WO2008109857A2 - System and method for treating ageing of the skin - Google Patents

System and method for treating ageing of the skin Download PDF

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Publication number
WO2008109857A2
WO2008109857A2 PCT/US2008/056286 US2008056286W WO2008109857A2 WO 2008109857 A2 WO2008109857 A2 WO 2008109857A2 US 2008056286 W US2008056286 W US 2008056286W WO 2008109857 A2 WO2008109857 A2 WO 2008109857A2
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WO
WIPO (PCT)
Prior art keywords
skin
approximately
oxygen
exfoliating
gtts
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PCT/US2008/056286
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French (fr)
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WO2008109857A3 (en
Inventor
John P. Gardner
John A. Ii Gardner
Hector Grajeda, Jr.
Original Assignee
Gardner John P
Gardner John A Ii
Grajeda Hector Jr
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Application filed by Gardner John P, Gardner John A Ii, Grajeda Hector Jr filed Critical Gardner John P
Publication of WO2008109857A2 publication Critical patent/WO2008109857A2/en
Publication of WO2008109857A3 publication Critical patent/WO2008109857A3/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/10Washing or bathing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208Tissues; Wipes; Patches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35Ketones, e.g. benzophenone
    • A61K8/355Quinones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42Amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4986Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with sulfur as the only hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • A61K8/602Glycosides, e.g. rutin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/676Ascorbic acid, i.e. vitamin C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9771Ginkgophyta, e.g. Ginkgoaceae [Ginkgo family]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/28Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants

Definitions

  • the present invention relates to the treatment of skin. More specifically, the present invention relates to intrinsic and extrinsic systems and methods for treating ageing of the skin.
  • Human skin is composed of a complex network of tissues and cells that make up the integumentary system. This complex covering for the body is an organ similar in operation to all the other organs in the body created for homeostasis. All of the vital nutrients necessary to maintain the continued life of the skin comes from the digestive and cardiorespiratory systems located within. Everything a person eats, drinks, and breathes eventually begins a complicated journey of homeosis, breaking down into cellular nutrients known as proteins, carbohydrates, vitamins and oxygen (O 2 ) supplying the internal, basal layer of the skin.
  • the skin As important as the skin is to the overall health and protection of the body (it is the "first line” of defense), it is the last organ to receive nutrients, hydration and oxygen needed to sustain its life. As a consequence, researchers have shown that it is the first portion of the body to show visible signs of ageing. Moreover, facial skin is the first part of the body's overall skin layer to display these signs.
  • the human body can go weeks without food, days without water and minutes without oxygen. The same thing is true for the cells that make up the skin. An appropriate intake of nutrients is required to insure that the cells remain healthy and function properly. Most individuals do not follow such a regimen. As a result, the effects of ageing are accelerated.
  • Ageing occurs as a result of a number of mechanisms. Some are natural factors of ageing such as a deterioration of the production of collagen and reduction of blood flow to the skin. Additionally, the presence of free-radicals in the body cause cellular damage. These free-radicals enter the body through a number of means and can be caused by dietary and environmental conditions such as smoking, sunlight and air pollution.
  • the mechanisms of ageing are broken down into two broad categories: intrinsic modalities of ageing (internal causes of ageing) and extrinsic modalities of ageing (external factors that contribute to skin damage). Since there are many factors that are working together to damage the skin, any solution to the effects of ageing must combat these effects on all levels. The skin cure products in use today only fight on one level, so only partial relief of the effects of ageing is provided.
  • Fig. 1 is an exploded perspective view of an expiratory breathing resistance exerciser in accordance with an embodiment
  • Fig. 2 is a side elevational view of the breathing exerciser of Fig. 1;
  • Fig. 3 is a top view of the breathing exerciser of Figs. 1 and 2;
  • Fig. 4 is a front elevational view of the breathing exerciser of Figs. 1-3.
  • the skin care system herein disclosed incorporates a vast array of new art and new science formulated as one complete system to introduce state of the art modalities systematically designed to be used by professionals in the field of cosmetics and cosmeceuticals as well by laymen in the comfort of their own environments.
  • the skin care system is the first system of its kind that will introduce a combined regimen of safe pharmaceuticals along with ambient (21%) oxygen that will not generate Reactive Oxygen Species (R.O.S.) and Free Radicals (F.R.'s) and introduce them into and onto the surface of skin cells.
  • Current technologies employ the use of 95% - 100% oxygen as a gas, liquid or cream that researchers have determined to be a direct cause of increasing the skin ageing mechanisms.
  • ambient 21% oxygen is a safe and effective alternative to deliver vital pH-balanced herbal and plant derived nutriments to the skin cells to safely exfoliate, hydrate, cleanse, moisturize and nourish the skin cells.
