WO2010088678A3 - Medical bead products - Google Patents

Medical bead products Download PDF

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Publication number
WO2010088678A3
WO2010088678A3 PCT/US2010/022910 US2010022910W WO2010088678A3 WO 2010088678 A3 WO2010088678 A3 WO 2010088678A3 US 2010022910 W US2010022910 W US 2010022910W WO 2010088678 A3 WO2010088678 A3 WO 2010088678A3
Authority
WO
WIPO (PCT)
Prior art keywords
ecm
bead
bioactive agent
medical
ecm material
Prior art date
Application number
PCT/US2010/022910
Other languages
French (fr)
Other versions
WO2010088678A2 (en
Inventor
Umesh H. Patel
Adam Yestrepsky
Original Assignee
Cook Biotech Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cook Biotech Incorporated filed Critical Cook Biotech Incorporated
Publication of WO2010088678A2 publication Critical patent/WO2010088678A2/en
Publication of WO2010088678A3 publication Critical patent/WO2010088678A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3633—Extracellular matrix [ECM]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A61L2300/622—Microcapsules

Abstract

Described, in certain aspects, are medical bead products including an extracellular matrix (ECM) bead comprised of reconstituted biotropic ECM material. Such an ECM bead can have a generally homogeneous network of self- assembled collagen fibers, and comprise at least one bioactive agent retained in the ECM material, wherein the bioactive agent is selected from the group consisting of a proteoglycan, a growth factor, a glycoprotein, and a glycosaminoglycan. In some forms, the ECM bead further comprises at least one additional bioactive agent disposed thereon, for example, a pharmaceutical such as an antineoplastic agent. Preferably, the ECM material comprises submucosa, for example, porcine small intestinal submucosa (SIS).
PCT/US2010/022910 2009-02-02 2010-02-02 Medical bead products WO2010088678A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14920809P 2009-02-02 2009-02-02
US61/149,208 2009-02-02

Publications (2)

Publication Number Publication Date
WO2010088678A2 WO2010088678A2 (en) 2010-08-05
WO2010088678A3 true WO2010088678A3 (en) 2011-01-20

Family

ID=42235458

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/022910 WO2010088678A2 (en) 2009-02-02 2010-02-02 Medical bead products

Country Status (1)

Country Link
WO (1) WO2010088678A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2874527C (en) * 2012-05-25 2018-11-06 Queen's University At Kingston Collagenous foam materials
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5424084A (en) * 1991-05-02 1995-06-13 Nippi, Incorporated Process for preparing collagen beads
WO1998022158A2 (en) * 1996-08-23 1998-05-28 Cook Biotech, Incorporated Graft prosthesis, materials and methods
WO2000032253A1 (en) * 1998-12-01 2000-06-08 Cook Biotech Incorporated Radiopaque implantable collagenous biomaterial device
WO2000032112A1 (en) * 1998-12-01 2000-06-08 Washington University Embolization device
WO2005020847A2 (en) * 2003-08-25 2005-03-10 Cook Biotech Incorporated Graft materials containing bioactive substances, and methods for their manufacture

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4902508A (en) 1988-07-11 1990-02-20 Purdue Research Foundation Tissue graft composition
US5275826A (en) 1992-11-13 1994-01-04 Purdue Research Foundation Fluidized intestinal submucosa and its use as an injectable tissue graft
US5554389A (en) 1995-04-07 1996-09-10 Purdue Research Foundation Urinary bladder submucosa derived tissue graft
CA2267310C (en) 1996-12-10 2012-09-18 Purdue Research Foundation Stomach submucosa derived tissue graft
US5993844A (en) 1997-05-08 1999-11-30 Organogenesis, Inc. Chemical treatment, without detergents or enzymes, of tissue to form an acellular, collagenous matrix
EP1056836B1 (en) 1998-02-27 2009-02-18 Purdue Research Foundation Submucosa gel compositions

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5424084A (en) * 1991-05-02 1995-06-13 Nippi, Incorporated Process for preparing collagen beads
WO1998022158A2 (en) * 1996-08-23 1998-05-28 Cook Biotech, Incorporated Graft prosthesis, materials and methods
WO2000032253A1 (en) * 1998-12-01 2000-06-08 Cook Biotech Incorporated Radiopaque implantable collagenous biomaterial device
WO2000032112A1 (en) * 1998-12-01 2000-06-08 Washington University Embolization device
WO2005020847A2 (en) * 2003-08-25 2005-03-10 Cook Biotech Incorporated Graft materials containing bioactive substances, and methods for their manufacture

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
J. H. FESSLER: "Self-assembly of Collagen", JOURNAL OF SUPRAMOLECULAR STRUCTURE, vol. 2, 1 January 1974 (1974-01-01), New York (USA), pages 99 - 102, XP002611777 *
JOACHIM KETTENBACH ET AL: "Drug-Loaded Microspheres for the Treatment of Liver Cancer: Review of Current Results", CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, SPRINGER-VERLAG, NE, vol. 31, no. 3, 29 January 2008 (2008-01-29), pages 468 - 476, XP019625205, ISSN: 1432-086X *
NICK MUCALHY: "Embolization Remains Good Option for Unresectable Liver Cancr", 24 January 2009 (2009-01-24), XP002611776, Retrieved from the Internet <URL:www.medscape.com/viewarticle/587305> [retrieved on 20101125] *

Also Published As

Publication number Publication date
WO2010088678A2 (en) 2010-08-05

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