WO2008093647A1 - Microarray, method for production thereof, and method for detection of interaction between organic molecule and active substance - Google Patents

Microarray, method for production thereof, and method for detection of interaction between organic molecule and active substance Download PDF

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Publication number
WO2008093647A1
WO2008093647A1 PCT/JP2008/051227 JP2008051227W WO2008093647A1 WO 2008093647 A1 WO2008093647 A1 WO 2008093647A1 JP 2008051227 W JP2008051227 W JP 2008051227W WO 2008093647 A1 WO2008093647 A1 WO 2008093647A1
Authority
WO
WIPO (PCT)
Prior art keywords
microarray
organic molecule
interaction
active substance
immobilized
Prior art date
Application number
PCT/JP2008/051227
Other languages
French (fr)
Japanese (ja)
Inventor
Masato Oikawa
Makoto Sasaki
Yuichi Ogawa
Shin'ichiro Hayashi
Original Assignee
Tohoku University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tohoku University filed Critical Tohoku University
Priority to JP2008556090A priority Critical patent/JPWO2008093647A1/en
Publication of WO2008093647A1 publication Critical patent/WO2008093647A1/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/3581—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using far infrared light; using Terahertz radiation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/3563—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solids; Preparation of samples therefor

Abstract

Disclosed are: a microarray having an organic molecule immobilized thereon, which enables the organic molecule to be immobilized on a solid substrate in various orientations, which enables to detect a complicated interaction between the organic molecule and an active substance, and has no restriction in orientation and therefore can analyze on structure-activity relationships, and can be produced in a simple manner and at low cost; a method for producing the microarray; and a method for detecting the interaction between an active substance and the organic molecule using the microarray. Specifically disclosed is a microarray having, immobilized thereon, an organic molecule which is used for the detection of the interaction between the organic molecule and the active substance. The microarray comprises a substrate (A), an organic carrier (B) immobilized on the substrate (A) by an intermolecular interaction, and an organic molecule (C) immobilized on the organic carrier (B). In a preferred embodiment, an analysis is made by measuring at least one item selected from transmission, reflection and interference of a terahertz (THz) wave by using the microarray.
PCT/JP2008/051227 2007-01-31 2008-01-28 Microarray, method for production thereof, and method for detection of interaction between organic molecule and active substance WO2008093647A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008556090A JPWO2008093647A1 (en) 2007-01-31 2008-01-28 Microarray, method for producing the same, and method for detecting interaction between organic molecule and active substance

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007022380 2007-01-31
JP2007-022396 2007-01-31
JP2007-022380 2007-01-31
JP2007022396 2007-01-31

Publications (1)

Publication Number Publication Date
WO2008093647A1 true WO2008093647A1 (en) 2008-08-07

Family

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Family Applications (1)

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PCT/JP2008/051227 WO2008093647A1 (en) 2007-01-31 2008-01-28 Microarray, method for production thereof, and method for detection of interaction between organic molecule and active substance

Country Status (2)

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JP (1) JPWO2008093647A1 (en)
WO (1) WO2008093647A1 (en)

Cited By (10)

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JP2010190837A (en) * 2009-02-20 2010-09-02 Kurabo Ind Ltd METHOD FOR DETERMINING LogP AND TWO-PHASE SYSTEM SOLVENT USED FOR METHOD
JP2010249564A (en) * 2009-04-13 2010-11-04 Nippon Telegr & Teleph Corp <Ntt> Solubility spectrometry and solubility spectrometric device
JP2011506673A (en) * 2007-12-14 2011-03-03 バイオティウム， インコーポレイテッド Fluorescent compound
JP2011112548A (en) * 2009-11-27 2011-06-09 Sony Corp Biosample analysis method, biosample analyzer, and biosample analysis program
WO2011125355A1 (en) * 2010-04-01 2011-10-13 株式会社村田製作所 Measuring method of characteristic of object to be measured, and sensing device used in same
CN108398400A (en) * 2018-01-18 2018-08-14 河南工业大学 Utilize the method for content of fatty acid in terahertz imaging non-destructive testing wheat
JP2020511652A (en) * 2016-12-01 2020-04-16 ユニバーシティ・オブ・ソウル・インダストリー・コーオパレイション・ファウンデイションＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｓｅｏｕｌ Ｉｎｄｕｓｔｒｙ Ｃｏｏｐｅｒａｔｉｏｎ Ｆｏｕｎｄａｔｉｏｎ DNA analysis method and DNA analysis apparatus using terahertz wave
WO2020080576A1 (en) * 2018-10-18 2020-04-23 연세대학교 산학협력단 Method for predicting absorbance change by intermolecular interaction
CN111366555A (en) * 2020-02-27 2020-07-03 浙江大学 Detection method for agricultural film residue in farmland soil
WO2022029135A1 (en) * 2020-08-03 2022-02-10 Jt International Sa Measurement method and tag arranged in a smoking article or smoking articles packaging

