WO2008142418A3 - Mass spectrometer - Google Patents

Mass spectrometer Download PDF

Info

Publication number
WO2008142418A3
WO2008142418A3 PCT/GB2008/001756 GB2008001756W WO2008142418A3 WO 2008142418 A3 WO2008142418 A3 WO 2008142418A3 GB 2008001756 W GB2008001756 W GB 2008001756W WO 2008142418 A3 WO2008142418 A3 WO 2008142418A3
Authority
WO
WIPO (PCT)
Prior art keywords
mass spectrometer
spectrum
combined
digitised
signals
Prior art date
Application number
PCT/GB2008/001756
Other languages
French (fr)
Other versions
WO2008142418A2 (en
Inventor
Martin Green
Steven Derek Pringle
Jason Lee Wildgoose
Original Assignee
Micromass Uk Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micromass Uk Limited filed Critical Micromass Uk Limited
Priority to CA2687420A priority Critical patent/CA2687420C/en
Priority to EP08750679A priority patent/EP2156460B1/en
Priority to JP2010508903A priority patent/JP5528331B2/en
Priority to US12/601,094 priority patent/US8354634B2/en
Publication of WO2008142418A2 publication Critical patent/WO2008142418A2/en
Publication of WO2008142418A3 publication Critical patent/WO2008142418A3/en
Priority to US13/738,507 priority patent/US8754364B2/en
Priority to US14/270,433 priority patent/US8941056B2/en

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0036—Step by step routines describing the handling of the data generated during a measurement
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/022—Circuit arrangements, e.g. for generating deviation currents or voltages ; Components associated with high voltage supply
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/40—Time-of-flight spectrometers

Abstract

A mass spectrometer is disclosed wherein an ion signal is split into a first and second signal. The first and second signals are multiplied by different gains and are digitised. Arrival time and intensity pairs are calculated for both digitised signals and the resulting time and intensity pairs are combined to form a high dynamic range spectrum. The spectrum is then combined with other corresponding spectra to form a summed spectrum.
PCT/GB2008/001756 2007-05-22 2008-05-22 Mass spectrometer WO2008142418A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA2687420A CA2687420C (en) 2007-05-22 2008-05-22 Mass spectrometer
EP08750679A EP2156460B1 (en) 2007-05-22 2008-05-22 Mass spectrometer
JP2010508903A JP5528331B2 (en) 2007-05-22 2008-05-22 Ion detection method and ion detector system
US12/601,094 US8354634B2 (en) 2007-05-22 2008-05-22 Mass spectrometer
US13/738,507 US8754364B2 (en) 2007-05-22 2013-01-10 Mass spectrometer
US14/270,433 US8941056B2 (en) 2007-05-22 2014-05-06 Mass spectrometer

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0709799A GB0709799D0 (en) 2007-05-22 2007-05-22 Mass spectrometer
GB0709799.1 2007-05-22
US94621107P 2007-06-26 2007-06-26
US60/946,211 2007-06-26

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/601,094 A-371-Of-International US8354634B2 (en) 2007-05-22 2008-05-22 Mass spectrometer
US13/738,507 Continuation US8754364B2 (en) 2007-05-22 2013-01-10 Mass spectrometer

Publications (2)

Publication Number Publication Date
WO2008142418A2 WO2008142418A2 (en) 2008-11-27
WO2008142418A3 true WO2008142418A3 (en) 2009-11-05

Family

ID=38234872

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2008/001756 WO2008142418A2 (en) 2007-05-22 2008-05-22 Mass spectrometer

Country Status (6)

Country Link
US (3) US8354634B2 (en)
EP (3) EP2184763B1 (en)
JP (1) JP5528331B2 (en)
CA (1) CA2687420C (en)
GB (2) GB0709799D0 (en)
WO (1) WO2008142418A2 (en)

