WO2009055076A3 - Methods and compositions for inhibition of immune responses and autoimmunity - Google Patents
Methods and compositions for inhibition of immune responses and autoimmunity Download PDFInfo
- Publication number
- WO2009055076A3 WO2009055076A3 PCT/US2008/012220 US2008012220W WO2009055076A3 WO 2009055076 A3 WO2009055076 A3 WO 2009055076A3 US 2008012220 W US2008012220 W US 2008012220W WO 2009055076 A3 WO2009055076 A3 WO 2009055076A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- immunoregulatory
- autoimmunity
- inhibition
- compositions
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/17—Immunomodulatory nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/314—Phosphoramidates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/331—Universal or degenerate base
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/336—Modified G
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/345—Spatial arrangement of the modifications having at least two different backbone modifications
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2008317261A AU2008317261B2 (en) | 2007-10-26 | 2008-10-27 | Methods and compositions for inhibition of immune responses and autoimmunity |
CA2703931A CA2703931C (en) | 2007-10-26 | 2008-10-27 | Methods and compositions for inhibition of immune responses and autoimmunity |
EP08841867.8A EP2209896B1 (en) | 2007-10-26 | 2008-10-27 | Methods and compositions for inhibition of immune responses and autoimmunity |
JP2010531068A JP5749492B2 (en) | 2007-10-26 | 2008-10-27 | Methods and compositions for inhibiting immune responses and autoimmunity |
US12/767,692 US8962579B2 (en) | 2007-10-26 | 2010-04-26 | Methods and compositions for inhibition of immune responses and autoimmunity |
US14/613,280 US9476053B2 (en) | 2007-10-26 | 2015-02-03 | Methods and compositions for inhibition of immune responses and autoimmunity |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98307307P | 2007-10-26 | 2007-10-26 | |
US60/983,073 | 2007-10-26 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/767,692 Continuation US8962579B2 (en) | 2007-10-26 | 2010-04-26 | Methods and compositions for inhibition of immune responses and autoimmunity |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009055076A2 WO2009055076A2 (en) | 2009-04-30 |
WO2009055076A3 true WO2009055076A3 (en) | 2009-11-05 |
Family
ID=40513681
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/012220 WO2009055076A2 (en) | 2007-10-26 | 2008-10-27 | Methods and compositions for inhibition of immune responses and autoimmunity |
Country Status (6)
Country | Link |
---|---|
US (2) | US8962579B2 (en) |
EP (2) | EP2209896B1 (en) |
JP (1) | JP5749492B2 (en) |
AU (1) | AU2008317261B2 (en) |
CA (1) | CA2703931C (en) |
WO (1) | WO2009055076A2 (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2385657T3 (en) | 2004-09-01 | 2012-07-27 | Dynavax Technologies Corporation | Methods and compositions for the inhibition of innate immune responses and autoimmunity |
AU2005316503A1 (en) * | 2004-12-17 | 2006-06-22 | Dynavax Technologies Corporation | Methods and compositions for induction or promotion of immune tolerance |
ES2542989T3 (en) | 2005-10-12 | 2015-08-13 | Idera Pharmaceuticals, Inc. | Immuno-regulatory oligonucleotide compounds (IRO) to modulate the Toll-like receptor-based immune response |
AU2008317261B2 (en) | 2007-10-26 | 2015-04-09 | Dynavax Technologies Corporation | Methods and compositions for inhibition of immune responses and autoimmunity |
AU2009302468A1 (en) * | 2008-10-06 | 2010-04-15 | Idera Pharmaceuticals, Inc. | Use of inhibitors of toll-like receptors in the prevention and treatment of hypercholesterolemia and hyperlipidemia and diseases related thereto |
