WO2009009520A3 - Nanoparticulate fillers - Google Patents

Nanoparticulate fillers Download PDF

Info

Publication number
WO2009009520A3
WO2009009520A3 PCT/US2008/069391 US2008069391W WO2009009520A3 WO 2009009520 A3 WO2009009520 A3 WO 2009009520A3 US 2008069391 W US2008069391 W US 2008069391W WO 2009009520 A3 WO2009009520 A3 WO 2009009520A3
Authority
WO
WIPO (PCT)
Prior art keywords
nanoparticulate fillers
composites
bioresorbable polymer
nanoparticulate
fillers
Prior art date
Application number
PCT/US2008/069391
Other languages
French (fr)
Other versions
WO2009009520A2 (en
Inventor
David Franklin Farrar
Marcia Elizabeth Clark
Colin Anthony Scotchford
David Malcolm Grant
Gavin Walker
Original Assignee
Smith & Nephew Inc
David Franklin Farrar
Marcia Elizabeth Clark
Colin Anthony Scotchford
David Malcolm Grant
Gavin Walker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith & Nephew Inc, David Franklin Farrar, Marcia Elizabeth Clark, Colin Anthony Scotchford, David Malcolm Grant, Gavin Walker filed Critical Smith & Nephew Inc
Priority to JP2010516192A priority Critical patent/JP5753687B2/en
Priority to AU2008275226A priority patent/AU2008275226B2/en
Priority to EP08781477A priority patent/EP2170983A2/en
Publication of WO2009009520A2 publication Critical patent/WO2009009520A2/en
Publication of WO2009009520A3 publication Critical patent/WO2009009520A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2/00—Processes of polymerisation
    • C08F2/44—Polymerisation in the presence of compounding ingredients, e.g. plasticisers, dyestuffs, fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L31/127—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix containing fillers of phosphorus-containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L31/128—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix containing other specific inorganic fillers not covered by A61L31/126 or A61L31/127
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
    • C08K3/24—Acids; Salts thereof
    • C08K3/26—Carbonates; Bicarbonates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/32—Phosphorus-containing compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
    • C08K3/24—Acids; Salts thereof
    • C08K3/26—Carbonates; Bicarbonates
    • C08K2003/265—Calcium, strontium or barium carbonate

Abstract

The present invention relates to the use of nanoparticles comprising a neutralising agent for incorporation within a bioresorbable polymer to neutralise the acidic degradation products of said bioresorbable polymer. Composites and a method of making the composites are also disclosed.
PCT/US2008/069391 2007-07-10 2008-07-08 Nanoparticulate fillers WO2009009520A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2010516192A JP5753687B2 (en) 2007-07-10 2008-07-08 Nano particle filler
AU2008275226A AU2008275226B2 (en) 2007-07-10 2008-07-08 Nanoparticulate fillers
EP08781477A EP2170983A2 (en) 2007-07-10 2008-07-08 Nanoparticulate fillers

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0713351.5 2007-07-10
GBGB0713351.5A GB0713351D0 (en) 2007-07-10 2007-07-10 Nanoparticulate fillers

Publications (2)

Publication Number Publication Date
WO2009009520A2 WO2009009520A2 (en) 2009-01-15
WO2009009520A3 true WO2009009520A3 (en) 2009-06-25

Family

ID=38461314

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/069391 WO2009009520A2 (en) 2007-07-10 2008-07-08 Nanoparticulate fillers

Country Status (5)

Country Link
EP (1) EP2170983A2 (en)
JP (1) JP5753687B2 (en)
AU (1) AU2008275226B2 (en)
GB (1) GB0713351D0 (en)
WO (1) WO2009009520A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105264014A (en) * 2013-05-16 2016-01-20 株式会社索夫塞拉 Biodegradable material
SG11201900618WA (en) * 2016-08-02 2019-02-27 B Braun Surgical Sa Permanently polarized hydroxyapatite, a process for its manufacture and uses thereof
JP6999562B2 (en) * 2016-09-21 2022-01-18 グンゼ株式会社 Production method of sustained release drug and sustained release drug
JP6462822B2 (en) * 2017-10-12 2019-01-30 株式会社ソフセラ Biodegradable material
JP7345478B2 (en) * 2018-01-17 2023-09-15 ザ・セカント・グループ・エルエルシー Cell culture media enhanced with pH-adjusting biodegradable polymers and poly(glycerol sebacic acid)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1600178A1 (en) * 2004-05-28 2005-11-30 Cordis Corporation Biodegradable vascular device with buffering agent
US20070282434A1 (en) * 2006-05-30 2007-12-06 Yunbing Wang Copolymer-bioceramic composite implantable medical devices

