WO2010121342A2 - Double-beveled needle for the lysis of microvaricose veins and telangiectasias - Google Patents

Double-beveled needle for the lysis of microvaricose veins and telangiectasias Download PDF

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Publication number
WO2010121342A2
WO2010121342A2 PCT/BR2010/000150 BR2010000150W WO2010121342A2 WO 2010121342 A2 WO2010121342 A2 WO 2010121342A2 BR 2010000150 W BR2010000150 W BR 2010000150W WO 2010121342 A2 WO2010121342 A2 WO 2010121342A2
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WO
WIPO (PCT)
Prior art keywords
needle
double
bevel
bisel
bevels
Prior art date
Application number
PCT/BR2010/000150
Other languages
French (fr)
Portuguese (pt)
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WO2010121342A3 (en
WO2010121342A8 (en
Inventor
Raimundo Rosendo De Oliveira
Original Assignee
Universidade Federal De Pernambuco
Universidade Estadual Do Rio Grande Do Norte
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by Universidade Federal De Pernambuco, Universidade Estadual Do Rio Grande Do Norte filed Critical Universidade Federal De Pernambuco
Publication of WO2010121342A2 publication Critical patent/WO2010121342A2/en
Publication of WO2010121342A3 publication Critical patent/WO2010121342A3/en
Publication of WO2010121342A8 publication Critical patent/WO2010121342A8/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00008—Vein tendon strippers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B17/320016—Endoscopic cutting instruments, e.g. arthroscopes, resectoscopes
    • A61B17/32002—Endoscopic cutting instruments, e.g. arthroscopes, resectoscopes with continuously rotating, oscillating or reciprocating cutting instruments
    • A61B2017/320028—Endoscopic cutting instruments, e.g. arthroscopes, resectoscopes with continuously rotating, oscillating or reciprocating cutting instruments with reciprocating movements

Definitions

  • the present invention relates to a double bevel needle for treating micro-varicose veins and telangiectasias coupled to a driving machine whose action causes forward and backward needle movements that are directed to cause destruction of dermal micro varices.
  • Sclerotherapy techniques are well known and their action is through the injection of sclerosing substances into the vessel lumen with the aim of causing a chemical inflammation and subsequent drying of the vessel, making it a fibrous cord to wait for its later absorption. by the body.
  • This technique although widely used and efficient, has limitations as its slow, passive staining result, requiring multiple applications, may be burned on the spot, and sometimes unwanted vessels may be struck during chemical injection.
  • sclerosing. Laser is a recent, promising technique, currently only used as a complement to sclerotherapy, its results are still very selective and very expensive, which hinders access to use as well as professional training.
  • This technical instrument can be safely used by any novice in the art, it only reaches the vessels to be destroyed, does not cause chronic stains, does not cause burns, its result is immediate, the cost is insignificant and the treatment is carried out with great care. there is no risk of injury to deeper vessels.
  • Fig. 1 shows in perspective the double bevel needle having at one end the locking tip and at the other showing the double bevel tip.
  • Fig. 2 shows the detail of the double bevel needle tip.
  • Fig. 3 shows that the needle is connected to a machine powered by a power source that, when triggered, causes forward and backward movements, according to the depth of the skin to be reached, causing the destruction of the dermal micro-varices.
  • the double bevel needle for treating varicose veins and telangiectasias (1) object of the present invention, consists of a double bevel needle with piercing / cutting ends on its medial face, connected to a machine formed by a disposable polypropylene wrap sleeve (2), rotation shaft (3), eccentric cardan (4), threaded insert (5) and induction motor (6) connected to a power source (7).
  • the double bevel needle (1) being connected to the rotation axis, for example 240 rpm (3) of the machine, will operate with an advance and retraction of the needle penetrating the skin in the treatment region causing painlessly destroying dermal micro-varicose veins.
  • the double bevel needle (1) can be obtained in different sizes to meet different needs, depending on the presentation and condition of the dermal micro-varicose veins.
  • the parallel double beveled end may be made of different size bevels, one bevel having a length of between 1.5 mm and 2.1 mm, and the other bevel shorter than the first bevel with length between 0.9 mm and 1.5 mm.
  • the construction angle of the bevels, joined together by the arched chamfer can vary from 10 degrees to 150 degrees according to the length of the bevels.
  • the configuration used in the prototype developed and tested had the distal end composed of double parallel bevels, one of which being 1.8 mm long and the other 1.2 mm long, measured from base to tip with a distance of 1 mm. .0 mm from one to the other, their tips tapered and prepared to pierce and cut at the same time, the ends of the bevels had two surfaces, the concave and smooth upper surface facing the outside, and the sharpened convective lower surface facing the inner side, needle was 142.5 mm long, 1.8 mm in diameter and weighed 2.475 g being made of solid surgical steel.
  • the diameter is the same as the proximal portion or fixation end to the distracting end or sharpening tip, but the needle can be manufactured with diameters of 1 mm to 3 mm with similar efficiency.
  • the length between said fixing ends with the syringe and bevel tip or cutting tip may also vary from 10 mm to 160 mm.

