WO2009144287A1 - Intracerebral injection instrument - Google Patents

Intracerebral injection instrument Download PDF

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Publication number
WO2009144287A1
WO2009144287A1 PCT/EP2009/056575 EP2009056575W WO2009144287A1 WO 2009144287 A1 WO2009144287 A1 WO 2009144287A1 EP 2009056575 W EP2009056575 W EP 2009056575W WO 2009144287 A1 WO2009144287 A1 WO 2009144287A1
Authority
WO
WIPO (PCT)
Prior art keywords
shaft
injection instrument
distal end
guide
microcannula
Prior art date
Application number
PCT/EP2009/056575
Other languages
German (de)
French (fr)
Inventor
Christoph Miethke
Ulrich-W. Thomale
Original Assignee
Charité Universitätsmedizin Berlin
Christoph Miethke Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Charité Universitätsmedizin Berlin, Christoph Miethke Gmbh & Co. Kg filed Critical Charité Universitätsmedizin Berlin
Priority to DE112009000644.2T priority Critical patent/DE112009000644B4/en
Publication of WO2009144287A1 publication Critical patent/WO2009144287A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3417—Details of tips or shafts, e.g. grooves, expandable, bendable; Multiple coaxial sliding cannulas, e.g. for dilating
    • A61B17/3421—Cannulas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0082—Catheter tip comprising a tool
    • A61M25/0084—Catheter tip comprising a tool being one or more injection needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3417—Details of tips or shafts, e.g. grooves, expandable, bendable; Multiple coaxial sliding cannulas, e.g. for dilating
    • A61B17/3421—Cannulas
    • A61B2017/3445—Cannulas used as instrument channel for multiple instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/10—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis
    • A61B2090/103—Cranial plugs for access to brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M2025/0042—Microcatheters, cannula or the like having outside diameters around 1 mm or less
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0082—Catheter tip comprising a tool
    • A61M25/0084—Catheter tip comprising a tool being one or more injection needles
    • A61M2025/0087—Multiple injection needles protruding laterally from the distal tip
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0082—Catheter tip comprising a tool
    • A61M25/0084—Catheter tip comprising a tool being one or more injection needles
    • A61M2025/0089—Single injection needle protruding axially, i.e. along the longitudinal axis of the catheter, from the distal tip
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0082—Catheter tip comprising a tool
    • A61M2025/0096—Catheter tip comprising a tool being laterally outward extensions or tools, e.g. hooks or fibres