  • the isobaric skin care system of the instant invention utilizes the exact amount of oxygen the skin needs and is "born" into. This skin care system will propel normo-baric O 2 into contact with the skin consistently at a concentration level of 21% without creating reactive oxygen species and free radicals.
  • Current facial exfoliation techniques do not take into account that the basal layer is alive and divided, having an outer layer of skin called the spinous layer overlaying it.
  • the two layers form the all important malpighian network of living cells.
  • the malpighian network is composed of a granular network composed of kerotin which become prominent keratimeytes that age and migrate to an outer layer commonly known as the cornified layer or stratum corneum. These combined cells become flattened sacs of keratin protein in which their nuclei are pushed to one edge of the cell. These cells begin the process of dying, death and shedding. After death they are replaced by "new" cells coming forth from the granular layer.
  • the skin care system herein disclosed takes considerable care in its approach to mechanical exfoliation due to the vast difference in the life cycles of dying, dead and shedding cells of the facial skin. There is “life” still present in “dying” cells and less life in dead cells. Such being the case, a gentle blend of natural surfactants obtained from plants is disclosed herein which is used to exfoliate and cleanse the surface of the facial skin of cells that have died. This process removes dead cells and leaves behind a residue of surface emollients capable of supporting the life left in the still viable "dying" cells.
  • the ingredients comprising the exfoliation and cleansing formulation are set forth in Table 1 below.
  • the isobaric skin care system uses an "isotonic" blend of naturally derived herbal extracts and humectants that are pH-balanced to effectively harmonize with the exfoliation and cleansing process. Together, these processes do not compromise the facial skin in any way.
  • Table 2 lists the preferred nutrients which may be applied using the isobaric moisturization technique. These nutrients may be applied with sterile and heated pads following exfoliation and cleansing to open the skin pores in preparation for the final treatment which will be discussed in greater detail below. This solution targets problem areas such as around the eyes, nose, forehead and the mouth-areas where wrinkles first appear.
  • the post-exfoliation/cleansing treatment also includes avocado oil to aid in moisturizing as well as borage oil, which has been found to be effective in combating the effects of eczema.
  • the skin care system of the present invention introduces a new and highly innovative delivery system designed to effectively moisturize, hydrate and oxygenate the skin via epidermal nebulizations, which may be characterized as skinhalation.
  • This treatment is designed to deliver an assortment of nutritive microparticulate substances via cosmetic-nebulization at a rate of over 200,000,000 particles per second (pps) to every single pore of the facial skin.
  • pps particles per second
  • This process is effectively accomplished by the use of a specially designed, compact generator attached to an additionally special designed "cosmetic-nebulizer," which is the subject of prior patents of the present inventors. Together these units will efficiently and effectively provide the moisture, hydration and oxygen (21%) that epidermal cells will accept as nutrients.
  • Table 3 lists preferred nutrients which may be applied using the nebulization oxygenation process.
  • the single most important element in cellular nutrition is oxygen.
  • a person can live weeks without food, days without water but only minutes to seconds without oxygen. Such is the same for the skin.
  • the breakdown and interruption of oxygen supply to the skin cells form the basis of intrinsic mechanisms of ageing.
  • Cellular oxygen availability supplies the mitochondria of all cells with the much needed oxygen for the production of energy. After the age of 20-21, the mitochondria supply of oxygen availability begins to decrease. This has been attributed to many factors such as increases of body size and mass, hormonal changes, diet and nutritional changes to metabolism response, various negative respiratory impairments accumulated from colds, flu's and pneumonias, tobacco exposure, alcohol and drug ingestion, smog and allergens from bacteria and mold spores, and so forth. In combination, these maladies contribute to accumulated deficits in cellular oxygen supply and cellular respiration.
  • the isobaric skin care system effectively addresses this intrinsic issue by providing a beneficial respiratory exercise program that has been tested and proven to be an effective method for cellular oxygen intake and uptake.
  • This new and innovative program is a 3 breath expiratory resistance maneuver done through a pipette, as shown in Figs. 1-4.
  • the exercise is to be done once daily in conjunction with a supplemental package of vitamins and minerals consumed in a 4-6 ounce glass of water before the respiratory exercise is completed.
  • the supplemental drink and respiratory exercise will provide an overall increase in cellular oxygen availability.
  • the vitamins and minerals contained in the supplemental package are listed in Table 4 as follows:
  • the breathing exerciser 100 is illustrated in an exploded view in Fig. 1 and as- assembled in Figs. 2-4. It includes a generally cylindrical body portion 102 having an internal diameter of approximately 1.4 to 1.6 inches, an external diameter in the range of 1.7 to 1.9 inches and a graduated scale 104 on the outer surface 106 of the cylinder for measuring exercise levels.
  • the cylinder is adapted to receive at least one sphere 108 constructed of a plastic, foam or other suitable material for positioning inside the cylinder.
