WO2008106659A3 - Methods of treating bipolar disorder and memory and/or cognitive impairment associated therewith - Google Patents

Methods of treating bipolar disorder and memory and/or cognitive impairment associated therewith Download PDF

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Publication number
WO2008106659A3
WO2008106659A3 PCT/US2008/055562 US2008055562W WO2008106659A3 WO 2008106659 A3 WO2008106659 A3 WO 2008106659A3 US 2008055562 W US2008055562 W US 2008055562W WO 2008106659 A3 WO2008106659 A3 WO 2008106659A3
Authority
WO
WIPO (PCT)
Prior art keywords
memory
cognitive impairment
associated therewith
impairment associated
methods
Prior art date
Application number
PCT/US2008/055562
Other languages
French (fr)
Other versions
WO2008106659A2 (en
Inventor
David Lowe
Christopher J Leonard
Vivo Michael De
Geoffrey Tombaugh
Original Assignee
Memory Pharm Corp
David Lowe
Christopher J Leonard
Vivo Michael De
Geoffrey Tombaugh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memory Pharm Corp, David Lowe, Christopher J Leonard, Vivo Michael De, Geoffrey Tombaugh filed Critical Memory Pharm Corp
Publication of WO2008106659A2 publication Critical patent/WO2008106659A2/en
Publication of WO2008106659A3 publication Critical patent/WO2008106659A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

The present invention is a method of treating or preventing mixed and/or manic episodes associated with bipolar I disorder or memory and/or cognitive impairment associated therewith in a patient in need thereof by administering an effective amount of at least one calcium channel modulator selected from (1 ) amlodipine, bepridil, clevidipine, felodipine, isradipine, lacidipine, lercanidipine, manidipine, niguldipine, nilvadipine, nisoldipine, or nitrendipine, or (2) the R-enantiomer of a 1,4-dihydropyridine compound, other than (+)-isopropyl 2-methoxyethyl 4-(2-chloro-3-cyano-phenyl)- l,4- dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylate.
PCT/US2008/055562 2007-03-01 2008-02-29 Methods of treating bipolar disorder and memory and/or cognitive impairment associated therewith WO2008106659A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89245507P 2007-03-01 2007-03-01
US60/892,455 2007-03-01

Publications (2)

Publication Number Publication Date
WO2008106659A2 WO2008106659A2 (en) 2008-09-04
WO2008106659A3 true WO2008106659A3 (en) 2008-10-16

Family

ID=39721861

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/055562 WO2008106659A2 (en) 2007-03-01 2008-02-29 Methods of treating bipolar disorder and memory and/or cognitive impairment associated therewith

Country Status (1)

Country Link
WO (1) WO2008106659A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
US9101545B2 (en) 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7820691B2 (en) 2006-08-28 2010-10-26 Medipropharma, Inc. Indoloquinoline compounds as calcium channel blockers
WO2014052849A1 (en) * 2012-09-28 2014-04-03 Elan Pharmaceuticals, Inc. Combination treatments for bipolar disorders

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4567271A (en) * 1977-06-20 1986-01-28 Sandoz Ltd. Benzoxadiazoles and benzothiadiazoles
US6458808B1 (en) * 2000-12-20 2002-10-01 Osmotica Corp. Pharmaceutical composition for the treatment of cognitive cerebrovascular disease

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4567271A (en) * 1977-06-20 1986-01-28 Sandoz Ltd. Benzoxadiazoles and benzothiadiazoles
US6458808B1 (en) * 2000-12-20 2002-10-01 Osmotica Corp. Pharmaceutical composition for the treatment of cognitive cerebrovascular disease

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SINGH ET AL.: "Renewed Interest in Calcium Channel as Antimania Agents in the Third Millenium", HONG KONG JOURNAL OF PSYCHIATRY, vol. 14, no. 2, 2004, pages 12 - 15 *
SKOLNICK: "New Pharmacological Strategies", 1997, HUMANA PRESS, TOTOWA, NEW JERSEY, ISBN: 0806034690, article PUCILOWSKI ET AL.: "Calcium Channel Antagonists in Mood Disorders, in Antidepressants", pages: 81 - 102 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
US8889190B2 (en) 2013-03-13 2014-11-18 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules
US9101545B2 (en) 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules
US9555005B2 (en) 2013-03-15 2017-01-31 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules

Also Published As

Publication number Publication date
WO2008106659A2 (en) 2008-09-04

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