WO2010004584A3 - Process for production of anti-diabetic compound in root culture of catharanthus roseus - Google Patents

Process for production of anti-diabetic compound in root culture of catharanthus roseus Download PDF

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Publication number
WO2010004584A3
WO2010004584A3 PCT/IN2009/000389 IN2009000389W WO2010004584A3 WO 2010004584 A3 WO2010004584 A3 WO 2010004584A3 IN 2009000389 W IN2009000389 W IN 2009000389W WO 2010004584 A3 WO2010004584 A3 WO 2010004584A3
Authority
WO
WIPO (PCT)
Prior art keywords
production
catharanthus roseus
root culture
present
diabetic compound
Prior art date
Application number
PCT/IN2009/000389
Other languages
French (fr)
Other versions
WO2010004584A2 (en
Inventor
Asis Datta
Samir Bhattacharya
C. Bikas Pal
Jayanti Sen
Suman Dasgupta
Anindita Biswas
Jyoti Batra
Original Assignee
Asis Datta
Samir Bhattacharya
Pal C Bikas
Jayanti Sen
Suman Dasgupta
Anindita Biswas
Jyoti Batra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asis Datta, Samir Bhattacharya, Pal C Bikas, Jayanti Sen, Suman Dasgupta, Anindita Biswas, Jyoti Batra filed Critical Asis Datta
Publication of WO2010004584A2 publication Critical patent/WO2010004584A2/en
Publication of WO2010004584A3 publication Critical patent/WO2010004584A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

The present invention provides treatment of diabetes using serpentine. The present invention particularly provides a process of production of serpentine in Catharanthus roseus hairy root culture, effect of hairy root extract in reducing blood glucose level in a subject. The present invention further provides identification and isolation of biologically active compound from the extract.
PCT/IN2009/000389 2008-07-09 2009-07-09 Process for production of anti-diabetic compound in root culture of catharanthus roseus WO2010004584A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1649/DEL/2008 2008-07-09
IN1649DE2008 2008-07-09

Publications (2)

Publication Number Publication Date
WO2010004584A2 WO2010004584A2 (en) 2010-01-14
WO2010004584A3 true WO2010004584A3 (en) 2010-08-19

Family

ID=41507518

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2009/000389 WO2010004584A2 (en) 2008-07-09 2009-07-09 Process for production of anti-diabetic compound in root culture of catharanthus roseus

Country Status (1)

Country Link
WO (1) WO2010004584A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102613088A (en) * 2012-04-23 2012-08-01 上海安体康生植物化学有限公司 Fast propagation method for cultivating salt-tolerant and low temperature-tolerant periwinkle strain
US20150173373A1 (en) 2013-12-19 2015-06-25 Rhizoflora, Inc. Plant Activator Composition
CN111500625A (en) * 2020-05-18 2020-08-07 扬州大学 Method for inducing and generating rose hairy roots by utilizing agrobacterium rhizogenes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2639876A1 (en) * 1976-09-04 1978-03-09 Boehringer Mannheim Gmbh PROCESS FOR PRODUCING THE ALKALOID RAUBBASIN AND SERPENTINE BY IN VITRO-BREEDING OF CELLS OF CATHARANTHUS
US4578531A (en) * 1982-06-09 1986-03-25 At&T Bell Laboratories Encryption system key distribution method and apparatus

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2639876A1 (en) * 1976-09-04 1978-03-09 Boehringer Mannheim Gmbh PROCESS FOR PRODUCING THE ALKALOID RAUBBASIN AND SERPENTINE BY IN VITRO-BREEDING OF CELLS OF CATHARANTHUS
US4578531A (en) * 1982-06-09 1986-03-25 At&T Bell Laboratories Encryption system key distribution method and apparatus

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BHADRA R ET AL: "Production of indole alkaloids by selected hairy root lines of Catharanthus roseus.", BIOTECHNOLOGY AND BIOENGINEERING 5 MAR 1993, vol. 41, no. 5, 5 March 1993 (1993-03-05), pages 581 - 592, XP002565273, ISSN: 0006-3592 *
BHADRA R ET AL: "Transient studies of nutrient uptake, growth, and indole alkaloid accumulation in heterotrophic cultures of hairy roots of Catharanthus roseus.", BIOTECHNOLOGY AND BIOENGINEERING 5 AUG 1997, vol. 55, no. 3, 5 August 1997 (1997-08-05), pages 527 - 534, XP002565274, ISSN: 0006-3592 *
PARKER JANICE C: "Troglitazone: the discovery and development of a novel therapy for the treatment of Type 2 diabetes mellitus", ADVANCED DRUG DELIVERY REVIEWS 5 NOV 2002,, vol. 54, no. 9, 5 November 2002 (2002-11-05), pages 1173 - 1197, XP002562968 *
PEEBLES CHRISTIE A M ET AL: "Effects of terpenoid precursor feeding on Catharanthus roseus hairy roots over-expressing the alpha or the alpha and beta subunits of anthranilate synthase", BIOTECHNOLOGY AND BIOENGINEERING, vol. 93, no. 3, February 2006 (2006-02-01), pages 534 - 540, XP002565276, ISSN: 0006-3592 *
SCRAGG A H ET AL: "Effect of scale-up on serpentine formation by Catharanthus roseus suspension cultures", ENZYME AND MICROBIAL TECHNOLOGY, STONEHAM, MA, US, vol. 9, no. 10, 1 October 1987 (1987-10-01), pages 619 - 624, XP023679097, ISSN: 0141-0229, [retrieved on 19871001] *
TOIVONEN L ET AL: "Studies on the optimization of growth and indole alkaloid production by hairy root cultures of Catharanthus roseus.", BIOTECHNOLOGY AND BIOENGINEERING 25 MAR 1991, vol. 37, no. 7, 25 March 1991 (1991-03-25), pages 673 - 680, XP002565275, ISSN: 0006-3592 *

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Publication number Publication date
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