TRANSDERMAL THERAPY
The present application relates to the therapeutic substance Zolpidem. More particularly, the present application relates to the transdermal administration of Zolpidem. Zolpidem, iVjN,6-trimethyl-2-(4-methylphenyl)-imidazo[ 1 ,2-α]pyridine-3- acetamide (N,N,6-trimethyl-2-p-toylimidazo(l,2,-a)pyridine-3-acetamide), has been described as a selective benzodiazepine receptor agonist, and is commonly prescribed as a sedative and hypnotic drug for the short-term treatment of insomnia.
It is described in US4382938.
More recently, Benincasa described the use of imidazo[l,2- α]pyridine-3-acetamide derivatives, in particular Zolpidem, for the treatment of neuropsychiatric syndromes associated with dysfunction of the neural circuits of the basal ganglia (WO 96/31210). This use was based on the observation that Zolpidem prescribed as a sleep-inducing agent improved the symptoms of a patient having Parkinson's disease with obsessive-compulsive disorder and dementia.
Clauss et al, S. Afr. Med. J. (2000 Jan), 90(l):68-72, subsequently describe a study in which semi-comatose patients were aroused transiently from their permanent vegetative state after application of Zolpidem.
Further studies in animals have ascribed this effect to GABA(A) omega- 1 receptor- specific effects in the primate brain (Clauss et al., Arznein.-Forsch./Drug Res. (2001) 51(ll):619-622). The use of Zolpidem in progressive supranuclear palsy is described by Mayr et al.
(Eur. J. Neurol. (2002) 9(2)3:184-185).
More recently, Clauss and NeI describe the use of Zolpidem and related compounds, such as those described in WO 96/31210 having utility in diseases exhibiting diaschisis (WO 2004/100948). The content of WO 2004/100948 is herein incorporated by reference. Other compositions are described in WO2004/066930, WO91/03998. Diaschisis can be described as a sudden loss of function at a site in the brain at a distance from a lesion or site of injury. The term "diaschisis" comes from the Greek meaning "shocked throughout". The concept was first described by von Monakow in 1914, and offers an explanation as to the phenomenon of acute phase central nervous system disorder symptoms which are more extensive and of a different nature to those of the chronic phase. The mechanism by which diaschisis occurs is not clear.
Various specific pathways of diaschisis have been investigated. One particular example is called crossed cerebellar diaschisis (CCD), first described by Baron in 1980. This finding has been observed subsequently using SPECT perfusion imaging studies of patients having suffered cerebral strokes. Patients have been observed having a decreased blood flow in, inter alia, the cerebellum contralateral to the cerebral hemisphere injured by the stroke.
It is postulated that brain injury triggers a set of events that can result in a state of dormancy of normal neuronal tissue at a site close to, or (as in classical diaschisis) removed from the brain injury site, which may be a feature of a neuroprotective reaction of the brain during damage. It is now believed that the majority of brain injuries or brain pathologies have associated with them a neural dormancy or diaschisis.
Without wishing to be bound by theory, it is postulated that dormancy or diaschisis results from a structural change or abnormal folding of the GABA receptor molecule; an effect or state which can be reversed by Zolpidem's selective GABAergic stimulation of, in particular, the omega 1 receptors. WO 2004/100948 describes a study in which brain injured patients exhibiting symptoms of both dormant but viable brain tissue and dead, non- viable brain tissue were administered Zolpidem. In such circumstances this was found to result in the reversal of dormancy/diaschisis in viable neuronal tissue. This effect can occur in areas of classical diaschisis and in other areas that may not have previously been recognised (in what can be termed ipsilateral diaschisis etc.).
Zolpidem taken orally has a short half life (approximately 2 to 3 hours). WO 2004/100948 describes oral administration of Zolpidem, and the use of a depot for sustained release. It would be desirable, however, to prolong the release profile of administered
Zolpidem. Indeed, it is acknowledged in WO 2004/100948 that the benefit of Zolpidem in brain-injured patients is transient and it occurs for the duration of drug action only.
The .present invention is based on the discovery that imidazo[l,2-α]pyridine-3- acetamides, such as those described in WO 96/31210, and in particular, Zolpidem, can be effectively administered transdermally.