  • the exerciser is constructed to accommodate three such spheres, 108, 110 and 112, each of which may be of the same weight or of a different weight; however, in practicality, any number of spheres may be included, depending upon the design of the exerciser.
  • a cap 114 may be positioned over the cylinder to retain the spheres when it is not in use.
  • the breathing exerciser includes a lower body portion 116 having an internal channel 118 extending therethrough at generally right angles to the cylinder 102 and in pneumatic communication therewith.
  • the channel 118 is adapted to removably receive tube or pipette 120 into which a user exhales while performing the breathing exercises.
  • the exhalation pressure causes the spheres to rise inside the cylinder which may be made of a clear plastic or other suitable material, thereby allowing the user to observe the sphere elevation vis-a-vis the graduated scale 104 and to assess his or her FeV 1 (forced expiratory volume in one second) as the exercises progress over time.
  • a simple test and evaluation of the improved breathing exerciser was conducted which involved 45 volunteers, ranging in age from 21 to 65, males and females designed to include 3 separate groups.
  • the actual test was to determine the improvement of FeV 1 of such subject by the use of an unrestricted 3mm pipette for exhalation.
  • a preliminary "base” FeV 1 score was done with subsequent FeV 1 taken each week thereafter for a period of three weeks.
  • Each subject complied with our request to come each time, at the same time of their preliminary testing while completing their daily required expiratory exercise regimens.
  • the test showed that there were measurable increases in the overall FeV 1 with slight, sustained increases at the third week.
  • the test was then expanded to include volunteer subjects living at higher elevations with similar results.
  • BMR basal metabolic rate
  • the skin care system herein disclosed provides a newly developed approach for recapture and re-absorption of these nutrients by a technique comprising an assortment of nutritional enzymes and herbal extracts that are sprayed onto the face prior to exercising, walking, running or performing any number of physical exercises. Any increase in one's overall activity will automatically cause an increase in the BMR of the skin; therefore, a simple application of the formulation disclosed in Table 6 will ultimately enhance topical facial skin cell nutrition.
  • the assortment of enzymes and extracts to be applied by spraying are as follows: TABLE 6

Abstract

A system and method for treating the skin includes exfoliating and cleansing the skin to remove surface impurities and dead skin cells, soothing and nourishing the live skin cells remaining following exfoliation and cleansing, treating the skin to open the pores and moisturize it and applying a mixture of oxygen, nutrients and anti-oxidants to the outer skin layer. An expiratory breathing resistance exercise and apparatus designed to increase oxygen intake into the blood stream is performed in conjunction with the extrinsic methods so as to simultaneously combat intrinsic factors associated with skin ageing.

Description

SYSTEM AND METHOD FOR TREATING AGEING OF THE SKIN
FIELD OF THE INVENTION
The present invention relates to the treatment of skin. More specifically, the present invention relates to intrinsic and extrinsic systems and methods for treating ageing of the skin.
CROSS REFERENCE TO RELATEDAPPLICATIONS
This application claims priority to U.S. Provisional Application No. 60/893,835, filed March 8, 2007 and to U.S. Provisional Application No. 60/954,977, filed August 9, 2007, both of which are incorporated herein by reference in their entirety as if fully set forth herein.
BACKGROUND
Human skin is composed of a complex network of tissues and cells that make up the integumentary system. This complex covering for the body is an organ similar in operation to all the other organs in the body created for homeostasis. All of the vital nutrients necessary to maintain the continued life of the skin comes from the digestive and cardiorespiratory systems located within. Everything a person eats, drinks, and breathes eventually begins a complicated journey of homeosis, breaking down into cellular nutrients known as proteins, carbohydrates, vitamins and oxygen (O2) supplying the internal, basal layer of the skin.
As important as the skin is to the overall health and protection of the body (it is the "first line" of defense), it is the last organ to receive nutrients, hydration and oxygen needed to sustain its life. As a consequence, researchers have shown that it is the first portion of the body to show visible signs of ageing. Moreover, facial skin is the first part of the body's overall skin layer to display these signs.
The human body can go weeks without food, days without water and minutes without oxygen. The same thing is true for the cells that make up the skin. An appropriate intake of nutrients is required to insure that the cells remain healthy and function properly. Most individuals do not follow such a regimen. As a result, the effects of ageing are accelerated.
Ageing occurs as a result of a number of mechanisms. Some are natural factors of ageing such as a deterioration of the production of collagen and reduction of blood flow to the skin. Additionally, the presence of free-radicals in the body cause cellular damage. These free-radicals enter the body through a number of means and can be caused by dietary and environmental conditions such as smoking, sunlight and air pollution.
The mechanisms of ageing are broken down into two broad categories: intrinsic modalities of ageing (internal causes of ageing) and extrinsic modalities of ageing (external factors that contribute to skin damage). Since there are many factors that are working together to damage the skin, any solution to the effects of ageing must combat these effects on all levels. The skin cure products in use today only fight on one level, so only partial relief of the effects of ageing is provided.