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US9330892B2 (en) 2009-12-31 2016-05-03 Spectro Analytical Instruments Gmbh Simultaneous inorganic mass spectrometer and method of inorganic mass spectrometry
JP5781545B2 (en) * 2010-02-02 2015-09-24 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド Method and system for operating a time-of-flight mass spectrometry detection system
GB201002447D0 (en) * 2010-02-12 2010-03-31 Micromass Ltd Mass spectrometer
DE102010011974B4 (en) 2010-03-19 2016-09-15 Bruker Daltonik Gmbh Saturation correction for ion signals in time-of-flight mass spectrometers
US10074528B2 (en) * 2010-12-17 2018-09-11 Thermo Fisher Scientific (Bremen) Gmbh Data acquisition system and method for mass spectrometry
GB201106689D0 (en) * 2011-04-20 2011-06-01 Micromass Ltd Function switching with fast asynchronous acquisition
CN107086166B (en) * 2011-06-03 2018-12-07 Dh科技发展私人贸易有限公司 It is scanned using variable window band-pass filter from measurement and removes ion to improve and scan interior dynamic range
GB201208841D0 (en) 2012-05-18 2012-07-04 Micromass Ltd Calibrating dual adc acquisition system
GB201312266D0 (en) * 2013-07-09 2013-08-21 Micromass Ltd Method of recording ADC saturation
US10354849B2 (en) * 2013-07-09 2019-07-16 Micromass Uk Limited Method of recording ADC saturation
WO2015004457A1 (en) * 2013-07-09 2015-01-15 Micromass Uk Limited Intelligent dynamic range enhancement
WO2015173562A1 (en) * 2014-05-13 2015-11-19 Micromass Uk Limited Multi-dimensional ion separation
DE112015002758T5 (en) 2014-06-11 2017-04-20 Micromass Uk Limited Marking of ADC coalescence
GB201410382D0 (en) * 2014-06-11 2014-07-23 Micromass Ltd Flagging ADC coalescence
GB201514643D0 (en) * 2015-08-18 2015-09-30 Micromass Ltd Mass Spectrometer data acquisition
GB201515357D0 (en) 2015-08-28 2015-10-14 Micromass Ltd Mass spectrometer with digitial step attenuator
GB2544959B (en) * 2015-09-17 2019-06-05 Thermo Fisher Scient Bremen Gmbh Mass spectrometer
US10026598B2 (en) * 2016-01-04 2018-07-17 Rohde & Schwarz Gmbh & Co. Kg Signal amplitude measurement and calibration with an ion trap
CN105609401B (en) * 2016-02-17 2017-10-24 广州禾信分析仪器有限公司 A kind of method and system for improving time-of-flight mass spectrometer dynamic detection range
US20170263426A1 (en) * 2016-03-10 2017-09-14 Leco Corporation Dynamic Baseline Adjuster
GB201613988D0 (en) 2016-08-16 2016-09-28 Micromass Uk Ltd And Leco Corp Mass analyser having extended flight path
GB201618023D0 (en) 2016-10-25 2016-12-07 Micromass Uk Limited Ion detection system
GB2567794B (en) 2017-05-05 2023-03-08 Micromass Ltd Multi-reflecting time-of-flight mass spectrometers
GB2563571B (en) 2017-05-26 2023-05-24 Micromass Ltd Time of flight mass analyser with spatial focussing
WO2019030472A1 (en) 2017-08-06 2019-02-14 Anatoly Verenchikov Ion mirror for multi-reflecting mass spectrometers
EP3662503A1 (en) 2017-08-06 2020-06-10 Micromass UK Limited Ion injection into multi-pass mass spectrometers
US11049712B2 (en) 2017-08-06 2021-06-29 Micromass Uk Limited Fields for multi-reflecting TOF MS
EP3662502A1 (en) 2017-08-06 2020-06-10 Micromass UK Limited Printed circuit ion mirror with compensation
US11817303B2 (en) 2017-08-06 2023-11-14 Micromass Uk Limited Accelerator for multi-pass mass spectrometers
US11081332B2 (en) 2017-08-06 2021-08-03 Micromass Uk Limited Ion guide within pulsed converters
US11211238B2 (en) 2017-08-06 2021-12-28 Micromass Uk Limited Multi-pass mass spectrometer
GB201806507D0 (en) 2018-04-20 2018-06-06 Verenchikov Anatoly Gridless ion mirrors with smooth fields
GB201807626D0 (en) 2018-05-10 2018-06-27 Micromass Ltd Multi-reflecting time of flight mass analyser
GB201807605D0 (en) 2018-05-10 2018-06-27 Micromass Ltd Multi-reflecting time of flight mass analyser
GB201808530D0 (en) 2018-05-24 2018-07-11 Verenchikov Anatoly TOF MS detection system with improved dynamic range
GB201810573D0 (en) 2018-06-28 2018-08-15 Verenchikov Anatoly Multi-pass mass spectrometer with improved duty cycle
GB201901411D0 (en) 2019-02-01 2019-03-20 Micromass Ltd Electrode assembly for mass spectrometer
GB202110412D0 (en) * 2021-07-20 2021-09-01 Micromass Ltd Mass spectrometer for generating and summing mass spectral data

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US20060020400A1 (en) * 2004-07-02 2006-01-26 Thermo Finnigan Llc Detector with increased dynamic range

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US7423259B2 (en) * 2006-04-27 2008-09-09 Agilent Technologies, Inc. Mass spectrometer and method for enhancing dynamic range
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GB0709799D0 (en) * 2007-05-22 2007-06-27 Micromass Ltd Mass spectrometer

Patent Citations (6)

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Publication number Priority date Publication date Assignee Title
WO1998026095A1 (en) * 1996-12-10 1998-06-18 Genetrace Systems Inc. Releasable nonvolatile mass-label molecules
US6259101B1 (en) * 1997-09-23 2001-07-10 University Of Delaware Method and instruments for the on-line detection, sizing or analysis of aerosol particles
US20050145788A1 (en) * 1999-09-03 2005-07-07 Stephen Davis High dynamic range mass spectrometer
US20020175292A1 (en) * 2001-05-25 2002-11-28 Whitehouse Craig M. Multiple detection systems
US20060000982A1 (en) * 2004-07-01 2006-01-05 Ciphergen Biosystems, Inc. Non-linear signal amplifiers and uses thereof in a mass spectrometer device
US20060020400A1 (en) * 2004-07-02 2006-01-26 Thermo Finnigan Llc Detector with increased dynamic range

Also Published As

Publication number Publication date
US20100213361A1 (en) 2010-08-26
US20140326867A1 (en) 2014-11-06
JP2010528280A (en) 2010-08-19
EP2156460B1 (en) 2013-01-30
US8941056B2 (en) 2015-01-27
GB0709799D0 (en) 2007-06-27
GB2457112C (en) 2016-02-03
US8754364B2 (en) 2014-06-17
EP2434526A1 (en) 2012-03-28
CA2687420A1 (en) 2008-11-27
CA2687420C (en) 2016-09-13
GB0809338D0 (en) 2008-07-02
EP2156460A2 (en) 2010-02-24
US20130119247A1 (en) 2013-05-16
US8354634B2 (en) 2013-01-15
EP2184763A2 (en) 2010-05-12
EP2184763B1 (en) 2012-07-18
WO2008142418A2 (en) 2008-11-27
EP2184763A3 (en) 2010-07-07
GB2457112A (en) 2009-08-05
GB2457112B (en) 2010-02-03
JP5528331B2 (en) 2014-06-25

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