WO2008063995A3 - Needle-less injector and method of fluid delivery - Google Patents

Needle-less injector and method of fluid delivery Download PDF

Info

Publication number
WO2008063995A3
WO2008063995A3 PCT/US2007/084510 US2007084510W WO2008063995A3 WO 2008063995 A3 WO2008063995 A3 WO 2008063995A3 US 2007084510 W US2007084510 W US 2007084510W WO 2008063995 A3 WO2008063995 A3 WO 2008063995A3
Authority
WO
WIPO (PCT)
Prior art keywords
spring
inner housing
hammer
dose
syringe
Prior art date
Application number
PCT/US2007/084510
Other languages
French (fr)
Other versions
WO2008063995A2 (en
WO2008063995A9 (en
Inventor
John Bingham
Robert Steinway
Original Assignee
Pharmajet Inc
John Bingham
Robert Steinway
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmajet Inc, John Bingham, Robert Steinway filed Critical Pharmajet Inc
Priority to EA200900682A priority Critical patent/EA200900682A1/en
Priority to EP07864321A priority patent/EP2089085A2/en
Priority to JP2009537307A priority patent/JP2010509030A/en
Priority to BRPI0718847-1A priority patent/BRPI0718847A2/en
Publication of WO2008063995A2 publication Critical patent/WO2008063995A2/en
Publication of WO2008063995A9 publication Critical patent/WO2008063995A9/en
Publication of WO2008063995A3 publication Critical patent/WO2008063995A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
    • A61M2005/208—Release is possible only when device is pushed against the skin, e.g. using a trigger which is blocked or inactive when the device is not pushed against the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/60—General characteristics of the apparatus with identification means
    • A61M2205/6063—Optical identification systems
    • A61M2205/6081—Colour codes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/002—Packages specially adapted therefor, e.g. for syringes or needles, kits for diabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/42—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
    • A61M5/425—Protruding skin to facilitate piercing, e.g. vacuum cylinders, vein immobilising means

Abstract

A needle-less injector device (10) for delivering a dose of fluid intradermally, subcutaneously or intramuscularly to an animal or human. The device includes an inner housing (12) having opposed ends. A syringe (18) is disposed in one end of the inner housing. The syringe includes a nozzle (40) for delivering a dose of fluid held within the syringe. A plunger (38) is movably disposed within the syringe. A spring powered hammer (44) is movably disposed within the inner housing. The hammer cooperates with the plunger to drive the dose of medicament from the nozzle. An injection delivery spring (36) for powering the hammer is positioned and compressed between the other end of the inner housing and the spring powered hammer. An outer housing (28) slideably supports the inner housing. A skin tensioning spring (30) is mounted between the inner housing and the outer housing, the skin tensioning spring biasing the nozzle, of the syringe against the animal or human. A trigger mechanism (32) is disposed in the outer housing, the trigger mechanism cooperating with the spring powered hammer to release the injection delivery spring, wherein the size of the injection delivery spring and the length of the hammer dictate the amount of dose delivered and whether the dose is delivered intradermally, subcutaneously or intramuscularly to an animal or human.
PCT/US2007/084510 2006-11-13 2007-11-13 Needle-less injector and method of fluid delivery WO2008063995A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EA200900682A EA200900682A1 (en) 2006-11-13 2007-11-13 RUNNING INJECTOR AND METHOD FOR ADMINISTRATING SOLUTIONS
EP07864321A EP2089085A2 (en) 2006-11-13 2007-11-13 Needle-less injector and method of fluid delivery
JP2009537307A JP2010509030A (en) 2006-11-13 2007-11-13 Needleless syringe and fluid delivery method
BRPI0718847-1A BRPI0718847A2 (en) 2006-11-13 2007-11-13 UNPROVED NEEDLE GUN AND FLUID DISPENSE METHOD

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/598,193 2006-11-13
US11/598,193 US7618393B2 (en) 2005-05-03 2006-11-13 Needle-less injector and method of fluid delivery

Publications (3)