Accordingly, a need exists for methods and cosmetic applications designed to address effectively the complex factors of both the extrinsic and the intrinsic mechanisms of ageing.
SUMMARY OF THE INVENTION
It is an object of the present invention to provide a system and a method for use by the consuming public which will combat both the intrinsic and extrinsic mechanisms which result in ageing of the skin.
It is a further object of the present invention to provide externally applied formulations for exfoliating and cleansing the skin.
It is another object of the present invention to provide externally applied emollients to soothe and nourish skin cells.
It is yet another object of the present invention to provide a pore-opening and moisturizing solution.
It is still another object of the present invention to provide a system for delivering the externally applied emollients and solutions to the surface of the skin using a stream of normo-baric oxygen (O2).
It is another object of the present invention to provide an expiratory breathing resistance exercise for increasing the oxygen intake into the bloodstream and for simultaneously enhancing the body's supply of vitamins and minerals in conjunction therewith. It is yet another object of the present invention to provide a method of recapturing and reabsorbing nutrients into the skin during exercise.
Further objects, features, and advantages of the invention will be apparent from the following detailed description when taken in conjunction with the accompanying drawings.
BRIEF DESCRIPTION OF THE DRAWINGS
Fig. 1 is an exploded perspective view of an expiratory breathing resistance exerciser in accordance with an embodiment;
Fig. 2 is a side elevational view of the breathing exerciser of Fig. 1;
Fig. 3 is a top view of the breathing exerciser of Figs. 1 and 2; and
Fig. 4 is a front elevational view of the breathing exerciser of Figs. 1-3.
DESCRIPTION OF THE INVENTION
Before proceeding with the detailed description, it should be noted that the present teaching is by way of example, not by limitation. The concepts presented herein are not limited to use or application with one specific type of skin treatment methodology or system.
Thus, although the instrumentalities described herein are for the convenience of illustration and explanation, shown and described with respect to exemplary embodiments, the principles disclosed herein may be applied to other types and applications of skin treatment modalities without departing from the scope of the present invention.
The Isobaric Organization of the Skin
The skin care system herein disclosed incorporates a vast array of new art and new science formulated as one complete system to introduce state of the art modalities systematically designed to be used by professionals in the field of cosmetics and cosmeceuticals as well by laymen in the comfort of their own environments. The skin care system is the first system of its kind that will introduce a combined regimen of safe pharmaceuticals along with ambient (21%) oxygen that will not generate Reactive Oxygen Species (R.O.S.) and Free Radicals (F.R.'s) and introduce them into and onto the surface of skin cells. Current technologies employ the use of 95% - 100% oxygen as a gas, liquid or cream that researchers have determined to be a direct cause of increasing the skin ageing mechanisms. However, ambient 21% oxygen is a safe and effective alternative to deliver vital pH-balanced herbal and plant derived nutriments to the skin cells to safely exfoliate, hydrate, cleanse, moisturize and nourish the skin cells.
I. The Extrinsic System Operation of the Isobaric Skin Care System
As discussed above, current cosmetic/cosmeceutical interventions employ gases, liquids and creams containing a very high level of oxygen to enhance efforts to deliver nourishment to topical skin cells. As used herein, the symbols Iso means normal homeosis; Baric means normal barometric pressure, and O2 means normal atmospheric oxygen (O2) at 21% concentration.
In-vivo and in-vitro examination of these prior art delivery systems has proven that the use of this high concentration of O2 does nothing more than degrade skin cells by exposing the cells' delicate membranes to destructive reactive oxygen species and free radicals. They do not take into account that, unlike the internal organ's ability to protect itself from R.O.S./F.R.'s damage by producing various internal "scavengers," the skin cells have no such protection. Consequently, skin cells become damaged and their regenerative network becomes dangerously compromised.
The isobaric skin care system of the instant invention utilizes the exact amount of oxygen the skin needs and is "born" into. This skin care system will propel normo-baric O2 into contact with the skin consistently at a concentration level of 21% without creating reactive oxygen species and free radicals.
Current cosmetic/cosmeceutical skin care programs utilize various assortments of lotions, creams and astringents to exfoliate and remove "dead" skin cells from the facial skin. These universally applied techniques further damage and degrade the epidermal cellular matrix by interfering with the homeosis of epidermal skin cell maintenance.
The basal layer or stratum germinativum germinates epithelium that give rise to all the cells of the epidermis, including the facial skin. Current facial exfoliation techniques do not take into account that the basal layer is alive and divided, having an outer layer of skin called the spinous layer overlaying it. The two layers form the all important malpighian network of living cells. The malpighian network is composed of a granular network composed of kerotin which become prominent keratimeytes that age and migrate to an outer layer commonly known as the cornified layer or stratum corneum. These combined cells become flattened sacs of keratin protein in which their nuclei are pushed to one edge of the cell. These cells begin the process of dying, death and shedding. After death they are replaced by "new" cells coming forth from the granular layer.