Abstract

A double-beveled needle for the lysis of microvaricose veins and telangiectasias comprises a double-beveled end and a coupling end. When the needle touches the skin, on the vessel to be destroyed, it causes the immediate and selective lysis of the vessel. Unlike conventional treatments that cause chemical inflammation, hardening and subsequent absorption of the vessel, the destruction ensured by this needle does not require these stages in the treatment, immediately destroying the vessel and avoiding spots, burns and hardening in the treated zone. The needle is easy to use, of low cost and accessible even to beginners in this discipline.

Description

"AGULHA COM DUPLO BISEL PARA LISE DE MICROVARIZES E TELANGIECTASIAS"  "DOUBLE BISEL NEEDLE FOR MICROVARISES AND TELANGIECTASIAS"
A presente Patente de Invenção refere-se a uma agulha de duplo bisel para tratamento de micro-varizes e telangiectasias acoplada a uma máquina acionadora cuja ação provoca movimentos de avanço e recuo na agulha que são direcionados para provocar destruição de microvarizes dérmicas.  The present invention relates to a double bevel needle for treating micro-varicose veins and telangiectasias coupled to a driving machine whose action causes forward and backward needle movements that are directed to cause destruction of dermal micro varices.
A medicina atual, em especial a cirurgia vascular, já usufrui de grandes progressos da ciência moderna e já dispõe de várias técnicas para o tratamento das microvarizes como seja: escleroterapia, crioescleroterapia, tratamentos com laser e microcirurgias, porém todas essas técnicas carecem de resultados mais precisos, custos mais baixos, diminuição do tempo de tratamento e dos efeitos indesejáveis.  Current medicine, especially vascular surgery, has already made great progress in modern science and already has several techniques for the treatment of micro-varicose veins such as sclerotherapy, cryosclerotherapy, laser treatments and microsurgery, but all these techniques lack more results. accurate, lower costs, reduced treatment time and undesirable effects.
São bastante conhecidas as técnicas de escleroterapia cuja ação se dá através da injeção de substâncias esclerosantes dentro da luz do vaso com o objetivo de provocar uma inflamação química e posterior secagem do vaso tornando-o um cordão fibroso para que se espere uma posterior absorção do mesmo pelo organismo. Essa técnica, apesar de muito usada e eficiente, tem como limitações o seu resultado lento, passiva de provocar manchas, necessitar de várias aplicações, pode haver queimaduras no local e, algumas vezes, vasos não desejados podem ser atingidos durante a injeção das substâncias químicas esclerosantes. O laser é uma técnica recente, promissora, no momento apenas usado como complemento da escleroterapia, tem seus resultados ainda bastante seletivos e é de custo bastante elevado, o que dificulta o acesso ao uso, bem como o treinamento profissional. Sclerotherapy techniques are well known and their action is through the injection of sclerosing substances into the vessel lumen with the aim of causing a chemical inflammation and subsequent drying of the vessel, making it a fibrous cord to wait for its later absorption. by the body. This technique, although widely used and efficient, has limitations as its slow, passive staining result, requiring multiple applications, may be burned on the spot, and sometimes unwanted vessels may be struck during chemical injection. sclerosing. Laser is a recent, promising technique, currently only used as a complement to sclerotherapy, its results are still very selective and very expensive, which hinders access to use as well as professional training.
