WO2008088588A3 - Biocompatible scaffold for sensing proteins - Google Patents
Biocompatible scaffold for sensing proteins Download PDFInfo
- Publication number
- WO2008088588A3 WO2008088588A3 PCT/US2007/078634 US2007078634W WO2008088588A3 WO 2008088588 A3 WO2008088588 A3 WO 2008088588A3 US 2007078634 W US2007078634 W US 2007078634W WO 2008088588 A3 WO2008088588 A3 WO 2008088588A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- biocompatible scaffold
- conductive layer
- containing nanowires
- thetav
- nanofibers
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
- G01N33/553—Metal or metal coated
Abstract
This invention related to a biocompatible scaffold that can detect redox-active chemicals and biomolecules electrochemically. In one embodiment, the biocompatible scaffold includes a substrate, and a conductive layer of Tiϑ2-containing nanowires or nano fibers formed on the substrate, wherein the conductive layer of Tiϑ2-containing nanowires or nanofibers is formed with a pore structure, and wherein when the biocompatible scaffold is in contact with a biological analyte, one or more proteins of the biological analyte are immobilized on a surface of the conductive layer Of TiO2- containing nanowires or nanofibers so as to generate a measurable faradic current signal.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2007800497563A CN101646401B (en) | 2007-01-12 | 2007-09-17 | Biocompatible scaffold for sensing proteins |
EP07814882A EP2101687A2 (en) | 2007-01-12 | 2007-09-17 | Biocompatible scaffold for sensing proteins |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/653,192 | 2007-01-12 | ||
US11/653,189 | 2007-01-12 | ||
US11/653,192 US7931812B2 (en) | 2006-01-12 | 2007-01-12 | TiO2 nanostructures, membranes and films, and applications of same |
US11/653,189 US8883115B2 (en) | 2006-01-12 | 2007-01-12 | TiO2 nanostructures, membranes and films, and methods of making same |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008088588A2 WO2008088588A2 (en) | 2008-07-24 |
WO2008088588A3 true WO2008088588A3 (en) | 2008-12-04 |
Family
ID=39636534
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/078634 WO2008088588A2 (en) | 2007-01-12 | 2007-09-17 | Biocompatible scaffold for sensing proteins |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP2101687A2 (en) |
WO (1) | WO2008088588A2 (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6503831B2 (en) * | 1997-10-14 | 2003-01-07 | Patterning Technologies Limited | Method of forming an electronic device |
US6914279B2 (en) * | 2002-06-06 | 2005-07-05 | Rutgers, The State University Of New Jersey | Multifunctional biosensor based on ZnO nanostructures |
-
2007
- 2007-09-17 EP EP07814882A patent/EP2101687A2/en not_active Withdrawn
- 2007-09-17 WO PCT/US2007/078634 patent/WO2008088588A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6503831B2 (en) * | 1997-10-14 | 2003-01-07 | Patterning Technologies Limited | Method of forming an electronic device |
US6914279B2 (en) * | 2002-06-06 | 2005-07-05 | Rutgers, The State University Of New Jersey | Multifunctional biosensor based on ZnO nanostructures |
Non-Patent Citations (3)
Title |
---|
BAVYKIN D. ET AL.: "A Novel Cation Binding TiO2 Nanotube Substrate for Electro- and Bioelectro-catalysis", ELECTROCHEMISTRY COMMUNICATIONS, vol. 7, no. 10, 2005, pages 1050 - 1058, XP005082477 * |
TOPOGLIDIS E. ET AL.: "Direct Electrochemistry and Nitric oxide Interaction of Heme Proteins Absorbed on Nanocrystalline Tin Oxide Electrodes", LANGMUIR, vol. 19, no. 17, 2003, pages 6894 - 6900, XP008111088 * |
WEBSTER T.J. ET AL.: "Increased Osteoblast Function on PLGA Composites Containing Nanophase Titania", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, vol. 74A, no. 4, PART A, 2005, pages 677 - 686, XP008111089 * |
Also Published As
Publication number | Publication date |
---|---|
EP2101687A2 (en) | 2009-09-23 |
WO2008088588A2 (en) | 2008-07-24 |
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