WO2009020793A3 - Multi-polymer hydrogels - Google Patents

Multi-polymer hydrogels Download PDF

Info

Publication number
WO2009020793A3
WO2009020793A3 PCT/US2008/071435 US2008071435W WO2009020793A3 WO 2009020793 A3 WO2009020793 A3 WO 2009020793A3 US 2008071435 W US2008071435 W US 2008071435W WO 2009020793 A3 WO2009020793 A3 WO 2009020793A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymeric
region
water
polymeric material
article
Prior art date
Application number
PCT/US2008/071435
Other languages
French (fr)
Other versions
WO2009020793A2 (en
Inventor
Brian Thomas
Kai Zhang
Original Assignee
Zimmer Inc
Brian Thomas
Kai Zhang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zimmer Inc, Brian Thomas, Kai Zhang filed Critical Zimmer Inc
Priority to EP08796762A priority Critical patent/EP2173792B1/en
Priority to AT08796762T priority patent/ATE537205T1/en
Priority to CA2693257A priority patent/CA2693257A1/en
Priority to AU2008284156A priority patent/AU2008284156A1/en
Publication of WO2009020793A2 publication Critical patent/WO2009020793A2/en
Publication of WO2009020793A3 publication Critical patent/WO2009020793A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2300/00—Characterised by the use of unspecified polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2329/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal, or ketal radical; Hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Derivatives of such polymer
    • C08J2329/02—Homopolymers or copolymers of unsaturated alcohols
    • C08J2329/04—Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)

Abstract

The invention provides a multi-polymer hydrogel article having a first polymeric, water-swellable material and a second polymeric material, organized such that a first region substantially comprises the first polymeric, water-swellable material, a second region adjacent the first region comprises a mixture of the first polymeric, water-swellable material and the second polymeric material, and a third region adjacent the second region substantially comprises the second polymeric material. The article exhibits an increasing concentration gradient of the second polymeric material moving from the first region, through the second region, to the third region. The invention also provides methods for forming a multi-polymer hydrogel article by (a) forming a hydrogel structure using a first polymeric, water-swellable material, (b) creating an aerogel structure having a plurality of open pores by dehydrating the hydrogel structure, (c) contacting the aerogel structure with a second polymeric material to incorporate the second polymeric material into at least a portion of the plurality of open pores to form the multi-polymer hydrogel article, and (d) rehydrating the multi-polymer hydrogel article.
PCT/US2008/071435 2007-08-03 2008-07-29 Multi-polymer hydrogels WO2009020793A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP08796762A EP2173792B1 (en) 2007-08-03 2008-07-29 Multi-polymer hydrogels
AT08796762T ATE537205T1 (en) 2007-08-03 2008-07-29 HYDROGELS MADE OF MULTIPLE POLYMERS
CA2693257A CA2693257A1 (en) 2007-08-03 2008-07-29 Multi-polymer hydrogels
AU2008284156A AU2008284156A1 (en) 2007-08-03 2008-07-29 Multi-polymer hydrogels

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/833,549 US7731988B2 (en) 2007-08-03 2007-08-03 Multi-polymer hydrogels
US11/833,549 2007-08-03

Publications (2)

Publication Number Publication Date
WO2009020793A2 WO2009020793A2 (en) 2009-02-12
WO2009020793A3 true WO2009020793A3 (en) 2009-03-26

Family

ID=40266013

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/071435 WO2009020793A2 (en) 2007-08-03 2008-07-29 Multi-polymer hydrogels

Country Status (6)

