WO2009020793A3 - Multi-polymer hydrogels - Google Patents

Multi-polymer hydrogels Download PDF

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Publication number
WO2009020793A3
WO2009020793A3 PCT/US2008/071435 US2008071435W WO2009020793A3 WO 2009020793 A3 WO2009020793 A3 WO 2009020793A3 US 2008071435 W US2008071435 W US 2008071435W WO 2009020793 A3 WO2009020793 A3 WO 2009020793A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymeric
region
water
polymeric material
article
Prior art date
Application number
PCT/US2008/071435
Other languages
French (fr)
Other versions
WO2009020793A2 (en
Inventor
Brian Thomas
Kai Zhang
Original Assignee
Zimmer Inc
Brian Thomas
Kai Zhang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zimmer Inc, Brian Thomas, Kai Zhang filed Critical Zimmer Inc
Priority to CA2693257A priority Critical patent/CA2693257A1/en
Priority to AU2008284156A priority patent/AU2008284156A1/en
Priority to EP08796762A priority patent/EP2173792B1/en
Priority to AT08796762T priority patent/ATE537205T1/en
Publication of WO2009020793A2 publication Critical patent/WO2009020793A2/en
Publication of WO2009020793A3 publication Critical patent/WO2009020793A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2300/00—Characterised by the use of unspecified polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2329/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal, or ketal radical; Hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Derivatives of such polymer
    • C08J2329/02—Homopolymers or copolymers of unsaturated alcohols
    • C08J2329/04—Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids

Abstract

The invention provides a multi-polymer hydrogel article having a first polymeric, water-swellable material and a second polymeric material, organized such that a first region substantially comprises the first polymeric, water-swellable material, a second region adjacent the first region comprises a mixture of the first polymeric, water-swellable material and the second polymeric material, and a third region adjacent the second region substantially comprises the second polymeric material. The article exhibits an increasing concentration gradient of the second polymeric material moving from the first region, through the second region, to the third region. The invention also provides methods for forming a multi-polymer hydrogel article by (a) forming a hydrogel structure using a first polymeric, water-swellable material, (b) creating an aerogel structure having a plurality of open pores by dehydrating the hydrogel structure, (c) contacting the aerogel structure with a second polymeric material to incorporate the second polymeric material into at least a portion of the plurality of open pores to form the multi-polymer hydrogel article, and (d) rehydrating the multi-polymer hydrogel article.
PCT/US2008/071435 2007-08-03 2008-07-29 Multi-polymer hydrogels WO2009020793A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA2693257A CA2693257A1 (en) 2007-08-03 2008-07-29 Multi-polymer hydrogels
AU2008284156A AU2008284156A1 (en) 2007-08-03 2008-07-29 Multi-polymer hydrogels
EP08796762A EP2173792B1 (en) 2007-08-03 2008-07-29 Multi-polymer hydrogels
AT08796762T ATE537205T1 (en) 2007-08-03 2008-07-29 HYDROGELS MADE OF MULTIPLE POLYMERS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/833,549 US7731988B2 (en) 2007-08-03 2007-08-03 Multi-polymer hydrogels
US11/833,549 2007-08-03

Publications (2)

Publication Number Publication Date
WO2009020793A2 WO2009020793A2 (en) 2009-02-12
WO2009020793A3 true WO2009020793A3 (en) 2009-03-26

Family

ID=40266013

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/071435 WO2009020793A2 (en) 2007-08-03 2008-07-29 Multi-polymer hydrogels

Country Status (6)

Country Link
US (2) US7731988B2 (en)
EP (2) EP2173792B1 (en)
AT (1) ATE537205T1 (en)
AU (1) AU2008284156A1 (en)
CA (1) CA2693257A1 (en)
WO (1) WO2009020793A2 (en)

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