WO2010014512A3 - Preparation of test plates for matrix assisted laser desorption ionization - Google Patents

Preparation of test plates for matrix assisted laser desorption ionization Download PDF

Info

Publication number
WO2010014512A3
WO2010014512A3 PCT/US2009/051740 US2009051740W WO2010014512A3 WO 2010014512 A3 WO2010014512 A3 WO 2010014512A3 US 2009051740 W US2009051740 W US 2009051740W WO 2010014512 A3 WO2010014512 A3 WO 2010014512A3
Authority
WO
WIPO (PCT)
Prior art keywords
test plates
laser desorption
assisted laser
desorption ionization
preparation
Prior art date
Application number
PCT/US2009/051740
Other languages
French (fr)
Other versions
WO2010014512A2 (en
Inventor
Nathalie Agar
Original Assignee
The Brigham And Women's Hospital, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Brigham And Women's Hospital, Inc. filed Critical The Brigham And Women's Hospital, Inc.
Priority to US13/056,511 priority Critical patent/US9455130B2/en
Priority to EP09803417A priority patent/EP2318819A2/en
Publication of WO2010014512A2 publication Critical patent/WO2010014512A2/en
Publication of WO2010014512A3 publication Critical patent/WO2010014512A3/en

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0409—Sample holders or containers
    • H01J49/0418—Sample holders or containers for laser desorption, e.g. matrix-assisted laser desorption/ionisation [MALDI] plates or surface enhanced laser desorption/ionisation [SELDI] plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/32—Polishing; Etching

Abstract

The present invention is directed, sample test plates that can be used in matrix assisted laser desorption ionization. These plates have an etched surface and a layer of MALDI matrix material. The invention also includes methods for making these sample test plates and to methods for using the plates in the MS imaging of cell and tissue samples.
PCT/US2009/051740 2008-07-30 2009-07-24 Preparation of test plates for matrix assisted laser desorption ionization WO2010014512A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US13/056,511 US9455130B2 (en) 2008-07-30 2009-07-24 Preparation of test plates for matrix assisted laser desorption ionization
EP09803417A EP2318819A2 (en) 2008-07-30 2009-07-24 Preparation of test plates for matrix assisted laser desorption ionization

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12992708P 2008-07-30 2008-07-30
US61/129,927 2008-07-30

Publications (2)

Publication Number Publication Date
WO2010014512A2 WO2010014512A2 (en) 2010-02-04
WO2010014512A3 true WO2010014512A3 (en) 2010-05-14

Family

ID=41610919

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/051740 WO2010014512A2 (en) 2008-07-30 2009-07-24 Preparation of test plates for matrix assisted laser desorption ionization

Country Status (3)

Country Link
US (1) US9455130B2 (en)
EP (1) EP2318819A2 (en)
WO (1) WO2010014512A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014521106A (en) 2011-07-21 2014-08-25 ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク How to collect and process electron diffraction data
JP7007845B2 (en) * 2017-09-21 2022-01-25 浜松ホトニクス株式会社 Laser desorption / ionization method, mass spectrometry method, sample support, and method for manufacturing sample support
JP6899295B2 (en) * 2017-09-21 2021-07-07 浜松ホトニクス株式会社 Laser desorption / ionization method and mass spectrometry method

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030057106A1 (en) * 2001-09-12 2003-03-27 Zhouxin Shen High throughput chemical analysis by improved desorption/ionization on silicon mass spectrometry
US20040119010A1 (en) * 2002-11-01 2004-06-24 The Regents Of The University Of Colorado Quantitative analysis of protein isoforms using matrix-assisted laser desorption/ionization time of flight mass spectrometry
US20040119013A1 (en) * 2002-12-23 2004-06-24 Arthur Schleifer Matrix-assisted laser desorption/ionization sample holders and methods of using the same
US20040185448A1 (en) * 2003-03-20 2004-09-23 Viorica Lopez-Avila Methods and devices for performing matrix assisted laser desorption/lonization protocols
US20080050834A1 (en) * 2006-04-18 2008-02-28 Pamula Vamsee K Protein Crystallization Droplet Actuator, System and Method
US20080128608A1 (en) * 2006-11-06 2008-06-05 The Scripps Research Institute Nanostructure-initiator mass spectrometry