Definitions

  • the invention relates to an intracerebral injection instrument for injecting fluids or introducing probes into the brain of a patient.
  • such an injection instrument has a shaft with a lumen for guiding a microcannula.
  • the microcannula itself in turn has a lumen through which liquid, for example a therapeutic, can be administered intracerebrally.
  • the shaft itself is inserted into the brain of a patient up to an application site.
  • the object of the invention is to provide an improved intracerebral injection device.
  • an intracerebral injection instrument having a shaft with a plurality of guide lumens, in each of which a microcannula is arranged so as to be longitudinally displaceable and which each have an open distal end from which a respective microcannula is to be pushed out.
  • At least some of the guide lumens have a distal distal end portion slanting with respect to the longitudinal axis of the shaft such that a respective microcannula advanced in such a guide lumen emerges obliquely from the shaft.
  • the injection instrument according to the invention allows several microcannulas to be advanced simultaneously to an application site.
  • the injection instrument according to the invention allows in particular, different
  • the size of the target volume can be adjusted by the fact that the microcannulas emerging obliquely from the shaft are more or less far from the corresponding ones
  • the shaft has a plurality of guide lumens that are evenly distributed around the longitudinal axis of the shaft.
  • the end portions of these guide lumens are formed so that they each have the same angle to the longitudinal axis of the shaft, so that the emerging from the guide lumens microcannules between each other (when each considered two adjacent microcannules) each include the same angle.
  • a central guide lumen is additionally provided, the end section of which is arranged exactly in the longitudinal direction. tion of the shaft extends, so that the guided in this central guide lumen microcannula is not deflected laterally when exiting the shaft.
  • a particularly preferred configuration has a central guide lumen and six guide lumens evenly distributed around this central guide lumen, each having a sloping distal end portion.
  • the shaft preferably consists of a magnetic resonance tomography compatible material, such as Delrin or titanium.
  • microcannulas are preferably made of titanium.
  • the shank preferably has an outer diameter of less than 3 mm (9 French).
  • the shaft preferably has a rounded, for example hemispherical, distal end in order to avoid injury to the brain when inserting the shaft as far as possible.
  • FIG. 1 a shows a longitudinal section through a distal end of an injection instrument according to the invention
  • FIG. 1 b shows a cross section through the distal end of the injection instrument of FIG. 1 a;
  • FIG. 2a shows a longitudinal section through a distal end of an alternative embodiment of the injection device according to the invention
  • FIG. 2b shows a cross section through the alternative embodiment of the injection instrument according to FIG. 2a; FIG. and
  • Fig. 3 an end view of the injection instrument according to the invention according to Figures 1 a and b with advanced microcannulas. - A -
  • FIG. 1 shows an injection instrument 10 with a shaft 12, which has a total of four guide lumens 14 for microcannulas 16. Of the four microcannulas 16, only one is shown by way of example in FIG.
  • the guide lumens 14 are arranged uniformly about a longitudinal axis of the shaft 12 around.
  • the guide lumens 14 each extend, except for a distal end portion 18 parallel to the longitudinal axis of the shaft 12.
  • the respective distal end portion 18 of a respective guide lumen 14 is angled outwardly with respect to the longitudinal axis of the shaft 12 and each has an orifice 20, one of which respective microcannula 16 can escape.
  • Fig. 2a the angle by which a respective distal end portion 18 of a guide lumen 14 is shown with respect to the longitudinal axis of the shaft 12, designated ⁇ .
  • FIG. 2 shows a variant in which a total of six guide lumens 14 'are arranged so as to be uniformly distributed around the longitudinal axis of the shaft 12' for ten end sections depicted with respect to the longitudinal axis of the shaft 12 '.
  • the shaft 12' of the injection instrument 10 'from FIG. 2 also has a central guide lumen 22 which runs concentrically parallel to the longitudinal axis of the shaft 12' as far as the distal end of the injection instrument 10 '.
  • the central guide lumen 22 thus has no angled distal end portion.
  • FIG. 3 shows an end view of the injection instrument from FIG. 1 with four microcannulas 16 pushed out of the shaft 12 at the same length.
  • the angled distal end sections 18 of the respective guide lumens 14 are arranged such that the microcannulas 16 in the front view each include the same angle ß between them.
  • the shaft 12 or 12 'of the injection instrument 10 or 10' from FIG. 1 or FIG. 2 is preferably each made of titanium or of a solid plastic, such as Delrin, in order to cause the lowest possible artifacts in magnetic resonance therapy.
  • the microcannulas 16 are preferably made of titanium and, alternatively, a solid plastic such as Delrin.

Abstract

The invention relates to an intracerebral injection instrument (10; 10') with a shaft (12; 12') that has a plurality of guide lumens (14; 14', 22) in each of which a micro-cannula (16) is longitudinally displaceable and which each have an open distal end (20) from which a respective micro-cannula (16) can be pushed out. At least some of the guide lumens have a distal end portion (18) extending obliquely with respect to a longitudinal axis of the shaft, such that a respective micro-cannula (16) advanced through such a guide lumen (14; 14') emerges obliquely from the shaft (12; 12').