The skin care system herein disclosed takes considerable care in its approach to mechanical exfoliation due to the vast difference in the life cycles of dying, dead and shedding cells of the facial skin. There is "life" still present in "dying" cells and less life in dead cells. Such being the case, a gentle blend of natural surfactants obtained from plants is disclosed herein which is used to exfoliate and cleanse the surface of the facial skin of cells that have died. This process removes dead cells and leaves behind a residue of surface emollients capable of supporting the life left in the still viable "dying" cells. The ingredients comprising the exfoliation and cleansing formulation are set forth in Table 1 below.
TABLE 1
1. Yucca Schidigera (Ph/3.94 @ 20%-48%/vol) w/counter balanced acid base surfactants.
2. Rosemary Extract - (7%- 12%/vol)
3. Rutin - (11%-15%/vol)
4. Aloe Vera Gel (soft) - (14%-19%/vol)
5. D. Panthenol
6. Xylitol
7. Green Tea
8. Cucumber
9. Isotonic Saline (0.9%)
Currently all cosmetic/cosmeceutical formulations that are designed to cleanse and "tone" act as "removal" compounds made of alcohols, acids and astringents. These agents are traditionally applied prior to moisturizing or hydrating the facial skin. In actuality, these compounds further compromise the facial skin by interfering with the protective "acid" mantle of the facial skin and leaving it vulnerable to irritations and infection from its own barrier protective adjustments, bacteria and or mold spores.
The isobaric skin care system uses an "isotonic" blend of naturally derived herbal extracts and humectants that are pH-balanced to effectively harmonize with the exfoliation and cleansing process. Together, these processes do not compromise the facial skin in any way.
Post-Exfoliation Treatment
Table 2 lists the preferred nutrients which may be applied using the isobaric moisturization technique. These nutrients may be applied with sterile and heated pads following exfoliation and cleansing to open the skin pores in preparation for the final treatment which will be discussed in greater detail below. This solution targets problem areas such as around the eyes, nose, forehead and the mouth-areas where wrinkles first appear. The post-exfoliation/cleansing treatment also includes avocado oil to aid in moisturizing as well as borage oil, which has been found to be effective in combating the effects of eczema.
TABLE 2
1. NaPCA
2. Tinctured Herbal Extracts
3. Rutin
4. Avocado Oil
5. Alpha Lipoic Acid
6. Borage Oil
7. Xylitol
8. D. Panthenol
9. Cranberry Seed Extract
10. Green Tea
11. CoEnzyme QlO
12. Vit. C ester
13. DMAE
14. Aloe Vera
15. Chamomile
16. Cucumber
Extrinsic Moisturization-Hydration-Oxygenation via Nebulization
Current cosmetic/cosmeceutical processes of moisturization, hydration and oxygenation combine the use of various nutriments deemed to nourish the facial skin. As discussed earlier, their targeted purpose is completely lost, inasmuch as they use a high oxygen concentration of 95%-100% to deliver these nutriments onto the facial skin.
The skin care system of the present invention introduces a new and highly innovative delivery system designed to effectively moisturize, hydrate and oxygenate the skin via epidermal nebulizations, which may be characterized as skinhalation. This treatment is designed to deliver an assortment of nutritive microparticulate substances via cosmetic-nebulization at a rate of over 200,000,000 particles per second (pps) to every single pore of the facial skin. This process is effectively accomplished by the use of a specially designed, compact generator attached to an additionally special designed "cosmetic-nebulizer," which is the subject of prior patents of the present inventors. Together these units will efficiently and effectively provide the moisture, hydration and oxygen (21%) that epidermal cells will accept as nutrients. Table 3 lists preferred nutrients which may be applied using the nebulization oxygenation process.
TABLE 3
1. Vitamin C ester - 0.9gtt' s
2. Alpha lipoic Acid - 1.2gtt' s
3. CoEnzyme QlO - 1.4gtt's
4. NaPCA - 5.0gtt's
5. Mycel Vit. A,B,D,E - 3gtt's
6. Trace Minerals - 0.4gtt's
7. Hyaluronic Acid - 2.0gtt' s
8. Jojoba Oil - 2gtt' s
9. Borage Oil - 2.5gtt' s
10. Sterile Distilled water - lόgtt's
The power of this process is that it delivers the precise amount of oxygen, natural nutrients and natural anti-oxidants right where they are needed. This is a breakthrough for two reasons. First, no other system adds oxygen to the skin in the state where it is needed (O2 gas at 21% concentration). Some skin care systems contain creams that have oxygenated compounds added to them. These can cause damage, as the compounds they contain are caustic. Others use high concentrations of oxygen gas without encapsulation techniques. Secondly, no other skin care system is able to get oxygen to the cells that need it most ... deep into the living epidermis.
