WO2008094620A3 - Fluidic methods - Google Patents

Fluidic methods Download PDF

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Publication number
WO2008094620A3
WO2008094620A3 PCT/US2008/001255 US2008001255W WO2008094620A3 WO 2008094620 A3 WO2008094620 A3 WO 2008094620A3 US 2008001255 W US2008001255 W US 2008001255W WO 2008094620 A3 WO2008094620 A3 WO 2008094620A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
fluidic methods
fluidic
samples
devices
Prior art date
Application number
PCT/US2008/001255
Other languages
French (fr)
Other versions
WO2008094620A2 (en
Inventor
Edward K Y Jung
Eric C Leuthardt
Royce A Levien
Robert W Lord
Mark A Malamud
John D Rinaldo Jr
Lowell L Wood Jr
Original Assignee
Searete Llc
Edward K Y Jung
Eric C Leuthardt
Royce A Levien
Robert W Lord
Mark A Malamud
John D Rinaldo Jr
Lowell L Wood Jr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/699,747 external-priority patent/US20080181821A1/en
Priority claimed from US11/699,920 external-priority patent/US20080181816A1/en
Priority claimed from US11/699,770 external-priority patent/US8617903B2/en
Priority claimed from US11/699,774 external-priority patent/US20080180259A1/en
Priority claimed from US11/729,274 external-priority patent/US20080241000A1/en
Priority claimed from US11/729,276 external-priority patent/US20080241910A1/en
Priority claimed from US11/729,275 external-priority patent/US20080241909A1/en
Priority claimed from US11/799,465 external-priority patent/US20080179255A1/en
Priority claimed from US11/799,462 external-priority patent/US20080178692A1/en
Priority to GB0915119A priority Critical patent/GB2460196B/en
Application filed by Searete Llc, Edward K Y Jung, Eric C Leuthardt, Royce A Levien, Robert W Lord, Mark A Malamud, John D Rinaldo Jr, Lowell L Wood Jr filed Critical Searete Llc
Publication of WO2008094620A2 publication Critical patent/WO2008094620A2/en
Publication of WO2008094620A3 publication Critical patent/WO2008094620A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/12—Measuring magnetic properties of articles or specimens of solids or fluids
    • G01R33/1269—Measuring magnetic properties of articles or specimens of solids or fluids of molecules labeled with magnetic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/005—Pretreatment specially adapted for magnetic separation
    • B03C1/01—Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/32—Magnetic separation acting on the medium containing the substance being separated, e.g. magneto-gravimetric-, magnetohydrostatic-, or magnetohydrodynamic separation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0636—Focussing flows, e.g. to laminate flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid

Abstract

The present disclosure relates to methods and devices that may be used to separate components from one or more samples.
PCT/US2008/001255 2007-01-29 2008-01-28 Fluidic methods WO2008094620A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB0915119A GB2460196B (en) 2007-01-29 2008-01-28 Fluidic methods

Applications Claiming Priority (20)

Application Number Priority Date Filing Date Title
US11/699,747 US20080181821A1 (en) 2007-01-29 2007-01-29 Microfluidic chips for allergen detection
US11/699,770 2007-01-29
US11/699,774 2007-01-29
US11/699,774 US20080180259A1 (en) 2007-01-29 2007-01-29 Devices for allergen detection
US11/699,770 US8617903B2 (en) 2007-01-29 2007-01-29 Methods for allergen detection
US11/699,747 2007-01-29
US11/699,920 2007-01-29
US11/699,920 US20080181816A1 (en) 2007-01-29 2007-01-29 Systems for allergen detection
US11/729,276 2007-03-27
US11/729,276 US20080241910A1 (en) 2007-03-27 2007-03-27 Devices for pathogen detection
US11/729,274 2007-03-27
US11/729,301 US20080241935A1 (en) 2007-03-27 2007-03-27 Methods for pathogen detection
US11/729,274 US20080241000A1 (en) 2007-03-27 2007-03-27 Systems for pathogen detection
US11/729,301 2007-03-27
US11/729,275 2007-03-27
US11/729,275 US20080241909A1 (en) 2007-03-27 2007-03-27 Microfluidic chips for pathogen detection
US11/799,462 2007-04-30
US11/799,465 2007-04-30
US11/799,465 US20080179255A1 (en) 2007-01-29 2007-04-30 Fluidic devices
US11/799,462 US20080178692A1 (en) 2007-01-29 2007-04-30 Fluidic methods

Publications (2)

Publication Number Publication Date
WO2008094620A2 WO2008094620A2 (en) 2008-08-07
WO2008094620A3 true WO2008094620A3 (en) 2009-01-15

Family

ID=39674716

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/001255 WO2008094620A2 (en) 2007-01-29 2008-01-28 Fluidic methods

Country Status (2)

Country Link
GB (1) GB2460196B (en)
WO (1) WO2008094620A2 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922210A (en) * 1995-06-16 1999-07-13 University Of Washington Tangential flow planar microfabricated fluid filter and method of using thereof
US6221677B1 (en) * 1997-09-26 2001-04-24 University Of Washington Simultaneous particle separation and chemical reaction
US6408884B1 (en) * 1999-12-15 2002-06-25 University Of Washington Magnetically actuated fluid handling devices for microfluidic applications
US6541213B1 (en) * 1996-03-29 2003-04-01 University Of Washington Microscale diffusion immunoassay
US6716642B1 (en) * 1999-03-15 2004-04-06 Aviva Biosciences Corporation Individually addressable micro-electromagnetic unit array chips in horizontal configurations
US6877892B2 (en) * 2002-01-11 2005-04-12 Nanostream, Inc. Multi-stream microfluidic aperture mixers

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922210A (en) * 1995-06-16 1999-07-13 University Of Washington Tangential flow planar microfabricated fluid filter and method of using thereof
US6541213B1 (en) * 1996-03-29 2003-04-01 University Of Washington Microscale diffusion immunoassay
US6221677B1 (en) * 1997-09-26 2001-04-24 University Of Washington Simultaneous particle separation and chemical reaction
US6716642B1 (en) * 1999-03-15 2004-04-06 Aviva Biosciences Corporation Individually addressable micro-electromagnetic unit array chips in horizontal configurations
US6408884B1 (en) * 1999-12-15 2002-06-25 University Of Washington Magnetically actuated fluid handling devices for microfluidic applications
US6877892B2 (en) * 2002-01-11 2005-04-12 Nanostream, Inc. Multi-stream microfluidic aperture mixers

Also Published As

Publication number Publication date
GB2460196A (en) 2009-11-25
GB2460196B (en) 2011-06-01
GB0915119D0 (en) 2009-10-07
WO2008094620A2 (en) 2008-08-07

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