WO2009011889A4 - Compounds and methods for treatment of sickle cell disease or complications associated therewith - Google Patents
Compounds and methods for treatment of sickle cell disease or complications associated therewith Download PDFInfo
- Publication number
- WO2009011889A4 WO2009011889A4 PCT/US2008/008745 US2008008745W WO2009011889A4 WO 2009011889 A4 WO2009011889 A4 WO 2009011889A4 US 2008008745 W US2008008745 W US 2008008745W WO 2009011889 A4 WO2009011889 A4 WO 2009011889A4
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- treatment
- compound
- associated therewith
- sickle cell
- cell disease
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract 11
- 208000007056 sickle cell anemia Diseases 0.000 title claims abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 claims abstract 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 abstract 1
- 208000024908 graft versus host disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Abstract
Compounds, compositions and methods are provided for treatment of sickle cell disease or a complication associated therewith, or graft versus host disease, in an individual. More specifically, the use of particular glycomimetics for the treatment is described.
Claims
AMENDED CLAIMS received by the International Bureau on 11 March 2009 (11.03.09)
10. Use of a compound for the preparation of a composition for the treatment of sickle cell disease or a complication associated therewith, the compound with the formula:
L = linker group; and n = 0-1.
11. Use of a compound for the preparation of a medicament for the treatment of sickle cell disease or a complication associated therewith, the compound with the formula:
L = linker group; and n = 0-1.
12. The use according to claim 10 or claim 11 wherein in the compound n=0.
AMENDED SHEET (ARTICLE 19)
13. The use according to claim 10 or claim 11 wherein in the compound n=1 and L is
where the N of L is attached to terminal C of C(=O) of the compound.
14. The use according to claim 10 or claim 11 wherein in the compound n=1 and L is
AMENDED SHEET (ARTICLE 19)
19
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2693590A CA2693590A1 (en) | 2007-07-18 | 2008-07-16 | Compounds and methods for treatment of sickle cell disease or complications associated therewith |
EP08794556A EP2173351A2 (en) | 2007-07-18 | 2008-07-16 | Compounds and methods for treatment of sickle cell disease or complications associated therewith |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95998407P | 2007-07-18 | 2007-07-18 | |
US60/959,984 | 2007-07-18 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2009011889A2 WO2009011889A2 (en) | 2009-01-22 |
WO2009011889A3 WO2009011889A3 (en) | 2009-03-05 |
WO2009011889A4 true WO2009011889A4 (en) | 2009-04-23 |
Family
ID=40044164
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/008745 WO2009011889A2 (en) | 2007-07-18 | 2008-07-16 | Compounds and methods for treatment of sickle cell disease or complications associated therewith |
Country Status (5)
Country | Link |
---|---|
US (2) | US8039442B2 (en) |
EP (1) | EP2173351A2 (en) |
CA (1) | CA2693590A1 (en) |
WO (1) | WO2009011889A2 (en) |
ZA (1) | ZA201000316B (en) |
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US20130261070A1 (en) * | 2010-10-04 | 2013-10-03 | John L. Magnani | Anti-epileptogenic agents |
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2008
- 2008-07-11 US US12/218,213 patent/US8039442B2/en active Active
- 2008-07-16 CA CA2693590A patent/CA2693590A1/en not_active Abandoned
- 2008-07-16 EP EP08794556A patent/EP2173351A2/en not_active Withdrawn
- 2008-07-16 WO PCT/US2008/008745 patent/WO2009011889A2/en active Application Filing
-
2010
- 2010-01-15 ZA ZA201000316A patent/ZA201000316B/en unknown
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2011
- 2011-09-23 US US13/243,873 patent/US8361975B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
WO2009011889A3 (en) | 2009-03-05 |
US20120015898A1 (en) | 2012-01-19 |
ZA201000316B (en) | 2010-10-27 |
EP2173351A2 (en) | 2010-04-14 |
US8039442B2 (en) | 2011-10-18 |
WO2009011889A2 (en) | 2009-01-22 |
US20090023679A1 (en) | 2009-01-22 |
CA2693590A1 (en) | 2009-01-22 |
US8361975B2 (en) | 2013-01-29 |
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