WO2009128606A3 - Method for detecting a cyanide ion using fluorescein aldehyde or fluorescein dialdehyde - Google Patents

Method for detecting a cyanide ion using fluorescein aldehyde or fluorescein dialdehyde Download PDF

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Publication number
WO2009128606A3
WO2009128606A3 PCT/KR2009/001109 KR2009001109W WO2009128606A3 WO 2009128606 A3 WO2009128606 A3 WO 2009128606A3 KR 2009001109 W KR2009001109 W KR 2009001109W WO 2009128606 A3 WO2009128606 A3 WO 2009128606A3
Authority
WO
WIPO (PCT)
Prior art keywords
fluorescein
detecting
chemical formula
cyanide ion
aldehyde
Prior art date
Application number
PCT/KR2009/001109
Other languages
French (fr)
Korean (ko)
Other versions
WO2009128606A2 (en
Inventor
윤주영
박성수
챵 첸샤오
남성원
권수경
김하나
마트하다 코트라이아 스와미쿠네마디할리
조민정
Original Assignee
이화여자대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020080036188A external-priority patent/KR100946998B1/en
Priority claimed from KR1020080044447A external-priority patent/KR101007847B1/en
Application filed by 이화여자대학교 산학협력단 filed Critical 이화여자대학교 산학협력단
Publication of WO2009128606A2 publication Critical patent/WO2009128606A2/en
Publication of WO2009128606A3 publication Critical patent/WO2009128606A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7786—Fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour

Abstract

The present invention relates to a method for detecting a cyanide ion using the derivatives expressed in Chemical Formula 1 and a method for detecting a cyanide toxin produced by Pseudomonas aeruginosa, i.e., opportunistic infectious bacteria, from a living body on a real-time basis. In detail, as shown in Reaction Formula 1 or 2, the method of the present invention is capable of precisely optically detecting a cyanide ion by measuring the fluorescence intensity or color change generated from the compound of Chemical Formula 5 or 7 obtained by the reaction between the fluorescein aldehyde of Chemical Formula 2 or fluorescein dialdehyde of Chemical Formula 3.
PCT/KR2009/001109 2008-04-18 2009-03-05 Method for detecting a cyanide ion using fluorescein aldehyde or fluorescein dialdehyde WO2009128606A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2008-0036188 2008-04-18
KR1020080036188A KR100946998B1 (en) 2008-04-18 2008-04-18 Method for sensing cyanide ion using fluorescein aldehyde
KR10-2008-0044447 2008-05-14
KR1020080044447A KR101007847B1 (en) 2008-05-14 2008-05-14 Method for sensing cyanide ion using fluorecein dialdehyde

Publications (2)

Publication Number Publication Date
WO2009128606A2 WO2009128606A2 (en) 2009-10-22
WO2009128606A3 true WO2009128606A3 (en) 2009-11-26

Family

ID=41199543

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/001109 WO2009128606A2 (en) 2008-04-18 2009-03-05 Method for detecting a cyanide ion using fluorescein aldehyde or fluorescein dialdehyde

Country Status (1)

Country Link
WO (1) WO2009128606A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104892469A (en) * 2015-06-26 2015-09-09 西北师范大学 Sensor molecule identifying cyanide ions by fluorescence and preparation and application of sensor molecule

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101653094B1 (en) * 2015-02-09 2016-08-31 충남대학교산학협력단 Chemical Sensor Compound Toward Hazardous Cyanide Ions And Its Preparation Method
CN106748954A (en) * 2016-09-22 2017-05-31 北京理工大学 A kind of fluorescent chemicals, preparation method and application for detecting micro cryanide ion

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5116759A (en) * 1990-06-27 1992-05-26 Fiberchem Inc. Reservoir chemical sensors
JP2560585B2 (en) * 1991-11-11 1996-12-04 株式会社島津製作所 Cyanide ion analyzer
JPH09297105A (en) * 1996-05-02 1997-11-18 Masao Karube Method of detecting cyan with high sensitivity, and device therefor
KR100690199B1 (en) * 2006-04-20 2007-03-12 이화여자대학교 산학협력단 Fluorescein derivative having selectivity for copper ion, preparation method thereof and detection method of copper ion in vivo using the same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5116759A (en) * 1990-06-27 1992-05-26 Fiberchem Inc. Reservoir chemical sensors
JP2560585B2 (en) * 1991-11-11 1996-12-04 株式会社島津製作所 Cyanide ion analyzer
JPH09297105A (en) * 1996-05-02 1997-11-18 Masao Karube Method of detecting cyan with high sensitivity, and device therefor
KR100690199B1 (en) * 2006-04-20 2007-03-12 이화여자대학교 산학협력단 Fluorescein derivative having selectivity for copper ion, preparation method thereof and detection method of copper ion in vivo using the same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104892469A (en) * 2015-06-26 2015-09-09 西北师范大学 Sensor molecule identifying cyanide ions by fluorescence and preparation and application of sensor molecule

Also Published As

Publication number Publication date
WO2009128606A2 (en) 2009-10-22

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