Publication Number Publication Date
WO2008063995A2 WO2008063995A2 (en) 2008-05-29
WO2008063995A9 WO2008063995A9 (en) 2008-09-18
WO2008063995A3 true WO2008063995A3 (en) 2008-10-30

Family

ID=39149747

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/084510 WO2008063995A2 (en) 2006-11-13 2007-11-13 Needle-less injector and method of fluid delivery

Country Status (7)

Country Link
US (7) US7618393B2 (en)
EP (1) EP2089085A2 (en)
JP (1) JP2010509030A (en)
CN (1) CN101631581A (en)
BR (1) BRPI0718847A2 (en)
EA (1) EA200900682A1 (en)
WO (1) WO2008063995A2 (en)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6942638B1 (en) * 2002-05-30 2005-09-13 Kerry Quinn Needleless injector and ampule system
GB2414402B (en) 2004-05-28 2009-04-22 Cilag Ag Int Injection device
GB2414400B (en) 2004-05-28 2009-01-14 Cilag Ag Int Injection device
GB2414775B (en) 2004-05-28 2008-05-21 Cilag Ag Int Releasable coupling and injection device
GB2427826B (en) 2005-04-06 2010-08-25 Cilag Ag Int Injection device comprising a locking mechanism associated with integrally formed biasing means
GB2424836B (en) 2005-04-06 2010-09-22 Cilag Ag Int Injection device (bayonet cap removal)
GB2425062B (en) 2005-04-06 2010-07-21 Cilag Ag Int Injection device
US20070027428A1 (en) * 2005-05-03 2007-02-01 Pharmajet, Inc. Vial system and method for needle-less injector
US7699802B2 (en) * 2005-05-03 2010-04-20 Pharmajet, Inc. Needle-less injector
US7618393B2 (en) 2005-05-03 2009-11-17 Pharmajet, Inc. Needle-less injector and method of fluid delivery
DE602005018480D1 (en) 2005-08-30 2010-02-04 Cilag Gmbh Int Needle device for a prefilled syringe
US20110098656A1 (en) 2005-09-27 2011-04-28 Burnell Rosie L Auto-injection device with needle protecting cap having outer and inner sleeves
GB2438593B (en) 2006-06-01 2011-03-30 Cilag Gmbh Int Injection device (cap removal feature)
GB2438590B (en) * 2006-06-01 2011-02-09 Cilag Gmbh Int Injection device
GB2438591B (en) 2006-06-01 2011-07-13 Cilag Gmbh Int Injection device
CN102112167A (en) * 2008-03-07 2011-06-29 医用注射器公司 Intradermal injector and uses thereof
GB2461086B (en) 2008-06-19 2012-12-05 Cilag Gmbh Int Injection device
GB2461084B (en) 2008-06-19 2012-09-26 Cilag Gmbh Int Fluid transfer assembly
GB2461085B (en) 2008-06-19 2012-08-29 Cilag Gmbh Int Injection device
US8805466B2 (en) 2008-11-11 2014-08-12 Shifamed Holdings, Llc Low profile electrode assembly
US9795442B2 (en) 2008-11-11 2017-10-24 Shifamed Holdings, Llc Ablation catheters
EP2229971A1 (en) 2009-03-17 2010-09-22 Sanofi-Aventis Deutschland GmbH Trigger mechanism for a drug delivery device
EP2438198A4 (en) * 2009-06-01 2014-05-14 Inviragen Inc Compositions and methods for administration of vaccines against dengue virus
US8968996B2 (en) 2009-06-01 2015-03-03 Takeda Vaccines, Inc. Compositions and methods for rapid immunization against dengue virus
JP4754645B2 (en) * 2009-12-22 2011-08-24 株式会社 資生堂 Massage equipment
WO2011119857A2 (en) 2010-03-24 2011-09-29 Shifamed, Llc Intravascular tissue disruption
US9655677B2 (en) 2010-05-12 2017-05-23 Shifamed Holdings, Llc Ablation catheters including a balloon and electrodes
US10045911B2 (en) * 2010-06-25 2018-08-14 Genetronics, Inc. Intradermal injection device
JP5940064B2 (en) 2010-07-06 2016-06-29 ノバルティス アーゲー Immunization of large mammals with low doses of RNA
LT3243526T (en) 2010-07-06 2020-02-10 Glaxosmithkline Biologicals S.A. Delivery of rna to trigger multiple immune pathways
US9770463B2 (en) * 2010-07-06 2017-09-26 Glaxosmithkline Biologicals Sa Delivery of RNA to different cell types
PL2590676T3 (en) 2010-07-06 2017-02-28 Glaxosmithkline Biologicals Sa Virion-like delivery particles for self-replicating rna molecules
BR112013000244A2 (en) 2010-07-06 2016-05-17 Novartis Ag lipid liposomes having advantageous pka for administration of rna
