WO2008067007A3 - A method for quantitative measurement of thyroid homrones and related antibodies in a serum sample - Google Patents

A method for quantitative measurement of thyroid homrones and related antibodies in a serum sample Download PDF

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Publication number
WO2008067007A3
WO2008067007A3 PCT/US2007/078665 US2007078665W WO2008067007A3 WO 2008067007 A3 WO2008067007 A3 WO 2008067007A3 US 2007078665 W US2007078665 W US 2007078665W WO 2008067007 A3 WO2008067007 A3 WO 2008067007A3
Authority
WO
WIPO (PCT)
Prior art keywords
thyroid
serum sample
related antibodies
homrones
quantitative measurement
Prior art date
Application number
PCT/US2007/078665
Other languages
French (fr)
Other versions
WO2008067007A2 (en
Inventor
Zhong Chen
Ning Liu
Yancun Li
Original Assignee
Cytotrend Biotech Engineering
Zhong Chen
Ning Liu
Yancun Li
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytotrend Biotech Engineering, Zhong Chen, Ning Liu, Yancun Li filed Critical Cytotrend Biotech Engineering
Priority to US12/442,381 priority Critical patent/US8158440B2/en
Publication of WO2008067007A2 publication Critical patent/WO2008067007A2/en
Publication of WO2008067007A3 publication Critical patent/WO2008067007A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/046—Thyroid disorders
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds

Abstract

This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of thyroid hormones and related antibodies in a serum sample, which can be used to evaluate thyroid functions and to diagnose thyroid diseases. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of relevant antibodies and antigens used for the detection of respective thyroid hormones and related antibodies in a serum sample.
PCT/US2007/078665 2006-09-28 2007-09-17 A method for quantitative measurement of thyroid homrones and related antibodies in a serum sample WO2008067007A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/442,381 US8158440B2 (en) 2006-09-28 2007-09-17 Method for quantitative measurement of thyroid related antibodies or antigens in a serum sample

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82725806P 2006-09-28 2006-09-28
US60/827,258 2006-09-28

Publications (2)

Publication Number Publication Date
WO2008067007A2 WO2008067007A2 (en) 2008-06-05
WO2008067007A3 true WO2008067007A3 (en) 2008-11-20

Family

ID=39468554

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/078665 WO2008067007A2 (en) 2006-09-28 2007-09-17 A method for quantitative measurement of thyroid homrones and related antibodies in a serum sample

Country Status (2)

Country Link
US (1) US8158440B2 (en)
WO (1) WO2008067007A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9562266B1 (en) 2012-01-14 2017-02-07 The University Of Toledo Amine-terminated aptamer functionalized surface plasmon resonanace sensors, methods of making and methods of using same
SG11201503467PA (en) 2012-12-05 2015-06-29 Agency Science Tech & Res System and method for deriving parameters for homeostatic feedback control of an individual
GB201709503D0 (en) * 2017-06-15 2017-08-02 Method and device for assay improvement
US20210215723A1 (en) * 2018-07-13 2021-07-15 Aegirbio Ab Biosensor for Diagnosis of Thyroid Dysfunction

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Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
US5478755A (en) * 1988-07-25 1995-12-26 Ares Serono Research & Development Ltd. Long range surface plasma resonance immunoassay
US5242828A (en) * 1988-11-10 1993-09-07 Pharmacia Biosensor Ab Sensing surfaces capable of selective biomolecular interactions, to be used in biosensor systems

Also Published As

Publication number Publication date
US20090280575A1 (en) 2009-11-12
WO2008067007A2 (en) 2008-06-05
US8158440B2 (en) 2012-04-17

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