O uso do instrumento técnico descrito nesse documento permite um resultado satisfatório e rápido, diminui os principais efeitos indesejáveis, não utiliza produtos químicos, é de fácil manuseio e de custo acessível. O resultado é imediato, não precisando de repetição das seções.  Use of the technical instrument described in this document provides a satisfactory and rapid result, reduces major undesirable effects, does not use chemicals, is easy to handle and affordable. The result is immediate, requiring no repeat of sections.
O presente instrumento técnico pode ser utilizado com segurança por qualquer profissional principiante na especialidade, só atinge os vasos que se deseja destruir, não provoca manchas crónicas, não provoca queimaduras, seu resultado é imediato, o custo é insignificante e o tratamento é realizado com muita rapidez não havendo risco de lesão de vasos mais profundos.  This technical instrument can be safely used by any novice in the art, it only reaches the vessels to be destroyed, does not cause chronic stains, does not cause burns, its result is immediate, the cost is insignificant and the treatment is carried out with great care. there is no risk of injury to deeper vessels.
Os desenhos anexos mostram a disposição da Agulha com duplo bisel para tratamento de micro varizes e telangiectasias, objeto da presente patente, nos quais:  The accompanying drawings show the arrangement of the double bevel needle for treatment of micro varicose veins and telangiectasias, object of the present patent, in which:
A fig. 1 mostra em perspectiva a agulha de duplo bisel, tendo em uma das extremidades a ponta de fixação e em outra mostrando a ponta em bisel duplo.  Fig. 1 shows in perspective the double bevel needle having at one end the locking tip and at the other showing the double bevel tip.
A fig. 2 mostra o detalhamento da ponta da agulha com duplo bisel.  Fig. 2 shows the detail of the double bevel needle tip.
A fig. 3 mostra que a agulha é conectada a uma máquina alimentada por uma fonte de energia que, ao ser acionada, provoca movimentos de avanço e recuo, de acordo com a profundidade na pele que se deseja atingir, provocando a destruição das micro- varizes dérmicas. Fig. 3 shows that the needle is connected to a machine powered by a power source that, when triggered, causes forward and backward movements, according to the depth of the skin to be reached, causing the destruction of the dermal micro-varices.
De conformidade com as ilustrações das figuras acima relacionadas, a agulha com duplo bisel para tratamento de microvarizes e telangiectasias (1 ), objeto da presente patente, consiste em uma agulha com duplo bisel com extremidades perfurantes/cortantes em sua face medial, conectada a uma máquina formada por uma luva envoltória em polipropileno descartável (2), eixo de rotação (3), cardan excêntrico (4), encaixe rosqueada (5) e motor de indução (6) ligado a uma fonte de energia (7).  In accordance with the illustrations of the above related figures, the double bevel needle for treating varicose veins and telangiectasias (1), object of the present invention, consists of a double bevel needle with piercing / cutting ends on its medial face, connected to a machine formed by a disposable polypropylene wrap sleeve (2), rotation shaft (3), eccentric cardan (4), threaded insert (5) and induction motor (6) connected to a power source (7).
Na presente disposição, a agulha com duplo bisel (1 ) estando conectada ao eixo de rotação, por exemplo, de 240 rpm (3) da máquina, funcionará com um avanço e recuo da agulha, penetrando na pele na região do tratamento, provocando de forma indolor a destruição das micro-varizes dérmicas.  In the present arrangement, the double bevel needle (1) being connected to the rotation axis, for example 240 rpm (3) of the machine, will operate with an advance and retraction of the needle penetrating the skin in the treatment region causing painlessly destroying dermal micro-varicose veins.