SI2611461T1 (en) 2010-08-31 2022-08-31 Glaxosmithkline Biologicals Sa Pegylated liposomes for delivery of immunogen-encoding rna
AU2011316707A1 (en) 2010-10-11 2013-05-09 Novartis Ag Antigen delivery platforms
WO2012096889A1 (en) * 2011-01-10 2012-07-19 Zogenix, Inc. Improved needle free injectors
ES2656050T3 (en) 2011-07-06 2018-02-22 Glaxosmithkline Biologicals Sa Immunogenic combination compositions and uses thereof
US9408972B2 (en) 2011-08-02 2016-08-09 Pharmajet, Inc. Needle-free injection device
MX350583B (en) * 2011-12-13 2017-09-11 Pharmajet Inc Needle-free intradermal injection device.
AU2013212265B2 (en) * 2012-01-23 2017-10-12 Shifamed Holdings, Llc Intravascular tissue disruption
WO2013188459A2 (en) * 2012-06-11 2013-12-19 Hns International, Inc. Lancet devices without needle and related methods
US11207241B2 (en) 2013-03-15 2021-12-28 Phd Preventative Health Care And Diagnostics, Inc. Prefilled medication device, method of making and using the same
US10349824B2 (en) 2013-04-08 2019-07-16 Apama Medical, Inc. Tissue mapping and visualization systems
US10098694B2 (en) 2013-04-08 2018-10-16 Apama Medical, Inc. Tissue ablation and monitoring thereof
CA2908517A1 (en) 2013-04-08 2014-10-16 Apama Medical, Inc. Cardiac ablation catheters and methods of use thereof
CN105120931A (en) * 2013-04-19 2015-12-02 诺和诺德股份有限公司 Drug delivery device with compact power unit
EP3003439B1 (en) * 2013-05-27 2021-06-23 Sanofi-Aventis Deutschland GmbH Assembly for a drug delivery device and drug delivery device
GB2517896B (en) 2013-06-11 2015-07-08 Cilag Gmbh Int Injection device
GB2515038A (en) 2013-06-11 2014-12-17 Cilag Gmbh Int Injection device
GB2515039B (en) 2013-06-11 2015-05-27 Cilag Gmbh Int Injection Device
GB2515032A (en) 2013-06-11 2014-12-17 Cilag Gmbh Int Guide for an injection device
GB2515040B (en) * 2013-06-11 2019-12-11 Cilag Gmbh Int Sliding Sleeve Attachment for an Injection Device
IL297356A (en) 2014-06-03 2022-12-01 Amgen Inc Controllable drug delivery system and method of use
US10799630B2 (en) 2014-12-19 2020-10-13 Amgen Inc. Drug delivery device with proximity sensor
ES2785311T3 (en) 2014-12-19 2020-10-06 Amgen Inc Mobile button drug delivery device or user interface field
CA2987959A1 (en) * 2015-07-06 2017-01-12 Merit Medical Systems, Inc. Reinforced syringe body
WO2017087549A1 (en) 2015-11-16 2017-05-26 Apama Medical, Inc. Energy delivery devices
KR102430181B1 (en) * 2015-11-27 2022-08-11 (주)아모레퍼시픽 Drug injection device for skin treatment
CN105413023A (en) * 2016-01-04 2016-03-23 苏州肯美威机械制造有限公司 Needless injector
KR20190039109A (en) * 2016-07-15 2019-04-10 게이트 사이언티픽 인코포레이티드 Wireless Sensing Characteristics of a Closed Environment and Its Apparatus
CN106421994A (en) * 2016-08-29 2017-02-22 南昌禾雅堂贸易有限公司 Automatic needle-free injection device with optical scanning feedback function
EP4147655A1 (en) * 2016-08-31 2023-03-15 DePuy Synthes Products, Inc. Orthopedic impacting device having a launched mass delivering a controlled, repeatable & reversible impacting force
KR101863355B1 (en) * 2016-12-01 2018-06-01 한국기계연구원 A Pressure-Increasing Needle Free Syringe for Variable Injection
EP3710100A4 (en) 2017-11-13 2021-08-11 Merit Medical Systems, Inc. Staged deflation syringe systems and associated methods
JP6526897B1 (en) * 2018-11-12 2019-06-05 昌樹 松本 High viscosity enteral nutrition suction adapter
KR20200082043A (en) * 2018-12-28 2020-07-08 주식회사 지티지웰니스 Device for injecting drug
US11793621B2 (en) 2019-02-27 2023-10-24 Hoodoo Voodoo, LLC. Dental anesthetic delivery devices and associated methods
US11752269B2 (en) * 2019-12-18 2023-09-12 Integrimedical Llc Spring loaded medical needle-free injection system
CN111110958B (en) * 2020-02-06 2021-08-17 唐文珍 Syringe used in medical field
CN115591055B (en) * 2022-08-24 2023-11-07 江苏乐聚医药科技有限公司 Differential needleless injector

