WO2008045576A3 - Compositions and methods of rnai therapeutics for treatment of cancer and other neovascularization diseases - Google Patents
Compositions and methods of rnai therapeutics for treatment of cancer and other neovascularization diseases Download PDFInfo
- Publication number
- WO2008045576A3 WO2008045576A3 PCT/US2007/021985 US2007021985W WO2008045576A3 WO 2008045576 A3 WO2008045576 A3 WO 2008045576A3 US 2007021985 W US2007021985 W US 2007021985W WO 2008045576 A3 WO2008045576 A3 WO 2008045576A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compositions
- methods
- cancer
- treatment
- rnai therapeutics
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
Abstract
The invention relates to oligonucleotide compositions for use in reducing the expression and activity of VEGF pathway genes and unwanted neovascularization, including tumor angiogenesis, by RNA interference and methods and compositions comprising the oligonucleotides.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85164706P | 2006-10-12 | 2006-10-12 | |
US60/851,647 | 2006-10-12 | ||
US85327406P | 2006-10-19 | 2006-10-19 | |
US60/853,274 | 2006-10-19 | ||
US92774407P | 2007-05-04 | 2007-05-04 | |
US60/927,744 | 2007-05-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008045576A2 WO2008045576A2 (en) | 2008-04-17 |
WO2008045576A3 true WO2008045576A3 (en) | 2009-02-26 |
Family
ID=39283488
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/021985 WO2008045576A2 (en) | 2006-10-12 | 2007-10-12 | Compositions and methods of rnai therapeutics for treatment of cancer and other neovascularization diseases |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008045576A2 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2604441A1 (en) | 2005-04-12 | 2006-10-19 | Intradigm Corporation | Composition and methods of rnai therapeutics for treatment of cancer and other neovascularization diseases |
SI2056845T1 (en) | 2006-08-08 | 2018-02-28 | Rheinische Friedrich-Wilhelms-Universitaet Bonn | Structure and use of 5' phosphate oligonucleotides |
US20100210710A1 (en) * | 2007-10-12 | 2010-08-19 | Intradigm Corporation | THERAPEUTIC siRNA MOLECULES FOR REDUCING VEGFR1 EXPRESSION IN VITRO AND IN VIVO |
US9738680B2 (en) | 2008-05-21 | 2017-08-22 | Rheinische Friedrich-Wilhelms-Universität Bonn | 5′ triphosphate oligonucleotide with blunt end and uses thereof |
SG10201510586PA (en) | 2008-06-30 | 2016-01-28 | Mesoblast Inc | Treatment of Eye Diseases And Excessive Neovascularization Using A Combined Therapy |
JP2013539456A (en) * | 2010-07-28 | 2013-10-24 | アルコン リサーチ,リミテッド | SiRNA Targeting VEGFA and Methods for In Vivo Treatment |
EP2508530A1 (en) | 2011-03-28 | 2012-10-10 | Rheinische Friedrich-Wilhelms-Universität Bonn | Purification of triphosphorylated oligonucleotides using capture tags |
EP2712870A1 (en) | 2012-09-27 | 2014-04-02 | Rheinische Friedrich-Wilhelms-Universität Bonn | Novel RIG-I ligands and methods for producing them |
CN107177598B (en) * | 2016-08-18 | 2019-12-27 | 广州市锐博生物科技有限公司 | Oligonucleotide molecule for inhibiting mRNA expression of BIRC5 target gene and its composition set |
EP3762497A4 (en) * | 2018-05-14 | 2022-08-03 | Murdoch University | Methods for treating vegf-related conditions |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004009769A2 (en) * | 2002-07-24 | 2004-01-29 | The Trustees Of The University Of Pennsylvania | COMPOSITIONS AND METHODS FOR siRNA INHIBITION OF ANGIOGENESIS |
WO2005076998A2 (en) * | 2004-02-05 | 2005-08-25 | Intradigm Corporation | Rnai therapeutics for treatment of eye neovascularization diseases |
WO2006110813A2 (en) * | 2005-04-12 | 2006-10-19 | Intradigm Corporation | Composition and methods of rnai therapeutics for treatment of cancer and other neovascularization diseases |
WO2007146953A2 (en) * | 2006-06-12 | 2007-12-21 | Exegenics, Inc., D/B/A Opko Health, Inc. | Compositions and methods for sirna inhibition of angiogenesis |
-
2007
- 2007-10-12 WO PCT/US2007/021985 patent/WO2008045576A2/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004009769A2 (en) * | 2002-07-24 | 2004-01-29 | The Trustees Of The University Of Pennsylvania | COMPOSITIONS AND METHODS FOR siRNA INHIBITION OF ANGIOGENESIS |
WO2005076998A2 (en) * | 2004-02-05 | 2005-08-25 | Intradigm Corporation | Rnai therapeutics for treatment of eye neovascularization diseases |
WO2006110813A2 (en) * | 2005-04-12 | 2006-10-19 | Intradigm Corporation | Composition and methods of rnai therapeutics for treatment of cancer and other neovascularization diseases |
WO2007146953A2 (en) * | 2006-06-12 | 2007-12-21 | Exegenics, Inc., D/B/A Opko Health, Inc. | Compositions and methods for sirna inhibition of angiogenesis |
Non-Patent Citations (1)
Title |
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TOLENTINO M J ET AL: "INTRAVITREAL INJECTION OF VASCULAR ENDOTHELIAL GROWTH FACTOR SMALL INTERFERING RNA INHIBITS GROWTH AND LEAKAGE IN A NONHUMAN PRIMATE, LASER-INDUCED MODEL OF CHOROIDAL NEOVASCULARIZATION", RETINA, PHILADELPHIA, PA, US, no. 1, 1 February 2004 (2004-02-01), pages 132 - 138, XP009063917, ISSN: 0275-004X * |
Also Published As
Publication number | Publication date |
---|---|
WO2008045576A2 (en) | 2008-04-17 |
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