WO2011159328A1 (en) * | 2010-06-16 | 2011-12-22 | Dynavax Technologies Corporation | Methods of treatment using tlr7 and/or tlr9 inhibitors |
CN103153346A (en) * | 2010-06-16 | 2013-06-12 | 戴纳瓦克斯技术公司 | Methods of treatment using tlr7 and/or tlr9 inhibitors |
CA2817891C (en) | 2010-11-19 | 2021-10-12 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response |
US9452212B2 (en) | 2011-04-14 | 2016-09-27 | Dynavax Technologies Corporation | Methods and compositions for eliciting an immune response against hepatitis B virus |
US9228184B2 (en) | 2012-09-29 | 2016-01-05 | Dynavax Technologies Corporation | Human toll-like receptor inhibitors and methods of use thereof |
US9868955B2 (en) | 2012-09-29 | 2018-01-16 | Dynavax Technologies Corporation | Human toll-like receptor inhibitors and methods of use thereof |
CN105597079A (en) * | 2016-01-11 | 2016-05-25 | 中国人民解放军第三军医大学第一附属医院 | Medicine for treating psoriasis |
CN105541947A (en) * | 2016-01-11 | 2016-05-04 | 中国人民解放军第三军医大学第一附属医院 | Drug molecule for antagonizing TLR7/8 and TLR9 activation and application |
WO2017173334A1 (en) | 2016-04-01 | 2017-10-05 | Checkmate Pharmaceuticals, Inc. | Fc receptor-mediated drug delivery |
WO2017214378A1 (en) | 2016-06-08 | 2017-12-14 | President And Fellows Of Harvard College | Engineered viral vector reduces induction of inflammatory and immune responses |
MX2022001870A (en) | 2019-08-14 | 2022-05-30 | Curevac Ag | Head-up display. |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001022972A2 (en) * | 1999-09-25 | 2001-04-05 | University Of Iowa Research Foundation | Immunostimulatory nucleic acids |
WO2001068697A2 (en) * | 2000-03-17 | 2001-09-20 | Gorczynski Reginald M | Methods and compositions for immunoregulation |
WO2003085110A2 (en) * | 2002-04-05 | 2003-10-16 | Santaris Pharma A/S | Oligomeric compounds for the modulation hif-1alpha expression |
WO2005086835A2 (en) * | 2004-03-05 | 2005-09-22 | Archemix Corp. | Aptamers to the human il-12 cytokine family and their use as autoimmune disease therapeutics |
US20060193821A1 (en) * | 2004-03-05 | 2006-08-31 | Diener John L | Aptamers to the human IL-12 cytokine family and their use as autoimmune disease therapeutics |
WO2007095387A2 (en) * | 2006-02-17 | 2007-08-23 | Dharmacon, Inc. | Compositions and methods for inhibiting gene silencing by rna interference |
Family Cites Families (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US983073A (en) | 1908-05-28 | 1911-01-31 | Arcade Mallet | Kinematographic apparatus. |
US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
US4948882A (en) | 1983-02-22 | 1990-08-14 | Syngene, Inc. | Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis |
US4650675A (en) | 1983-08-18 | 1987-03-17 | The Children's Medical Center Corporation | Oligonucleotide conjugates |
US4849513A (en) | 1983-12-20 | 1989-07-18 | California Institute Of Technology | Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups |
US5118800A (en) | 1983-12-20 | 1992-06-02 | California Institute Of Technology | Oligonucleotides possessing a primary amino group in the terminal nucleotide |
US5015733A (en) | 1983-12-20 | 1991-05-14 | California Institute Of Technology | Nucleosides possessing blocked aliphatic amino groups |
US5118802A (en) | 1983-12-20 | 1992-06-02 | California Institute Of Technology | DNA-reporter conjugates linked via the 2' or 5'-primary amino group of the 5'-terminal nucleoside |
US4587329A (en) | 1984-08-17 | 1986-05-06 | The Dow Chemical Company | Dense star polymers having two dimensional molecular diameter |
US4910300A (en) | 1985-12-11 | 1990-03-20 | Chiron Corporation | Method for making nucleic acid probes |
US5093232A (en) | 1985-12-11 | 1992-03-03 | Chiron Corporation | Nucleic acid probes |