Description

Intracerebrales Injektionsinstrument Intracerebral injection instrument
Die Erfindung betrifft ein intracerebrales Injektionsinstrument zum Injizieren von Flüssigkeiten oder Einführen von Sonden in das Hirn eines Patienten.The invention relates to an intracerebral injection instrument for injecting fluids or introducing probes into the brain of a patient.
Ein solches intracerebrales Injektionsinstrument ist beispielsweise in Cunningham et al. "Preclinical Evaluation of a Novel Intracerebral Microinjection Instrument Permitting Electrophysiologically Guided Delivery of Therapeutics", Neurosurgery, Band 54, Nr. 6, Juni 2004, Seiten 1497 bis 1507, beschrieben.Such an intracerebral injection instrument is described, for example, in Cunningham et al. "Preclinical Evaluation of a Novel Intracerebral Microinjection Instrument Permitting Electrophysiologically Guided Delivery of Therapeutics," Neurosurgery, Vol. 54, No. 6, June 2004, pages 1497 to 1507.
Typischerweise weist ein derartiges Injektionsinstrument einen Schaft mit einem Lumen zum Führen einer Mikrokanüle auf. Die Mikrokanüle selbst besitzt wiederum ein Lumen, durch das Flüssigkeit, beispielsweise ein Therapeutikum, intracerebral appliziert werden kann.Typically, such an injection instrument has a shaft with a lumen for guiding a microcannula. The microcannula itself in turn has a lumen through which liquid, for example a therapeutic, can be administered intracerebrally.
Dazu wird der Schaft selbst bis zu einem Applikationsort in das Hirn eines Patienten eingeführt. Um ein Therapeutikum nicht nur an einem einzigen Ort, sondern an mehreren Orten eines Zielareals im Hirn eines Patienten applizieren zu können, wird in der vorge- nannten Veröffentlichung vorgeschlagen, den Schaft zur Führung der Mikrokanüle so auszuprägen, dass ein Ausgang am distalen Ende des Schafts der Mikrokanüle einen Austrittswinkel aufprägt, so dass die Mikrokanüle schräg zur Längsachse des Schaftes aus dem distalen Ende des Schaftes austritt.For this purpose, the shaft itself is inserted into the brain of a patient up to an application site. In order to be able to apply a therapeutic in a patient's brain not only at a single location but at several locations of a target area, Publication proposed to emboss the shaft for guiding the microcannula so that an output at the distal end of the shaft of the microcannula imparting an exit angle, so that the microcannula emerges obliquely to the longitudinal axis of the shaft from the distal end of the shaft.
Aufgabe der Erfindung ist es, eine verbesserte intracerebrale Injektionsvorrichtung zu schaffen.The object of the invention is to provide an improved intracerebral injection device.
Erfindungsgemäß wird diese Aufgabe durch ein intracerebrales Injektionsinstrument mit einem Schaft mit einer Mehrzahl Führungslumina erreicht, in denen jeweils eine Mikrokanüle längsverschieblich angeordnet ist und die je ein offenes distales Ende besitzen, aus dem eine jeweilige Mikrokanüle hinauszuschieben ist. Wenigstens einige der Führungslumina besitzen einen in Bezug auf die Längsachse des Schaftes schräg verlaufenden distalen Endabschnitt, so dass eine jeweilige in einem solchen Führungslumen vorgeschobene Mikrokanüle schräg aus dem Schaft austritt.According to the invention, this object is achieved by an intracerebral injection instrument having a shaft with a plurality of guide lumens, in each of which a microcannula is arranged so as to be longitudinally displaceable and which each have an open distal end from which a respective microcannula is to be pushed out. At least some of the guide lumens have a distal distal end portion slanting with respect to the longitudinal axis of the shaft such that a respective microcannula advanced in such a guide lumen emerges obliquely from the shaft.
Infolge der Mehrzahl von Führungslumina erlaubt es das erfindungsgemäße Injektionsin- strument, mehrere Mikrokanülen gleichzeitig zu einem Applikationsort vorzuschieben.As a result of the plurality of guide lumens, the injection instrument according to the invention allows several microcannulas to be advanced simultaneously to an application site.
Das erfindungsgemäße Injektionsinstrument erlaubt es insbesondere, verschiedeneThe injection instrument according to the invention allows in particular, different
Mikrokanülen gleichzeitig in verschiedene Richtungen schräg (oder auch gerade, also inMicrocannulas simultaneously in different directions obliquely (or even, ie in
