-13 2017-02-28 Incyte Holdings Corp Crystalline salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile
CN101683538B (en) * 2008-09-28 2013-01-02 上海市第十人民医院 Lacrimal passage stopper and preparation method thereof
JP5890182B2 (en) 2009-02-12 2016-03-22 インセプト エルエルシー Drug delivery with hydrogel plugs
WO2010135650A1 (en) 2009-05-22 2010-11-25 Incyte Corporation N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS
WO2010135621A1 (en) 2009-05-22 2010-11-25 Incyte Corporation 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors
TW201113285A (en) 2009-09-01 2011-04-16 Incyte Corp Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
ES2662588T3 (en) 2010-03-10 2018-04-09 Incyte Holdings Corporation Piperidin-4-IL azetidine derivatives as JAK1 inhibitors
CN103002875B (en) 2010-05-21 2016-05-04 因塞特控股公司 Topical formulations of JAK inhibitors
WO2012068440A1 (en) 2010-11-19 2012-05-24 Incyte Corporation Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors
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TW201313721A (en) 2011-08-18 2013-04-01 Incyte Corp Cyclohexyl azetidine derivatives as JAK inhibitors
UA111854C2 (en) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн METHODS AND INTERMEDIATE COMPOUNDS FOR JAK INHIBITORS
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
US9193733B2 (en) 2012-05-18 2015-11-24 Incyte Holdings Corporation Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors
EA201590930A1 (en) 2012-11-15 2015-08-31 Инсайт Корпорейшн DOSAGE FORMS OF RUXOLITINIB WITH Slow Release.
CN105189509B (en) 2013-03-06 2017-12-19 因赛特公司 For preparing the method and intermediate of JAK inhibitor
SI3030227T1 (en) 2013-08-07 2020-08-31 Incyte Corporation Sustained release dosage forms for a jak1 inhibitor
WO2015184305A1 (en) 2014-05-30 2015-12-03 Incyte Corporation TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
TW201924683A (en) 2017-12-08 2019-07-01 美商英塞特公司 Low dose combination therapy for treatment of myeloproliferative neoplasms
MX2020007973A (en) 2018-01-30 2020-12-07 Incyte Corp Processes for preparing (1 -(3-fluoro-2-(trifluoromethyl)isonicot inyl)piperidine-4-one).
CN113768934A (en) 2018-03-30 2021-12-10 因赛特公司 Treatment of hidradenitis suppurativa with JAK inhibitors
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4164559A (en) * 1977-09-21 1979-08-14 Cornell Research Foundation, Inc. Collagen drug delivery device
US5185152A (en) * 1990-01-10 1993-02-09 Peyman Gholam A Method and apparatus for controlled release drug delivery to the cornea and anterior chamber of the eye
WO2000059420A1 (en) * 1999-04-01 2000-10-12 The Uab Research Foundation Improved conjunctival inserts for topical delivery of medication or lubrication
WO2006031658A2 (en) * 2004-09-10 2006-03-23 Allergan, Inc. Therapeutic lacrimal canalicular inserts and related methods

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4164559A (en) * 1977-09-21 1979-08-14 Cornell Research Foundation, Inc. Collagen drug delivery device
US5185152A (en) * 1990-01-10 1993-02-09 Peyman Gholam A Method and apparatus for controlled release drug delivery to the cornea and anterior chamber of the eye
WO2000059420A1 (en) * 1999-04-01 2000-10-12 The Uab Research Foundation Improved conjunctival inserts for topical delivery of medication or lubrication
WO2006031658A2 (en) * 2004-09-10 2006-03-23 Allergan, Inc. Therapeutic lacrimal canalicular inserts and related methods

Also Published As

Publication number Publication date
WO2008035376A2 (en) 2008-03-27
WO2008035376A4 (en) 2009-01-29

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