WO2008064072A3 - Anti-tsg101 antibodies and their uses for treatment of viral infections - Google Patents

Anti-tsg101 antibodies and their uses for treatment of viral infections Download PDF

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Publication number
WO2008064072A3
WO2008064072A3 PCT/US2007/084808 US2007084808W WO2008064072A3 WO 2008064072 A3 WO2008064072 A3 WO 2008064072A3 US 2007084808 W US2007084808 W US 2007084808W WO 2008064072 A3 WO2008064072 A3 WO 2008064072A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
viral infections
tsg101
antibodies
tsg101 antibodies
Prior art date
Application number
PCT/US2007/084808
Other languages
French (fr)
Other versions
WO2008064072A2 (en
Inventor
Limin Li
Michael Kinch
Michael Goldblatt
Original Assignee
Functional Genetics Inc
Limin Li
Michael Kinch
Michael Goldblatt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Functional Genetics Inc, Limin Li, Michael Kinch, Michael Goldblatt filed Critical Functional Genetics Inc
Priority to AU2007323799A priority Critical patent/AU2007323799B2/en
Priority to JP2009537363A priority patent/JP2010510235A/en
Priority to CA002669095A priority patent/CA2669095A1/en
Priority to NZ576878A priority patent/NZ576878A/en
Priority to MX2009005026A priority patent/MX2009005026A/en
Priority to EP07871484A priority patent/EP2094282A4/en
Publication of WO2008064072A2 publication Critical patent/WO2008064072A2/en
Publication of WO2008064072A3 publication Critical patent/WO2008064072A3/en
Priority to IL198598A priority patent/IL198598A0/en
Priority to ZA2009/04068A priority patent/ZA200904068B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Abstract

The present invention provides antibodies that bind to the C-terminal region of TSG101. The invention also provides methods of using the TSG101 antibodies for the treatment of viral infections, including HIV and Ebola virus infection.
PCT/US2007/084808 2006-11-15 2007-11-15 Anti-tsg101 antibodies and their uses for treatment of viral infections WO2008064072A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
AU2007323799A AU2007323799B2 (en) 2006-11-15 2007-11-15 Anti-TSG101 antibodies and their uses for treatment of viral infections
JP2009537363A JP2010510235A (en) 2006-11-15 2007-11-15 Anti-TSG101 antibody and its use for the treatment of viral infections
CA002669095A CA2669095A1 (en) 2006-11-15 2007-11-15 Anti-tsg101 antibodies and their uses for treatment of viral infections
NZ576878A NZ576878A (en) 2006-11-15 2007-11-15 Anti-TSG101 antibody (ATCC deposit PTA-9611) and its use for treatment of viral infection
MX2009005026A MX2009005026A (en) 2006-11-15 2007-11-15 Anti-tsg101 antibodies and their uses for treatment of viral infections.
EP07871484A EP2094282A4 (en) 2006-11-15 2007-11-15 Anti-tsg101 antibodies and their uses for treatment of viral infections
IL198598A IL198598A0 (en) 2006-11-15 2009-05-06 Anti-tsg101 antibodies and their uses for treatment of viral infections
ZA2009/04068A ZA200904068B (en) 2006-11-15 2009-06-10 Anti-tsg101 antibodies and their uses for treatment of viral infections

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85892206P 2006-11-15 2006-11-15
US60/858,922 2006-11-15

Publications (2)

Publication Number Publication Date
WO2008064072A2 WO2008064072A2 (en) 2008-05-29
WO2008064072A3 true WO2008064072A3 (en) 2008-10-16

Family

ID=39430501

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/084808 WO2008064072A2 (en) 2006-11-15 2007-11-15 Anti-tsg101 antibodies and their uses for treatment of viral infections

Country Status (11)

Country Link
US (2) US7964708B2 (en)
EP (2) EP2514439A1 (en)
JP (2) JP2010510235A (en)
CN (1) CN101641106A (en)
AU (1) AU2007323799B2 (en)
CA (1) CA2669095A1 (en)
IL (1) IL198598A0 (en)
MX (1) MX2009005026A (en)
NZ (1) NZ576878A (en)
WO (1) WO2008064072A2 (en)
ZA (1) ZA200904068B (en)

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EP2091971A4 (en) * 2006-11-13 2010-05-05 Functional Genetics Inc Therapeutic targeting of escort proteins
WO2011091395A1 (en) * 2010-01-25 2011-07-28 Functional Genetics, Inc. Antibodies for diagnosis and therapeutic treatment of prostate cancer
US11918728B2 (en) 2014-04-17 2024-03-05 ImMutriX Therapeutics, Inc. Therapeutic compositions for viral-associated disease states and methods of making and using same
US9669151B2 (en) 2014-04-17 2017-06-06 ImMutriX Therapeutics, Inc. Therapeutic compositions for viral-associated disease states and methods of making and using same
CN112630449B (en) * 2020-12-30 2022-10-18 广西壮族自治区水牛研究所 Blood exosome marker for judging buffalo birth time and application thereof
GB202203066D0 (en) * 2022-03-04 2022-04-20 Univ Swansea Anti-rage antibody

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WO2004071462A2 (en) * 2003-02-12 2004-08-26 Johns Hopkins University Methods and compositions for treatment of viral infections based on tsg101-vps28 interaction

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Also Published As

Publication number Publication date
ZA200904068B (en) 2012-09-29
JP2010510235A (en) 2010-04-02
AU2007323799A1 (en) 2008-05-29
CA2669095A1 (en) 2008-05-29
AU2007323799B2 (en) 2013-07-18
CN101641106A (en) 2010-02-03
US20080187528A1 (en) 2008-08-07
US8796423B2 (en) 2014-08-05
EP2514439A1 (en) 2012-10-24
WO2008064072A2 (en) 2008-05-29
EP2094282A2 (en) 2009-09-02
US20090186041A1 (en) 2009-07-23
EP2094282A4 (en) 2010-05-05
NZ576878A (en) 2011-10-28
MX2009005026A (en) 2009-07-31
IL198598A0 (en) 2010-02-17
JP2013227331A (en) 2013-11-07
US7964708B2 (en) 2011-06-21

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