US6312679B1 (en) | 1986-08-18 | 2001-11-06 | The Dow Chemical Company | Dense star polymer conjugates as dyes |
US5338532A (en) | 1986-08-18 | 1994-08-16 | The Dow Chemical Company | Starburst conjugates |
JP3012244B2 (en) | 1987-09-21 | 2000-02-21 | ジェン―プローブ インコーポレイテッド | Non-nucleotide ligation reagent for nucleotide probes |
US5124246A (en) | 1987-10-15 | 1992-06-23 | Chiron Corporation | Nucleic acid multimers and amplified nucleic acid hybridization assays using same |
US5278302A (en) | 1988-05-26 | 1994-01-11 | University Patents, Inc. | Polynucleotide phosphorodithioates |
US5391723A (en) | 1989-05-31 | 1995-02-21 | Neorx Corporation | Oligonucleotide conjugates |
US5552391A (en) | 1990-01-16 | 1996-09-03 | La Jolla Pharmaceutical Company | Chemically-defined non-polymeric valency platform molecules and conjugates thereof |
US5171264A (en) | 1990-02-28 | 1992-12-15 | Massachusetts Institute Of Technology | Immobilized polyethylene oxide star molecules for bioapplications |
US5460831A (en) | 1990-06-22 | 1995-10-24 | The Regents Of The University Of California | Targeted transfection nanoparticles |
US6096722A (en) * | 1990-08-14 | 2000-08-01 | Isis Pharmaceuticals Inc. | Antisense modulation of cell adhesion molecule expression and treatment of cell adhesion molecule-associated diseases |
DK0748382T3 (en) | 1993-09-02 | 2003-02-17 | Ribozyme Pharm Inc | Enzymatic nucleic acid containing non-nucleotide |
US5874409A (en) | 1995-06-07 | 1999-02-23 | La Jolla Pharmaceutical Company | APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies |
JP2000512981A (en) | 1996-06-06 | 2000-10-03 | ラ ホヤ ファーマシューティカル カンパニー | aPL immunoreactive peptide, conjugate thereof and method of treatment for aPL antibody-mediated pathology |
ES2241042T3 (en) | 1996-10-11 | 2005-10-16 | The Regents Of The University Of California | IMMUNO STIMULATOR POLINUCLEOTIDE CONJUGATES / IMMUNOMODULATOR MOLECULA. |
WO2002090526A2 (en) | 2001-03-21 | 2002-11-14 | Human Genome Sciences, Inc. | Human secreted proteins |
US6489304B2 (en) * | 1997-05-01 | 2002-12-03 | Hybridon, Inc. | Hyperstructure-forming carriers |
EP2085090A3 (en) | 1997-06-06 | 2012-05-02 | The Regents of the University of California | Inhibitors of DNA immunostimulatory sequence activity |
US6080580A (en) * | 1998-10-05 | 2000-06-27 | Isis Pharmaceuticals Inc. | Antisense oligonucleotide modulation of tumor necrosis factor-α (TNF-α) expression |
US6458953B1 (en) | 1998-12-09 | 2002-10-01 | La Jolla Pharmaceutical Company | Valency platform molecules comprising carbamate linkages |
AU4343700A (en) | 1999-04-12 | 2000-11-14 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Oligodeoxynucleotide and its use to induce an immune response |
EP1183230A1 (en) | 1999-06-08 | 2002-03-06 | La Jolla Pharmaceutical | Valency platform molecules comprising aminooxy groups |
US7585847B2 (en) * | 2000-02-03 | 2009-09-08 | Coley Pharmaceutical Group, Inc. | Immunostimulatory nucleic acids for the treatment of asthma and allergy |
WO2002010438A2 (en) | 2000-07-28 | 2002-02-07 | The Johns Hopkins University | Serial analysis of transcript expression using long tags |
US20040009949A1 (en) * | 2002-06-05 | 2004-01-15 | Coley Pharmaceutical Group, Inc. | Method for treating autoimmune or inflammatory diseases with combinations of inhibitory oligonucleotides and small molecule antagonists of immunostimulatory CpG nucleic acids |
SE0201701D0 (en) | 2002-06-05 | 2002-06-05 | Gotovax Ab | Treatment of epithelial tumors and infections |
US20040053880A1 (en) * | 2002-07-03 | 2004-03-18 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
WO2004014322A2 (en) | 2002-08-12 | 2004-02-19 | Dynavax Technologies Corporation | Immunomodulatory compositions, methods of making, and methods of use thereof |