Assim, o uso do instrumento técnico descrito com a utilização da agulha com duplo bisel (1) destruirá de forma imediata e sem repetições, e sem a utilização de produtos químicos as microvarizes dérmicas.  Thus, the use of the technical instrument described with the use of the double bevel needle (1) will immediately and without repetition destroy, and without the use of chemicals, dermal microwaves.
A agulha com duplo bisel (1 ) poderá ser obtida em diversos tamanhos para atender a diferentes necessidades, conforme a apresentação e estado das micro-varizes dérmicas. Por exemplo: A ponta em duplo bisel paralelo pode ser fabricada com biséis de tamanhos diferentes, um dos biséis com um comprimento compreendido entre 1 ,5 mm e 2,1 mm, e o outro bisel, com comprimento inferior ao primeiro bisel, com comprimento compreendido entre 0,9 mm e 1 ,5 mm. De fato o ângulo de construção dos biséis, unidos extremidade pela chanfradura arqueada, pode variar de 10 graus a 150 graus de acordo com o comprimento dos biséis. The double bevel needle (1) can be obtained in different sizes to meet different needs, depending on the presentation and condition of the dermal micro-varicose veins. For example: The parallel double beveled end may be made of different size bevels, one bevel having a length of between 1.5 mm and 2.1 mm, and the other bevel shorter than the first bevel with length between 0.9 mm and 1.5 mm. In fact, the construction angle of the bevels, joined together by the arched chamfer, can vary from 10 degrees to 150 degrees according to the length of the bevels.
A configuração usada no protótipo desenvolvido e testado tinha a extremidade distai composta de duplo bisel paralelo, sendo um dos biseis com 1 ,8 mm, e o outro com 1 ,2 mm de comprimento, medidos de sua base à ponta com uma distância de 1 ,0 mm de um para o outro, suas pontas afiladas e preparadas para furar e cortar ao mesmo tempo, as extremidades dos biséis possuíam duas superfícies, a superfície superior côncava e lisa, voltada ao lado externo, e a superfície inferior convêxa perfurocortante voltada para o lado interno, agulha tinha 142,5 mm de comprimento, 1 ,8 mm de diâmetro e pesava 2,475 g sendo confeccionada em aço cirúrgico maciço.  The configuration used in the prototype developed and tested had the distal end composed of double parallel bevels, one of which being 1.8 mm long and the other 1.2 mm long, measured from base to tip with a distance of 1 mm. .0 mm from one to the other, their tips tapered and prepared to pierce and cut at the same time, the ends of the bevels had two surfaces, the concave and smooth upper surface facing the outside, and the sharpened convective lower surface facing the inner side, needle was 142.5 mm long, 1.8 mm in diameter and weighed 2.475 g being made of solid surgical steel.
Apesar do uso da agulha de 1 ,8 mm de diâmetro no protótipo, é importante destacar que o diâmetro é o mesmo da porção proximal ou extremidade de fixação, até a extremidade distrai ou ponta perfurocortante, mas, a agulha pode ser fabricada com diâmetros de 1 mm a 3 mm com semelhante eficiência. O comprimento entre as referidas extremidades de fixação com a seringa e a extremidade dos biséis ou ponta cortante, também pode variar de 1 0 mm a 160 mm. Despite the use of the 1.8 mm diameter needle in the prototype, it is important to note that the diameter is the same as the proximal portion or fixation end to the distracting end or sharpening tip, but the needle can be manufactured with diameters of 1 mm to 3 mm with similar efficiency. The length between said fixing ends with the syringe and bevel tip or cutting tip may also vary from 10 mm to 160 mm.