Längsrichtung des Schaftes) aus dem Schaft austreten zu lassen, um auf einfache Weise ein definiertes Zielvolumen im Hirn eines Patienten simultan mit Flüssigkeit zu versorgen. Dabei lässt sich die Größe des Zielvolumens dadurch einstellen, dass die schräg aus dem Schaft austretenden Mikrokanülen mehr oder weniger weit aus den entsprechendenLongitudinal direction of the shaft) from the shaft to allow to easily provide a defined target volume in the brain of a patient with liquid. The size of the target volume can be adjusted by the fact that the microcannulas emerging obliquely from the shaft are more or less far from the corresponding ones
Austrittsöffnungen des Schaftes herausgeschoben werden.Outlet openings of the shaft are pushed out.
Vorzugsweise besitzt der Schaft mehrere Führungslumina, die um die Längsachse des Schaftes herum gleichmäßig verteilt angeordnet sind. Vorzugsweise sind die Endab- schnitte dieser Führungslumina so ausgebildet, dass sie jeweils den gleichen Winkel zur Längsachse des Schaftes besitzen, so dass die aus den Führungslumina austretenden Mikrokanülen auch zwischeneinander (wenn man jeweils zwei benachbarte Mikrokanülen betrachtet) jeweils den gleichen Winkel einschließen.Preferably, the shaft has a plurality of guide lumens that are evenly distributed around the longitudinal axis of the shaft. Preferably, the end portions of these guide lumens are formed so that they each have the same angle to the longitudinal axis of the shaft, so that the emerging from the guide lumens microcannules between each other (when each considered two adjacent microcannules) each include the same angle.
Gemäß einer weiteren bevorzugten Ausführungsvariante ist zusätzlich ein zentrales Führungslumen vorgesehen angeordnet sein, dessen Endabschnitt genau in Längsrich- tung des Schaftes verläuft, so dass die in diesem zentralen Führungslumen geführte Mikrokanüle beim Austritt aus dem Schaft nicht seitlich abgelenkt wird.According to a further preferred embodiment, a central guide lumen is additionally provided, the end section of which is arranged exactly in the longitudinal direction. tion of the shaft extends, so that the guided in this central guide lumen microcannula is not deflected laterally when exiting the shaft.
Eine besonders bevorzugte Konfiguration besitzt ein zentrales Führungslumen und sechs um dieses zentrale Führungslumen herum gleichmäßig verteilte Führungslumina mit jeweils schräg verlaufendem distalen Endabschnitt.A particularly preferred configuration has a central guide lumen and six guide lumens evenly distributed around this central guide lumen, each having a sloping distal end portion.
Der Schaft besteht vorzugsweise aus einem Magnetresonanztomographie-kompatiblen Material, wie beispielsweise Delrin oder Titan.The shaft preferably consists of a magnetic resonance tomography compatible material, such as Delrin or titanium.
Die Mikrokanülen bestehen vorzugsweise aus Titan.The microcannulas are preferably made of titanium.
Der Schaft hat vorzugsweise einen Außendurchmesser von weniger als 3 mm (9 French). Außerdem besitzt der Schaft vorzugsweise ein abgerundetes, beispielsweise halbkugelförmiges, distales Ende, um Verletzungen des Hirns beim Einführen des Schafts möglichst zu vermeiden.The shank preferably has an outer diameter of less than 3 mm (9 French). In addition, the shaft preferably has a rounded, for example hemispherical, distal end in order to avoid injury to the brain when inserting the shaft as far as possible.
Die Erfindung soll nun anhand eines Ausführungsbeispiels in Bezug auf die Figuren näher erläutert werden. Von den Figuren zeigen:The invention will now be explained in more detail with reference to an embodiment with reference to the figures. From the figures show:
Fig. 1 a: Einen Längsschnitt durch ein distales Ende eines erfindungsgemäßen Injektionsinstruments;1 a shows a longitudinal section through a distal end of an injection instrument according to the invention;
Fig. 1 b: einen Querschnitt durch das distale Ende des Injektionsinstruments aus Fig. 1 a;FIG. 1 b shows a cross section through the distal end of the injection instrument of FIG. 1 a; FIG.
Fig. 2a: einen Längsschnitt durch ein distales Ende einer alternativen Ausführungs- form des erfindungsgemäßen Injektionsgerätes;2a shows a longitudinal section through a distal end of an alternative embodiment of the injection device according to the invention;
Fig. 2b: einen Querschnitt durch die alternative Ausführungsform des Injektionsinstrumentes gemäß Fig. 2a; undFIG. 2b shows a cross section through the alternative embodiment of the injection instrument according to FIG. 2a; FIG. and