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1093826A1 (en) * 1999-10-18 2001-04-25 Terumo Kabushiki Kaisha Pre-filled syringe
US20030132547A1 (en) * 1993-11-03 2003-07-17 Gayle Heffernan Method for the preparation of pre-filled plastic syringes
US20060089593A1 (en) * 2004-10-26 2006-04-27 Sergio Landau Needle-free injection device for individual users
WO2006106291A1 (en) * 2005-04-06 2006-10-12 Cilag Ag International Injection device
WO2006118616A1 (en) * 2005-05-03 2006-11-09 Pharmajet, Incorporated Needle-less injector

Family Cites Families (119)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE24419E (en) * 1958-01-21 Ziherl et au
CA569887A (en) 1959-02-03 P. Scherer Robert Hypo jet injector
US2704543A (en) * 1955-03-22 Hypo jet injector
US569887A (en) * 1896-10-20 Scraper
US2517099A (en) * 1946-12-23 1950-08-01 Hilma C Gettner Universal paint striper
US2800903A (en) * 1947-07-30 1957-07-30 Becton Dickinson Co Injection apparatus
US2605763A (en) * 1948-01-31 1952-08-05 Becton Dickinson Co Injection device
US2547099A (en) * 1948-03-11 1951-04-03 Becton Dickinson Co Injection device and ampoule
US2704542A (en) * 1949-02-21 1955-03-22 Scherer Corp R P Jet therapy method
US2699166A (en) * 1949-07-29 1955-01-11 Becton Dickinson Co Hypodermic injection unit
US2737946A (en) * 1949-09-01 1956-03-13 Jr George N Hein Hypodermic injection apparatus
US2687724A (en) * 1950-03-02 1954-08-31 Geoffrey W Walker Inoculant injector instrument
US2645223A (en) * 1951-02-17 1953-07-14 Becton Dickinson Co Injection device
US2764977A (en) * 1951-05-24 1956-10-02 Becton Dickinson Co Hypodermic injection mechanism
US2635601A (en) * 1951-11-15 1953-04-21 Becton Dickinson Co Injection device
US2821193A (en) * 1952-07-22 1958-01-28 Geoffrey W Walker Multiple injection inoculator instrument
US2821981A (en) * 1954-07-21 1958-02-04 Geoffrey W Walker Multi-shot inoculant injector instrument with adjustable ejection pressure control
US3057349A (en) * 1959-12-14 1962-10-09 Ismach Aaron Multi-dose jet injection device
GB964585A (en) * 1960-03-23
US3138157A (en) * 1961-05-12 1964-06-23 Z & W Mfg Corp Inoculant injector instrument
US3115133A (en) * 1962-05-15 1963-12-24 Morando Emilio Donald Needleless prefilled disposable hypodermic injector
US3202151A (en) * 1963-04-08 1965-08-24 Scherer Corp R P Multidose jet injector
US3292621A (en) * 1963-07-19 1966-12-20 Oscar H Banker Jet type protable inoculator
US3335722A (en) * 1963-11-01 1967-08-15 Olin Mathieson Hypodermic device
US3292622A (en) * 1964-09-21 1966-12-20 Oscar H Banker Power operated inoculator
US3424154A (en) * 1965-11-08 1969-01-28 Charles W Kinsley Injection system
US3461867A (en) * 1966-03-14 1969-08-19 Mizzy Inc Needleless injector
US3540444A (en) * 1968-01-15 1970-11-17 Scherer Corp R P Plastic ampoule for use with hypodermic injector
US3688765A (en) * 1969-10-03 1972-09-05 Jack S Gasaway Hypodermic injection device
US3695266A (en) * 1970-06-18 1972-10-03 Maurice G Lussier Needleless sequential dosing syringe