Country Link
US (2) US7731988B2 (en)
EP (2) EP2173792B1 (en)
AT (1) ATE537205T1 (en)
AU (1) AU2008284156A1 (en)
CA (1) CA2693257A1 (en)
WO (1) WO2009020793A2 (en)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090088846A1 (en) 2007-04-17 2009-04-02 David Myung Hydrogel arthroplasty device
US7235592B2 (en) 2004-10-12 2007-06-26 Zimmer Gmbh PVA hydrogel
US7723262B2 (en) 2005-11-21 2010-05-25 Energ2, Llc Activated carbon cryogels and related methods
CA2632120C (en) 2005-12-07 2014-07-08 Zimmer, Inc. Methods of bonding or modifying hydrogels using irradiation
US8017107B2 (en) 2005-12-22 2011-09-13 Zimmer, Inc. Perfluorocyclobutane crosslinked hydrogels
EP2100317B1 (en) 2006-11-15 2016-01-27 Energ2, Inc. Electric double layer capacitance device
US20090123985A1 (en) * 2007-11-10 2009-05-14 Chung Yuan Christian University Method for fabricating aerogels and their application in biocomposites
US8062739B2 (en) 2007-08-31 2011-11-22 Zimmer, Inc. Hydrogels with gradient
US7947784B2 (en) 2007-11-16 2011-05-24 Zimmer, Inc. Reactive compounding of hydrogels
US20090240337A1 (en) * 2008-03-21 2009-09-24 David Myung Methods, Devices and Compositions for Adhering Hydrated Polymer Implants to Bone
US20120209396A1 (en) 2008-07-07 2012-08-16 David Myung Orthopedic implants having gradient polymer alloys
CA2727777A1 (en) 2008-07-07 2010-01-14 Biomimedica, Inc. Hydrophilic interpenetrating polymer networks derived from hydrophobic polymers
KR20110040969A (en) 2008-08-05 2011-04-20 바이오미메디카, 인코포레이티드 Polyurethane-grafted hydrogels
KR101627127B1 (en) * 2009-09-24 2016-06-03 삼성전자 주식회사 Organic aerogel and composition for the organic aerogel
KR101782624B1 (en) * 2010-02-12 2017-09-28 삼성전자주식회사 Aerogel and method of making the aerogel
KR101666098B1 (en) 2010-04-01 2016-10-14 삼성전자 주식회사 Aerogel, composition for the aerogel and method of making the aerogel
KR20110049572A (en) * 2009-11-05 2011-05-12 삼성전자주식회사 Organic aerogel, composition for the organic aerogel and method of manufacturing the organic aerogel
US8691883B2 (en) 2009-02-11 2014-04-08 Samsung Electronics Co., Ltd. Aerogel-foam composites
KR101560738B1 (en) * 2009-02-11 2015-10-16 삼성전자 주식회사 Organic aerogel composition for forming the same and method of preparing the same
KR101660316B1 (en) 2010-03-30 2016-09-28 삼성전자 주식회사 Organic aerogel and composition for the organic aerogel
US20100233266A1 (en) * 2009-03-13 2010-09-16 Cleek Robert L Articles and methods of treating vascular conditions
US8293818B2 (en) 2009-04-08 2012-10-23 Energ2 Technologies, Inc. Manufacturing methods for the production of carbon materials
EP2440319B1 (en) * 2009-06-11 2016-12-21 Case Western Reserve University Porous material having controlled voids and method of making the same
JP5710605B2 (en) 2009-06-11 2015-04-30 ケース ウエスタン リザーブ ユニバーシティ Low density hydrophobic substance and method for producing the same
WO2011003033A1 (en) 2009-07-01 2011-01-06 Energ2, Inc. Ultrapure synthetic carbon materials
EP2510569B1 (en) * 2009-12-11 2020-07-22 Basf Se Carbon materials comprising an electrochemical modifier
EP2512354A4 (en) * 2009-12-18 2015-09-09 Biomimedica Inc Method, device, and system for shaving and shaping of a joint
US8916296B2 (en) 2010-03-12 2014-12-23 Energ2 Technologies, Inc. Mesoporous carbon materials comprising bifunctional catalysts
EP2368925B1 (en) * 2010-03-27 2016-05-11 Samsung Electronics Co., Ltd. Aerogel, composition for the aerogel, and method of making the aerogel
CA2808528A1 (en) 2010-08-27 2012-03-01 Biomimedica, Inc. Hydrophobic and hydrophilic interpenetrating polymer networks derived from hydrophobic polymers and methods of preparing the same
WO2012045002A1 (en) 2010-09-30 2012-04-05 Energ2 Technologies, Inc. Enhanced packing of energy storage particles
WO2012064787A2 (en) 2010-11-08 2012-05-18 W&L Polymers, Ltd. Gels and hydrogels
WO2012092210A1 (en) 2010-12-28 2012-07-05 Energ2 Technologies, Inc. Carbon materials comprising enhanced electrochemical properties
EP3235522A1 (en) 2011-01-10 2017-10-25 Biomimedica, Inc Orthopedic implants having gradient polymer alloys
US20120262127A1 (en) 2011-04-15 2012-10-18 Energ2 Technologies, Inc. Flow ultracapacitor
CA3048443C (en) 2011-05-26 2021-01-05 Cartiva, Inc. Tapered joint implant and related tools
US10522836B2 (en) 2011-06-03 2019-12-31 Basf Se Carbon-lead blends for use in hybrid energy storage devices
CA2885996A1 (en) 2011-10-03 2013-04-11 Biomimedica, Inc. Polymeric adhesive for anchoring compliant materials to another surface
US9381112B1 (en) 2011-10-06 2016-07-05 William Eric Sponsell Bleb drainage device, ophthalmological product and methods
US9114024B2 (en) 2011-11-21 2015-08-25 Biomimedica, Inc. Systems, devices, and methods for anchoring orthopaedic implants to bone
US8632489B1 (en) 2011-12-22 2014-01-21 A. Mateen Ahmed Implantable medical assembly and methods
US9409777B2 (en) 2012-02-09 2016-08-09 Basf Se Preparation of polymeric resins and carbon materials
AU2013308058A1 (en) * 2012-08-30 2015-04-02 Moasis Inc. Porous gels and uses thereof
US20140148506A1 (en) * 2012-11-26 2014-05-29 Allergan, Inc. Drug elating silicone gel sheeting for wound healing and scar reduction
CN103007789A (en) * 2012-12-13 2013-04-03 江南大学 Preparation method of cross-linking oil-water separation film
WO2014143213A1 (en) 2013-03-14 2014-09-18 Energ2 Technologies, Inc. Composite carbon materials comprising lithium alloying electrochemical modifiers