In addition, the present invention is based on the discovery that the therapeutic effect of Zolpidem, particularly when used for treating conditions of the brain which exhibit diaschisis and/or dormancy, is enhanced when it is administered with caffeine (1,3,7- trimethyl-lH-purine-2,6(3Hr,7H)-dione). In a first aspect of the present invention, there is provided a transdermal therapeutic formulation comprising an imidazo[l,2-α]ρyridine-3-acetamide and a carrier. The imidazo[l,2-α]pyridine-3-acetamide is preferably Zolpidem. The benefits of transdermal delivery include increased patient compliance, localized drug targeting, control over the rate of absorption and the avoidance of reduced bioavailability due to first pass metabolism effects in the liver.
Classic topical/transdermal delivery vehicles include ointments, creams, lotions, pastes and gels. In an especially advantageous embodiment, the Zolpidem is formulated as a transdermal patch; although the formulation of pharmaceuticals in a patch is a well known technology, transdermal patches are not suitable for every pharmaceutical. It had not previously been appreciated that Zolpidem could be formulated as a transdermal patch or that such a formulation would provide an effective means of delivery the pharmaceutical. The patch may be a preformed patch containing a single dosage of the imidazo[l,2-α]pyridine-3- acetamide. Alternatively, the patch may be a spray-on patch material, which sets into a patch or film once sprayed onto the skin. In this embodiment, the patch material may be stored in a dispensing device, operable to dispense a single dosage of the imidazo[l,2-α]pyridine-3- acetamide.
The patch may utilise a reservoir system, i.e., the patch comprises an impermeable backing layer, a reservoir containing the active material (e.g. Zolpidem) in a suitable solvent, and a rate limiting membrane, which controls diffusion of the active material therethrough to the skin of the patient. The rate limiting membrane may also be adhesive, whereby the patch can be adhered to the skin, or a separate adhesive layer may be provided.
Alternatively, the patch may utilise a matrix system, whereby the active material (e.g. Zolpidem) is dispersed or dissolved in a polymer. Such systems may utilise an impermeable
backing layer to which a layer of the polymer containing dispersed or dissolved active material may be attached. The polymer layer may be adhesive in itself, or a separate polymer layer may be applied to the polymer layer.
Transdermal patches are known in the art. It is to be appreciated that the present invention is not limited to a particular form of transdermal patch, and that variations may be made to the patch formulation to adjust the rate of API uptake, API dosage, pharmacokinetic properties, pharmacodynamic properties, size, etc., without departing from the principles of present invention.
Reference is made to Figure 1, which is a schematic cross-sectional view of a transdermal patch according to the invention.
In figure 1, a patch generally designated 10 comprises a back layer 12, a reservoir 14 containing an active material, such as Zolpidem, in solution, a permeable membrane 16, which controls delivery of the active material to the skin, and adhesive layer 18 which serves to adhere the patch 10 to the skin, and a releasable protective layer 20, which may be peeled away from the other layers when it is desired to apply the patch to the skin of a patient.
In another aspect of the invention, there is provided the use of an imidazo[l,2- α]pyridine-3-acetamide in the manufacture of a medicament, wherein the medicament is suitable for transdermal administration to a subject in need thereof.
In another aspect of the invention, there is provided a pharmaceutical composition comprising an imidazo[l,2-α]pyridine-3-acetamide and caffeine.
In another aspect of the invention, there is provided the use of an imidazo[l,2- α]pyridine-3-acetamide and caffeine in the manufacture of a medicament for the treatment of conditions of the brain which has a lesion and/ which or exhibits diaschisis/dormant cells.
Preferably, the imidazo[l,2-α]pyridine-3-acetamide is Zolpidem. Administration of Zolpidem can result in drowsiness. The combination of Zolpidem and caffeine according to the present invention can offset the drowsiness imparted by the Zolpidem, thereby improving the functionality of the treatment.
The present invention may be useful for the treatment of conditions of the brain which has a lesion or exhibits diaschisis/dormant cells. Examples of such conditions are described in WO 2004/100948. The invention may help reverse dormancy or diaschisis, or non- functionality induced by ischaemia or post-ischaemia or brain damage, in viable neuronal tissue. This can result in the reversal of brain damage effects. This effect can occur in areas
of classical diaschisis and in other areas which may not have previously been recognised as exhibiting diaschisis.
The present invention is of particularly benefit to patients suffering from trauma- induced injury, but who do not exhibit akinesia or tremor, as in Parkinsonism. In particular, the patient may have lost cognition, e.g. have had a cerebellar or cerebral infarct such as in a stroke. The patient may exhibit cortical dysfunction, ataxia, e.g. spinocerebellar ataxia, or other symptoms related to ischaemic injury or brain damage. Other conditions are ruptured brain aneurism and intracerebral bleed. Alternatively or in addition, the patient may exhibit one or more of strabismus, salivation and muscle spasm, or impaired swallowing, smell or taste, or require long-term rehabilitation, e.g. over a period of a month or up to a year or more.
