WO2008048620A3 - Gels with predetermined conductivity used in irreversible electroporation of tissue - Google Patents

Gels with predetermined conductivity used in irreversible electroporation of tissue Download PDF

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Publication number
WO2008048620A3
WO2008048620A3 PCT/US2007/022110 US2007022110W WO2008048620A3 WO 2008048620 A3 WO2008048620 A3 WO 2008048620A3 US 2007022110 W US2007022110 W US 2007022110W WO 2008048620 A3 WO2008048620 A3 WO 2008048620A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
gels
irreversible electroporation
predetermined conductivity
conductivity used
Prior art date
Application number
PCT/US2007/022110
Other languages
French (fr)
Other versions
WO2008048620A2 (en
Inventor
Antoni Ivorra
Boris Rubinsky
Original Assignee
Univ California
Antoni Ivorra
Boris Rubinsky
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Antoni Ivorra, Boris Rubinsky filed Critical Univ California
Priority to JP2009533353A priority Critical patent/JP2010506657A/en
Priority to EP07852804A priority patent/EP2076313A4/en
Publication of WO2008048620A2 publication Critical patent/WO2008048620A2/en
Publication of WO2008048620A3 publication Critical patent/WO2008048620A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416—Anode and cathode
    • A61N1/042—Material of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/329—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles characterised by features of the needle shaft
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation

Abstract

Gel compositions with adjusted conductivity are disclosed which compositions are used for directing reversible electroporation and irreversible electroporation of cells and tissue. The gel compositions are also used in a similar manner in order to carry out thermotherapy on cells and tissues.
PCT/US2007/022110 2006-10-16 2007-10-16 Gels with predetermined conductivity used in irreversible electroporation of tissue WO2008048620A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2009533353A JP2010506657A (en) 2006-10-16 2007-10-16 Gel with a certain conductivity used for irreversible electroporation of tissue
EP07852804A EP2076313A4 (en) 2006-10-16 2007-10-16 Gels with predetermined conductivity used in irreversible electroporation of tissue

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82958706P 2006-10-16 2006-10-16
US60/829,587 2006-10-16

Publications (2)

Publication Number Publication Date
WO2008048620A2 WO2008048620A2 (en) 2008-04-24
WO2008048620A3 true WO2008048620A3 (en) 2008-08-28

Family

ID=39314648

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/022110 WO2008048620A2 (en) 2006-10-16 2007-10-16 Gels with predetermined conductivity used in irreversible electroporation of tissue

Country Status (4)

Country Link
US (3) US7674249B2 (en)
EP (1) EP2076313A4 (en)
JP (1) JP2010506657A (en)
WO (1) WO2008048620A2 (en)

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EP2076313A2 (en) 2009-07-08
US7674249B2 (en) 2010-03-09
US8162918B2 (en) 2012-04-24
US20080214986A1 (en) 2008-09-04
JP2010506657A (en) 2010-03-04
US20120179091A1 (en) 2012-07-12
EP2076313A4 (en) 2012-07-25
US8348921B2 (en) 2013-01-08
US20100160850A1 (en) 2010-06-24
WO2008048620A2 (en) 2008-04-24

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