US9206298B2 (en) 2013-05-23 2015-12-08 Nexolve Corporation Method of aerogel synthesis
US10195583B2 (en) 2013-11-05 2019-02-05 Group 14 Technologies, Inc. Carbon-based compositions with highly efficient volumetric gas sorption
US9764301B2 (en) * 2013-11-14 2017-09-19 Nanyang Technological University Silica aerogel composite
KR102347131B1 (en) 2014-03-14 2022-01-04 그룹14 테크놀로지스, 인코포레이티드 Novel methods for sol-gel polymerization in absence of solvent and creation of tunable carbon structure from same
US10016341B2 (en) 2015-03-30 2018-07-10 Elwha Llc Systems and devices for controlling delivery of breast milk supplementation
US9925122B2 (en) 2015-03-30 2018-03-27 Elwha Llc Systems and methods for controlling delivery of breast milk supplementation
US10290372B2 (en) 2015-03-30 2019-05-14 Elwha Llc Systems and devices for controlling delivery of breast milk supplementation
US9968523B2 (en) 2015-03-30 2018-05-15 Elwha Llc Systems and devices for controlling delivery of breast milk supplementation
CA2981064C (en) 2015-03-31 2024-01-02 Cartiva, Inc. Carpometacarpal (cmc) implants and methods
EP3753531A1 (en) 2015-03-31 2020-12-23 Cartiva, Inc. Hydrogel implants with porous materials
KR102023531B1 (en) 2015-04-07 2019-09-24 주식회사 엘지화학 Aerogel containing composition and thermal insulation blanket prepared by using the same
WO2016168363A1 (en) 2015-04-14 2016-10-20 Cartiva, Inc. Tooling for creating tapered opening in tissue and related methods
WO2017004136A1 (en) 2015-06-30 2017-01-05 Tela Bio, Inc. Corner-lock stitch patterns
US10098574B1 (en) 2015-07-07 2018-10-16 Verily Life Sciences Llc Porous microneedles through sacrificial sugar incorporation, analyte detection system, and method for intradermal optode nanosensor implantation
EP3324882B1 (en) 2015-07-21 2023-10-25 Tela Bio, Inc. Compliance control stitching in substrate materials
EP4227363A1 (en) 2015-08-10 2023-08-16 Hyalex Orthopaedics, Inc. Interpenetrating polymer networks
US11077228B2 (en) 2015-08-10 2021-08-03 Hyalex Orthopaedics, Inc. Interpenetrating polymer networks
US20190097222A1 (en) 2015-08-14 2019-03-28 Energ2 Technologies, Inc. Composites of porous nano-featured silicon materials and carbon materials
WO2017040299A1 (en) 2015-08-28 2017-03-09 Energ2 Technologies, Inc. Novel materials with extremely durable intercalation of lithium and manufacturing methods thereof
US10624987B2 (en) * 2015-09-03 2020-04-21 The Texas A&M University System Implant-based repair of osteochondral defects
US10471183B2 (en) 2015-12-22 2019-11-12 Access Vascular, Inc. High strength biomedical materials
WO2017189772A1 (en) 2016-04-26 2017-11-02 Tela Bio, Inc. Hernia repair grafts having anti-adhesion barriers
CN105963793B (en) * 2016-05-06 2019-04-02 北京林业大学 A kind of preparation method of artificial load-bearing cartilage hydrogel
KR102402097B1 (en) 2016-08-04 2022-05-25 웨이크 포리스트 유니버시티 헬스 사이언시즈 Blood-brain barrier model and methods of making and using the same
EP3593369A4 (en) 2017-03-09 2021-03-03 Group14 Technologies, Inc. Decomposition of silicon-containing precursors on porous scaffold materials
GB201708909D0 (en) * 2017-06-05 2017-07-19 Orthox Ltd Implantable tissue repair devices and methods for manufacturing the same
CA3067850A1 (en) * 2017-06-21 2018-12-27 Access Vascular, Inc High strength porous materials incorporating water soluble polymers
WO2019173792A1 (en) 2018-03-09 2019-09-12 Tela Bio, Inc. Surgical repair graft
US10869950B2 (en) 2018-07-17 2020-12-22 Hyalex Orthopaedics, Inc. Ionic polymer compositions
CN110894301B (en) * 2018-09-12 2021-10-08 天津大学 Biodegradable natural polymer-based high-strength hydrogel and preparation method thereof
CN109438887B (en) * 2018-10-25 2021-07-02 江南大学 Nanofiber aerogel with photo-thermal conversion, sound insulation, heat insulation and good mechanical recovery and preparation method thereof
AU2019404045A1 (en) * 2018-12-19 2021-06-24 Access Vascular, Inc. High strength porous materials for controlled release
WO2020132532A1 (en) * 2018-12-21 2020-06-25 Advanced Aesthetic Technologies, Inc. Crosslinked polysaccharides and related methods
EP3934575A4 (en) 2019-03-08 2022-12-28 Tela Bio, Inc. Textured medical textiles
US11335903B2 (en) 2020-08-18 2022-05-17 Group14 Technologies, Inc. Highly efficient manufacturing of silicon-carbon composites materials comprising ultra low z
US11639292B2 (en) 2020-08-18 2023-05-02 Group14 Technologies, Inc. Particulate composite materials
US11174167B1 (en) 2020-08-18 2021-11-16 Group14 Technologies, Inc. Silicon carbon composites comprising ultra low Z
US11203004B1 (en) * 2020-08-25 2021-12-21 Ford Global Technologies, Llc Systems and methods for aerogel preparation via vacuum-assisted solvent exchange and ambient pressure drying
CN113072719B (en) * 2021-03-30 2022-07-12 武汉纺织大学 High-strength multi-element cross-linked hydrogel and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999067320A1 (en) * 1998-06-20 1999-12-29 Vorlop Klaus Dieter Process for preparing a polyvinyl alcohol gel and mechanically highly stable gel produced by this process
WO2004064693A1 (en) * 2003-01-16 2004-08-05 Replication Medical, Inc. Hydrogel-based prosthetic device for replacing at least a part of the nucleus of a spinal disc
WO2006091706A1 (en) * 2005-02-23 2006-08-31 Zimmer Technology, Inc. Blend hydrogels and methods of making