US3714943A (en) * 1970-12-01 1973-02-06 H Yanof Medicament injectors
US3805783A (en) * 1971-02-12 1974-04-23 A Ismach Hand powered hypodermic jet injector gun
US3788315A (en) * 1971-04-20 1974-01-29 S Laurens Disposable cutaneous transjector
US3853125A (en) * 1971-10-05 1974-12-10 W Clark Disposable needleless injector
US3763859A (en) * 1971-11-11 1973-10-09 Pigmy Health Prod Inc Injector apparatus
US3763359A (en) * 1972-05-15 1973-10-02 Bell Telephone Labor Inc Apparatus for equalizing a transmission system
US3815594A (en) * 1972-08-10 1974-06-11 N Doherty Needleless inoculator
US3859996A (en) * 1973-07-18 1975-01-14 Mizzy Inc Multi-dose injector
SE399514B (en) * 1974-04-02 1978-02-20 Sarstedt Kunststoff DEVICE FOR CONSTRUCTION OF BLOOD TAKING DEVICES FOR THE ESTABLISHMENT OF A PRESSURE IN THESE
US3908651A (en) * 1974-05-17 1975-09-30 Daystrol Scient Inc Medicament injection device
US3945379A (en) * 1974-08-08 1976-03-23 Smithkline Corporation Injection device
US3945383A (en) * 1974-08-08 1976-03-23 Smithkline Corporation Unit dose ampul for jet injector
US3933155A (en) * 1975-01-23 1976-01-20 Mizzy Inc. Pressure injector apparatus having improved trigger mechanism
US4031889A (en) * 1975-03-25 1977-06-28 William Floyd Pike Power operated aspirating hypodermic syringe
JPS51130094A (en) * 1975-05-08 1976-11-12 Asahi Chemical Ind Twoostage pressure injector
US4089334A (en) * 1976-10-07 1978-05-16 Schwebel Paul R Pyrotechnically powered needleless injector
US4128098A (en) * 1976-12-06 1978-12-05 American Hospital Supply Corporation Valved spike transfer device
US4103684A (en) * 1976-12-30 1978-08-01 Aaron Ismach Hydraulically powered hypodermic injector with adapters for reducing and increasing fluid injection force
US4124024A (en) * 1977-03-03 1978-11-07 Schwebel Paul R Disposable hypodermic injection ampule
DE2832252A1 (en) * 1978-07-22 1980-01-31 Hoechst Ag VACCINE GUN
US4342310A (en) * 1980-07-08 1982-08-03 Istvan Lindmayer Hydro-pneumatic jet injector
US4329988A (en) * 1980-12-23 1982-05-18 Survival Technology, Inc. Plural injection assembly
US4421508A (en) * 1981-02-24 1983-12-20 Cohen Edgar C Vacuum-compression injector
US4403609A (en) * 1981-02-24 1983-09-13 Cohen Edgar C Vacuum-compression injector
DE3115373A1 (en) * 1981-04-16 1982-11-11 Hoechst Ag, 6000 Frankfurt NEEDLE-FREE INJECTION DEVICE
US4403989A (en) * 1981-09-14 1983-09-13 Syntex (U.S.A.) Inc. Injection device
US4447225A (en) * 1982-03-22 1984-05-08 Taff Barry E Multidose jet injector
CA1178503A (en) * 1982-05-27 1984-11-27 Health-Mor Personal Care Corporation Needleless hypodermic injector
US4475905A (en) * 1982-09-30 1984-10-09 Himmelstrup Anders B Injection device
US4507113A (en) * 1982-11-22 1985-03-26 Derata Corporation Hypodermic jet injector
US4518385A (en) * 1983-06-13 1985-05-21 Preci-Tech Ltd. Disposable syringe for needleless injector
BR8404286A (en) * 1984-08-28 1986-04-08 Sergio Landau PRESSURE HYPODERMIC SYRINGE