Claims

REIVINDICAÇÕES
1. AGULHA COM DUPLO BISEL, compreendendo agulha metálica, de fino diâmetro, com ponta em duplo bisel paralelo com as extremidades da ponta perfuro cortantes, tendo na extremidade de fixação, um encaixe rosqueado para se adaptar a qualquer tipo de seringa ou estrutura similar, com uma chanfradura arqueada não cortante que une os biséis em sua base. 1. DOUBLE BISEL NEEDLE, comprising a thin diameter metal needle with a double bevel tip parallel to the piercing tip ends having a threaded fitting at the end of attachment to fit any type of syringe or similar structure; with a non-cutting arched chamfer that joins the bevels at its base.
2. AGULHA COM DUPLO BISEL PARA LISE DE MICROVARIZES E TELANGIECTASIAS de acordo com a reivindicação 1, caracterizada por ser confeccionada em aço cirúrgico leve e maciço. DOUBLE BISEL NEEDLE FOR MICROVARISES AND TELANGIECTASIES LYSIS according to claim 1, characterized in that it is made of light and solid surgical steel.
3. AGULHA COM DUPLO BISEL PARA LISE DE MICROVARIZES E TELANGIECTASIAS de acordo com a reivindicação 1, caracterizada pela dita ponta em duplo bisel paralelo ser fabricada com biséis de tamanhos diferentes, um dos biséis com um comprimento compreendido entre 1,5 mm e 2,1 mm, incluindo as extremidades deste intervalo, e o outro bisel, com comprimento inferior ao primeiro bisel, com comprimento compreendido entre 0,9 mm e 1,5 mm, incluindo as extremidades deste intervalo. DOUBLE BISEL NEEDLE FOR MICROVARISES AND TELANGIECTASIES according to claim 1, characterized in that said parallel double bevel tip is made of different size bevels, one of the bevels having a length of between 1.5 mm and 2 µm; 1 mm, including the ends of this range, and the other bevel, less than the first bevel, of a length between 0,9 mm and 1,5 mm, including the ends of this range.
4. AGULHA COM DUPLO BISEL PARA LISE DE MICROVARIZES E TELANGIECTASIAS de acordo com a reivindicação 3, caracterizada pela extremidade de cada bisel, possuir pontos afilados e preparados para furar e cortar ao mesmo tempo em sua face medial, conforme figura 2. A double bevel needle for microlysis and telangiectasia according to claim 3, characterized in that the end of each bevel has tapered points and prepared to pierce and cut at the same time on its medial surface, as shown in Figure 2.
5. AGULHA COM DUPLO BISEL PARA LISE DE MIC RO VARIZES E TELANGIECTASIAS de acordo com a reivindicação 4, caracterizada pelas extremidades dos biséis possuírem duas superfícies, a superfície superior côncava e lisa, voltada ao lado externo, e a superfície inferior convexa perfurocortante voltada para o lado interno. MICRO VARICE AND TELANGIECTASIA DOUBLE BISEL NEEDLE NEEDLE according to claim 4, characterized in that the bevel ends have two surfaces, the concave and smooth upper surface facing the outside and the perforating convex lower surface facing the inner side.
6. AGULHA COM DUPLO BISEL PARA LISE DE MICROVARIZES E TELANGIECTASIAS de acordo com a reivindicação 3, caracterizada pelo fato de que o ângulo de construção dos ditos biséis, unidos na dita extremidade pela chanfradura arqueada, poder variar de 10 graus a 150 graus. The double bevel needle for lysis and telangiectasia according to claim 3, characterized in that the construction angle of said bevels, joined at said end by the arcuate chamfer, may vary from 10 degrees to 150 degrees.
7. AGULHA COM DUPLO BISEL PARA LISE DE MICROVARIZES E TELANGIECTASIAS de acordo com a reivindicação 1, caracterizada pelo diâmetro de toda a superfície da agulha, da porção proximal ou extremidade de fixação, até a extremidade distrai ou ponta perfurocortante, ser o mesmo, mas, podendo ser fabricada com diâmetros de 1 mm a 3 mm . 8. AGULHA COM DUPLO BISEL PARA LISE DE MICROVARIZES E TELANGIECTASIAS de acordo com a reivindicação 7, caracterizada pelo diâmetro ser de 1 ,A dual bevel needle for microlysis and telelangiasis according to claim 1, characterized in that the diameter of the entire needle surface, proximal portion or end of attachment, to the distract end or sharp point is the same but It can be manufactured with diameters from 1 mm to 3 mm. A DOUBLE BISEL NEEDLE FOR MICROVARISES AND TELANGIECTASIES according to claim 7, characterized in that the diameter is 1,
8 mm. 8 mm.
9. AGULHA COM DUPLO BISEL PARA LISE DE MICROVARIZES E TELANGIECTASIAS de acordo com a reivindicação 1, caracterizada pelo comprimento entre as referidas extremidades de fixação com a seringa e a extremidade dos biséis ou ponta cortante, poder variar de 110 mm a 160 mm. A DOUBLE BISEL NEEDLE FOR MICROVARISIS AND TELANGIECTASY LYSIS according to claim 1, characterized in that the length between said attachment ends with the syringe and the end of the bevels or cutting tip may range from 110 mm to 160 mm.
10. AGULHA COM DUPLO BISEL PARA LISE DE MICROVARIZES E TELANGIECTASIAS de acordo com a reivindicação 9, caracterizada pelo comprimento entre as referidas extremidades de fixação com a seringa e a extremidade dos biséis ou ponta cortante, ser de 142,5 mm. A DOUBLE BISEL NEEDLE FOR MICROVARISES AND TELANGIECTASIES LYSIS according to claim 9, characterized in that the length between said attachment ends with the syringe and the end of the bevels or cutting tip is 142.5 mm.
PCT/BR2010/000150 2009-04-22 2010-04-15 Double-beveled needle for the lysis of microvaricose veins and telangiectasias WO2010121342A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
BR000177/PE 2009-04-22
BRPI0910083 BRPI0910083A2 (en) 2009-04-22 2009-04-22 double bevel needle for microlysis and telangiectasia
BRPI0910083-0 2009-04-22

