WO2008064948A1

WO2008064948A1 - Stabilized mouthwashes and mouthwash concentrates comprising cyclodextrin (derivative)

Info

Publication number: WO2008064948A1
Application number: PCT/EP2007/060814
Authority: WO
Inventors: Wilfried Howorka; Ullrich Bernecker; Adolf Peter Barth
Original assignee: Henkel Ag & Co. Kgaa
Priority date: 2006-11-30
Filing date: 2007-10-11
Publication date: 2008-06-05
Also published as: EP2099419A1; DE102006057047A1

Abstract

Mouthwash compositions, i.e. both ready-to-use mouthwashes and also mouthwash concentrates to be diluted, which at low viscosity are more sedimentation-stable and flocculation-stable than mouthwashes hitherto, comprise - based on their weight - ethanol, water and 0.001 to 5% by weight of at least one cyclodextrin.

Description

STABILIZED MOUTH WATERS AND MOUTHWATER CONCENTRATES CONTAINING

CYCLODEXTRIN (DERIVATIVE)

The invention relates to ready-to-use mouthwashes and mouthwash concentrates to be diluted, which are more stable to sedimentation and / or flocculation of ingredients due to special ingredients.

In the oral and dental care in addition to toothpastes often liquid preparations are used, in which the cleaning and care effect is achieved by the contact of the preparation with the oral cavity, without the need for an additional tool, such as a toothbrush. These preparations, which are commonly referred to as mouthwashes, thereby offering a special ease of use and also ensure that even difficult to reach areas of the oral cavity, especially on the teeth, come into contact with the preparation.

While mouthwashes were used in the past merely to refresh the mouth and throat and to improve the bad breath, they take over today tasks such. A plaque-dissolving effect, and they serve as carriers of anti-caries agents or antibacterial agents for plaque control. Mouthwashes are available as low-viscosity aqueous or aqueous-alcoholic formulations or as water-dilutable concentrates. The application in the form of a low-viscosity preparation is a good distribution availability and good contact with the oral cavity achieved. In addition to the cleaning of the teeth, the consumer of the generic products also expected a care of the teeth and the oral cavity. In particular, a "clean" feel, ie a smooth and shiny tooth surface as well as a fresh mouthfeel are essential aspects for the buying incentive of oral and dental care and cleaning preparations. A successful agent of the generic type should therefore thoroughly clean the teeth, without damaging the tooth or the tooth surface while reducing and / or preventing bad breath. Mouthwashes are widely described in the art. DE 33 41 466 A1 discloses aqueous oral care products containing in addition to 1 to 3 wt .-% hydrogen peroxide 3 to 15 wt .-% glycerol and / or sorbitol and 3 to 10 wt .-% ethanol.

European Patent Application EP 0 497 476 A2 discloses antiplaque compositions which in the form of mouthwashes comprise 1 to 20% by weight of glycerol, 1 to 20% by weight of propylene glycol, 1 to 25% by weight of sorbitol and 5 to 20% by weight. -% ethanol can contain.

Finally, U.S. Patent 4,130,638 discloses mouthwash compositions comprising 10- 25% ethanol, 0.5- 2.5% Pluronic ^® surfactant and thymol, menthol and eucalyptol.

Mouthwash is often offered in the form of concentrates, which are diluted with water by the consumer just before use. Since this requires access to water and a mixing container, ready-to-use mouthwashes, which, for example, can be taken directly from the packaging into the mouth and spit out after use, are met with increased consumer interest.

A problem that both the ready-to-use mouthwashes and the

Have mouthwash concentrates, is the sedimentation and / or flocculation of ingredients that are difficult to dissolve in the composition, such as preservatives, flavors, oils, etc. This problem can not be solved with the usual methods (addition of thickeners), since the viscosity of mouthwash composition is set to a narrow range. Too high viscosities prevent gargling and mouth rinsing and are perceived by the consumer as unpleasant.

It is an object of the present invention to provide mouthwash compositions, i. to provide both ready-to-use mouthwashes and mouthwash concentrates to be thinned, which are less susceptible to sedimentation and flocculation at low viscosity than current mouthwashes.

It has now been found that the use of cyclodextrins and certain cyclodextrin derivatives in defined amounts solves the problems mentioned.

In a first embodiment, the present invention relates to mouthwash compositions containing, based on their weight, a) ethanol; b) water; c) 0.001 to 5 wt .-% of at least one cyclodextrin.

"Mouthwash" or "mouthwash" in the context of the present invention are also so-called mouthwashes, anti-plaque rinses, etc. "Ready to use" in the context of the present invention means that the composition without further processing steps (eg dilution) removed from the package and can and should be used by consumers.

The mouthwash compositions of the present invention contain ethanol, with preferred mouthwash compositions containing by weight 0.5 to 60% by weight of ethanol, and the claim refers to pure alcohol (100%), even if not used as 100% ethanol, since ethanol forms an azeotrope with water, which consists of 95.57 wt .-% ethanol and 4.43 wt .-% water and boiling constant at 78.2 ° C.

With particular preference, the mouthwash compositions according to the invention contain higher amounts of ethanol, mouthwash compositions according to the invention being particularly preferred which contain 1 to 50% by weight, preferably 1 to 5 to 45% by weight, particularly preferably 3 to 40% by weight. % and in particular 5 to 35 wt .-% ethanol.

The mouthwash compositions according to the invention additionally contain, as further obligatory ingredient, water which may be present in the compositions according to the invention in quantities of up to 99.5% by weight. Preferred mouthwash compositions according to the invention contain, based on their weight, 1 to 99.5% by weight, preferably 20 to 80% by weight, more preferably 30 to 70% by weight and in particular 40 to 60% by weight of water.

The water contained in the mouthwash compositions according to the invention may be tap water, the degree of hardness of which may vary depending on the place of manufacture or the source of the water. However, it is possible and preferred to use water with degrees of hardness between 0 and 20 ° dH, preferably between 1 and 16 ° dH. Particularly preferred is the use of technically demineralized water ("water VE"), which has been largely freed from salts with the aid of ion exchangers.

As a third essential component, the compositions according to the invention contain from 0.001 to 5% by weight of at least one cyclodextrin, cyclodextrin in the context of the present invention also to be understood as meaning cyclodextrin derivatives. Preferably, too this third ingredient is used within narrower ranges of amounts, so that preferred mouthwash compositions of the invention are from 0.01% to 2.5%, preferably from 0.02% to 2%, more preferably from 0.03% to 1% by weight, more preferably 0.04 to 0.5 wt .-% and in particular 0.05 to 0.25 wt .-% cyclodextrin (s), said information in turn relate to the total mouthwash composition.