US4596556A (en) * 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
US4680027A (en) * 1985-12-12 1987-07-14 Injet Medical Products, Inc. Needleless hypodermic injection device
US4722728A (en) * 1987-01-23 1988-02-02 Patents Unlimited, Ltd. Needleless hypodermic injector
US5578015A (en) * 1989-09-18 1996-11-26 Robb Pascal Patent Limited Safety syringe incorporating automatic needle holder release
US5312335A (en) * 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
US5106371A (en) * 1990-02-28 1992-04-21 Mo Zhao Clinical Syringe to be rendered useless after being used once
DK285990A (en) * 1990-11-30 1992-05-31 Nujenko Pty Ltd SPRAY UNIT
US5123684A (en) * 1991-05-17 1992-06-23 Yeh Ming Tien Door lock with invertable bolt
BR9103269A (en) * 1991-07-18 1993-02-24 Fernando Antonio Franco Da Enc SELF-DESTRUCTIVE SYRINGE
US5211628A (en) * 1991-09-30 1993-05-18 Marshall John M Syringe with automatic retracting needle
WO1994007554A1 (en) 1992-09-28 1994-04-14 Equidyne Systems, Incorporated Hypodermic jet injector
US5569189A (en) 1992-09-28 1996-10-29 Equidyne Systems, Inc. hypodermic jet injector
US5312348A (en) * 1993-07-30 1994-05-17 Sans Ten S Single-usage disposable hypodermic syringe
US5891086A (en) 1993-07-31 1999-04-06 Weston Medical Limited Needle-less injector
DE4332308C1 (en) * 1993-09-23 1994-09-29 Heraeus Kulzer Gmbh Syringe for the metered dispensing of viscous materials, especially of dental materials
US5569181A (en) 1993-10-28 1996-10-29 Medrad, Inc. Sterility assurance for contrast delivery system
US5397313A (en) * 1994-01-27 1995-03-14 The Kendall Company Low friction syringe
WO1995024176A1 (en) * 1994-03-07 1995-09-14 Bioject, Inc. Ampule filling device
US5527284A (en) * 1994-05-18 1996-06-18 Randall E. Ohnemus Single use syringes
US5599302A (en) * 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
US5569203A (en) * 1995-06-23 1996-10-29 Chen; Long-Hsiung Simplified safety syringe with retractable self-biased needle and minimized plunger
US5575774A (en) * 1995-10-24 1996-11-19 Chen; Long-Hsiung Structure of safety hypodermic syringe
US5899879A (en) * 1995-12-19 1999-05-04 Genesis Medical Technologies, Inc. Spring-actuated needleless injector
US5865795A (en) * 1996-02-29 1999-02-02 Medi-Ject Corporation Safety mechanism for injection devices
US5782802A (en) 1996-03-22 1998-07-21 Vitajet Corporation Multiple use needle-less hypodermic injection device for individual users
US5769138A (en) 1996-04-01 1998-06-23 Medi-Ject Corporation Nozzle and adapter for loading medicament into an injector
US6053895A (en) * 1996-11-05 2000-04-25 Schering Aktiengesellschaft Syringe with a new and improved plug
US5993412A (en) 1997-05-19 1999-11-30 Bioject, Inc. Injection apparatus
US6224577B1 (en) 1998-03-02 2001-05-01 Medrad, Inc. Syringes and plungers for use therein
WO2000006227A1 (en) * 1998-07-27 2000-02-10 Medi-Ject Corporation Loading mechanism for medical injector assembly
US6506177B2 (en) 1998-10-14 2003-01-14 Sergio Landau Needle-less injection system