II. Intrinsic Factors
The untoward introduction of toxicogenic substances into the body via food, water and the very air that a person breathes will ultimately lead to graduated breakdowns in the moment to moment cellular supply of food, water and oxygen to the skin. These breakdowns and interruptions contribute the newly discovered factors in the mechanisms of ageing known today as intrinsic factors.
The single most important element in cellular nutrition is oxygen. A person can live weeks without food, days without water but only minutes to seconds without oxygen. Such is the same for the skin. As a major organ of protection for the body, the breakdown and interruption of oxygen supply to the skin cells form the basis of intrinsic mechanisms of ageing.
Cellular oxygen availability supplies the mitochondria of all cells with the much needed oxygen for the production of energy. After the age of 20-21, the mitochondria supply of oxygen availability begins to decrease. This has been attributed to many factors such as increases of body size and mass, hormonal changes, diet and nutritional changes to metabolism response, various negative respiratory impairments accumulated from colds, flu's and pneumonias, tobacco exposure, alcohol and drug ingestion, smog and allergens from bacteria and mold spores, and so forth. In combination, these maladies contribute to accumulated deficits in cellular oxygen supply and cellular respiration.
Again, bearing in mind that the skin is the "first line" of defense of the human body, it cannot be over-emphasized that the skin is the last in the order to receive its vital nutrients. The isobaric skin care system effectively addresses this intrinsic issue by providing a beneficial respiratory exercise program that has been tested and proven to be an effective method for cellular oxygen intake and uptake.
This new and innovative program is a 3 breath expiratory resistance maneuver done through a pipette, as shown in Figs. 1-4. The exercise is to be done once daily in conjunction with a supplemental package of vitamins and minerals consumed in a 4-6 ounce glass of water before the respiratory exercise is completed. Together, the supplemental drink and respiratory exercise will provide an overall increase in cellular oxygen availability. The vitamins and minerals contained in the supplemental package are listed in Table 4 as follows:
TABLE 4
1. NaPCA
2. Mycel Multi Vitamins
3. Green Tea
4. Xylitol
5. Glycerin (purified/heat infused)
6. Borage Oil
7. Cranberry Seed extract
8. Cucumber
The breathing exerciser 100 is illustrated in an exploded view in Fig. 1 and as- assembled in Figs. 2-4. It includes a generally cylindrical body portion 102 having an internal diameter of approximately 1.4 to 1.6 inches, an external diameter in the range of 1.7 to 1.9 inches and a graduated scale 104 on the outer surface 106 of the cylinder for measuring exercise levels. The cylinder is adapted to receive at least one sphere 108 constructed of a plastic, foam or other suitable material for positioning inside the cylinder. In the embodiment shown, the exerciser is constructed to accommodate three such spheres, 108, 110 and 112, each of which may be of the same weight or of a different weight; however, in practicality, any number of spheres may be included, depending upon the design of the exerciser. The unit used in the evaluation of the exercise methodology of the present invention employed three spheres of varying weights, 3 grams, 6 grams and 9 grams respectively; however, spheres of different weights could be employed without departing from the scope of the present invention. A cap 114 may be positioned over the cylinder to retain the spheres when it is not in use.
Referring to Figs. 2 and 3, the breathing exerciser includes a lower body portion 116 having an internal channel 118 extending therethrough at generally right angles to the cylinder 102 and in pneumatic communication therewith. The channel 118 is adapted to removably receive tube or pipette 120 into which a user exhales while performing the breathing exercises. The exhalation pressure causes the spheres to rise inside the cylinder which may be made of a clear plastic or other suitable material, thereby allowing the user to observe the sphere elevation vis-a-vis the graduated scale 104 and to assess his or her FeV1 (forced expiratory volume in one second) as the exercises progress over time.
A simple test and evaluation of the improved breathing exerciser was conducted which involved 45 volunteers, ranging in age from 21 to 65, males and females designed to include 3 separate groups.
1. Smoker
2. X-smoker
3. Non-smoker
The actual test was to determine the improvement of FeV1 of such subject by the use of an unrestricted 3mm pipette for exhalation.
A preliminary "base" FeV1 score was done with subsequent FeV1 taken each week thereafter for a period of three weeks. Each subject complied with our request to come each time, at the same time of their preliminary testing while completing their daily required expiratory exercise regimens.
The test showed that there were measurable increases in the overall FeV1 with slight, sustained increases at the third week. The test was then expanded to include volunteer subjects living at higher elevations with similar results.
The following table of exercises (Active Resistance Expiratory Exercise — AREE) using the breathing exerciser has been developed with a view of enhancing aerobic fitness and health:
TABLE 5 Exercise — (Clinical Definition)
The act of bringing into play voluntary muscular movements designed to increase muscular strength and health.