Fig. 3: eine Stirnansicht des erfindungsgemäßen Injektionsinstrumentes gemäß Figuren 1 a und b mit vorgeschobenen Mikrokanülen. - A -Fig. 3: an end view of the injection instrument according to the invention according to Figures 1 a and b with advanced microcannulas. - A -
In Fig. 1 ist ein Injektionsinstrument 10 mit einem Schaft 12 dargestellt, der insgesamt vier Führungslumina 14 für Mikrokanülen 16 aufweist. Von den vier Mikrokanülen 16 ist nur eine einzige beispielhaft in Fig. 1 dargestellt. Die Führungslumina 14 sind gleichmäßig um eine Längsachse des Schaftes 12 herum angeordnet.FIG. 1 shows an injection instrument 10 with a shaft 12, which has a total of four guide lumens 14 for microcannulas 16. Of the four microcannulas 16, only one is shown by way of example in FIG. The guide lumens 14 are arranged uniformly about a longitudinal axis of the shaft 12 around.
Die Führungslumina 14 verlaufen jeweils, mit Ausnahme eines distalen Endabschnitts 18 parallel zur Längsachse des Schaftes 12. Der jeweilige distale Endabschnitt 18 eines jeweiligen Führungslumens 14 ist in Bezug auf die Längsachse des Schaftes 12 nach außen abgewinkelt und besitzt jeweils eine Mündungsöffnung 20, aus der eine jeweilige Mikrokanüle 16 austreten kann. In Fig. 2a ist der Winkel, um den ein jeweiliger distaler Endabschnitt 18 eines Führungslumens 14 gegenüber der Längsachse des Schaftes 12 abgebildet ist, mit α bezeichnet.The guide lumens 14 each extend, except for a distal end portion 18 parallel to the longitudinal axis of the shaft 12. The respective distal end portion 18 of a respective guide lumen 14 is angled outwardly with respect to the longitudinal axis of the shaft 12 and each has an orifice 20, one of which respective microcannula 16 can escape. In Fig. 2a, the angle by which a respective distal end portion 18 of a guide lumen 14 is shown with respect to the longitudinal axis of the shaft 12, designated α.
Fig. 2 zeigt eine Ausführungsvariante, bei der insgesamt sechs Führungslumina 14' für zehn mit gegenüber der Längsachse des Schaftes 12' abgebildeten Endabschnitten um die Längsachse des Schaftes 12' herum gleichmäßig verteilt angeordnet sind. Neben den lateralen Führungslumina 14' besitzt der Schaft 12' des Injektionsinstruments 10' aus Fig. 2 außerdem noch ein zentrales Führungslumen 22, welches bis zum distalen Ende des Injektionsinstruments 10' konzentrisch parallel zur Längsachse des Schaftes 12' verläuft. Das zentrale Führungslumen 22 besitzt somit keinen abgewinkelten distalen Endabschnitt.FIG. 2 shows a variant in which a total of six guide lumens 14 'are arranged so as to be uniformly distributed around the longitudinal axis of the shaft 12' for ten end sections depicted with respect to the longitudinal axis of the shaft 12 '. In addition to the lateral guide lumens 14 ', the shaft 12' of the injection instrument 10 'from FIG. 2 also has a central guide lumen 22 which runs concentrically parallel to the longitudinal axis of the shaft 12' as far as the distal end of the injection instrument 10 '. The central guide lumen 22 thus has no angled distal end portion.
Fig. 3 zeigt eine Stirnansicht auf das Injektionsinstrument aus Fig. 1 mit vier auf gleicher Länge aus dem Schaft 12 hervorgeschobenen Mikrokanülen 16. Wie Fig. 3 zu entnehmen ist, sind die abgewinkelten distalen Endabschnitte 18 der jeweiligen Führungslumina 14 so angeordnet, dass die Mikrokanülen 16 in der Stirnansicht jeweils den gleichen Winkel ß zwischen sich einschließen.FIG. 3 shows an end view of the injection instrument from FIG. 1 with four microcannulas 16 pushed out of the shaft 12 at the same length. As can be seen from FIG. 3, the angled distal end sections 18 of the respective guide lumens 14 are arranged such that the microcannulas 16 in the front view each include the same angle ß between them.
Der Schaft 12 bzw. 12' des Injektionsinstruments 10 bzw. 10' aus Fig. 1 bzw. Fig. 2 besteht jeweils vorzugsweise aus Titan oder aus einem festen Kunststoff, wie Delrin, um möglichst geringe Artefakte in der Magnetresonanztherapie zu verursachen. Im gleichen Sinne bestehen die Mikrokanülen 16 vorzugsweise aus Titan und alternativ aus einem festen Kunststoff, wie Delrin. The shaft 12 or 12 'of the injection instrument 10 or 10' from FIG. 1 or FIG. 2 is preferably each made of titanium or of a solid plastic, such as Delrin, in order to cause the lowest possible artifacts in magnetic resonance therapy. In the same sense, the microcannulas 16 are preferably made of titanium and, alternatively, a solid plastic such as Delrin.

