WO2009011889A3 - Compounds and methods for treatment of sickle cell disease or complications associated therewith - Google Patents

Compounds and methods for treatment of sickle cell disease or complications associated therewith Download PDF

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Publication number
WO2009011889A3
WO2009011889A3 PCT/US2008/008745 US2008008745W WO2009011889A3 WO 2009011889 A3 WO2009011889 A3 WO 2009011889A3 US 2008008745 W US2008008745 W US 2008008745W WO 2009011889 A3 WO2009011889 A3 WO 2009011889A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
compounds
methods
associated therewith
sickle cell
Prior art date
Application number
PCT/US2008/008745
Other languages
French (fr)
Other versions
WO2009011889A2 (en
WO2009011889A4 (en
Inventor
John L Magnani
Original Assignee
Glycomimetics Inc
John L Magnani
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycomimetics Inc, John L Magnani filed Critical Glycomimetics Inc
Priority to EP08794556A priority Critical patent/EP2173351A2/en
Priority to CA2693590A priority patent/CA2693590A1/en
Publication of WO2009011889A2 publication Critical patent/WO2009011889A2/en
Publication of WO2009011889A3 publication Critical patent/WO2009011889A3/en
Publication of WO2009011889A4 publication Critical patent/WO2009011889A4/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Abstract

Compounds, compositions and methods are provided for treatment of sickle cell disease or a complication associated therewith, or graft versus host disease, in an individual. More specifically, the use of particular glycomimetics for the treatment is described.
PCT/US2008/008745 2007-07-18 2008-07-16 Compounds and methods for treatment of sickle cell disease or complications associated therewith WO2009011889A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP08794556A EP2173351A2 (en) 2007-07-18 2008-07-16 Compounds and methods for treatment of sickle cell disease or complications associated therewith
CA2693590A CA2693590A1 (en) 2007-07-18 2008-07-16 Compounds and methods for treatment of sickle cell disease or complications associated therewith

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95998407P 2007-07-18 2007-07-18
US60/959,984 2007-07-18

Publications (3)

Publication Number Publication Date
WO2009011889A2 WO2009011889A2 (en) 2009-01-22
WO2009011889A3 true WO2009011889A3 (en) 2009-03-05
WO2009011889A4 WO2009011889A4 (en) 2009-04-23

Family

ID=40044164

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/008745 WO2009011889A2 (en) 2007-07-18 2008-07-16 Compounds and methods for treatment of sickle cell disease or complications associated therewith

Country Status (5)

Country Link
US (2) US8039442B2 (en)
EP (1) EP2173351A2 (en)
CA (1) CA2693590A1 (en)
WO (1) WO2009011889A2 (en)
ZA (1) ZA201000316B (en)

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US8039442B2 (en) 2007-07-18 2011-10-18 Glycomimetics, Inc. Compounds and methods for treatment of sickle cell disease or complications associated therewith
WO2009126556A1 (en) 2008-04-08 2009-10-15 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
ES2426784T3 (en) * 2008-06-13 2013-10-25 Glycomimetics, Inc. Treatment of blood cancers using selected glyomimetic compounds
US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
WO2012047918A1 (en) * 2010-10-04 2012-04-12 Glycomimetics, Inc. Anti-epileptogenic agents
WO2013096926A1 (en) 2011-12-22 2013-06-27 Glycomimetics, Inc. E-selectin antagonist compounds, compositions, and methods of use
ES2668045T3 (en) 2012-12-07 2018-05-16 Glycomimetics, Inc. Compounds, compositions and methods that use E-selectin antagonists for the mobilization of hematopoietic cells
SI3227310T1 (en) 2014-12-03 2019-11-29 Glycomimetics Inc Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors
US11291678B2 (en) 2016-03-02 2022-04-05 Glycomimetics, Inc Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin
WO2018031445A1 (en) 2016-08-08 2018-02-15 Glycomimetics, Inc. Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4
CA3037850A1 (en) 2016-10-07 2018-04-12 Glycomimetics, Inc. Highly potent multimeric e-selectin antagonists
CA3054605A1 (en) 2017-03-15 2018-09-20 Glycomimetics, Inc. Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
WO2019108750A1 (en) 2017-11-30 2019-06-06 Glycomimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
EP3732186A1 (en) 2017-12-29 2020-11-04 GlycoMimetics, Inc. Heterobifunctional inhibitors of e-selectin and galectin-3
AU2019230013A1 (en) 2018-03-05 2020-09-10 Glycomimetics, Inc. Methods for treating acute myeloid leukemia and related conditions
EP3886984A1 (en) 2018-11-29 2021-10-06 Pfizer Inc. Pyrazoles as modulators of hemoglobin
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3

Citations (2)

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Also Published As

Publication number Publication date
ZA201000316B (en) 2010-10-27
WO2009011889A2 (en) 2009-01-22
US8361975B2 (en) 2013-01-29
CA2693590A1 (en) 2009-01-22
WO2009011889A4 (en) 2009-04-23
US20120015898A1 (en) 2012-01-19
EP2173351A2 (en) 2010-04-14
US20090023679A1 (en) 2009-01-22
US8039442B2 (en) 2011-10-18

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