Family Cites Families (207)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US536083A (en) * 1895-03-19 And joseph k
GB919390A (en) 1960-12-14 1963-02-27 Kurashiki Rayon Kk Polyvinyl alcohol fibres having excellent dyeability and whiteness
US3875302A (en) 1970-09-16 1975-04-01 Kuraray Co Gelled vinyl alcohol polymers and articles therefrom
US3862265A (en) 1971-04-09 1975-01-21 Exxon Research Engineering Co Polymers with improved properties and process therefor
DE2364675C2 (en) 1972-12-29 1983-06-23 Kuraray Co., Ltd., Kurashiki, Okayama Copolymer consisting of a polymer main chain and polymer side chains and its use for the manufacture of articles for biomedical purposes
US4058491A (en) 1975-02-11 1977-11-15 Plastomedical Sciences, Inc. Cationic hydrogels based on heterocyclic N-vinyl monomers
US4036788A (en) 1975-02-11 1977-07-19 Plastomedical Sciences, Inc. Anionic hydrogels based on heterocyclic N-vinyl monomers
US4060678A (en) 1975-02-11 1977-11-29 Plastomedical Sciences, Inc. Cationic hydrogels based on hydroxyalkyl acrylates and methacrylates
US4071508A (en) 1975-02-11 1978-01-31 Plastomedical Sciences, Inc. Anionic hydrogels based on hydroxyalkyl acrylates and methacrylates
SU1243627A3 (en) 1979-12-05 1986-07-07 Дзе Кендалл Компани (Фирма) Jelly-forming composition
US4379874A (en) 1980-07-07 1983-04-12 Stoy Vladimir A Polymer composition comprising polyacrylonitrile polymer and multi-block copolymer
CA1181915A (en) 1981-02-05 1985-02-05 Nippon Oil Co., Ltd. Process for preparing a hydrogel
US4378874A (en) * 1981-03-24 1983-04-05 Transco Northwest, Inc. Pallet elevator for a ship
US4451599A (en) 1981-04-01 1984-05-29 American Can Company Plasticized EVOH and process and products utilizing same
US4734097A (en) 1981-09-25 1988-03-29 Nippon Oil Company, Ltd. Medical material of polyvinyl alcohol and process of making
US4699146A (en) 1982-02-25 1987-10-13 Valleylab, Inc. Hydrophilic, elastomeric, pressure-sensitive adhesive
US4956122A (en) 1982-03-10 1990-09-11 Uniroyal Chemical Company, Inc. Lubricating composition
JPS5930881A (en) 1982-08-13 1984-02-18 Nippon Oil Co Ltd Manufacture of low-temperature insulating gel
JPS5956446A (en) 1982-09-24 1984-03-31 Nippon Oil Co Ltd Method for lowering flexibility of frozen polyvinyl alcohol gel
GB8311788D0 (en) 1983-04-29 1983-06-02 Coopervision Uk Hydrogel contact lenses
US4464438A (en) 1983-05-02 1984-08-07 Mobil Oil Corporation Blends of polyvinyl alcohol and ethylene-vinyl alcohol copolymer as grease resistant melt extrudable films
US4859719A (en) 1983-09-08 1989-08-22 Minnesota Mining And Manufacturing Company Polymer blends with high water absorption
US4771089A (en) 1983-09-08 1988-09-13 Minnesota Mining And Manufacturing Co. Polymer blends with high water absorption
DE3410241A1 (en) 1984-03-21 1985-10-03 Hoechst Ag, 6230 Frankfurt THERMOPLASTICALLY PROCESSABLE POLYVINYL ALCOHOL COMPOSITIONS, METHOD FOR THEIR PRODUCTION AND FILMS AND MOLDED PARTS MADE THEREOF
JPH0678460B2 (en) 1985-05-01 1994-10-05 株式会社バイオマテリアル・ユニバース Porous transparent polyvinyl alcohol gel
US4640941A (en) 1985-11-25 1987-02-03 Alcon Laboratories Hydrogels containing siloxane comonomers
JPS6323126A (en) 1986-02-13 1988-01-30 Bio Material Yunibaasu:Kk Soft contact lens and its production
GB8611838D0 (en) 1986-05-15 1986-06-25 Yarsley Technical Centre Ltd Hydrophilic copolymers
JPS6317904A (en) 1986-07-09 1988-01-25 Mitsubishi Chem Ind Ltd Production of crosslinked porous polyvinyl alcohol particle
JPH0611290B2 (en) 1986-11-05 1994-02-16 住友ベークライト株式会社 Γ-ray sterilization method for polyvinyl alcohol gel
PL151581B1 (en) 1986-12-30 1990-09-28 Method of manufacturing of hydrogel dressing
US5244799A (en) 1987-05-20 1993-09-14 Anderson David M Preparation of a polymeric hydrogel containing micropores and macropores for use as a cell culture substrate
US5306311A (en) 1987-07-20 1994-04-26 Regen Corporation Prosthetic articular cartilage
US4772287A (en) 1987-08-20 1988-09-20 Cedar Surgical, Inc. Prosthetic disc and method of implanting
JPH0286838A (en) 1988-09-22 1990-03-27 Terumo Corp Water insoluble hydrogel and production thereof
JP2746387B2 (en) 1988-09-22 1998-05-06 株式会社ビーエムジー Method for producing polyvinyl alcohol hydrogel
DE3835840A1 (en) 1988-10-21 1990-05-31 Hoechst Ag GRAY POLYMERISATES CONTAINING POLYVINYL ACETAL GROUPS ON POLYURETHANE GRAIN BASES, METHOD FOR THEIR PRODUCTION AND THEIR USE
US4851168A (en) 1988-12-28 1989-07-25 Dow Corning Corporation Novel polyvinyl alcohol compositions and products prepared therefrom
US4915974A (en) 1989-02-17 1990-04-10 Nabisco Brands, Inc. Polyvinyl oleate as a fat replacement
IT1233599B (en) 1989-05-30 1992-04-06 Butterfly Srl POLYMERIC COMPOSITIONS FOR THE PRODUCTION OF BIODEGRADABLE PLASTIC ITEMS AND PROCEDURES FOR THEIR PREPARATION
AU5941990A (en) 1989-06-30 1991-01-17 Poqet Computer Corporation Memory card tray for portable computer
US5288765A (en) 1989-08-03 1994-02-22 Spherilene S.R.L. Expanded articles of biodegradable plastics materials and a method for their production
US5118779A (en) 1989-10-10 1992-06-02 Polymedica Industries, Inc. Hydrophilic polyurethane elastomers
US5157093A (en) 1990-05-10 1992-10-20 Ciba-Geigy Corporation Hydroxyethyl cellulose derivatives containing pendant (meth)acryloyl units bound through urethane groups and hydrogel contact lenses made therefrom
US5028648A (en) 1990-07-12 1991-07-02 Air Products And Chemicals, Inc. Extrudable polyvinyl alcohol compositions containing thermoplastic polyurethane
US5122565A (en) 1990-10-26 1992-06-16 Shell Oil Company Stabilized polyketone polymers containing a mixture of a hydroxyapatite and an alumina hydrogel
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
TW203065B (en) 1990-10-24 1993-04-01 Hoechst Ag
US5189097A (en) 1990-12-07 1993-02-23 Rohm And Haas Company Polymeric blends
US5362803A (en) 1990-12-07 1994-11-08 Rohm And Haas Company Polymeric blends of polyvinyl alcohol copolymers with copolymers of unsaturated monomers
US5192326A (en) 1990-12-21 1993-03-09 Pfizer Hospital Products Group, Inc. Hydrogel bead intervertebral disc nucleus
US5047055A (en) 1990-12-21 1991-09-10 Pfizer Hospital Products Group, Inc. Hydrogel intervertebral disc nucleus
JP3007903B2 (en) 1991-03-29 2000-02-14 京セラ株式会社 Artificial disc