Cyclodextrins, which according to their discoverer are also called Schardinger-dextrins or cycloamyloses or cycloglucans, are non-reducing dextrins which are formed on the action of cyclodextrin glycosyltransferase (CGTase) on soluble starch or amylose or amylodextrin (= higher malto-oligosaccharides). The cyclodextrins consist of 6, 7 or 8 alpha-1, 4-linked glucose units u. are referred to as alpha, beta or gamma cyclodextrins. Alpha-cyclodextrin is therefore also referred to as cyclohexaamylose, beta-cyclodextrin also as cycloheptaamylose and gamma-cyclodextrin as Cyclooctyamylose. Due to their molecular structure, cyclodextrins form continuous channels in which "guest molecules" can be trapped to saturation. The ability to record and capacity depends on the size ratio guest molecule / cavity; the latter is between 0.6 and 1 nm.

Alpha-cyclodextrin can be exemplified by the following formula:

Preferred mouthwash compositions of the present invention contain one or more cyclodextrins derived from starch degradation. Preferred mouthwash compositions according to the invention are characterized in that they comprise at least one natural cyclodextrin, preferred natural cyclodextrins being selected from alpha-cyclodextrin with six glucose units and / or beta-cyclodextrin with seven glucose units and / or gamma-cyclodextrin with eight glucose units.

The free hydroxyl groups of the glucose units can be chemically modified, for example esterified or etherified. A particularly preferred derivatization is the etherification, with particular preference being given to methyl and / or hydroxypropyl ethers.

These derivatives can also be used according to the invention. Here, preferred mouthwash compositions according to the invention are characterized in that they contain at least one cyclodextrin derivative, preferred cyclodextrin derivatives being selected from

Hydroxypropyl-alpha-cyclodextrin and / or

Hydroxypropyl-beta-cyclodextrin and / or

Hydroxypropyl gamma cyclodextrin and / or

Methyl alpha cyclodextrin and / or

Methyl-beta-cyclodextrin and / or

Methyl-gamma-cyclodextrin.

With particular preference, 2-hydroxypropyl-beta-cyclodextrin can be used according to the invention. This is a ring of seven alpha-1, 4-linked glucose units in which some of the H atoms are replaced by the moiety - [CH ₂ -CH (CH ₃ ) -O] _n -H. The subscript n can stand for values of 0 (unsubstituted), 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, with values of 1 or 2 being preferred and the value 1 being particularly preferred. In preferred compounds, the degree of substitution per anhydroglucose unit is 0.6 to 0.9, ie per anhydroglucose unit statistically 0.6 to 0.9 hydrogen atoms of the OH groups are replaced by the above-mentioned grouping. Accordingly, there are statistically 3.5 to 6.3 2-hydroxypropyl units per cyclodextrin molecule. The average molecular weight of these preferred compounds is between 1380 and 1500 daltons.

With particular preference, 2-hydroxypropyl-alpha-cyclodextrin can also be used according to the invention. This is a ring of six alpha-1, 4-linked glucose units in which some of the H atoms are replaced by the moiety - [CH ₂ -CH (CH ₃ ) -O] _n -H. The subscript n can stand for values of 0 (unsubstituted), 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, with values of 1 or 2 being preferred and the value 1 being particularly preferred. In preferred compounds, the degree of substitution per anhydroglucose unit is 0.5 to 0.8, ie per anhydroglucose unit statistically 0.5 to 0.8 hydrogen atoms of the OH groups are replaced by the above-mentioned grouping. Per Accordingly, cyclodextrin molecules are statistically present in 3 to 4.8 2-hydroxypropyl units. The average molecular weight of these preferred compounds is between 1150 to 1250 daltons.

With particular preference can be used according to the invention also methyl-beta-cyclodextrin. This is a ring of seven alpha-1, 4-linked glucose units, in which a part of the H atoms is replaced by the group -CH ₃ . In preferred compounds, the degree of substitution per anhydroglucose unit is 1, 7 to 1, 9, ie per anhydroglucose unit statistically 1, 7 to 1, 9 hydrogen atoms of the OH groups are replaced by the methyl group. Accordingly, there are statistically 11, 9 to 13.3 methyl groups per cyclodextrin molecule. The average molecular weight of these preferred compounds is between 1290 to 1330 daltons, more preferably narrow at 1310 daltons.

The mouthwash compositions of the present invention may contain, in addition to the foregoing essential ingredients and water, other ingredients of oral cleansers, mouthwashes, dentifrices and / or dentifrices. The preferred further ingredients are described below.

The mouthwash compositions according to the invention may contain polyhydric alcohols, in particular xylitol or sorbitol or glycerol or 1,2-propylene glycol. Xylitol, also called "xylitol", is a polyol (xy / o-1, 2,3,4,5-pentane pentene) belonging to the pentitols (5-hydric alcohols) which is obtained by catalytic hydrogenation of xylose Mouthwash compositions contain, based on their weight, 0.25 to 5% by weight of xylitol, preferably 0.5 to 4% by weight, particularly preferably 0.75 to 3.75% by weight and in particular 1.00 to 2.75 wt .-%.

The mouthwash compositions of the invention may also contain glycerol. Glycerol is referred to IUPAC as 1, 2,3-propanetriol, the INCI name is: glycerol, other names are for example 1, 2,3-trihydroxypropane, glycerol, oil sweet, or E 422. According to the invention preferred mouthwash compositions contain by weight 0.25 to 15 wt .-% glycerol, wherein inventive

Mouthwash compositions are preferred which, based on their weight, contain 0.5 to 12% by weight, preferably 0.75 to 11% by weight and in particular 1.00 to 10% by weight, of glycerol.

In addition to glycerol and xylitol, the mouthwash compositions according to the invention may contain further polyhydroxy compounds, preferably alcohols at least 2 OH groups, more preferably mannitol, xylitol, polyethylene glycol, polypropylene glycol and mixtures thereof.

Among the polyhydroxy compounds, those having 2 to 12 OH groups and especially those having 2, 3, 4, 5, 6 or 10 OH groups are preferred.

Polyhydroxy compounds having 2 OH groups are, for example, glycol (CH ₂ (OH) CH ₂ OH) and other 1, 2-diols such as H- (CHz) _n -CH (OH) CH ₂ OH where n = 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20. Also 1,3-diols such as H- (CH ₂ ) _n -CH ( OH) CH ₂ CH ₂ OH with n = 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 used according to the invention. The (n, n + 1) or (n, n + 2) diols with non-terminal OH groups can also be used.

Important representatives of polyhydroxy compounds having 2 OH groups are also the polyethylene and polypropylene glycols.

Particular preference is given to mouthwash compositions according to the invention which additionally contain sorbitol, preferably in amounts of from 0.5 to 20% by weight, particularly preferably from 0.75 to 15% by weight and in particular from 1 to 10% by weight, in each case based on the total mean, included.

It is furthermore particularly preferred for the total amount of polyhydroxy compounds in the mouthwash compositions according to the invention to be 1.5 to 35% by weight, preferably 2.5 to 32.5% by weight, more preferably 5 to 30% by weight and in particular 7 to 24 wt .-%, each based on the total agent is.