US6319224B1 (en) 1999-08-20 2001-11-20 Bioject Medical Technologies Inc. Intradermal injection system for injecting DNA-based injectables into humans
US6673035B1 (en) * 1999-10-22 2004-01-06 Antares Pharma, Inc. Medical injector and medicament loading system for use therewith
US6398763B1 (en) * 2000-02-16 2002-06-04 Ultradent Products, Inc. Syringe apparatus having a plunger tip with a flexible spring lever
CA2331030A1 (en) * 2000-02-16 2001-08-16 Roche Diagnostics Gmbh Hypodermic needleless injection system
US6558348B2 (en) * 2000-04-07 2003-05-06 Equidyne Systems, Inc. Low cost disposable needleless injector system for variable and fixed dose applications
US6554812B2 (en) 2000-04-13 2003-04-29 Sca Hygiene Products Ab Sanitary napkin
DE10034270A1 (en) 2000-07-14 2002-02-14 Disetronic Licensing Ag Storage container with a metering device for the metered delivery of an injectable product to an injection device
EP1180377A1 (en) * 2000-08-16 2002-02-20 Schering Aktiengesellschaft Syringe with piston
US6471669B2 (en) * 2001-03-05 2002-10-29 Bioject Medical Technologies Inc. Disposable needle-free injection apparatus and method
US6585685B2 (en) * 2001-06-08 2003-07-01 Bioject Inc. Jet injector apparatus and method
DE10129585A1 (en) * 2001-06-20 2003-01-09 Disetronic Licensing Ag Device for the dosed administration of an injectable product
US7235063B2 (en) 2001-08-21 2007-06-26 D'antonio Consultants International, Inc. Hypodermic injection system
US6942638B1 (en) * 2002-05-30 2005-09-13 Kerry Quinn Needleless injector and ampule system
US6676630B2 (en) 2002-06-04 2004-01-13 Bioject Medical Technologies, Inc. Needle-free injection system
KR20050075373A (en) * 2002-11-01 2005-07-20 앤태어스 파머, 인코퍼레이티드 Administration of insulin by jet injection
US6935384B2 (en) * 2003-02-19 2005-08-30 Bioject Inc. Needle-free injection system
US20040186437A1 (en) * 2003-03-20 2004-09-23 Frenette Claude E. Content-coded medical syringe, syringe set and syringe content identification method
US7442182B2 (en) 2003-10-24 2008-10-28 Bioject, Inc. Spring powered needle-free injection system
US20050209554A1 (en) * 2004-03-19 2005-09-22 Sergio Landau Needle-free single-use cartridge and injection system
US20060089594A1 (en) * 2004-10-26 2006-04-27 Sergio Landau Needle-free injection device
US20060225368A1 (en) * 2005-04-12 2006-10-12 Roe J P Rainwater gutter and eave trough repair system
US20070027428A1 (en) 2005-05-03 2007-02-01 Pharmajet, Inc. Vial system and method for needle-less injector
US7618393B2 (en) * 2005-05-03 2009-11-17 Pharmajet, Inc. Needle-less injector and method of fluid delivery
US20080161755A1 (en) 2006-01-27 2008-07-03 Bioject Inc. Needle-free injection device and priming system
US20080228147A1 (en) 2007-03-15 2008-09-18 Bristol-Myers Squibb Company Injector for use with pre-filled syringes and method of assembly
US8617099B2 (en) * 2007-11-26 2013-12-31 Bioject Inc. Injection device plunger auto-disable