CN101955976A (en) | 2002-11-21 | 2011-01-26 | 贝希尔治疗学股份有限公司 | Methods and immune modulatory nucleic acid compositions for preventing and treating disease |
CN100546998C (en) | 2002-12-23 | 2009-10-07 | 戴纳伐克斯技术股份有限公司 | Immunostimulatory sequence oligonucleotides and using method |
JP2005055812A (en) | 2003-08-07 | 2005-03-03 | Olympus Corp | Projector device and desk having the projector device fitted therein |
US20070009899A1 (en) | 2003-10-02 | 2007-01-11 | Mounts William M | Nucleic acid arrays for detecting gene expression in animal models of inflammatory diseases |
US20050239733A1 (en) * | 2003-10-31 | 2005-10-27 | Coley Pharmaceutical Gmbh | Sequence requirements for inhibitory oligonucleotides |
US20050288246A1 (en) | 2004-05-24 | 2005-12-29 | Iversen Patrick L | Peptide conjugated, inosine-substituted antisense oligomer compound and method |
ES2385657T3 (en) | 2004-09-01 | 2012-07-27 | Dynavax Technologies Corporation | Methods and compositions for the inhibition of innate immune responses and autoimmunity |
AU2005316503A1 (en) | 2004-12-17 | 2006-06-22 | Dynavax Technologies Corporation | Methods and compositions for induction or promotion of immune tolerance |
CN101379195B (en) * | 2005-12-20 | 2012-05-09 | 艾德拉药物股份有限公司 | Immunostimulatory activity of palindromic immune modulatory oligonucleotides (IMO tm) contiaining different lengths of palindromic segments |
MX2008012993A (en) * | 2006-04-07 | 2008-12-18 | Idera Pharmaceuticals Inc | Stabilized immune modulatory rna (simra) compounds for tlr7 and tlr8. |
EP1881080A1 (en) | 2006-07-18 | 2008-01-23 | Institut Gustave Roussy | Toll like receptor 4 dysfunction and the biological applications thereof |
AU2008317261B2 (en) | 2007-10-26 | 2015-04-09 | Dynavax Technologies Corporation | Methods and compositions for inhibition of immune responses and autoimmunity |
CN103153346A (en) * | 2010-06-16 | 2013-06-12 | 戴纳瓦克斯技术公司 | Methods of treatment using tlr7 and/or tlr9 inhibitors |
-
2008
- 2008-10-27 AU AU2008317261A patent/AU2008317261B2/en active Active
- 2008-10-27 CA CA2703931A patent/CA2703931C/en active Active
- 2008-10-27 JP JP2010531068A patent/JP5749492B2/en active Active
- 2008-10-27 EP EP08841867.8A patent/EP2209896B1/en active Active
- 2008-10-27 EP EP11155868.0A patent/EP2361980B1/en active Active
- 2008-10-27 WO PCT/US2008/012220 patent/WO2009055076A2/en active Application Filing
-
2010
- 2010-04-26 US US12/767,692 patent/US8962579B2/en active Active
-
2015
- 2015-02-03 US US14/613,280 patent/US9476053B2/en active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001022972A2 (en) * | 1999-09-25 | 2001-04-05 | University Of Iowa Research Foundation | Immunostimulatory nucleic acids |
WO2001068697A2 (en) * | 2000-03-17 | 2001-09-20 | Gorczynski Reginald M | Methods and compositions for immunoregulation |
WO2003085110A2 (en) * | 2002-04-05 | 2003-10-16 | Santaris Pharma A/S | Oligomeric compounds for the modulation hif-1alpha expression |
WO2005086835A2 (en) * | 2004-03-05 | 2005-09-22 | Archemix Corp. | Aptamers to the human il-12 cytokine family and their use as autoimmune disease therapeutics |
US20060193821A1 (en) * | 2004-03-05 | 2006-08-31 | Diener John L | Aptamers to the human IL-12 cytokine family and their use as autoimmune disease therapeutics |
WO2007095387A2 (en) * | 2006-02-17 | 2007-08-23 | Dharmacon, Inc. | Compositions and methods for inhibiting gene silencing by rna interference |
Non-Patent Citations (2)
Title |
---|
COOK P D: "MAKING DRUGS OUT OF OLIGONUCLEOTIDES: A BRIEF REVIEW AND PERSPECTIVE", NUCLEOSIDES & NUCLEOTIDES, MARCEL DEKKER, INC, US, vol. 18, no. 6/07, 1 June 1999 (1999-06-01), pages 1141 - 1162, XP008049860, ISSN: 0732-8311 * |