US5276079A (en) 1991-11-15 1994-01-04 Minnesota Mining And Manufacturing Company Pressure-sensitive poly(n-vinyl lactam) adhesive composition and method for producing and using same
US5552096A (en) 1991-12-13 1996-09-03 Exxon Chemical Patents Inc. Multiple reaction process in melt processing equipment
US5681300A (en) 1991-12-17 1997-10-28 The Procter & Gamble Company Absorbent article having blended absorbent core
US5260066A (en) 1992-01-16 1993-11-09 Srchem Incorporated Cryogel bandage containing therapeutic agent
CA2096386A1 (en) 1992-05-18 1993-11-19 Masahiro Kamauchi Lithium secondary battery
US6162456A (en) 1992-09-24 2000-12-19 Ortho-Mcneil Pharmaceutical, Inc. Adhesive transdermal drug delivery matrix of a physical blend of hydrophilic and hydrophobic polymers
US5407055A (en) 1992-11-19 1995-04-18 Kao Corporation Conveyor apparatus and method having flexible goods receptacle members
US5336551A (en) 1992-12-14 1994-08-09 Mizu Systems, Inc. Reinforced polyvinyl alcohol hydrogels containing uniformly dispersed crystalline fibrils and method for preparing same
US5358525A (en) 1992-12-28 1994-10-25 Fox John E Bearing surface for prosthesis and replacement of meniscal cartilage
US5256751A (en) 1993-02-08 1993-10-26 Vistakon, Inc. Ophthalmic lens polymer incorporating acyclic monomer
US5709854A (en) 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
FR2704431B1 (en) 1993-04-30 1995-07-21 Sebbin Laboratoires Use of hydrogels based on hyaluronic acid and / or polydeoxyribonucleotides as filling materials for prostheses and prostheses resulting therefrom.
DE69426414T2 (en) 1993-09-24 2001-05-03 Takiron Co IMPLANT MATERIAL
US5540033A (en) 1994-01-10 1996-07-30 Cambrex Hydrogels Integrated Manufacturing process for hydrogels
US5527271A (en) 1994-03-30 1996-06-18 Bristol-Myers Squibb Co. Thermoplastic hydrogel impregnated composite material
US5723331A (en) 1994-05-05 1998-03-03 Genzyme Corporation Methods and compositions for the repair of articular cartilage defects in mammals
AU2621295A (en) 1994-05-24 1995-12-18 Smith & Nephew Plc Intervertebral disc implant
US5834029A (en) 1994-07-20 1998-11-10 Cytotherapeutics, Inc. Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell adhesive peptide fragment
EP0700671B1 (en) 1994-09-08 2001-08-08 Stryker Technologies Corporation Hydrogel intervertebral disc nucleus
US6180606B1 (en) 1994-09-28 2001-01-30 Gensci Orthobiologics, Inc. Compositions with enhanced osteogenic potential, methods for making the same and uses thereof
ATE198979T1 (en) 1994-10-12 2001-02-15 Focal Inc TARGETED DISHES ADMINISTERED USING BIODEGRADABLE POLYMERS
CA2201607C (en) 1994-10-17 2001-02-13 Charles D. Ray Prosthetic spinal disc nucleus
US5716404A (en) 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
US5632774A (en) 1995-01-17 1997-05-27 Babian; Hamik In-the-shell hydration to make implant filler material and prosthesis employing same
US6017577A (en) 1995-02-01 2000-01-25 Schneider (Usa) Inc. Slippery, tenaciously adhering hydrophilic polyurethane hydrogel coatings, coated polymer substrate materials, and coated medical devices
US5576072A (en) 1995-02-01 1996-11-19 Schneider (Usa), Inc. Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with at least one other, dissimilar polymer hydrogel
US5919570A (en) 1995-02-01 1999-07-06 Schneider Inc. Slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with a poly(N-vinylpyrrolidone) polymer hydrogel, coated polymer and metal substrate materials, and coated medical devices
US5941909A (en) 1995-02-14 1999-08-24 Mentor Corporation Filling material for soft tissue implant prostheses and implants made therewith
US6962979B1 (en) 1995-03-14 2005-11-08 Cohesion Technologies, Inc. Crosslinkable biomaterial compositions containing hydrophobic and hydrophilic crosslinking agents
US5900245A (en) 1996-03-22 1999-05-04 Focal, Inc. Compliant tissue sealants
BR9607977A (en) 1995-03-23 1998-01-13 Univ Texas Photoinitiated and redox preparation systems for improved gel adhesion to substrates
JPH08283570A (en) 1995-04-17 1996-10-29 Sumitomo Chem Co Ltd Resin composition
US6129761A (en) 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
US6509098B1 (en) 1995-11-17 2003-01-21 Massachusetts Institute Of Technology Poly(ethylene oxide) coated surfaces
JP4193917B2 (en) 1995-12-18 2008-12-10 アンジオデバイス インターナショナル ゲーエムベーハー Crosslinked polymer composition and method of use thereof
EP0784987B1 (en) 1996-01-16 2003-10-01 Mentor Corporation Method of making in situ filler material for mammary, penile and testicular prosthesis and tissue expanders
US6207185B1 (en) 1996-03-22 2001-03-27 Bio-Sphere Technology Method for inducing a systemic immune response to an HIV antigen
US6015576A (en) 1997-08-29 2000-01-18 Bio-Sphere Technology, Inc. Method for inducing a systemic immune response to an antigen
US6117449A (en) 1996-03-22 2000-09-12 Bio-Sphere Technology, Inc. Method for inducing a systemic immune response to a hepatitis antigen
ES2196252T3 (en) 1996-05-10 2003-12-16 Chienna Bv DEVICE FOR THE INCORPORATION AND ADMINISTRATION OF ACTIVE BIOLOGICAL AGENTS.
DK0910412T3 (en) 1996-07-01 2003-08-11 Univ Utrecht Controlled release hydrolyzable hydrogels
US6063061A (en) 1996-08-27 2000-05-16 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US6706690B2 (en) 1999-06-10 2004-03-16 Baxter Healthcare Corporation Hemoactive compositions and methods for their manufacture and use
US6184197B1 (en) 1996-09-19 2001-02-06 The Procter & Gamble Company Polymeric compound comprising one or more active alcohols
ATE512650T1 (en) 1996-10-24 2011-07-15 Covidien Ag HYDROGEL WOUND DRESSING AND ASSOCIATED METHOD OF MANUFACTURING AND USE
EP0873145A2 (en) 1996-11-15 1998-10-28 Advanced Bio Surfaces, Inc. Biomaterial system for in situ tissue repair
US6139963A (en) 1996-11-28 2000-10-31 Kuraray Co., Ltd. Polyvinyl alcohol hydrogel and process for producing the same
US6224893B1 (en) 1997-04-11 2001-05-01 Massachusetts Institute Of Technology Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering
US5981826A (en) 1997-05-05 1999-11-09 Georgia Tech Research Corporation Poly(vinyl alcohol) cryogel
US20030008396A1 (en) 1999-03-17 2003-01-09 Ku David N. Poly(vinyl alcohol) hydrogel
US6271278B1 (en) 1997-05-13 2001-08-07 Purdue Research Foundation Hydrogel composites and superporous hydrogel composites having fast swelling, high mechanical strength, and superabsorbent properties