Citations (5)

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JPH11201971A (en) * 1997-11-09 1999-07-30 Bayer Corp Method for detection of object to be analyzed in fluidic sample
JP2005233955A (en) * 2004-02-16 2005-09-02 Samsung Electronics Co Ltd Method for fixing biomolecules on solid substrate via non-covalent bond, and microarray manufactured by it
JP2005283143A (en) * 2004-03-26 2005-10-13 Fuji Photo Film Co Ltd Biosensor
JP2006084422A (en) * 2004-09-17 2006-03-30 Pentax Corp Method and apparatus for forming transmission image
WO2006137824A2 (en) * 2004-08-04 2006-12-28 Intel Corporation Methods and systems for detecting biomolecular binding using terahertz radiation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11201971A (en) * 1997-11-09 1999-07-30 Bayer Corp Method for detection of object to be analyzed in fluidic sample
JP2005233955A (en) * 2004-02-16 2005-09-02 Samsung Electronics Co Ltd Method for fixing biomolecules on solid substrate via non-covalent bond, and microarray manufactured by it
JP2005283143A (en) * 2004-03-26 2005-10-13 Fuji Photo Film Co Ltd Biosensor
WO2006137824A2 (en) * 2004-08-04 2006-12-28 Intel Corporation Methods and systems for detecting biomolecular binding using terahertz radiation
JP2006084422A (en) * 2004-09-17 2006-03-30 Pentax Corp Method and apparatus for forming transmission image

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9791450B2 (en) 2007-12-14 2017-10-17 Biotium, Inc. Fluorescent compounds
JP2011506673A (en) * 2007-12-14 2011-03-03 バイオティウム， インコーポレイテッド Fluorescent compound
US9097667B2 (en) 2007-12-14 2015-08-04 Biotium, Inc. Fluorescent compounds
JP2015172199A (en) * 2007-12-14 2015-10-01 バイオティウム， インコーポレイテッド Fluorescent compounds
JP2010190837A (en) * 2009-02-20 2010-09-02 Kurabo Ind Ltd METHOD FOR DETERMINING LogP AND TWO-PHASE SYSTEM SOLVENT USED FOR METHOD
JP2010249564A (en) * 2009-04-13 2010-11-04 Nippon Telegr & Teleph Corp <Ntt> Solubility spectrometry and solubility spectrometric device
JP2011112548A (en) * 2009-11-27 2011-06-09 Sony Corp Biosample analysis method, biosample analyzer, and biosample analysis program
WO2011125355A1 (en) * 2010-04-01 2011-10-13 株式会社村田製作所 Measuring method of characteristic of object to be measured, and sensing device used in same
JP5859955B2 (en) * 2010-04-01 2016-02-16 株式会社村田製作所 Method for measuring characteristics of object to be measured and sensing device used therefor
JP2020511652A (en) * 2016-12-01 2020-04-16 ユニバーシティ・オブ・ソウル・インダストリー・コーオパレイション・ファウンデイションＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｓｅｏｕｌ Ｉｎｄｕｓｔｒｙ Ｃｏｏｐｅｒａｔｉｏｎ Ｆｏｕｎｄａｔｉｏｎ DNA analysis method and DNA analysis apparatus using terahertz wave
CN108398400A (en) * 2018-01-18 2018-08-14 河南工业大学 Utilize the method for content of fatty acid in terahertz imaging non-destructive testing wheat
CN108398400B (en) * 2018-01-18 2020-12-22 河南工业大学 Method for nondestructive testing of fatty acid content in wheat by terahertz imaging
WO2020080576A1 (en) * 2018-10-18 2020-04-23 연세대학교 산학협력단 Method for predicting absorbance change by intermolecular interaction
CN111366555A (en) * 2020-02-27 2020-07-03 浙江大学 Detection method for agricultural film residue in farmland soil
CN111366555B (en) * 2020-02-27 2021-01-26 浙江大学 Detection method for agricultural film residue in farmland soil
WO2022029135A1 (en) * 2020-08-03 2022-02-10 Jt International Sa Measurement method and tag arranged in a smoking article or smoking articles packaging

Also Published As

Publication number Publication date
JPWO2008093647A1 (en) 2010-05-20

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