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WO2010121342A2 true WO2010121342A2 (en) 2010-10-28
WO2010121342A3 WO2010121342A3 (en) 2010-12-09
WO2010121342A8 WO2010121342A8 (en) 2012-07-05

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Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1122916A (en) * 1914-08-15 1914-12-29 Ernst Hanschen Hoof-gouge.
US3119391A (en) * 1962-07-09 1964-01-28 Baxter Laboratories Inc Non-coring needle
FR1378284A (en) * 1962-10-05 1964-11-13 American Home Prod Prong needle for vaccination and method for its application
US3905371A (en) * 1972-10-13 1975-09-16 Helmut Stickl Inoculating tools for cutaneous vaccination using a dry vaccine
US4712548A (en) * 1980-04-23 1987-12-15 Enstroem Hans Blood lancing device
US4838877A (en) * 1985-08-06 1989-06-13 Massau Bruce A Polymeric hypodermic device
US5632728A (en) * 1994-02-22 1997-05-27 Lincoln Diagnostics, Inc. Skin testing and vaccinating needles
US20040087915A1 (en) * 2002-10-31 2004-05-06 Ross Chauncey F. Hypodermic needle

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6726649B2 (en) * 2001-12-28 2004-04-27 Becton, Dickinson And Company Medical needle assemblies

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1122916A (en) * 1914-08-15 1914-12-29 Ernst Hanschen Hoof-gouge.
US3119391A (en) * 1962-07-09 1964-01-28 Baxter Laboratories Inc Non-coring needle
FR1378284A (en) * 1962-10-05 1964-11-13 American Home Prod Prong needle for vaccination and method for its application
US3905371A (en) * 1972-10-13 1975-09-16 Helmut Stickl Inoculating tools for cutaneous vaccination using a dry vaccine
US4712548A (en) * 1980-04-23 1987-12-15 Enstroem Hans Blood lancing device
US4838877A (en) * 1985-08-06 1989-06-13 Massau Bruce A Polymeric hypodermic device
US5632728A (en) * 1994-02-22 1997-05-27 Lincoln Diagnostics, Inc. Skin testing and vaccinating needles
US20040087915A1 (en) * 2002-10-31 2004-05-06 Ross Chauncey F. Hypodermic needle

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BRPI0910083A2 (en) 2012-02-28
WO2010121342A3 (en) 2010-12-09
WO2010121342A8 (en) 2012-07-05

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