WO2008060378A3 - Glycomimetic replacements for hexoses and n-acetyl hexosamines - Google Patents

Glycomimetic replacements for hexoses and n-acetyl hexosamines Download PDF

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Publication number
WO2008060378A3
WO2008060378A3 PCT/US2007/021541 US2007021541W WO2008060378A3 WO 2008060378 A3 WO2008060378 A3 WO 2008060378A3 US 2007021541 W US2007021541 W US 2007021541W WO 2008060378 A3 WO2008060378 A3 WO 2008060378A3
Authority
WO
WIPO (PCT)
Prior art keywords
glycomimetic
hexoses
replacements
hexosamines
acetyl
Prior art date
Application number
PCT/US2007/021541
Other languages
French (fr)
Other versions
WO2008060378A2 (en
Inventor
Beat Ernst
Daniel Schwizer
Arun K Sarkar
John L Magnani
Original Assignee
Glycomimetics Inc
Beat Ernst
Daniel Schwizer
Arun K Sarkar
John L Magnani
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycomimetics Inc, Beat Ernst, Daniel Schwizer, Arun K Sarkar, John L Magnani filed Critical Glycomimetics Inc
Priority to JP2009532370A priority Critical patent/JP5298020B2/en
Priority to CA2666103A priority patent/CA2666103C/en
Priority to EP07867214.4A priority patent/EP2074132B1/en
Publication of WO2008060378A2 publication Critical patent/WO2008060378A2/en
Publication of WO2008060378A3 publication Critical patent/WO2008060378A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/207—Cyclohexane rings not substituted by nitrogen atoms, e.g. kasugamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Compounds and methods are provided for obtaining oligosaccharide mimics. More specifically, compounds and methods are described wherein oligosaccharide mimics are obtained by incorporating or substituting in a cyclohexane derivative.
PCT/US2007/021541 2006-10-12 2007-10-09 Glycomimetic replacements for hexoses and n-acetyl hexosamines WO2008060378A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009532370A JP5298020B2 (en) 2006-10-12 2007-10-09 Glucose mimic substitution of hexose and N-acetylhexosamine
CA2666103A CA2666103C (en) 2006-10-12 2007-10-09 Glycomimetic replacements for hexoses and n-acetyl hexosamines
EP07867214.4A EP2074132B1 (en) 2006-10-12 2007-10-09 Glycomimetic replacements for hexoses and n-acetyl hexosamines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85146706P 2006-10-12 2006-10-12
US60/851,467 2006-10-12

Publications (2)

Publication Number Publication Date
WO2008060378A2 WO2008060378A2 (en) 2008-05-22
WO2008060378A3 true WO2008060378A3 (en) 2008-10-02

Family

ID=39402172

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/021541 WO2008060378A2 (en) 2006-10-12 2007-10-09 Glycomimetic replacements for hexoses and n-acetyl hexosamines

Country Status (5)

Country Link
US (2) US7964569B2 (en)
EP (1) EP2074132B1 (en)
JP (2) JP5298020B2 (en)
CA (1) CA2666103C (en)
WO (1) WO2008060378A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3

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AU2008336249B2 (en) 2007-12-10 2015-01-29 The University Of Queensland Treatment and prophylaxis
CN102421441B (en) 2009-05-01 2015-04-01 糖模拟物有限公司 Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors
JPWO2011040574A1 (en) * 2009-09-30 2013-02-28 国立大学法人京都大学 Method for producing azetidinylmethoxypyridine derivative and use thereof
WO2012061662A1 (en) 2010-11-03 2012-05-10 Glycomimetics, Inc. Glycomimetic-peptidomimetic inhibitors of e-selectins and cxcr4 chemokine receptors
PL2794626T6 (en) * 2011-12-22 2020-11-02 Glycomimetics, Inc. E-selectin antagonist compounds
EP2928476B1 (en) 2012-12-07 2018-02-14 GlycoMimetics, Inc. Compounds, compositions and methods using e-selectin antagonists for mobilization of hematopoietic cells
WO2014149837A1 (en) * 2013-03-15 2014-09-25 Glycomimetics, Inc. Compounds and methods to enhance the oral availability of glycomimetics
US20160333043A1 (en) * 2014-01-17 2016-11-17 Glycomimetics, Inc. E-Selectin Antagonists Modified By Macrocycle Formation to the Galactose
HUE045542T2 (en) 2014-12-03 2019-12-30 Glycomimetics Inc Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors
US11045485B2 (en) * 2016-01-22 2021-06-29 Glycomimetics, Inc. Glycomimetic inhibitors of PA-IL and PA-IIL lectins
US11291678B2 (en) 2016-03-02 2022-04-05 Glycomimetics, Inc Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin
US11433086B2 (en) 2016-08-08 2022-09-06 Glycomimetics, Inc. Combination of T-cell checkpoint inhibitors with inhibitors of e-selectin or CXCR4, or with heterobifunctional inhibitors of both E-selectin and CXCR4
CA3037850A1 (en) * 2016-10-07 2018-04-12 Glycomimetics, Inc. Highly potent multimeric e-selectin antagonists
US11197877B2 (en) 2017-03-15 2021-12-14 Glycomimetics. Inc. Galactopyranosyl-cyclohexyl derivauves as E-selectin antagonists
WO2019108750A1 (en) 2017-11-30 2019-06-06 Glycomimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
CN111566117A (en) 2017-12-29 2020-08-21 糖模拟物有限公司 Heterobifunctional inhibitors of E-selectin and galectin-3
CA3091454A1 (en) 2018-03-05 2019-09-12 Glycomimetics, Inc. Methods for treating acute myeloid leukemia and related conditions
WO2020219417A1 (en) 2019-04-24 2020-10-29 Glycomimetics, Inc. Galactose-linked multimeric glycomimetic inhibitors of e-selectins, galectin-3, and/or cxcr4 chemokine receptors

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Cited By (2)

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Publication number Priority date Publication date Assignee Title
US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3

Also Published As

Publication number Publication date
CA2666103C (en) 2014-02-18
CA2666103A1 (en) 2008-05-22
EP2074132B1 (en) 2013-05-15
US7964569B2 (en) 2011-06-21
EP2074132A2 (en) 2009-07-01
WO2008060378A2 (en) 2008-05-22
JP2013189471A (en) 2013-09-26
JP2010506832A (en) 2010-03-04
JP5298020B2 (en) 2013-09-25
US20080161546A1 (en) 2008-07-03
US20110257380A1 (en) 2011-10-20

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