WO2008097885A3 - Decellularization of soft tissue - Google Patents

Decellularization of soft tissue Download PDF

Info

Publication number
WO2008097885A3
WO2008097885A3 PCT/US2008/052885 US2008052885W WO2008097885A3 WO 2008097885 A3 WO2008097885 A3 WO 2008097885A3 US 2008052885 W US2008052885 W US 2008052885W WO 2008097885 A3 WO2008097885 A3 WO 2008097885A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
skin
disinfecting
decellularization
soft tissue
Prior art date
Application number
PCT/US2008/052885
Other languages
French (fr)
Other versions
WO2008097885A2 (en
Inventor
Manh-Dan Ngo
Arthur Gertzman
Michael Kawas
Katherine G Truncale
Moon Hae Sunwoo
Original Assignee
Manh-Dan Ngo
Arthur Gertzman
Michael Kawas
Katherine G Truncale
Moon Hae Sunwoo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Manh-Dan Ngo, Arthur Gertzman, Michael Kawas, Katherine G Truncale, Moon Hae Sunwoo filed Critical Manh-Dan Ngo
Priority to CA002677229A priority Critical patent/CA2677229A1/en
Priority to EP08728897A priority patent/EP2114136A2/en
Publication of WO2008097885A2 publication Critical patent/WO2008097885A2/en
Publication of WO2008097885A3 publication Critical patent/WO2008097885A3/en
Priority to US12/534,613 priority patent/US20100112543A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Materials For Medical Uses (AREA)
  • Detergent Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Prostheses (AREA)

Abstract

In certain embodiments, the present invention relates to a process for preparing skin removed from a human donor and removing cellular components and forming a decellular matrix having as major components collagens and elastins while disinfecting the tissue. In a particular embodiment, the process comprises the following: (1) removing hair from the skin; (2) decellularizing the skin including inspection for visual defects; (3) soaking the tissue in a detergent and rinsing same with sterile water; (4) disinfecting the skin in a disinfection solution containing about 0.5% to about 0.7% peracetic acid; and (5) processing the tissue by cutting the tissue to size.
PCT/US2008/052885 2005-03-16 2008-02-04 Decellularization of soft tissue WO2008097885A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002677229A CA2677229A1 (en) 2007-02-02 2008-02-04 Decellularization of soft tissue
EP08728897A EP2114136A2 (en) 2007-02-02 2008-02-04 Decellularization of soft tissue
US12/534,613 US20100112543A1 (en) 2005-03-16 2009-08-03 Processing soft tissue, methods and compositions related thereto

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US89901807P 2007-02-02 2007-02-02
US89902007P 2007-02-02 2007-02-02
US89902107P 2007-02-02 2007-02-02
US60/899,021 2007-02-02
US60/899,018 2007-02-02
US60/899,020 2007-02-02
US92424907P 2007-05-04 2007-05-04
US60/924,249 2007-05-04

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US11/375,026 Continuation-In-Part US7723108B2 (en) 2005-03-16 2006-03-15 Soft tissue processing

Related Child Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/052884 Continuation-In-Part WO2008097884A2 (en) 2005-03-16 2008-02-04 Processing skin from living donors

Publications (2)

Publication Number Publication Date
WO2008097885A2 WO2008097885A2 (en) 2008-08-14
WO2008097885A3 true WO2008097885A3 (en) 2008-11-27

Family

ID=39682082

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2008/052885 WO2008097885A2 (en) 2005-03-16 2008-02-04 Decellularization of soft tissue
PCT/US2008/052882 WO2008097882A1 (en) 2005-03-16 2008-02-04 Treatment of soft tissue to increase porosity
PCT/US2008/052884 WO2008097884A2 (en) 2005-03-16 2008-02-04 Processing skin from living donors

Family Applications After (2)

Application Number Title Priority Date Filing Date
PCT/US2008/052882 WO2008097882A1 (en) 2005-03-16 2008-02-04 Treatment of soft tissue to increase porosity
PCT/US2008/052884 WO2008097884A2 (en) 2005-03-16 2008-02-04 Processing skin from living donors

Country Status (3)

Country Link
EP (3) EP2117462A1 (en)
CA (3) CA2677229A1 (en)
WO (3) WO2008097885A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103272278A (en) * 2013-05-28 2013-09-04 北京博辉瑞进生物科技有限公司 Method for preparing animal derived implantable medical biomaterial

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102600508B (en) * 2012-02-14 2014-03-19 上海交通大学医学院附属上海儿童医学中心 Porcine arterial vacuum lyophilization acellular matrix, as well as preparation method and application thereof
CN108079363A (en) * 2017-12-19 2018-05-29 广州昕生医学材料有限公司 A kind of kit and its application that cell processing is taken off for animal tissue
KR102171320B1 (en) * 2018-04-27 2020-10-28 이화여자대학교 산학협력단 A method for decellularizing of a tracheal mucosa tissue

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4776853A (en) * 1986-07-28 1988-10-11 Hsc Research Development Corporation Process for preparing biological mammalian implants
US5993844A (en) * 1997-05-08 1999-11-30 Organogenesis, Inc. Chemical treatment, without detergents or enzymes, of tissue to form an acellular, collagenous matrix
US6734018B2 (en) * 1999-06-07 2004-05-11 Lifenet Process for decellularizing soft-tissue engineered medical implants, and decellularized soft-tissue medical implants produced

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5976878A (en) * 1987-04-28 1999-11-02 The Regents Of The University Of California Method and apparatus for preparing composite skin replacement
US5336616A (en) * 1990-09-12 1994-08-09 Lifecell Corporation Method for processing and preserving collagen-based tissues for transplantation
TWI284665B (en) * 2001-08-17 2007-08-01 Univ Nat Cheng Kung Fabrication method of the porous collagen matrix
CA2602100A1 (en) * 2005-03-16 2006-09-28 Musculoskeletal Transplant Foundation Soft tissue processing

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4776853A (en) * 1986-07-28 1988-10-11 Hsc Research Development Corporation Process for preparing biological mammalian implants
US5993844A (en) * 1997-05-08 1999-11-30 Organogenesis, Inc. Chemical treatment, without detergents or enzymes, of tissue to form an acellular, collagenous matrix
US6734018B2 (en) * 1999-06-07 2004-05-11 Lifenet Process for decellularizing soft-tissue engineered medical implants, and decellularized soft-tissue medical implants produced
US7338757B2 (en) * 1999-06-07 2008-03-04 Lifenet Health Process for decellularizing soft-tissue engineered medical implants, and decellularized soft-tissue medical implants produced

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103272278A (en) * 2013-05-28 2013-09-04 北京博辉瑞进生物科技有限公司 Method for preparing animal derived implantable medical biomaterial
CN103272278B (en) * 2013-05-28 2015-04-15 北京博辉瑞进生物科技有限公司 Method for preparing animal derived implantable medical biomaterial

Also Published As

Publication number Publication date
WO2008097884A3 (en) 2008-10-09
EP2114136A2 (en) 2009-11-11
CA2677305A1 (en) 2008-08-14
WO2008097885A2 (en) 2008-08-14
WO2008097882A1 (en) 2008-08-14
CA2677308A1 (en) 2008-08-14
WO2008097884A2 (en) 2008-08-14
EP2117462A1 (en) 2009-11-18
EP2114135A2 (en) 2009-11-11
CA2677229A1 (en) 2008-08-14

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