Claims

Patentansprüche claims
1. Intracerebrales Injektionsinstrument (10;10') mit einem Schaft (12;12') mit einer Mehrzahl Führungslumina (14;14',22) in denen jeweils eine Mikrokanüle (16) läng- sverschieblich angeordnet ist und je ein offenes distales Ende (20) besitzen, aus dem eine jeweilige Mikrokanüle (16) herauszuschieben ist, wobei wenigstens einige der Führungslumina einen in Bezug auf eine Längsachse des Schaftes schräg verlaufenden distalen Endabschnitt (18) besitzen, so dass eine jeweilige in einem solchen Führungslumen (14;14') vorgeschobene Mikrokanüle (16) schräg aus dem Schaft (12; 12') austritt.1. intracerebral injection instrument (10; 10 ') having a shaft (12; 12') with a plurality of guide lumens (14; 14 ', 22) in each of which a microcannula (16) is arranged longitudinally displaceable and one open distal end each (20) from which a respective microcannula (16) is to be pushed out, wherein at least some of the guide lumens have a distal end portion (18) inclined with respect to a longitudinal axis of the stem so that a respective one in such a guide lumen (14; 14 ') advanced microcannula (16) obliquely from the shaft (12, 12') emerges.
2. Injektionsinstrument nach Anspruch 1 , dadurch gekennzeichnet, dass der Schaft (12; 12') aus einem Magnetresonanztomographie kompatiblen Material besteht.2. Injection instrument according to claim 1, characterized in that the shaft (12, 12 ') consists of a magnetic resonance tomography compatible material.
3. Injektionsinstrument nach Anspruch 1 oder 2, dadurch gekennzeichnet, dass die Mikrokanülen (16) aus Titan bestehen.3. Injection instrument according to claim 1 or 2, characterized in that the microcannulas (16) consist of titanium.
4. Injektionsinstrument nach einem der Ansprüche 1 bis 3, dadurch gekennzeichnet, dass der Schaft (12; 12') ein abgerundetes distales Ende besitzt.4. Injection instrument according to one of claims 1 to 3, characterized in that the shaft (12, 12 ') has a rounded distal end.
5. Injektionsinstrument nach einem der Ansprüche 1 bis 4, dadurch gekennzeichnet, dass der Schaft (12; 12') einen Außendurchmesser von weniger als 3 mm besitzt.5. Injection instrument according to one of claims 1 to 4, characterized in that the shaft (12, 12 ') has an outer diameter of less than 3 mm.
6. Injektionsinstrument nach einem der Ansprüche 1 bis 5, dadurch gekennzeichnet, dass die Lumina (14; 14') zur Führung der Mikrokanülen rotationssymmetrisch um die Längsachse des Schaftes herum angeordnet sind. 6. Injection instrument according to one of claims 1 to 5, characterized in that the lumens (14, 14 ') are arranged to guide the microcannules rotationally symmetrical about the longitudinal axis of the shaft around.
PCT/EP2009/056575 2008-05-28 2009-05-28 Intracerebral injection instrument WO2009144287A1 (en)

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DE102008030942A1 (en) 2008-07-02 2010-01-07 Christoph Miethke Gmbh & Co Kg Cerebrospinal fluid drainage

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EP0132215A1 (en) * 1983-06-14 1985-01-23 FOGARTY, Thomas J. Deflector guiding catheter
US4817624A (en) * 1985-12-20 1989-04-04 The General Hospital Corporation Mini-bolus technique for thermodilution cardiac output measurements
US5704361A (en) * 1991-11-08 1998-01-06 Mayo Foundation For Medical Education And Research Volumetric image ultrasound transducer underfluid catheter system
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US20030032936A1 (en) * 2001-08-10 2003-02-13 Lederman Robert J. Side-exit catheter and method for its use

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DE102008026237A1 (en) 2009-12-03
DE112009000644A5 (en) 2011-09-29

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