JARVIS T C; ET AL: "OPTIMIZING THE CELL EFFICACY OF SYNTHETIC RIBOZYMES. SITE SELECTIONAND CHEMICAL MODIFICATIONS OF RIBOZYMES TARGETING THE PROTO-ONCOGENE C-MYB", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM, US, vol. 271, no. 46, 15 November 1996 (1996-11-15), pages 29107 - 29112, XP002042583, ISSN: 0021-9258 * |
Also Published As
Publication number | Publication date |
---|---|
EP2209896A2 (en) | 2010-07-28 |
US8962579B2 (en) | 2015-02-24 |
US20110003885A1 (en) | 2011-01-06 |
AU2008317261B2 (en) | 2015-04-09 |
EP2361980A1 (en) | 2011-08-31 |
US20150275216A1 (en) | 2015-10-01 |
EP2361980B1 (en) | 2016-12-07 |
WO2009055076A2 (en) | 2009-04-30 |
JP5749492B2 (en) | 2015-07-15 |
CA2703931C (en) | 2016-08-16 |
AU2008317261A1 (en) | 2009-04-30 |
EP2209896B1 (en) | 2017-03-01 |
CA2703931A1 (en) | 2009-04-30 |
JP2011500084A (en) | 2011-01-06 |
US9476053B2 (en) | 2016-10-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2009055076A3 (en) | Methods and compositions for inhibition of immune responses and autoimmunity | |
WO2007109812A3 (en) | Immunopotentiating compounds | |
HK1211463A1 (en) | Sprayable gel-type skin/mucosa-adhesive preparation and administration system using the preparation | |
WO2006031878A3 (en) | Imidazoquinoline compounds | |
AP2965A (en) | Therapeutic compositions and the use thereof | |
RS20070305A (en) | Formulations in the form of foam as modificators of immune response foamlike formulations as immunity modificators | |
WO2008037380A3 (en) | Alkyl benzoate mixtures | |
GT200900049A (en) | DERIVATIVES OF 2-ARIL-6-FENIL-IMIDAZO [1,2-A] PIRIDINAS, ITS PREPARATION AND THERAPEUTIC APPLICATION | |
WO2009056550A3 (en) | Bupropion hydrobromide and therapeutic applications | |
ZA200800206B (en) | "One-way valve for medical infusion lines and the like" | |
ZA201000468B (en) | Therapeutic compositions and the use thereof | |
WO2008116078A3 (en) | Stimulation of an immune response by cationic lipids | |
WO2009027820A3 (en) | Substituted-quinoxaline-type-piperidine compounds and the uses thereof | |
WO2009089494A3 (en) | Pharmaceutical compositions | |
WO2009059048A3 (en) | (+)-opioids and methods of use | |
EP2152304A4 (en) | Nanoemulsion therapeutic compositions and methods of using the same | |
WO2008003007A3 (en) | Compositions and methods for treating parasitic infections | |
WO2009114810A3 (en) | Use of ellagitannins as inhibitors of bacterial quorum sensing | |
WO2009002867A3 (en) | Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement | |
WO2005094554A3 (en) | Therapeutic agents, methods, and treatments | |
WO2008089201A3 (en) | Heterocyclic-substituted piperidine as orl-1 ligands | |
EP2045253A4 (en) | alpha-AMINO ACID DERIVATIVE AND PHARMACEUTICAL COMPRISING THE SAME AS ACTIVE INGREDIENT | |
WO2009019294A3 (en) | Bupropion hydrobromide and therapeutic applications | |
WO2007075923A3 (en) | Treatment of synucleinopathies | |
AU2008303948A8 (en) | Use of the peptide Asn-Asp-Asp-Cys-Glu- Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu alone or in combination with the peptide Thr-Thr-Ser-Gln-Val- Arg-Pro-Arg as a therapeutic agent |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 08841867 Country of ref document: EP Kind code of ref document: A2 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2008317261 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2703931 Country of ref document: CA Ref document number: 2010531068 Country of ref document: JP |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
REEP | Request for entry into the european phase |
Ref document number: 2008841867 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2008841867 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: 2008317261 Country of ref document: AU Date of ref document: 20081027 Kind code of ref document: A |