Units of Exercise —
1. Active
2. Passive
3. Resistance
I. Active Exercise —
• Incorporates the use of activity employing the use of devices or solitary movement to induce muscular energy by action.
• The 12 to 16 breaths per minute of the respiratory (inspiratory phase) incorporate the use of voluntary muscles of respiratory muscular parenchyma.
• Any mechanical technique or device used towards substantially increasing the strengths and tone of this musculature can be questioned as to its validity as clinical exercise.
• Claims made to increase respiratory strength via incentive devices should be restricted to include increases to Inspiratory Volume (IV) and Inspiratory Capacity (IC).
II. Passive Exercise —
• Incorporates the use of sustained and metered volumetric release of muscular energy (stored) by the use of active muscular exertion; so as to cause a graduated and measurable "counter" re-action of energy in release. • The 12 to 16 breaths per minute during normal expiration is "passive" resulting from the natural elastic recoil of the lung's respiratory parenchyma.
• Passive exhalation only becomes active as a result of strenuous physical activity.
• Passive exhalation also serves to reduce and replenish the residual volume (RV).
III. Resistance Exercise —
• Incorporates the use of devices designed to "resist" normal muscular recoil, thus creating a measurable release of energy normally "lost" through passive recoil.
• Resistance applied to passive exhalation can induce the overall passive respiratory musculature to become "active," thus giving it the energy otherwise lost via normal passive elastic recoil.
• Therefore, active resistance directly applied to passive exhalation can be termed "true" respiratory exercise.
III. Intrinsic Anti-Ageing Maintenance and After Care
Skin, as an organ, has its own basal metabolic rate or BMR. Exercise physiologists have determined that the BMR of skin at rest is in the range of 10 to 15 k/cals per minute. Normal trans/epidermal water loss (TEWL) from the skin is customarily measured as sensitive vs. insensitive perspiration. Sensitive and insensitive perspiration produce varied amounts of expired nutrients atop the epidermis.
The skin care system herein disclosed provides a newly developed approach for recapture and re-absorption of these nutrients by a technique comprising an assortment of nutritional enzymes and herbal extracts that are sprayed onto the face prior to exercising, walking, running or performing any number of physical exercises. Any increase in one's overall activity will automatically cause an increase in the BMR of the skin; therefore, a simple application of the formulation disclosed in Table 6 will ultimately enhance topical facial skin cell nutrition. The assortment of enzymes and extracts to be applied by spraying are as follows: TABLE 6
1. Cranberry Concentrate (unsweetened)
2. Ascorbic Acid
3. Gingo biloba
4. Selenium
5. CoEnzyme QlO
6. Xylitol
7. Sucrose
8. Fructuse
Changes may be made to the above methods, systems, devices and formulations without departing from the scope hereof. It should be noted that the matter contained in the above description and/or shown in the accompanying drawings should be interpreted as illustrative and not in a limiting sense. The following claims are intended to cover all generic and specific features described herein as well as statements of the scope of the present invention, which, as a matter of language, might be aid to fall therebetween.

Claims

1. A method for treating the skin comprising: exfoliating and cleansing the skin to remove surface impurities and dead skin cells; applying a layer of preselected surface emollients to soothe and nourish live skin cells remaining following exfoliation and cleansing; treating the skin with a pore-opening and moisturizing solution; and applying a mixture of oxygen, nutrients and anti-oxidants to the skin.
2. The method of claim 1 wherein the exfoliating and cleansing step includes the application of an exfoliating and cleansing formulation comprising ingredients from the group consisting of yucca schidigera coupled with counter-balanced acid base surfactants, rosemary extract, rutin, aloe vera gel, D. panthenol, xylitol, green tea, cucumber and isotonic saline.
3. The method of claim 2 wherein the exfoliating and cleansing formulation comprises yucca schidigera with a pH of approximately 3.50-4.25 at approximately 20% to 45% by volume; rosemary extract at approximately 7% to 12% by volume; rutin at approximately 11% to 15% by volume; aloe vera gel at approximately 14% to 19% by volume; D. panthenol (trace); xylitol (trace); green tea (trace); cucumber (trace) and isotonic saline at 0.5% to 1.5% by volume.
4. The method of claim 1 including means for delivering the exfoliating and cleansing formulation to the skin using a stream of normo-baric oxygen (O2) at a concentration level of approximately 20% to 22%.
5. The method of claim 4 wherein the means for delivering comprises a cosmetic submicron generator for mixing the exfoliating and cleansing formulation with a stream of normo-baric oxygen for application to the skin.
6. The method of claim 1 wherein the surface emollients for soothing and nourishing live skin cells comprise emollients from the group consisting of sodium PCA; aloe vera; avocado oil; alpha lipoic acid; borage oil; xylitol; D. panthenol; coenzyme QlO; green tea; vitamin C ester; DMAE; tinctured herbal extracts; cranberry seed extract; rutin; chamomile; spin traps; and cucumber.