The present invention may also benefit patients suffering from Ramsay-Hunt syndrome, a complication of Herpes Zoster infection. According to some authors, many cases previously described as exhibiting Ramsay-Hunt syndrome, as well as other hitherto unclassified system degenerations associated with myoclonus epilepsy, are examples of myoclonus, epilepsy and ragged red fibres (MERRF).
In addition, patients suffering from vascular and multi-infarct dementia, and Bell's palsy (e.g. of cerebral origin) may be benefited by the present invention.
The invention may lead to increased mobility and functionality in the patient, and the patient may exhibit regeneration.
We have also found that Zolpidem may also be used in the treatment of a number of conditions not previously mentioned in the prior art. Thus according to another aspect of the invention, there is provided the use of imidazo[l,2-α]pyridine-3-acetamide, preferably Zolpidem, in the manufacture of a medicament for treating: 1. Chemotherapy or radiation damage to the brain (after radiotherapy- so called
'radiotherapy fog1 and 'chemo fog').
2. Obsessive Compulsive disorder.
3. Depression.
4. Panic attacks. 5. Central sleep apnoea syndrome.
6. Central auditory impairment The disorders may involve diaschisis and/or dormancy.
We have also found that the administration of Zolpidem may be effective to permanently restore dormant cells to normalcy, i.e., previously dormant cells become permanently functional after the administration of Zolpidem or other imidazo[l,2-α]pyridine- 3-acetamides. The dosage of Zolpidem administered in the present invention may be any suitable sufficient to have therapeutic effect. Typical dosages may be, for example, from 1 to lOOmg per day. The administration may be via transdermal means, eg patch, as described above, or via oral route, such as tablet or sublingual. Sustained release administration is possible either via transdermal or oral route. The imidazo[l,2-α]pyridine-3-acetamide is preferably Zolpidem. The imidazo[l,2- α]pyridine-3-acetamide may be formulated as a patch, as described above. In addition, the imidazo[l,2-α]pyridine-3-acetamide may be formulated with caffeine as described above.
The transdermal formulation may be a conventional transdermal formulation as described in the prior art. Thus the formulation may be provided in the form of a transdermal cream or gel containing the active agent, such as Zolpidem or a salt thereof, and any desirable pharmaceutically acceptable carrier. In addition, the formulation may be provided in the form of a transdermal release layer which is coated with, or impregnated with the active agent, such as Zolpidem or a salt thereof, and any desirable pharmaceutically acceptable carrier.
In all the above embodiments, the Zolpidem may be provided in the form of the tartrate salt, but it is preferably provided in the form of the hemitartrate salt, or a salt having a molecular weight lower than or equal to the molecular weight of the hemitartrate salt.
The compositions according to the invention may also be used in the treatment of patients with auditory impairment (for example hearing loss).
The dosage of Zolpidem administered in the present invention may be any suitable sufficient to have therapeutic effect. Typical dosages may be, for example, from 1 to lOOmg per day.
In a another aspect of the present invention, there is provided the use of an imidazo[l,2-α]pyridine-3-acetamide in the manufacture of a medicament for treating leukoencephalopathy. In another aspect of the present invention, there is provided the use of an imidazo [ 1 ,2- α]pyridine-3-acetamide in the manufacture of a medicament for treating heavy metal poisoning.
The imidazo[l,2-α]pyridine-3-acetamide is preferably Zolpidem. The imidazo[l,2- α]pyridine-3-acetamide may be formulated as a patch, as described above, hi addition, the imidazo[l,2-α]pyridine-3-acetamide maybe formulated with caffeine as described above.
The transdermal formulation may be a conventional transdermal formulation as described in the prior art. Thus the formulation may be provided in the form of a transdermal cream or gel containing the active agent, such as Zolpidem or a salt thereof, and any desirable pharmaceutically acceptable carrier. In addition, the formulation may be provided in the form of a transdermal release layer which is coated with, or impregnated with the active agent, such as Zolpidem or a salt thereof, and any desirable pharmaceutically acceptable carrier. In all the above embodiments, the Zolpidem may be provided in the form of the hemitartrate salt, or preferably a lower molecular weight salt.