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3077448B2 (en) * 1993-04-28 2000-08-14 東洋インキ製造株式会社 Highly concentrated colored polyester resin and colored composition for polyester fiber using the same
US20020115742A1 (en) * 2001-02-22 2002-08-22 Trieu Hai H. Bioactive nanocomposites and methods for their use
JP2006249184A (en) * 2005-03-09 2006-09-21 Osaka Univ Inorganic fine particle-containing polymerizable composition and method for producing the same, and inorganic fine particle-containing polymer composition

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1600178A1 (en) * 2004-05-28 2005-11-30 Cordis Corporation Biodegradable vascular device with buffering agent
US20070282434A1 (en) * 2006-05-30 2007-12-06 Yunbing Wang Copolymer-bioceramic composite implantable medical devices

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
AGRAWAL C M ET AL: "Technique to control pH in vicinity of biodegrading PLA-PGA implants", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, WILEY, NEW YORK, NY, US, vol. 38, no. 2, 1 July 1997 (1997-07-01), pages 105 - 114, XP002342232, ISSN: 0021-9304 *
KASUGA T ET AL: "Preparation of poly(lactic acid) composites containing calcium carbonate (vaterite)", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 24, no. 19, 1 August 2003 (2003-08-01), pages 3247 - 3253, XP004425369, ISSN: 0142-9612 *

Also Published As

Publication number Publication date
AU2008275226A1 (en) 2009-01-15
WO2009009520A2 (en) 2009-01-15
GB0713351D0 (en) 2007-08-22
JP5753687B2 (en) 2015-07-22
JP2011506619A (en) 2011-03-03
AU2008275226B2 (en) 2014-08-21
EP2170983A2 (en) 2010-04-07

Similar Documents

Publication Publication Date Title
EP2072545A4 (en) Propylene polymer, process for production of the propylene polymer, and propylene resin composition
EP2338919A4 (en) Modified conjugated diene polymer, method for producing the same, modified conjugated diene polymer composition, and tire
EP2146250A4 (en) Water-soluble resin composition for the formation of micropatterns and process for the formation of micropatterns with the same
EP1980576A4 (en) Propylene polymer, method for production of the propylene polymer, propylene polymer composition, and molded article manufactured from the composition
EP2113534B8 (en) Resin composition, prepreg and metal-foil-clad laminate
EP2166060B8 (en) Stabilized aqueous polymer compositions
SG155870A1 (en) Conjugated diene polymer, process for producing same, and conjugated diene polymer composition and vulcanizate
BRPI0817220A2 (en) method of forming a modified phenolic resin composition, modified phenolic resin composition, abrasive product and the method of manufacture thereof
EP2479614A4 (en) Radiation-sensitive resin composition, method for forming resist pattern, polymer and polymerizable compound
IL206148A0 (en) Polymeric composition, method for the manufacture of the polymeric composition, articles based on this polymeric composition and use of these articles
EP1887026A4 (en) Aqueous resin dispersion, method for producing same, coating material, and multilayer body
ZA200901007B (en) Process for producing biopolymer nanoparticles
ZA200906551B (en) Method for producing modified conjugated diene polymer, modified conjugated diene polymer, and rubber composition
EP2003158A4 (en) Dendritic polyester, method for producing the same, and thermoplastic resin composition
EP2325694A4 (en) Radiation-sensitive resin composition, and resist pattern formation method
GB0623334D0 (en) Polymer composites
EP2050789A4 (en) Polylactic acid resin composition, molded body thereof and polylactic acid compound
WO2009099768A3 (en) Biodegradable coatings for implantable medical devices
EP2170970A4 (en) Functionalized polymers, articles prepared therefrom, and methods for making the same
WO2010078900A3 (en) Novel aliphatically substituted pyrazolopyridines, and the use thereof
EP2213708A4 (en) Aqueous resin composition for coating, and aqueous coating
EP2022829A4 (en) Photoluminescent pigment, method for production of the pigment, and aqueous resin composition comprising the pigment
EP2180033A4 (en) Flame retardant agent, method for production of the flame retardant agent, resin composition, and method for production of the resin composition
EP2439590A4 (en) Radiation-sensitive resin composition, polymer and method for forming resist pattern
WO2011038325A3 (en) Dust-repellent nanoparticle surfaces

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08781477

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2008275226

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2010516192

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 2008275226

Country of ref document: AU

Date of ref document: 20080708

Kind code of ref document: A

REEP Request for entry into the european phase

Ref document number: 2008781477

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2008781477

Country of ref document: EP