GB9714580D0 (en) 1997-07-10 1997-09-17 Wardlaw Douglas Prosthetic intervertebral disc nucleus
US6180132B1 (en) 1997-09-18 2001-01-30 Sherwood Services, Ag Hydrogel wound dressing and the method of making and using the same
US6375634B1 (en) 1997-11-19 2002-04-23 Oncology Innovations, Inc. Apparatus and method to encapsulate, kill and remove malignancies, including selectively increasing absorption of x-rays and increasing free-radical damage to residual tumors targeted by ionizing and non-ionizing radiation therapy
US5891826A (en) 1997-11-26 1999-04-06 Eastman Kodak Company Affixing thermal dye transfer image on magnet
US6428811B1 (en) 1998-03-11 2002-08-06 Wm. Marsh Rice University Temperature-sensitive polymer/nanoshell composites for photothermally modulated drug delivery
US6007833A (en) 1998-03-19 1999-12-28 Surmodics, Inc. Crosslinkable macromers bearing initiator groups
US6040493A (en) 1998-04-24 2000-03-21 Replication Medical, Inc. Bioreactor wound dressing
GB2338958A (en) 1998-06-26 2000-01-12 Eastman Kodak Co Hyperbranched-graft hybrid copolymers from vinyl branching monomers and vinyl macromonomers
JP2000080445A (en) 1998-09-02 2000-03-21 Natl Res Inst For Metals Oxide-dispersed steel and its production
US6132468A (en) 1998-09-10 2000-10-17 Mansmann; Kevin A. Arthroscopic replacement of cartilage using flexible inflatable envelopes
US6861067B2 (en) 1998-09-17 2005-03-01 Sherwood Services Ag Hydrogel wound dressing and the method of making and using the same
US6630457B1 (en) 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
US6211296B1 (en) 1998-11-05 2001-04-03 The B. F. Goodrich Company Hydrogels containing substances
FR2786400B1 (en) 1998-11-30 2002-05-10 Imedex Biomateriaux PROCESS FOR THE PREPARATION OF A COLLAGENIC MATERIAL HAVING IN VIVO CONTROLLED BIODEGRADATION SPEED AND MATERIALS OBTAINED
US6451346B1 (en) 1998-12-23 2002-09-17 Amgen Inc Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents
NZ513517A (en) 1999-02-19 2003-08-29 Denki Kagaku Kogyo Kk Hyaluronic acid gel composition containing a polymer for use as a wound dressing
US6372283B1 (en) 1999-04-02 2002-04-16 Medtronic, Inc. Plasma process for surface modification of pyrolitic carbon
EP1168934B1 (en) 1999-04-12 2008-02-13 Cornell Research Foundation, Inc. Hydrogel-forming system with hydrophobic and hydrophilic components
US6268405B1 (en) 1999-05-04 2001-07-31 Porex Surgical, Inc. Hydrogels and methods of making and using same
US7491235B2 (en) 1999-05-10 2009-02-17 Fell Barry M Surgically implantable knee prosthesis
KR100698559B1 (en) 1999-06-11 2007-03-21 넥타르 테라퓨틱스 에이엘, 코포레이션 Hydrogels derived from chitosan and polyethylene glycol or related polymers
US6445202B1 (en) * 1999-06-30 2002-09-03 Cascade Microtech, Inc. Probe station thermal chuck with shielding for capacitive current
US6333029B1 (en) 1999-06-30 2001-12-25 Ethicon, Inc. Porous tissue scaffoldings for the repair of regeneration of tissue
US6306424B1 (en) 1999-06-30 2001-10-23 Ethicon, Inc. Foam composite for the repair or regeneration of tissue
WO2002054978A2 (en) 1999-08-18 2002-07-18 Intrinsic Orthopedics Inc Devices and method for nucleus pulposus augmentation and retention
US6287870B1 (en) 1999-08-20 2001-09-11 Robert A. Levine Method and assembly for separating formed constituents from a liquid constituent in a complex biologic fluid sample
US6371984B1 (en) 1999-09-13 2002-04-16 Keraplast Technologies, Ltd. Implantable prosthetic or tissue expanding device
US6783546B2 (en) 1999-09-13 2004-08-31 Keraplast Technologies, Ltd. Implantable prosthetic or tissue expanding device
US6232406B1 (en) 1999-09-30 2001-05-15 Replication Medical Inc. Hydrogel and method of making
US6387325B1 (en) 1999-10-08 2002-05-14 Becton Dickinson & Company Assembly for separating formed constituents from a liquid constituent in a complex biologic fluid sample
US6710126B1 (en) 1999-11-15 2004-03-23 Bio Cure, Inc. Degradable poly(vinyl alcohol) hydrogels
AU2001231196A1 (en) 2000-01-27 2001-08-07 The General Hospital Corporation Delivery of therapeutic biological from implantable tissue matrices
US6626945B2 (en) 2000-03-14 2003-09-30 Chondrosite, Llc Cartilage repair plug
US6632246B1 (en) 2000-03-14 2003-10-14 Chondrosite, Llc Cartilage repair plug
US6629997B2 (en) 2000-03-27 2003-10-07 Kevin A. Mansmann Meniscus-type implant with hydrogel surface reinforced by three-dimensional mesh
US6969480B2 (en) 2000-05-12 2005-11-29 Matregen Corp. Method of producing structures using centrifugal forces
US6710104B2 (en) 2000-05-29 2004-03-23 Kawamura Institute Of Chemical Research Organic/inorganic hybrid hydrogel and manufacturing method therefor
US6533817B1 (en) 2000-06-05 2003-03-18 Raymedica, Inc. Packaged, partially hydrated prosthetic disc nucleus
US7186419B2 (en) 2000-08-25 2007-03-06 Contura Sa Polyacrylamide hydrogel for arthritis
US6620196B1 (en) 2000-08-30 2003-09-16 Sdgi Holdings, Inc. Intervertebral disc nucleus implants and methods
US20020026244A1 (en) 2000-08-30 2002-02-28 Trieu Hai H. Intervertebral disc nucleus implants and methods
AU1538702A (en) 2000-10-24 2002-05-06 Cryolife Inc In situ bioprosthetic filler and methods, particularly for the in situ formationof vertebral disc bioprosthetics
US9050192B2 (en) 2001-02-05 2015-06-09 Formae, Inc. Cartilage repair implant with soft bearing surface and flexible anchoring device
US6436883B1 (en) 2001-04-06 2002-08-20 Huntsman Petrochemical Corporation Hydraulic and gear lubricants
US8840918B2 (en) 2001-05-01 2014-09-23 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences Hydrogel compositions for tooth whitening
ATE438418T1 (en) 2001-05-01 2009-08-15 Av Topchiev Inst Petrochemical HYDROGEL COMPOSITIONS
US6803420B2 (en) 2001-05-01 2004-10-12 Corium International Two-phase, water-absorbent bioadhesive composition
US6608117B1 (en) 2001-05-11 2003-08-19 Nanosystems Research Inc. Methods for the preparation of cellular hydrogels
EP1406536A4 (en) 2001-06-20 2005-09-21 Microvention Inc Medical devices having full or partial polymer coatings and their methods of manufacture
US6780840B1 (en) 2001-10-09 2004-08-24 Tissue Adhesive Technologies, Inc. Method for making a light energized tissue adhesive