7. The method of claim 6 wherein the surface emollients are applied with sterilized and heated pads.
8. The method of claim 1 wherein the pore-opening and moisturizing solution comprises ingredients from the group consisting of sodium PCA; alpha lipoic acid; borage oil; jojoba oil, trace minerals; coenzyme QlO; vitamin C ester; mycellized vitamin A, B, D and E; hyaluronic acid; and sterile distilled water.
9. The method of claim 8 wherein the pore-opening and moisturizing solution comprises approximately 4 to 6 gtts of sodium PCA; approximately 0.7 to 1.7 gtts of alpha lipoic acid; approximately 1.9 to 3.0 gtts of borage oil; approximately 1.0 to 3.0 gtts of jojoba oil; approximately 0.25 to 0.75 gtt of trace minerals; approximately 0.9 to 1.8 gtts of coenzyme QlO; approximately 0.6 to 1.3 gtts of vitamin C ester; approximately 1.5 to 4.0 gtts of mycellated vitamins A, B, D and E; approximately 1.0 to 3.0 gtts of hyaluronic acid; and approximately 0.6 to 14 to 20 gtts of sterile distilled water.
10. The method of claim 1 including means for delivering the pore-opening and moisturizing solution to the skin using a stream of normo-baric oxygen (O2) at a concentration level of approximately 20% to 22%.
11. The method of claim 10 wherein the means for delivering comprises a cosmetic submicron generator for mixing the pore-opening and moisturizing solution with the stream of normo-baric oxygen for application to the skin.
12. The method of claim 11 wherein the generator delivers the solution to the skin at a rate of approximately 200 million submicron particles per second.
13. The method of claim 1 further including an expiratory breathing resistance exercise for increasing the oxygen uptake in the bloodstream.
14. The method of claim 13 further including consuming a supplemental mixture of vitamins and minerals in conjunction with the breathing resistance exercise.
15. The method of claim 14 wherein the supplemental mixture of vitamins and minerals comprises ingredients from the group consisting of sodium PCA; mycellated multivitamins; green tea; xylitol; purified and heat infused glycerin; borage oil; cranberry seed extract; and cucumber.
16. The method of claim 1 further comprising the step of recapturing and reabsorbing nutrients into the skin during exercise.
17. The method of claim 16 wherein the recapturing and reabsorbing step comprises applying a mixture of preselected nutrients and enzymes to the skin prior to exercise; the nutrients and enzymes comprising ingredients from the group consisting of unsweetened cranberry concentrate; ascorbic acid; ginkgo biloba; selenium; coenzyme QlO; xylitol; sucrose and fructose.
18. The method of claim 13 wherein the expiratory breathing resistance exercise includes exhaling into a pipette.
19. A system for treating the skin comprising: an exfoliating and cleansing formulation for removing surface impurities and dead skin cells; a formulation of surface emollients for soothing and nourishing live skin cells; a pore-opening and moisturizing solution; means for delivering the exfoliating and cleansing formulation and the pore-opening and moisturizing solution to the skin using a stream of normo-baric oxygen (O2) at a concentration level of approximately
20% to 22%; and means for applying the surface emollients.
20. The system of claim 19 wherein the means for delivering the exfoliating and cleansing formulation and the pore-opening and moisturizing solution comprises a cosmetic submission generator.
21. The system of claim 19 wherein the means for applying the surface emollients comprises sterilized and heated pads.
PCT/US2008/056286 2007-03-08 2008-03-07 System and method for treating ageing of the skin WO2008109857A2 (en)

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WO2019211567A1 (en) * 2018-05-04 2019-11-07 Naos Institute Of Life Science Composition comprising alpha-lipoic acid or an alpha-lipoic acid salt, a vitamin c derivative and hyaluronic acid and its use
CN114632050A (en) * 2020-12-16 2022-06-17 江西初芙化妆品有限公司 Moisture-preserving, water-replenishing and safe cutin-removing gel and preparation method thereof

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US20060198800A1 (en) * 2003-08-14 2006-09-07 Natalie Dilallo Skin care compositions including hexapeptide complexes and methods of their manufacture

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US20160250130A1 (en) * 2014-12-18 2016-09-01 The Ionto Team, S.L. Cosmetic formulation and device for the treatment of deep wrinkles of the skin by means of iontophoresis
WO2019211567A1 (en) * 2018-05-04 2019-11-07 Naos Institute Of Life Science Composition comprising alpha-lipoic acid or an alpha-lipoic acid salt, a vitamin c derivative and hyaluronic acid and its use
CN114632050A (en) * 2020-12-16 2022-06-17 江西初芙化妆品有限公司 Moisture-preserving, water-replenishing and safe cutin-removing gel and preparation method thereof

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