WO2009105265A3 - Treatment of aneurysm with application of connective tissue stabilization agent in combination with a delivery vehicle - Google Patents

Treatment of aneurysm with application of connective tissue stabilization agent in combination with a delivery vehicle Download PDF

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Publication number
WO2009105265A3
WO2009105265A3 PCT/US2009/001116 US2009001116W WO2009105265A3 WO 2009105265 A3 WO2009105265 A3 WO 2009105265A3 US 2009001116 W US2009001116 W US 2009001116W WO 2009105265 A3 WO2009105265 A3 WO 2009105265A3
Authority
WO
WIPO (PCT)
Prior art keywords
stabilization agent
connective tissue
aneurysm
treatment
delivery vehicle
Prior art date
Application number
PCT/US2009/001116
Other languages
French (fr)
Other versions
WO2009105265A2 (en
Inventor
Jason C. Isenburg
Narendra R. Vyavahare
Matthew F. Ogle
Original Assignee
Vatrix Medical, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vatrix Medical, Inc. filed Critical Vatrix Medical, Inc.
Priority to EP09713562A priority Critical patent/EP2257274A4/en
Priority to JP2010547649A priority patent/JP2011513220A/en
Publication of WO2009105265A2 publication Critical patent/WO2009105265A2/en
Publication of WO2009105265A3 publication Critical patent/WO2009105265A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Abstract

Delivery vehicles for controlled release of connective tissue stabilization agent for the treatment of vascular aneurysms are described. The delivery vehicle generally is combined with a connective tissue stabilization agent to form a therapeutic composition. The treatment of an aneurysm can be achieved through release of connective tissue stabilization agent from the delivery vehicle to the aneurysm. The connective tissue stabilization agent can be collagen stabilization agent, elastin stabilization agent, or a combination thereof. The aneurysm can be treated individually, simultaneously or sequentially with collagen stabilization agent and elastin stabilization agent embedded in separate delivery vehicles.
PCT/US2009/001116 2008-02-21 2009-02-20 Treatment of aneurysm with application of connective tissue stabilization agent in combination with a delivery vehicle WO2009105265A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP09713562A EP2257274A4 (en) 2008-02-21 2009-02-20 Treatment of aneurysm with application of connective tissue stabilization agent in combination with a delivery vehicle
JP2010547649A JP2011513220A (en) 2008-02-21 2009-02-20 Treatment of aneurysms by application of connective tissue stabilizer in combination with delivery vehicle

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6668808P 2008-02-21 2008-02-21
US61/066,688 2008-02-21

Publications (2)

Publication Number Publication Date
WO2009105265A2 WO2009105265A2 (en) 2009-08-27
WO2009105265A3 true WO2009105265A3 (en) 2009-12-03

Family

ID=40986113

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/001116 WO2009105265A2 (en) 2008-02-21 2009-02-20 Treatment of aneurysm with application of connective tissue stabilization agent in combination with a delivery vehicle

Country Status (4)

Country Link
US (1) US20090214654A1 (en)
EP (1) EP2257274A4 (en)
JP (1) JP2011513220A (en)
WO (1) WO2009105265A2 (en)

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US8496911B2 (en) * 2009-07-29 2013-07-30 Vatrix CHF, Inc. Tissue stabilization for heart failure
WO2011044455A1 (en) * 2009-10-09 2011-04-14 Vatrix Medical, Inc. In vivo chemical stabilization of vulnerable plaque
US8444624B2 (en) 2009-10-19 2013-05-21 Vatrix Medical, Inc. Vascular medical devices with sealing elements and procedures for the treatment of isolated vessel sections
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US8911468B2 (en) 2011-01-31 2014-12-16 Vatrix Medical, Inc. Devices, therapeutic compositions and corresponding percutaneous treatment methods for aortic dissection
WO2012158944A1 (en) * 2011-05-18 2012-11-22 Vatrix Medical, Inc. Coated balloons for blood vessel stabilization
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WO2014165023A1 (en) * 2013-03-12 2014-10-09 Carnegie Mellon University Coated vaso-occclusive device for treatment of aneurysms
US10779964B2 (en) * 2015-03-15 2020-09-22 Board Of Trustees Of The Leland Stanford Junior University Methods, devices, and compositions for treating abdominal aortic aneurysms
US11077287B2 (en) 2017-10-02 2021-08-03 Anlvr, Llc Non-occluding balloon for cardiovascular drug delivery
KR20210068392A (en) * 2018-08-03 2021-06-09 넥테로 메디칼, 인크. Purified Pentagaloyl Glucose and Devices for Delivery
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CN116870046A (en) * 2020-06-02 2023-10-13 中国科学院上海药物研究所 Use of natural compounds and derivatives thereof for the treatment of arterial lesions

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Also Published As

Publication number Publication date
US20090214654A1 (en) 2009-08-27
JP2011513220A (en) 2011-04-28
EP2257274A4 (en) 2011-07-20
WO2009105265A2 (en) 2009-08-27
EP2257274A2 (en) 2010-12-08

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