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6177266B1 (en) * 1996-04-29 2001-01-23 The United States Of America As Represented By The Secretary Of The Army Rapid identification of bacteria by mass spectrometry
GB0120131D0 (en) * 2001-08-17 2001-10-10 Micromass Ltd Maldi target plate
US6624409B1 (en) * 2002-07-30 2003-09-23 Agilent Technologies, Inc. Matrix assisted laser desorption substrates for biological and reactive samples
DE10258674A1 (en) * 2002-12-13 2004-06-24 Sunyx Surface Nanotechnologies Gmbh Manufacturing sample carrier with points for matrix-assisted laser desorption and ionization, forms MALDI matrix points by gas phase sublimation
JP4761144B2 (en) * 2005-04-28 2011-08-31 独立行政法人産業技術総合研究所 Ionization substrate for mass spectrometry and mass spectrometer
EP1814137A3 (en) * 2006-01-27 2008-04-23 Sony DADC Austria AG Mass spectrometry target assembly
WO2007139989A2 (en) 2006-05-26 2007-12-06 Brandeis University Tissue sample preparation, and maldi ms imaging thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030057106A1 (en) * 2001-09-12 2003-03-27 Zhouxin Shen High throughput chemical analysis by improved desorption/ionization on silicon mass spectrometry
US20040119010A1 (en) * 2002-11-01 2004-06-24 The Regents Of The University Of Colorado Quantitative analysis of protein isoforms using matrix-assisted laser desorption/ionization time of flight mass spectrometry
US20040119013A1 (en) * 2002-12-23 2004-06-24 Arthur Schleifer Matrix-assisted laser desorption/ionization sample holders and methods of using the same
US20040185448A1 (en) * 2003-03-20 2004-09-23 Viorica Lopez-Avila Methods and devices for performing matrix assisted laser desorption/lonization protocols
US20080050834A1 (en) * 2006-04-18 2008-02-28 Pamula Vamsee K Protein Crystallization Droplet Actuator, System and Method
US20080128608A1 (en) * 2006-11-06 2008-06-05 The Scripps Research Institute Nanostructure-initiator mass spectrometry

Also Published As

Publication number Publication date
WO2010014512A2 (en) 2010-02-04
US9455130B2 (en) 2016-09-27
EP2318819A2 (en) 2011-05-11
US20110192974A1 (en) 2011-08-11

Similar Documents

Publication Publication Date Title
EP2264465A4 (en) Sample preparation apparatus and sample preparation method, and cell analysis apparatus and cell analysis method
EP2054140A4 (en) Sample component trapping, release, and separation with membrane assemblies interfaced to electrospray mass spectrometry
EP4250336A3 (en) Methods for detecting estradiol by mass spectrometry
EP1820021B8 (en) Improved method of electrochemical analysis of an analyte
WO2009121032A3 (en) Sample preparation devices and methods for processing analytes
WO2008005464A3 (en) Quantifiable internal reference standards for immunohistochemistry and uses thereof
WO2011022369A3 (en) Method for processing tissues
WO2009034951A1 (en) Method for quantification of steroid hormone
WO2007035498A3 (en) Devices and methods for magnetic enrichment of cells and other particles
WO2010138182A3 (en) Methods and apparatus for measuring analytes
WO2007087339A3 (en) Multiplexed analyte quantitation by two-dimensional planar electrochromatography
WO2007106598A3 (en) Devices and methods for detecting cells and other analytes
WO2007100934A3 (en) Methods and compositions for the rapid isolation of small rna molecules
WO2012122564A3 (en) Diagnostic and sample preparation devices and methods
WO2014164026A3 (en) Preparation enhancements and methods of use for maldi mass spectrometry
WO2009136157A3 (en) A system and method for cell characterisation
WO2006109073A3 (en) Inprovements in or relating to methods and apparatus for analyzing biological samples by mass spectrometry
WO2008154523A3 (en) Improved methods and devices for concentration and fractionation of analytes for chemical analysis including matrix-assisted laser desorption/ionization (maldi) mass spectrometry (ms)
WO2009114185A3 (en) Methods and compositions for translational profiling and molecular phenotyping
TWI365564B (en) Cathode for fuel cell having two kinds of water-repellency and method of preparing the same and membrane electrode assembly and fuel cell comprising the same
WO2011116006A3 (en) A rapid method to measure cyanide in biological samples
EP1835282A4 (en) Method of preparing sample for maldi mass spectrometry and reagent composition therefor
IL210787A0 (en) Methods for the cytological analysis of cervical cells
EP2274098A4 (en) Multicapillary sample preparation devices and methods for processing analytes
EP2063265A4 (en) Method of preparing sample for matrix-assisted laser desorption ionization mass spectrometry and matrix-assisted laser desorption ionization mass spectrometry

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09803417

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 13056511

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: DE

REEP Request for entry into the european phase

Ref document number: 2009803417

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2009803417

Country of ref document: EP