WO2008039898A3 - Methods for the treatment of a traumatic central nervous system injury - Google Patents

Methods for the treatment of a traumatic central nervous system injury Download PDF

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Publication number
WO2008039898A3
WO2008039898A3 PCT/US2007/079655 US2007079655W WO2008039898A3 WO 2008039898 A3 WO2008039898 A3 WO 2008039898A3 US 2007079655 W US2007079655 W US 2007079655W WO 2008039898 A3 WO2008039898 A3 WO 2008039898A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
progesterone
subject
nervous system
central nervous
Prior art date
Application number
PCT/US2007/079655
Other languages
French (fr)
Other versions
WO2008039898A2 (en
Inventor
Donald G Stein
Douglas W Lowery-North
David W Wright
Stuart W Hoffman
Arthur L Kellermann
Original Assignee
Univ Emory
Donald G Stein
Douglas W Lowery-North
David W Wright
Stuart W Hoffman
Arthur L Kellermann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Emory, Donald G Stein, Douglas W Lowery-North, David W Wright, Stuart W Hoffman, Arthur L Kellermann filed Critical Univ Emory
Publication of WO2008039898A2 publication Critical patent/WO2008039898A2/en
Publication of WO2008039898A3 publication Critical patent/WO2008039898A3/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a two-level dosing regime of progesterone. In one method, a subject in need thereof is administered at least one cycle of therapy, wherein the cycle of therapy comprises administering a therapeutically effective two- level intravenous dosing regime of progesterone. The two-level dosing regime comprises a first time period, wherein a higher hourly dose of progesterone is administered to the subject, followed by a second time period, wherein a lower hourly dose of progesterone is administered to the subject.
PCT/US2007/079655 2006-09-27 2007-09-27 Methods for the treatment of a traumatic central nervous system injury WO2008039898A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/527,816 2006-09-27
US11/527,816 US7473687B2 (en) 2005-03-24 2006-09-27 Methods for the treatment of a traumatic central nervous system injury

Publications (2)

Publication Number Publication Date
WO2008039898A2 WO2008039898A2 (en) 2008-04-03
WO2008039898A3 true WO2008039898A3 (en) 2008-05-22

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/079655 WO2008039898A2 (en) 2006-09-27 2007-09-27 Methods for the treatment of a traumatic central nervous system injury

Country Status (2)

Country Link
US (3) US7473687B2 (en)
WO (1) WO2008039898A2 (en)

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US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
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EP3700525A4 (en) 2017-10-27 2021-08-25 Beyond Barriers Therapeutics, Inc. Enhanced delivery of antioxidants for treatment of central nervous system disorders involving oxidative stress
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Also Published As

Publication number Publication date
US8455468B2 (en) 2013-06-04
US7473687B2 (en) 2009-01-06
US20070078117A1 (en) 2007-04-05
WO2008039898A2 (en) 2008-04-03
US20080318914A1 (en) 2008-12-25
US7915244B2 (en) 2011-03-29
US20110224181A1 (en) 2011-09-15

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