Particularly preferred mouthwash compositions according to the invention are characterized in that they contain 0.5 to 20% by weight, preferably 1 to 15% by weight, particularly preferably 2 to 12% by weight and in particular 3 to 10% by weight of at least one polyhydric Alcohol from the group sorbitol and / or glycerol and / or 1, 2-Propylenglycol .-%, each based on the weight of the total mouthwash composition.

A preferred class of ingredients which may be included in the mouthwash compositions of the present invention are the surfactants.

The term "surfactants" is understood as meaning surface-active substances which form adsorption layers on the upper and boundary surfaces or which can aggregate in volume phases to give micelle colloids or lyotropic mesophases. One distinguishes anionic surfactants consisting of a hydrophobic radical and a negatively charged hydrophilic head group, amphoteric surfactants which carry both a negative and a compensating positive charge, cationic surfactants which, in addition to a hydrophobic radical, have a positively charged hydrophilic group, and nonionic surfactants which do not contain any charges; have strong dipole moments and are highly hydrated in aqueous solution.

Suitable anionic surfactants (E1) in preparations according to the invention are all anionic surfactants suitable for use on the human body. These are characterized by a water-solubilizing, anionic group such as. As a carboxylate, sulfate, sulfonate or phosphate group and a lipophilic alkyl group having about 8 to 30 carbon atoms. In addition, glycol or polyglycol ether groups, ester, ether and amide groups and hydroxyl groups may be present in the molecule. Examples of suitable anionic surfactants are, in each case in the form of the sodium, potassium and ammonium as well as the mono-, di- and trialkanolammonium salts having 2 to 4 C atoms in the alkanol group, linear and branched fatty acids having 8 to 30 C atoms (Soaps), ether carboxylic acids of the formula RO- (CH 2 -CH 2 O) _χ -CH 2 -COOH, in which R is a linear alkyl group having 8 to 30 carbon atoms and x = 0 or 1 to 16, acylsarcosides having 8 to 24 carbon atoms Atoms in the acyl group, acyl taurides having 8 to 24 carbon atoms in the acyl group, acyl isethionates having 8 to 24 carbon atoms in the acyl group,

Sulfobernsteinsäuremono- and dialkyl ester having 8 to 24 carbon atoms in the alkyl group and sulfosuccinic monoalkylpolyoxyethylester having 8 to 24 carbon atoms in the alkyl group and 1 to 6 oxyethyl groups, linear alkanesulfonates having 8 to 24 carbon atoms, linear alpha-olefinsulfonates with 8 to 24 carbon atoms, alpha-sulfofatty acid methyl esters of fatty acids having 8 to 30 carbon atoms, - alkyl sulfates and alkyl polyglycol ether sulfates of the formula RO (CH ₂ -CH ₂ O) _x -OSO ₃ H, in which R is a preferably linear alkyl group with 8 to 30 carbon atoms and x = 0 or 1 to 12, sulfated hydroxyalkylpolyethylene and / or hydroxyalkylenepropylene glycol sulfonates of unsaturated fatty acids having 8 to 24 carbon atoms and 1 to 6 double bonds esters of tartaric acid and citric acid with alcohols, the adducts of about 2 15 molecules represent ethylene oxide and / or propylene oxide with fatty alcohols having 8 to 22 C atoms, alkyl and / or alkenyl ether phosphates of the formula (E1-I),

R ¹ (OCH ₂ CH ₂ ) _n -OP (O) (OX) -OR ² (EM) in the R ^{1 is} preferably an aliphatic hydrocarbon radical having 8 to 30 carbon atoms, R ^{2 is} hydrogen, a radical (CH ₂ CH ₂ O) _n R ² or X, n is from 1 to 10 and X is hydrogen, an alkali metal radical or alkaline earth metal or NR ³ R ⁴ R ⁵ R ⁶ , where R ³ to R ⁶ independently of one another represent hydrogen or a C ₁ to C ₄ hydrocarbon radical, sulfated fatty acid alkylene glycol esters of the formula (EΞ1-11) R ⁷ CO (AlkO ) _n SO ₃ M (EMI) in the R ⁷ CO- for a linear or branched, aliphatic, saturated and / or unsaturated acyl radical having 6 to 22 carbon atoms, Alk for CH ₂ CH ₂ , CHCH ₃ CH ₂ and / or CH ₂ CHCH ₃ , n is from 0.5 to 5 and M is a cation, monoglyceride sulfates and monoglyceride ether sulfates of the formula (E1-III)

CH ₂ O (CH ₂ CH ₂ O) _x -COR ⁸

I CHO (CH ₂ CH ₂ O) _y H (EMII)

I CH ₂ O (CH ₂ CH ₂ O) _Z SO ₃ X

in which R ⁸ CO is a linear or branched acyl radical having 6 to 22 carbon atoms, x, y and z are in total 0 or numbers of 1 to 30, preferably 2 to 10, and X is an alkali or alkaline earth metal. Typical examples of monoglyceride (ether) sulfates suitable for the purposes of the invention are the reaction products of lauric acid monoglyceride, coconut fatty acid monoglyceride, palmitic acid monoglyceride, stearic acid monoglyceride, oleic acid monoglyceride and tallow fatty acid monoglyceride and their ethylene oxide adducts with sulfur trioxide or chlorosulfonic acid in the form of their sodium salts. Preferably, monoglyceride sulfates of the formula (E1-III) are used in which R ⁸ CO is a linear acyl radical having 8 to 18 carbon atoms, amide-ether carboxylic acids,

Condensation products of C ₈ - C ₃₀ - fatty alcohols with protein hydrolysates and / or amino acids and their derivatives, which are known to the skilled person as protein fatty acid condensates, such as Lamepon ^® - types Gluadin ^® - types Hostapon ^® KCG or Amisoft ^® - types.

Preferred anionic surfactants are alkyl sulfates, alkyl polyglycol ether sulfates and ether carboxylic acids having 10 to 18 C atoms in the alkyl group and up to 12 glycol ether groups in the molecule, sulfosuccinic acid mono- and dialkyl esters having 8 to 18 C atoms in the alkyl group and sulfosuccinic acid mono-alkylpolyoxyethyl esters having 8 to 18 carbon atoms in the alkyl group and 1 to 6 oxyethyl groups, monoglycerol disulfates, alkyl and alkenyl ether phosphates, and egg lisside ethers.

Zwitterionic surfactants (E2) are those surface-active compounds which carry at least one quaternary ammonium group and at least one -COO ⁽⁾ or -SO ₃ '^"' group in the molecule. Alkyl-N, N-dimethylammonium glycinates, for example, the cocoalkyl-di-methylammoniumglycinat, N-acyl-aminopropyl-N, N-dimethylammoniumglycinate, for example Kokosacylaminopropyl-dimethylammoniumglycinat, and 2-alkyl-3-carboxymethyl-3-hydroxyethyl-imidazoline each having 8 to 18 carbon atoms in the alkyl or acyl group and the Kokosacylaminoethylhydroxyethylcarboxymethylglycinat.A preferred zwitterionic surfactant is known under the INCI name Cocamidopropyl Betaine fatty acid amide derivative.