US6855743B1 (en) 2001-10-29 2005-02-15 Nanosystems Research, Inc. Reinforced, laminated, impregnated, and composite-like materials as crosslinked polyvinyl alcohol hydrogel structures
US6783721B2 (en) 2001-10-30 2004-08-31 Howmedica Osteonics Corp. Method of making an ion treated hydrogel
EP1463457A4 (en) 2002-01-04 2006-12-20 Massachusetts Gen Hospital A high modulus crosslinked polyethylene with reduced residual free radical concentration prepared below the melt
US6949590B2 (en) 2002-01-10 2005-09-27 University Of Washington Hydrogels formed by non-covalent linkages
US20040131582A1 (en) 2002-02-26 2004-07-08 Grinstaff Mark W. Novel dendritic polymers and their biomedical uses
AU2003234159A1 (en) 2002-04-22 2003-11-03 Purdue Research Foundation Hydrogels having enhanced elasticity and mechanical strength properties
US7015262B2 (en) 2002-05-01 2006-03-21 Lifescan, Inc. Hydrophilic coatings for medical implements
AU2002309026A1 (en) * 2002-05-01 2003-11-17 Hokkaido Technology Licensing Office Co., Ltd. Gel having multiple network structure and method for preparation thereof
US7122602B2 (en) 2002-06-21 2006-10-17 Isp Investments Inc. Process of making polymeric hydrogels by reactive extrusion
US7033393B2 (en) 2002-06-27 2006-04-25 Raymedica, Inc. Self-transitioning spinal disc anulus occulsion device and method of use
US7745532B2 (en) 2002-08-02 2010-06-29 Cambridge Polymer Group, Inc. Systems and methods for controlling and forming polymer gels
US7485670B2 (en) 2002-08-02 2009-02-03 Cambridge Polymer Group, Inc. Systems and methods for controlling and forming polymer gels
US20050249790A1 (en) 2002-09-27 2005-11-10 Basf Aktiengesellschaft Polymerized hydrogel adhesives with high levels of monomer units in salt form
WO2004031253A1 (en) 2002-10-02 2004-04-15 Coloplast A/S A hydrogel
US20050069572A1 (en) 2002-10-09 2005-03-31 Jennifer Elisseeff Multi-layered polymerizing hydrogels for tissue regeneration
CA2501617C (en) 2002-10-11 2012-04-24 Ronald A. Sahatjian Expandable polymeric endoprosthesis with shape memory
US6844067B2 (en) 2002-10-24 2005-01-18 Toda Kogyo Corporation Black iron-based particles and black toner containing the same
US8110222B2 (en) 2002-11-15 2012-02-07 Ut-Battelle, Llc. Composite material
US6733533B1 (en) 2002-11-19 2004-05-11 Zimmer Technology, Inc. Artificial spinal disc
EP1575459B1 (en) 2002-11-21 2008-05-21 Warsaw Orthopedic, Inc. Systems for interbody spinal stabilization with expandable devices
EP1565130A2 (en) 2002-11-26 2005-08-24 RayMedica, Inc. Prosthetic spinal disc nucleus with elevated swelling rate
MXPA05005478A (en) 2002-11-27 2005-07-25 Isp Investments Inc Tough polymers.
WO2004056321A2 (en) 2002-12-18 2004-07-08 The Regents Of The University Of California Biocompatible hydrogel bone-like composites
US20060127878A1 (en) 2002-12-18 2006-06-15 Salomon David H Hydrogel preparation and process of manufacture thereof
US7264859B2 (en) 2002-12-19 2007-09-04 Kimberly-Clark Worldwide, Inc. Lubricious coating for medical devices
US7004971B2 (en) 2002-12-31 2006-02-28 Depuy Acromed, Inc. Annular nucleus pulposus replacement
US6982298B2 (en) 2003-01-10 2006-01-03 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
EP1631375B1 (en) 2003-01-17 2011-11-02 Cornell Research Foundation, Inc. Injectable hydrogel microspheres from aqueous two-phase system
AU2004208821B2 (en) 2003-01-31 2009-01-15 Zimmer Orthobiologics Inc. Hydrogel compositions comprising nucleus pulposus tissue
US6994730B2 (en) 2003-01-31 2006-02-07 Howmedica Osteonics Corp. Meniscal and tibial implants
DE602004024288D1 (en) 2003-02-17 2010-01-07 Kawamura Inst Chem Res POLYMER GEL WITH BIOKOMPATIBLE MATERIAL, DRY GEL AND PRODUCTION PROCESS FOR POLYMER GEL
RU2326893C2 (en) 2003-04-16 2008-06-20 Кориум Интернэшнл Covalent and non-covalent linking of hydrophilic polymers and adhesive compositions with them
EP1626799B1 (en) 2003-04-30 2010-04-14 Drexel University Thermogelling polymer blends for biomaterial applications
US7067169B2 (en) 2003-06-04 2006-06-27 Chemat Technology Inc. Coated implants and methods of coating
WO2004109053A2 (en) 2003-06-04 2004-12-16 Sun Drilling Products Corporation Lost circulation material blend offering high fluid loss with minimum solids
NL1023924C2 (en) 2003-07-15 2005-01-18 Stichting Tech Wetenschapp Tissue replacement material.
US7736619B2 (en) 2003-11-05 2010-06-15 Ust Inc. Hydrogel compositions and manufacturing process for ultrasound couplants
KR100553327B1 (en) 2003-11-18 2006-02-20 광주과학기술원 Siloxane monomers containing trifluorovinylether group, sol-gel hybrid polymers prepared by using the siloxane monomers
FR2865939B1 (en) 2004-02-06 2007-08-31 Biomatlante USE OF SILANIZED ORGANIC POLYMERS FOR CREATING BIOACTIVE COATING, FOR IMPLANT OR PROSTHESIS
FR2866571B1 (en) 2004-02-20 2007-09-21 Philippe Zanchetta USE OF A MIXTURE OF SPECIFIC POLYSACCHARIDES AS INDICATED BY THE EZBONE INVENTOR COMPRISING HYALURONIC ACID, CHONDROID SULFATE, DERMATANE SULFATE AND HEPARIN IN BONE HEALING.
EP1571161B1 (en) 2004-03-05 2007-05-16 Nippon Synthetic Chemical Industry Co., Ltd Aqueous emulsion and use thereof
EP1593400A1 (en) 2004-05-04 2005-11-09 Depuy Products, Inc. Hybrid biologic-synthetic bioabsorbable scaffolds
EP1775311B1 (en) 2004-08-04 2018-09-05 Sekisui Chemical Co., Ltd. Process for producing polyvinyl acetal resin
US9029349B2 (en) 2004-08-27 2015-05-12 Antonio Lauto Bioadhesive for tissue repair
US7235592B2 (en) 2004-10-12 2007-06-26 Zimmer Gmbh PVA hydrogel
WO2006075392A1 (en) 2005-01-14 2006-07-20 Mitsui Chemicals, Inc. Polyvinyl acetal resin varnish, gelling agent, nonaqueous electrolyte and electrochemical element
US7291169B2 (en) 2005-04-15 2007-11-06 Zimmer Technology, Inc. Cartilage implant
US20070004861A1 (en) 2005-07-01 2007-01-04 Kevin Cai High melt strength polypropylene resins and method for making same
ITTO20050549A1 (en) 2005-08-03 2007-02-04 Consiglio Nazionale Ricerche COMPOSITE MATERIAL INJECTABLE TO BE USED AS A BONUS SUBSTITUTE
CA2632120C (en) * 2005-12-07 2014-07-08 Zimmer, Inc. Methods of bonding or modifying hydrogels using irradiation
US7601383B2 (en) 2006-02-28 2009-10-13 Advanced Cardiovascular Systems, Inc. Coating construct containing poly (vinyl alcohol)
FR2918377B1 (en) * 2007-07-05 2010-10-08 Estelle Piron CO-RETICLE GEL OF POLYSACCHARIDES
US20090053318A1 (en) 2007-08-21 2009-02-26 Sharon Mi Lyn Tan Forming Embolic Particles