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030132547A1 (en) * 1993-11-03 2003-07-17 Gayle Heffernan Method for the preparation of pre-filled plastic syringes
EP1093826A1 (en) * 1999-10-18 2001-04-25 Terumo Kabushiki Kaisha Pre-filled syringe
US20060089593A1 (en) * 2004-10-26 2006-04-27 Sergio Landau Needle-free injection device for individual users
WO2006106291A1 (en) * 2005-04-06 2006-10-12 Cilag Ag International Injection device
WO2006118616A1 (en) * 2005-05-03 2006-11-09 Pharmajet, Incorporated Needle-less injector

Also Published As

Publication number Publication date
US11878147B2 (en) 2024-01-23
WO2008063995A2 (en) 2008-05-29
US7618393B2 (en) 2009-11-17
US20160235917A1 (en) 2016-08-18
US20070118094A1 (en) 2007-05-24
US20110251581A1 (en) 2011-10-13
US20180361070A1 (en) 2018-12-20
JP2010509030A (en) 2010-03-25
US20100168662A1 (en) 2010-07-01
US10099011B2 (en) 2018-10-16
US8529500B2 (en) 2013-09-10
US20140005632A1 (en) 2014-01-02
US9333300B2 (en) 2016-05-10
CN101631581A (en) 2010-01-20
WO2008063995A9 (en) 2008-09-18
BRPI0718847A2 (en) 2014-02-04
US20210146051A1 (en) 2021-05-20
EA200900682A1 (en) 2009-12-30
EP2089085A2 (en) 2009-08-19

Similar Documents

Publication Publication Date Title
WO2008063995A3 (en) Needle-less injector and method of fluid delivery
NZ593153A (en) Medication delivery device with spring to cushion piston recoil
JP4771508B2 (en) Auto-injector powered by pneumatic pressure
RU2179864C2 (en) Needleless injector
MY149438A (en) Medication delivery device
WO2007027204A3 (en) Injector device with force lock-out and injection rate limiting mechanisms
MY155197A (en) Drive mechanism for a medication delivery device and medication delivery device
US20080281261A1 (en) Needle-less injector
WO2005097238A3 (en) Automatic injection device
EP2526987A3 (en) Device for delivering medicament
NZ593137A (en) Auto-injector apparatus with a pump for engaging with a flexible medicament container to expel the medicament
DE60336940D1 (en) Medical injection device
AU2002363335A1 (en) Pneumatic powered autoinjector
GB2443606B (en) Injection device
WO2010066592A3 (en) Medicament delivery device
WO2006057604A8 (en) Injection device
WO2003099358A3 (en) Apparatus for rapid auto-injection of medication
WO2012045836A3 (en) Reusable engine for an auto-injector
WO2012000940A3 (en) Needle safety arrangement and method for operating it
MX2022003292A (en) Drug delivery device and methods of delivering a drug.
MX2022002580A (en) Activatable injection device for drug delivery.
CN205322929U (en) Needle -free syringe
WO2004067067A1 (en) Pneumatic powered autoinjector

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200780045625.8

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07864321

Country of ref document: EP

Kind code of ref document: A2

ENP Entry into the national phase

Ref document number: 2009537307

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 3126/DELNP/2009

Country of ref document: IN

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2007864321

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 200900682

Country of ref document: EA

ENP Entry into the national phase

Ref document number: PI0718847

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20090513