Ampholytic surfactants (E3) are understood as meaning those surface-active compounds which contain, in addition to a C ₈ -C ₂₄ -alkyl or -acyl group, at least one free amino group and at least one -COOH or -SO ₃ H group in the molecule and for forming internal Salts are capable. Examples of suitable ampholytic surfactants are N-alkylglycines, N-alkylpropionic acids, N-alkylaminobutyric acids, N-alkyliminodipropionic acids, N-hydroxyethyl-N-alkylamidopropylglycines, N-alkyltaurines, N-alkylsarcosines, 2-alkylaminopropionic acids and alkylaminoacetic acids each having about 8 to 24 C Atoms in the alkyl group. Particularly preferred ampholytic surfactants are N-cocoalkylaminopropionate, cocoacylaminoethylaminopropionate and C ₁₂ -C ₁₈ acylsarcosine.

Nonionic surfactants (E4) contain as hydrophilic group e.g. a polyol group, a polyalkylene glycol ether group, or a combination of polyol and polyglycol ether groups. Such compounds are, for example

Addition products of 2 to 50 moles of ethylene oxide and / or 0 to 5 moles of propylene oxide to linear and branched fatty alcohols having 8 to 30 carbon atoms, to fatty acids having 8 to 30 carbon atoms and alkylphenols having 8 to 15 carbon atoms in the alkyl group , end-capped adducts of 2 to 50 moles of ethylene oxide and / or 0 to 5 moles of propylene oxide with linear or branched fatty alcohols containing 8 to 30 carbon atoms, with fatty acids containing 8 to 30 carbon atoms, with a methyl or C ₂ -C ₆ -alkyl radical. atoms and onto alkylphenols having 8 to 15 carbon atoms in the alkyl group, such as those available under the trade names Dehydol ^® LS, Dehydol ^® LT types (Cognis), C ₁₂ -C ₃₀ fatty acid monoesters and diesters of addition products of 1 to 30 moles of ethylene oxide with glycerol, Addition products of 5 to 60 moles of ethylene oxide with castor oil and hydrogenated castor oil,

Polyol fatty acid esters, such as the commercial product Hydagen ^® HSP (Cognis) or

Sovermol types (Cognis), alkoxylated triglycerides, alkoxylated fatty acid alkyl esters of the formula (E4-I)

R ¹ CO- (OCH ₂ CHR ² ) _W OR ³ (E4-I)

in which R ¹ CO is a linear or branched, saturated and / or unsaturated acyl radical having 6 to 22 carbon atoms, R ² is hydrogen or methyl, R ³ is linear or branched alkyl radicals having 1 to 4 carbon atoms, and w is a number from 1 to 20 stands,

Amine oxides,

hydroxy mixed,

Sorbitan fatty acid esters and adducts of ethylene oxide with sorbitan fatty acid esters such as the polysorbates,

Sugar fatty acid esters and addition products of ethylene oxide with sugar fatty acid esters,

Addition products of ethylene oxide to fatty acid alkanolamides and fatty amines,

Sugar surfactants of the alkyl and alkenyl oligoglycoside type of formula (E4-II),

in which R ^{4 is} an alkyl or alkenyl radical having 4 to 22 carbon atoms, G is a sugar radical having 5 or 6 carbon atoms and p is a number from 1 to 10. They can be obtained by the relevant methods of preparative organic chemistry. The alkyl and alkenyl oligoglycosides can be derived from aldoses or ketoses with 5 or 6 carbon atoms, preferably glucose. The preferred alkyl and / or alkenyl oligoglycosides are thus alkyl and / or alkenyl oligoglucosides. The index number p in the general formula (E4-II) indicates the degree of oligomerization (DP), ie the distribution of mono- and oligoglycosides and stands for a number between 1 and 10. While p in the individual molecule must always be integer and here before For all given values p = 1 to 6, the value p for a given alkyloligoglycoside is an analytically determined arithmetic quantity, which usually represents a fractional number. Preference is given to using alkyl and / or alkenyl oligoglycosides having an average degree of oligomerization p of from 1.1 to 3.0. From an application point of view, those alkyl and / or alkenyl oligoglycosides whose degree of oligomerization is less than 1.7 and in particular between 1.2 and 1.4 are preferred. The alkyl or alkenyl radical R ⁴ may differ from primary Derive alcohols having 4 to 11, preferably 8 to 10 carbon atoms. Typical examples are butanol, caproic alcohol, caprylic alcohol, capric alcohol and undecyl alcohol and technical mixtures thereof, as obtained, for example, in the hydrogenation of technical fatty acid methyl esters or in the hydrogenation of aldehydes from Roelen's oxo synthesis. Preference is given to alkyl oligoglucosides of the chain length C ₈ -C ₁₀ (DP = 1 to 3) which are obtained as a feedstock in the distillative separation of technical C ₈ -C ₁₈ coconut fatty alcohol and in a proportion of less than 6% by weight C ₁₂ - AIkOhOl can be contaminated as well as Alkyloligoglucoside on the basis of technical C _9Z11 - Oxoalkohole (DP = 1 to 3). The alkyl or alkenyl radical R ¹⁵ can also be derived from primary alcohols having 12 to 22, preferably 12 to 14 carbon atoms. Typical examples are lauryl alcohol, myristyl alcohol, cetyl alcohol, palmoleyl alcohol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, elaidyl alcohol, petroselinyl alcohol, arachyl alcohol, gadoleyl alcohol, behenyl alcohol, erucyl alcohol, brassidyl alcohol and technical mixtures thereof which can be obtained as described above. Alkyl oligoglucosides based on hydrogenated _{C12 /} -i ₄ coconut alcohol with a DP of 1 to 3

Sugar surfactants of the fatty acid N-alkylpolyhydroxyalkylamide type, a nonionic surfactant of the formula (E4-III),

R ⁵ CO-NR ⁶ - [Z] (E4-III)

R ^{5 is} CO for an aliphatic acyl radical having 6 to 22 carbon atoms, R ^{6 is} hydrogen, an alkyl or hydroxyalkyl radical having 1 to 4 carbon atoms and [Z] is a linear or branched polyhydroxyalkyl radical having 3 to 12 carbon atoms and 3 to 10 hydroxyl groups stands. The fatty acid N-alkyl polyhydroxyalkylamides are known substances which are usually obtained by reductive amination of a reducing sugar with ammonia, an alkylamine or an alkanolamine and subsequent acylation with a fatty acid, a fatty acid alkyl ester or a fatty acid chloride. Preferably, the fatty acid N-alkylpolyhydroxyalkylamides are derived from reducing sugars having 5 or 6 carbon atoms, especially glucose. The preferred fatty acid N-alkylpolyhydroxyalkylamides are therefore fatty acid N-alkylglucamides, as represented by the formula (E4-IV):

R ⁷ CO-NR ⁸ -CH ₂ - (CHOH) ₄ -CH ₂ OH (E4-IV)

The fatty acid N-alkylpolyhydroxyalkylamides used are preferably glucamides of the formula (E4-IV) in which R ^{8 is} hydrogen or an alkyl group and R ⁷ CO is the acyl radical of caproic acid, caprylic acid, capric acid, lauric acid, myristic acid, Palmitic acid, palmitoleic acid, stearic acid, isostearic acid, oleic acid, elaidic acid, petro-, linoleic acid, linolenic acid, arachidic acid, gadoleic acid, behenic acid or erucic acid or those technical mixtures. Particular preference is given to fatty acid N-alkylglucamides of the formula (E4-IV) which are obtained by reductive amination of glucose with methylamine and subsequent acylation with lauric acid or C12 / 14 coconut fatty acid or a corresponding derivative. Furthermore, the polyhydroxyalkylamides can also be derived from maltose and palatinose.

The preferred nonionic surfactants are the alkylene oxide addition products of saturated linear fatty alcohols and fatty acids having in each case 2 to 30 moles of ethylene oxide per mole of fatty alcohol or fatty acid. Preparations having excellent properties are also obtained if they contain fatty acid esters of ethoxylated glycerol as nonionic surfactants.

These connections are identified by the following parameters. The alkyl radical R contains 6 to 22 carbon atoms and may be both linear and branched. Preference is given to primary linear and methyl-branched in the 2-position aliphatic radicals. Such alkyl radicals are, for example, 1-octyl, 1-decyl, 1-lauryl, 1-myristyl, 1-cetyl and 1-stearyl. Particularly preferred are 1-octyl, 1-decyl, 1-lauryl, 1-myristyl. When using so-called "oxo-alcohols" as starting materials, compounds with an odd number of carbon atoms in the alkyl chain predominate.

Furthermore, very particularly preferred nonionic surfactants are the sugar surfactants. These may preferably be present in the agents used according to the invention in amounts of from 0.1 to 20% by weight, based on the total agent. Amounts of 0.5-15% by weight are preferred, and most preferred are amounts of 0.5-7.5% by weight.

The compounds used as surfactant with alkyl groups may each be uniform substances. However, it is usually preferred to start from the production of these substances from native plant or animal raw materials, so as to obtain substance mixtures with different, depending on the particular raw material alkyl chain lengths.

In the case of the surfactants which are adducts of ethylene oxide and / or propylene oxide with fatty alcohols or derivatives of these addition products, both products with a "normal" homolog distribution and those with a narrow homolog distribution can be used. Under "normal" homolog distribution are mixtures of Homologs obtained in the reaction of fatty alcohol and alkylene oxide using alkali metals, alkali metal hydroxides or alkali metal alcoholates as catalysts. Narrowed homolog distributions are obtained when, for example, hydrotalcites, alkaline earth metal salts of ether carboxylic acids, alkaline earth metal oxides, hydroxides or alkoxides are used as catalysts. The use of products with narrow homolog distribution may be preferred.

Cationic surfactants of the quaternary ammonium compound type, the esterquats and the amidoamines can be used according to the invention. Preferred quaternary ammonium compounds are ammonium halides, in particular chlorides and bromides, such as alkyltrimethylammonium chlorides, dialkyldimethylammonium chlorides and trialkyl methylammonium chlorides, eg. For example, cetyltrimethylammonium chloride, stearyltrimethylammonium chloride, distearyldimethylammonium chloride, lauryldimethylammonium chloride, lauryldimethylbenzylammonium chloride and tricetylmethylammonium chloride, as well as the imidazolium compounds known under the INCI names Quaternium-27 and Quaternium-83. The long alkyl chains of the above-mentioned surfactants preferably have 10 to 18 carbon atoms.

According to the invention, preference is given to using QAV with behenyl radicals, in particular those known as behentrimonium chloride or bromide (docosanyltrimethylammonium chloride or bromide). Other preferred QAV's have at least two behenyl residues, with QAV being particularly preferred, which are two behenyl residues on an imidazolinium backbone. Commercially available, these substances, for example, under the names Genamin ^® KDMP (Clariant) and Crodazosoft ^® DBQ (Crodauza) are.

Esterquats are known substances which contain both at least one ester function and at least one quaternary ammonium group as a structural element. Preferred ester quats are quaternized ester salts of fatty acids with triethanolamine, quaternized ester salts of fatty acids with diethanolalkylamines and quaternized ester salts of fatty acids with 1,2-dihydroxypropyldialkylamines. Such products are marketed under the trade names Stepantex® ^®, ^® and Dehyquart® Armocare® ^®. The products Armocare ^® VGH-70, a N, N-bis (2-palmitoyloxyethyl) dimethylammonium chloride, as well as Dehyquart ^® F-75, Dehyquart ^® C-4046, Dehyquart ^® L80 and Dehyquart ^® AU-35 are examples of such esterquats.

The alkylamidoamines are usually prepared by amidation of natural or synthetic fatty acids and fatty acid cuts with dialkylaminoamines. An invention Particularly suitable compound from this group of substances is the commercially available under the name Tegoamid ^® S 18 stearamidopropyl-dimethylamine.

The surfactant (s) are preferably used in the mouthwash compositions according to the invention in amounts of from 0.01 to 10% by weight, smaller amounts, for example from 0.05 to 5% by weight or from 0.1 to 2, 5 wt .-%, each based on the total agent, are preferred. With particular preference nonionic surfactants are used, among which the ethoxylated nonionic surfactants and the sugar surfactants are particularly preferred. Preferred mouthwash compositions of the invention contain sugar surfactants of the alkyl and alkenyl oligoglycoside type of the formula R ⁴ O- [G] _P in which R ^{4 is} an alkyl or alkenyl radical of 4 to 22 carbon atoms, G is a sugar radical of 5 or 6 carbon atoms and p represents numbers from 1 to 10, preferred sugar surfactants being from the group of the alkyl polyglucosides which have a degree of oligomerization p of from 1 to 3, preferably from 1, 1 to 2 and in particular from 1.2 to 1.5, and as alkyl radical R ⁴ a radical having 8 to 14 carbon atoms, preferably having 10 to 12 carbon atoms, carry.

Mouthwash compositions preferred according to the invention are characterized in that they additionally contain from 0.05 to 5% by weight, preferably from 0.1 to 2.5% by weight and in particular from 0.15 to 1.2% by weight, of nonionic surfactant (s) (E), preferably ethoxylated nonionic surfactant (s) and in particular ethoxylated nonionic surfactant (s) having from 30 to 100, preferably 40 to 80 and in particular 50 to 70 EO groups ,

The mouthwash compositions of the invention may, for. B. also contain antimicrobial substances as preservatives or as antiplaque agents. Such substances may, for. B. be selected from p-Hydroxybenzoesäuremethyl-, ethyl or propyl ester, sodium sorbate, sodium benzoate, bromochlorophene, triclosan, phenyl salicylates, biguanides z. Chlorhexidine, thymol, etc. According to the invention preferred mouthwash compositions are characterized in that they additionally antiplaque agents, preferably p-hydroxybenzoic acid methyl, ethyl or propyl, sodium sorbate, sodium benzoate, bromochlorophene, triclosan, phenyl salicylic, biguanides z. B. chlorhexidine, thymol, preferably in amounts of 0.01 to 5 wt.%, Preferably from 0.02 to 2.5 wt.% And in particular from 0.03 to 1, 5 wt.%, Each based on the total Means, included.

Particularly preferred according to the invention is the use of biguanidine compounds. These antimicrobially effective biguanide compounds are preferably contained in a very low concentration of 0.0025 to 0.04% by weight. As an antimicrobial Biguanidverbindung is preferably the 1, 1 in-hexamethylene-bis (4-chlorophenyl) - biguanide ("chlorhexidine") in the form of a water-soluble, physiologically acceptable salt, eg. B. used in the form of acetate or as gluconate. Other antimicrobial biguanide compounds which are suitable according to the invention are e.g. B. the polyhexamethylene biguanide compounds of the type Vantocil ^<R) IB (ICI) or the 1, 6-bis (4-chlorobenzylbiguanido) hexane (fluorohexidine).

According to preferred mouthwash compositions according to the invention are characterized in that they additionally antiplaque agents, preferably p-hydroxybenzoic acid methyl, ethyl or propyl esters, sodium sorbate, sodium benzoate, bromochlorophene, triclosan, phenyl salicylic, biguanides z. As chlorhexidine, thymol, preferably in amounts of 0.01 to 2.5 wt.%, Preferably from 0.05 to 1 wt.% And in particular from 0.1 to 0.5 wt.%, Each based on the total Means, included.

Another preferred group of ingredients that may be included in the compositions of the invention are the anti-caries agents. These may be selected, for example, from organic or inorganic fluorides, for. Example of sodium fluoride, potassium fluoride, sodium monofluorophosphate and sodium fluorosilicate. Also zinc fluoride, stannous fluoride are preferred. An amount of 0.01-0.2% by weight of fluorine should preferably be present in the form of the compounds mentioned.

The mouthwash composition according to the invention additionally contains anti-caries agents, preferably fluorine compound (s), in particular sodium fluoride, potassium fluoride, sodium monofluorophosphate, zinc fluoride, tin fluoride and sodium fluorosilicate, preferably in amounts of from 0.01 to 2.5% by weight, preferably from 0.02 to 1% by weight .% And in particular from 0.03 to 0.5 wt.%, Each based on the total agent, are inventively preferred.

The mouthwash compositions may also contain the insensitivity of the teeth-enhancing substances, for example, potassium salts such. As potassium nitrate, potassium citrate, potassium chloride, potassium bicarbonate and potassium oxalate. According to the invention preferred mouthwash compositions are characterized in that they the insensitivity of the teeth-enhancing substances, preferably potassium salts, more preferably potassium nitrate and / or potassium citrate and / or potassium chloride and / or potassium bicarbonate and / or potassium oxalate, preferably in amounts of 0.05 to 5 wt. %, particularly preferably from 0.1 to 2.5% by weight, more preferably from 0.2 to 1% by weight and in particular from 0.25 to 0.75% by weight, in each case based on the total agent , The compositions according to the invention can also additionally other wound-healing and anti-inflammatory substances, eg. B. agents for gingivitis included. Such substances may, for. B. be selected from allantoin, azulen, chamomile extracts, tocopherol, panthenol, bisabolol, sage extracts.

As a non-cationic, bactericidal component, e.g. Phenols, resorcinols, bisphenols, salicylanilides and their halogenated derivatives, halogenated carbanilides and p-hydroxybenzoic acid esters. Particularly preferred antimicrobial components are halogenated diphenyl ethers, e.g. 2,4-dichloro-2'-hydroxydiphenyl ether, 4,4'-dichloro-2'-hydroxydiphenyl ether, 2,4,4'-tribromo-2'-hydroxydiphenyl ether and 2,4,4'-trichloro-2'-hydroxydiphenyl ether (triclosan). They are preferably used in amounts of from 0.01 to 1% by weight in the mouthwash compositions according to the invention. Triclosan is particularly preferably used in an amount of 0.01-0.3% by weight.

D-panthenol D - (+) - 2,4-dihydroxy-N- (3-hydroxypropyl) -3,3-dimethyl-butyramide exhibits a biological activity corresponding to pantothenic acid. The pantothenic acid (R - (+) - N - (2,4-dihydroxy-3,3-dimethylbutyryl-β-alanine) is a precursor in the biosynthesis of coenzyme A and is counted to the vitamin B complex (B3). These substances are known to promote wound healing and have a beneficial effect on the skin, and have therefore been occasionally described in toothpastes The mouthwash compositions of the present invention preferably contain 0.05-5% by weight of panthenol or a salt of pantothenic acid ,

Retinol (3,7-dimethyl-9- (2,6,6-trimethyl-1-cyclohexenyl) -2,4,6,8-nonatetraen-1-ol is the international common name for vitamin A1, but may also be used instead of retinol one of its derivatives having similar biological activity, for example an ester or the retinoic acid (tretinoin), one of its salts or its esters is preferably used, preferably a retinol ester, in particular a fatty acid ester of a fatty acid having 12-22 carbon atoms if retinol palmitate is used, an amount of 0.001 to 0.1% by weight is preferred when using a retinol ester, for example retinol palmitate with an activity of 1.710 ⁶ IU per g When other retinol derivatives are used It is recommended to use at a concentration of 10 ³ to 10 ⁶ IU (international units) per 100 g.

Preferred mouthwash compositions according to the present invention contain, in addition to the abovementioned mandatory ingredients, preferably 0.01-1% by weight of a halogenated diphenyl ether 0.05-5% by weight of panthenol or a salt of pantothenic acid and 0.01-0.1% by weight .-% of a retinol ester, preferably retinol palmitate. Suitable water-insoluble aroma oils are all natural and synthetic flavors customary for oral and dental care products. Natural flavors can be used both in the form of the essential oils isolated from the drugs and in the form of the individual components isolated from them. Preferably, at least one aromatic oil should be selected from the group of peppermint oil, spearmint oil, aniseed oil, star aniseed oil, caraway oil, eucalyptus oil, fennel oil, cinnamon oil, clove oil, geranium oil, sage oil, pimento oil, thyme oil, marjoram oil, basil oil, citrus oil, Gaultheria oil or one or more thereof isolated or synthetically produced Components of these oils should be included. The most important components of the oils mentioned are z. Menthol, carvone, anethole, cineole, eugenol, cinnamaldehyde, caryophyllene, geraniol, citronellol, linalool, salvos, thymol, terpinene, terpinol, methylchavicol and methyl salicylate. Other suitable flavors are z. For example, menthyl acetate, vanillin, ionone, linalyl acetate, rhodinol and piperitone.

Solubilizers from the group of ethoxylated Fettsäureglyceride include especially adducts of 20-60 moles of ethylene oxide with mono- and diglycerides of linear fatty acids having 12-18 carbon atoms or triglycerides of hydroxy fatty acids such as oxystearic acid or ricinoleic acid. Further suitable solubilizers are ethoxylated fatty acid sorbitan partial esters; these are preferably addition products of 20-60 moles of ethylene oxide with sorbitan monoesters and sorbitan diesters of fatty acids with 12-18 carbon atoms. Also suitable solubilizers are fatty acid partial esters of glycerol or sorbitan ethoxylates; these are preferably mono- and diesters of C 12-18 fatty acids and adducts of 20-60 moles of ethylene oxide with 1 mole of glycerol or 1 mole of sorbitol.

The formulations of the present invention preferably contain as solubilizers addition products of 20-60 moles of ethylene oxide with hydrogenated or uncured castor oil (i.e., oxystearic acid or ricinoleic acid triglyceride), with glycerol mono- and / or distearate, or with sorbitan mono- and / or distearate.

In addition to the compulsory components mentioned, the preparations according to the invention may contain further components which are known per se and which are customary in antimicrobial preparations for the field of personal hygiene in order to improve their appearance, taste or handling. To improve the appearance z. As physiologically acceptable dyes, opacifiers or pearlescing agents are added. To improve the taste, natural or synthetic sweeteners, preferably cariogenic carbohydrate-free sweeteners may be added. These include, for example, saccharin sodium, cyclamates, acesulfame potassium, aspartame ^(R) (L-aspartyl-L-phenylalanine methyl ester). Further suitable sweeteners are, for example, sucrose, lactose, meltose, fructose. The mouthwash compositions according to the invention preferably have viscosities (measured at 20 ^° C. with Brookfield viscometer DV IM, spindle 4, 4 rpm) below 1000 mPas. Particular preference is given to viscosities below 500 mPas, more preferably below 250 mPas and in particular below 100 mPas.

If higher viscosities are desired in individual cases, the mouthwash compositions according to the invention can be used as consistency regulators, for. As natural and / or synthetic water-soluble polymers such as alginates, carrageenan, tragacanth, starch and starch ethers, cellulose ethers such. Carboxymethylcellulose (Na-SaIz), hydroxyethylcellulose, methylhydroxypropylcellulose, guar, acacia, agar, xanthan gum, succinoglycan gum, locust bean gum, pectins, water-soluble carboxyvinyl polymers (e.g., CarbopoKD types), polyvinyl alcohol, polyvinylpyrrolidone, polyethylene glycols , in particular those with molecular weights of 1 500-1 000 000.

Other substances that are suitable for viscosity control, z. B. phyllosilicates such. As montmorillonite clays, colloidal thickened silicas such. As airgel silicas, fumed silicas or finely ground precipitated silicas. It is also possible to use viscosity-stabilizing additives from the group of cationic, zwitterionic or ampholytic nitrogenous surfactants, hydroxypropyl-substituted hydrocolloids or polyethylene glycol / polypropylene glycol copolymers having an average molecular weight of from 1000 to 5000 or a combination of the compounds mentioned.

The mouthwash compositions according to the invention are distinguished from mouthwash compositions which do not contain cyclodextrins by a high stability against flocculation and sedimentation. They can be prepared by simply mixing the ingredients, for example, stirred tanks can be used. In this case, all ingredients can be mixed together at the same time or added to the mixing vessel one after the other. It has surprisingly been found that the stability of the compositions can be increased even further by adding the cyclodextrin as the last component, i. first mix all other ingredients of the mouthwash composition and then add the cyclodextrin or cyclodextrins.

Another object of the present invention is therefore a method for producing a mouthwash composition, wherein the ethanol, water and optionally further Ingredients are mixed together, wherein 0.001 to 5 wt .-% of at least one cyclodextrin - based on the produced mouthwash composition - as an ingredient in the mouthwash composition stirs.

To facilitate the incorporation of the powdered cyclodextrins, they can be premixed with liquid compounds. For this purpose, in particular alcohol (s) and / or the aroma oils have proven to be suitable. Processes according to the invention in which the cyclodextrin is premixed with an alcohol, preferably ethanol or an oil, preferably with peppermint oil, before the mixture is added to the mouthwash composition, are preferred according to the invention.

Another object of the present invention is a method for cleaning the oral cavity, in which a mouthwash composition according to the invention is diluted or introduced undiluted into the oral cavity and removed from it again after a contact time.

In preferred processes according to the invention, the reaction time is 5 seconds to 5 minutes, preferably 20 to 240 seconds, more preferably 30 to 180 seconds and especially 60 to 120 seconds. In further preferred inventive method, the ready solution is moved within the contact time in the mouth, which can assist the user by rinsing or Gurgelbewegungen.

Preferably, the introduction of the mouthwash composition according to the invention in the oral cavity in amounts of 3 to 50 ml, preferably from 5 to 40 ml, more preferably from 10 to 30 ml and in particular from 15 to 50 ml per application.

Particularly preferably, the use of the method according to the invention by the consumer can be ensured if the mouthwash compositions according to the invention are provided with a corresponding instruction for use. Such mouthwash compositions are essentially a "kit" of the packaged mouthwash composition and instructions for use.

Such kits of the invention comprise at least one package. This packaging is used in the not even dimensionally stable mouthwash compositions according to the invention for their storage and facilitates their dosage and use. Packaging preferred according to the invention is, for example, tubes, dispensers, bottles, cans, pots, pots, spray cans, boxes, buckets, boxes, tubs, etc. They can be made of a wide variety of materials, for example plastic, metal, glass, composites, etc. Packaging for cosmetic products in general, and for mouthwashes in particular, are broadly described in the art, and depending on the cosmetic product to be packaged, a wide variety of commercial packaging exists in a wide variety of shapes and sizes.

The packaged mouthwash compositions according to the invention can be provided in a kit with an outer packaging - but for cost reasons, this will only be practiced in higher-valued and higher-priced agents of the invention.

The outer packaging, like the packaging, can be made from a wide variety of materials and can take on a wide variety of shapes. For higher quality products, a tinplate can with removable lid can recommend. Also plastic boxes are possible embodiments. These outer packaging have the advantage of being appropriately decorated and used as a storage container after consumption. For products whose outer packaging is to be disposed of after use, a cardboard box is recommended. Cardboards have the advantage of low cost and easy printability. Colored and formal designs can be varied widely in these outer packaging.

Kits according to the invention which have at least one packaging directly surrounding the mouthwash composition and an outer packaging containing this packaging, which is preferably selected from cardboard boxes, are preferred according to the invention.

As a further component, the above-mentioned kit according to the invention comprises an instruction manual which gives the consumer instructions for use for the mouthwash composition. "Instructions for use" in the sense of the present application can not only be written versions in any language, but also visual representations such as pictograms.

The instructions for use may be permanently attached to or attached to the packaging. Thus, in one embodiment of the present invention, the instructions for use may be applied to the outside of the package. The instructions for use may also be applied to the inside of the package in preferred embodiments of the present invention. This embodiment is particularly recommended in kits according to the invention, which have an outer packaging.

In the simplest case, the instructions for use may be printed directly on the outside and / or inside of the package become. But it is also possible and preferred, separately prefabricated instructions for use, which may be configured fragrant, adherent to the packaging. Possibilities for this include gluing on labels, shrinking of films, the mechanical attachment of labels, papers, boxes, cards, etc. by means of snap, snap or clamp connections. The scope of design for packaging developers is almost limitless.

Of course, it is also possible to design the instructions for use as a separate sheet, which is placed in the packaging. This embodiment is again recommended in kits according to the invention, which have an additional outer packaging. The separate instructions for use can be made on paper, cardboard, plastic, etc. in the form of sheets, sheets, cards, cards, flyers, fanfolds, etc. The separate instructions for use has the advantage that the consumer can fix them in an exposed position and read repeatedly when using the agent. Also, such a separate instruction manual can be taken out of the packaging and read several times in changing places, without always the complete kit must be carried.

Kits according to the invention, in which the instructions for use are designed as a separate supplement, are a further preferred embodiment of the present invention.

The instructions for use preferably lead the consumer to use the method according to the invention.

With regard to preferred methods according to the invention, what has been said about the mouthwash compositions according to the invention applies mutatis mutandis.

When used in the context of the process according to the invention, the compositions according to the invention lead to a number of consumer advantages, the list below not being exhaustive. Particular preference is given to the use of mouthwash compositions according to the invention for cleaning the oral cavity and / or for reducing plaque and / or for preventing and / or reducing halitosis for whitening the teeth and / or for prophylactic prevention of caries and / or for prophylactic prevention of gingivitis and / or prophylactic prevention of periodontitis and / or prophylactic prevention of aphthae and / or prophylactic prevention of bite irritation and / or prophylactic prevention of mucosal infections and / or prophylactic prevention of herpes stomatitis.

Also with regard to preferred uses according to the invention, what has been said about the mouthwash compositions according to the invention applies mutatis mutandis.

The following examples illustrate the invention in more detail

Examples:

Two mouthwash compositions were prepared:

By saponification at 90 ^° C., 410 g of coconut oil raffinate and 220 g of 50% strength KOH in 270 g

Water prepared a soap solution, which was cooled to room temperature (20 ⁰ C). 9 g of this soap solution was diluted with 44 ml of water. There were 7 g of sorbitol, 0.5 g

Added sodium benzoate, flavors (camomile and sage extract) and an ethanolic

Solution of menthol and clove oil added.

For Example E according to the invention, 0.1 g of a compound containing from 0.6 to 0.9 - [CH ₂ -CH (CH ₃ ) -O] _n -H

Groups (n = 1 or 2) per amylose unit substituted beta-cyclodextrin mixed with 1 g of peppermint oil and added to the rest of the composition.

In the comparative example, only 1 g of peppermint oil was added.

The composition of the mouthwashes is shown in the following table:

The mouthwashes were filled into glass bottles and stored for four weeks at room temperature. The comparative example showed marked flocculation after storage, while the mouthwash according to the invention remained completely clear (see FIG. 1).

Claims

claims:

A mouthwash composition containing by weight a) ethanol; b) water; c) 0.001 to 5 wt .-% of at least one cyclodextrin.

2. Mouthwash composition according to claim 1, characterized in that it is based on its weight 1 to 50 wt .-%, preferably 1, 5 to 45 wt .-%, particularly preferably 3 to 40 wt .-% and in particular 5 to 35 wt .-% ethanol.

3. Mouthwash composition according to one of claims 1 or 2, characterized in that it is based on their weight 1 to 99.5 wt .-%, preferably 20 to 80 wt .-%, particularly preferably 30 to 70 wt .-% and in particular Contains 40 to 60 wt .-% water.

4. Mouthwash composition according to one of claims 1 to 3, characterized in that it contains 0.01 to 2.5 wt .-%, preferably 0.02 to 2 wt .-%, particularly preferably 0.03 to 1 wt .-% , more preferably 0.04 to 0.5 wt .-% and in particular 0.05 to 0.25 wt .-% cyclodextrin (s).

5. Mouthwash composition according to one of claims 1 to 4, characterized in that it contains at least one natural cyclodextrin, wherein preferred natural cyclodextrins are selected from alpha-cyclodextrin with six glucose units and / or - beta-cyclodextrin with seven glucose units and / or gamma Cyclodextrin with eight glucose units.

6. Mouthwash composition according to one of claims 1 to 5, characterized in that it contains at least one cyclodextrin derivative, preferred cyclodextrin derivatives are selected from i. Hydroxypropyl-alpha-cyclodextrin and / or ii. Hydroxypropyl-beta-cyclodextrin and / or iii. Hydroxypropyl gamma cyclodextrin and / or iv. Methyl alpha cyclodextrin and / or v. Methyl-beta-cyclodextrin and / or vi. Methyl-gamma-cyclodextrin.

7. Mouthwash composition according to one of claims 1 to 6, characterized in that it contains 0.5 to 20 wt .-%, preferably 1 to 15 wt .-%, particularly preferably 2 to 12 wt .-% and in particular 3 to 10 wt .-% of at least one polyhydric alcohol from the group sorbitol and / or glycerol and / or 1, 2-propylene glycol .-%, each based on the weight of the total mouthwash composition contains.

8. Mouthwash composition according to one of claims 1 to 7, characterized in that it additionally 0.05 to 5 wt .-%, preferably 0.1 to 2.5 wt .-% and in particular 0.15 to 1, 2 wt. % nonionic surfactant (s), preferably ethoxylated nonionic surfactant (s), and in particular ethoxylated nonionic surfactant (s) having from 30 to 100, preferably 40 to 80 and especially 50 to 70 EO groups.

9. A process for the preparation of a mouthwash composition in which ethanol, water and optionally other ingredients are mixed together, characterized in that 0.001 to 5 wt .-% of at least one cyclodextrin - based on the produced mouthwash composition - stirred as an ingredient in the mouthwash composition.

10. The method according to claim 9, characterized in that the cyclodextrin with an alcohol, preferably ethanol, or an oil, preferably with peppermint oil, is premixed before the mixture is added to the mouthwash composition.

11. A method for cleaning the oral cavity, characterized in that a mouthwash composition according to any one of claims 1 to 8 diluted or introduced undiluted into the oral cavity and is removed after a contact time again from her.

12. Use of mouthwash compositions according to any one of claims 1 to 8 for cleaning the oral cavity and / or for the reduction of plaque and / or

- To prevent and / or reduce bad breath to whiten teeth and / or

- for prophylactic prevention of tooth decay and / or for prophylactic prevention of gingivitis and / or prophylactic prevention of periodontitis and / or prophylactic prevention of aphthae and / or prophylactic prevention of bite irritation and / or prophylactic prevention of mucosal infections and / or prophylactic prevention of herpes stomatitis.