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999067320A1 (en) * 1998-06-20 1999-12-29 Vorlop Klaus Dieter Process for preparing a polyvinyl alcohol gel and mechanically highly stable gel produced by this process
WO2004064693A1 (en) * 2003-01-16 2004-08-05 Replication Medical, Inc. Hydrogel-based prosthetic device for replacing at least a part of the nucleus of a spinal disc
WO2006091706A1 (en) * 2005-02-23 2006-08-31 Zimmer Technology, Inc. Blend hydrogels and methods of making

Also Published As

Publication number Publication date
CA2693257A1 (en) 2009-02-12
US20090035344A1 (en) 2009-02-05
US20100204800A1 (en) 2010-08-12
ATE537205T1 (en) 2011-12-15
US8236342B2 (en) 2012-08-07
WO2009020793A2 (en) 2009-02-12
EP2173792A2 (en) 2010-04-14
EP2439227A1 (en) 2012-04-11
AU2008284156A1 (en) 2009-02-12
EP2439227B1 (en) 2013-06-12
EP2173792B1 (en) 2011-12-14
US7731988B2 (en) 2010-06-08

Similar Documents

Publication Publication Date Title
WO2009020793A3 (en) Multi-polymer hydrogels
WO2010048585A3 (en) Oligomeric compounds and methods
EP2528002A3 (en) Defined glycoprotein products and related methods
EP2103635A4 (en) Oil-repellent copolymer, method for producing the same and oil-repellent processing liquid
WO2007014930A3 (en) Polyammonium/polysiloxane copolymers
ZA200905976B (en) Method for making microfluid devices
DK1991472T3 (en) Container and pressure-resistant, permeable cap for the same
WO2009058379A3 (en) Protein scaffolds
WO2013119966A3 (en) Single-chain antibodies and other heteromultimers
WO2007136893A3 (en) Anti-fgf19 antibodies and methods using same
EP2085419A4 (en) Process for producing modified polymer, modified polymer obtained by the process, and rubber composition containing the same
IL206148A0 (en) Polymeric composition, method for the manufacture of the polymeric composition, articles based on this polymeric composition and use of these articles
BRPI0905076A2 (en) Polypeptide, antibody, variable region, heavy chain or light chain, gene, vector, host cell, method for producing said polypeptide, and pharmaceutical composition comprising the same
ATE488623T1 (en) POLYMERIC STRUCTURES AND METHODS FOR THE PRODUCTION THEREOF
EP2076326A4 (en) Ce-zr-r-o catalysts, articles comprising the ce-zr-r-o catalysts and methods of making and using the ce-zr-r-o catalysts
WO2007130697A3 (en) Anti-ephb4 antibodies and methods using same
WO2011005710A3 (en) Zone migration in network access
BRPI0909916A2 (en) "Method for optically examining the interior of cloudy medium, device for optically examining the interior of cloudy medium".
WO2010003567A3 (en) Fluorosurfactants
WO2010059902A3 (en) 3d cell-culture article and methods thereof
WO2009039307A3 (en) Hydrogels and methods for producing and using the same
FR2897775B1 (en) BIOMATERIAU, INJECTABLE IMPLANT COMPRISING IT, PROCESS FOR PREPARING THE SAME AND USES THEREOF
WO2010054107A3 (en) Kinase knockdown via electrophilically enhanced inhibitors
WO2007127506A8 (en) Anti-ephrinb2 antibodies and methods using same
BRPI0920270A2 (en) polymerizable liquid compositions of the polyurethane type, method for producing organic glass, organic glass, and manufactured optical products or items.

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08796762

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2008284156

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2693257

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2008796762

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2008284156

Country of ref document: AU

Date of ref document: 20080729

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE