WO2010132447A3 - Methods for detecting pre-diabetes and diabetes using differential protein glycosylation - Google Patents

Methods for detecting pre-diabetes and diabetes using differential protein glycosylation Download PDF

Info

Publication number
WO2010132447A3
WO2010132447A3 PCT/US2010/034385 US2010034385W WO2010132447A3 WO 2010132447 A3 WO2010132447 A3 WO 2010132447A3 US 2010034385 W US2010034385 W US 2010034385W WO 2010132447 A3 WO2010132447 A3 WO 2010132447A3
Authority
WO
WIPO (PCT)
Prior art keywords
diabetes
methods
diabetic
protein glycosylation
biological fluid
Prior art date
Application number
PCT/US2010/034385
Other languages
French (fr)
Other versions
WO2010132447A2 (en
Inventor
Srinivasa R. Nagalla
Charles T. Roberts
Original Assignee
Diabetomics, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diabetomics, Llc filed Critical Diabetomics, Llc
Publication of WO2010132447A2 publication Critical patent/WO2010132447A2/en
Publication of WO2010132447A3 publication Critical patent/WO2010132447A3/en
Priority to US13/457,225 priority Critical patent/US8530175B2/en
Priority to US13/457,243 priority patent/US8497077B2/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/415—Assays involving biological materials from specific organisms or of a specific nature from plants
    • G01N2333/42—Lectins, e.g. concanavalin, phytohaemagglutinin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
    • G01N2440/38—Post-translational modifications [PTMs] in chemical analysis of biological material addition of carbohydrates, e.g. glycosylation, glycation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Abstract

Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include the identification of an overall glycosylation profile of proteins in a biological fluid, such as saliva, urine, or serum. In some examples, the methods include determining the amount of one or more protein in a biological fluid or determining the glycosylation pattern of one or more proteins in a biological fluid.
PCT/US2010/034385 2009-05-11 2010-05-11 Methods for detecting pre-diabetes and diabetes using differential protein glycosylation WO2010132447A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US13/457,225 US8530175B2 (en) 2009-05-11 2012-04-26 Methods for detecting pre-diabetes and diabetes using differential protein glycosylation
US13/457,243 US8497077B2 (en) 2009-05-11 2012-04-26 Methods for detecting pre-diabetes and diabetes using differential protein glycosylation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17713009P 2009-05-11 2009-05-11
US61/177,130 2009-05-11

Publications (2)

Publication Number Publication Date
WO2010132447A2 WO2010132447A2 (en) 2010-11-18
WO2010132447A3 true WO2010132447A3 (en) 2011-03-03

Family

ID=43062545

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/034385 WO2010132447A2 (en) 2009-05-11 2010-05-11 Methods for detecting pre-diabetes and diabetes using differential protein glycosylation

Country Status (2)

Country Link
US (4) US8168396B2 (en)
WO (1) WO2010132447A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8748352B2 (en) * 2011-08-16 2014-06-10 Battelle Memorial Institute Peptide and protein biomarkers for type 1 diabetes mellitus
CN102426231B (en) * 2011-09-15 2014-09-03 长沙三诺生物传感技术股份有限公司 Immunochromatography reagent strip and sealing agent composition used for same
US20150083906A1 (en) * 2012-04-20 2015-03-26 Merck Sharp & Dohme Corp. Biomarkers for monitoring intervention therapies for diabetes
WO2013159025A1 (en) * 2012-04-20 2013-10-24 Ezose Sciences, Inc Biomarkers for diagnosis of diabetes and monitoring of anti-diabetic therapy
US9383352B2 (en) 2014-03-26 2016-07-05 Diabetomics, Inc. Salivary protein glycosylation test for diagnosis and monitoring of diabetes
AU2016254150B2 (en) * 2015-04-30 2021-09-30 Idexx Laboratories, Inc. Specific detection of clusterin isoforms
US10441620B2 (en) * 2016-09-21 2019-10-15 Wellstrong Biotech Co., Ltd. Method for protection of bladder from damage
CN106771120B (en) * 2016-11-29 2018-10-30 陕西中药研究所 The quickly method and test strips of detection bird flu and human influenza Susceptible population
TWI688770B (en) * 2018-10-11 2020-03-21 臺北醫學大學 Method for detecting diabetic nephropathy
CN110045127A (en) * 2019-04-03 2019-07-23 中国医学科学院北京协和医院 A kind of biomarker and application thereof of the diseases related multiple organ involvement of IgG4
CN110763849B (en) * 2019-11-28 2023-03-31 陕西医药控股医药研究院有限公司 Method for detecting content of SA alpha 2-3Gal sugar chains in saliva sample by ELISA
US20210311043A1 (en) * 2020-04-06 2021-10-07 Medicortex Finland Oy Method for determining a lectin-binding glycan indicative to traumatic brain injury
CN111735963A (en) * 2020-06-15 2020-10-02 中国人民解放军总医院 Use of specific lectins for the identification of diabetic/non-diabetic nephropathy based on the carbohydrate chains of sialoglycoproteins

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE388694B (en) 1975-01-27 1976-10-11 Kabi Ab WAY TO PROVIDE AN ANTIGEN EXV IN SAMPLES OF BODY WHEATS, USING POROST BERAR MATERIAL BONDED OR ADSORBING ANTIBODIES
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
NL7807532A (en) 1978-07-13 1980-01-15 Akzo Nv METAL IMMUNO TEST.
US4277560A (en) 1978-10-24 1981-07-07 Technicon Instruments Corporation Enzyme immunoassays using immobilized reagents in a flowing stream
US4246339A (en) 1978-11-01 1981-01-20 Millipore Corporation Test device
NL8000173A (en) 1980-01-11 1981-08-03 Akzo Nv USE OF WATER-DISPERSIBLE HYDROPHOBIC DYES AS LABELS IN IMMUNOCHEMICAL TESTS.
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4371374A (en) 1980-11-17 1983-02-01 The Rockefeller University Monitoring metabolic control in diabetic patients by measuring glycosylated amino acids and peptides in urine
US5073484A (en) 1982-03-09 1991-12-17 Bio-Metric Systems, Inc. Quantitative analysis apparatus and method
US4435504A (en) 1982-07-15 1984-03-06 Syva Company Immunochromatographic assay with support having bound "MIP" and second enzyme
US4496654A (en) 1983-04-08 1985-01-29 Quidel Detection of HCG with solid phase support having avidin coating
GB8331514D0 (en) 1983-11-25 1984-01-04 Janssen Pharmaceutica Nv Visualization method
US4703017C1 (en) 1984-02-14 2001-12-04 Becton Dickinson Co Solid phase assay with visual readout
US4743560A (en) 1984-03-26 1988-05-10 Becton Dickinson And Company Solid phase assay
US4632901A (en) 1984-05-11 1986-12-30 Hybritech Incorporated Method and apparatus for immunoassays
DE3445816C1 (en) 1984-12-15 1986-06-12 Behringwerke Ag, 3550 Marburg Flat diagnostic agent
US4740468A (en) 1985-02-14 1988-04-26 Syntex (U.S.A.) Inc. Concentrating immunochemical test device and method
US4806312A (en) 1985-08-28 1989-02-21 Miles Inc. Multizone analytical element having detectable signal concentrating zone
US4806311A (en) 1985-08-28 1989-02-21 Miles Inc. Multizone analytical element having labeled reagent concentration zone
US4812293A (en) 1986-06-30 1989-03-14 Becton, Dickinson And Company Vacuum actuated assay device and method of using same
US4770853A (en) 1986-12-03 1988-09-13 New Horizons Diagnostics Corporation Device for self contained solid phase immunodiffusion assay
US4920046A (en) 1987-02-20 1990-04-24 Becton, Dickinson And Company Process, test device, and test kit for a rapid assay having a visible readout
DE3705686C2 (en) 1987-02-23 1995-11-30 Boehringer Mannheim Gmbh Methods for the determination of antibodies
CA1303983C (en) 1987-03-27 1992-06-23 Robert W. Rosenstein Solid phase assay
US4857453A (en) 1987-04-07 1989-08-15 Syntex (U.S.A.) Inc. Immunoassay device
DE3887771C5 (en) 1987-04-27 2009-06-04 Inverness Medical Switzerland Gmbh Immunoassays and devices therefor.
US4855240A (en) 1987-05-13 1989-08-08 Becton Dickinson And Company Solid phase assay employing capillary flow
US4943522A (en) 1987-06-01 1990-07-24 Quidel Lateral flow, non-bibulous membrane assay protocols
CA1313616C (en) 1987-06-01 1993-02-16 Robert B. Sargeant Lateral flow, non-bibulous membrane protocols
US4954452A (en) 1987-07-09 1990-09-04 Abbott Laboratories Non-metal colloidal particle immunoassay
US5120643A (en) 1987-07-13 1992-06-09 Abbott Laboratories Process for immunochromatography with colloidal particles
US5334513A (en) 1988-05-17 1994-08-02 Syntex (U.S.A.) Inc. Method for immunochromatographic analysis
DE3834766A1 (en) 1988-10-12 1990-04-26 Boehringer Mannheim Gmbh METHOD FOR DETERMINING A SPECIFICALLY BINDABLE SUBSTANCE
DE3901857A1 (en) 1989-01-23 1990-07-26 Boehringer Mannheim Gmbh METHOD FOR DETERMINING HIV 2 ANTIBODY
GB8903627D0 (en) 1989-02-17 1989-04-05 Unilever Plc Assays
US5075078A (en) 1989-10-05 1991-12-24 Abbott Laboratories Self-performing immunochromatographic device
US5279935A (en) 1990-03-01 1994-01-18 Becton, Dickinson And Company Method of immunossay including deactivation of endogenous alkaline phosphatase
DE69229334T2 (en) 1991-01-11 1999-12-16 Quidel Corp ONE-STAGE CROSS-FLOW ANALYZING METHOD AND A NON-SUCTIONABLE CARRIER USED IN IT
US5607863A (en) 1991-05-29 1997-03-04 Smithkline Diagnostics, Inc. Barrier-controlled assay device
US5451504A (en) 1991-07-29 1995-09-19 Serex, Inc. Method and device for detecting the presence of analyte in a sample
US5229073A (en) 1992-02-27 1993-07-20 Abbott Laboratories One-step competitive immunoassay for the semiquantitative determination of plasma lipoprotein(a)
EP0648334A4 (en) 1992-07-02 1996-11-20 Quidel Corp Immunoassay using dye complexed enzyme conjugates.
US6283761B1 (en) 1992-09-08 2001-09-04 Raymond Anthony Joao Apparatus and method for processing and/or for providing healthcare information and/or healthcare-related information
US5424193A (en) 1993-02-25 1995-06-13 Quidel Corporation Assays employing dyed microorganism labels
US5712172A (en) 1995-05-18 1998-01-27 Wyntek Diagnostics, Inc. One step immunochromatographic device and method of use
WO1997006439A1 (en) 1995-08-09 1997-02-20 Quidel Corporation Test strip and method for one step lateral flow assay
AUPO071396A0 (en) 1996-06-28 1996-07-25 Chandler, Howard Milne Chromatographic assay or test device
GB9618934D0 (en) 1996-09-11 1996-10-23 Univ London Inositol phosphoglycans for therapeutic use in the treatment of diabetes and obesity
US6001658A (en) 1996-09-13 1999-12-14 Diagnostic Chemicals Limited Test strip apparatus and method for determining presence of analyte in a fluid sample
US5798273A (en) 1996-09-25 1998-08-25 Becton Dickinson And Company Direct read lateral flow assay for small analytes
WO1998036278A1 (en) 1997-02-15 1998-08-20 Beth Israel Deaconess Medical Center, Inc. Multiple-site antibody capture immunoassays and kits
US6258548B1 (en) 1997-06-05 2001-07-10 A-Fem Medical Corporation Single or multiple analyte semi-quantitative/quantitative rapid diagnostic lateral flow test system for large molecules
SE9801563D0 (en) 1998-04-30 1998-04-30 Pharmacia & Upjohn Diag Ab Method of separation and kit to be used in the process
AU1861001A (en) 1999-11-29 2001-06-12 Syntesome Gesellschaft Fur Medizinische Biochemie Mbh Arrays of glycan molecules (glycoarrays) on the surface of biochips (glycochips)and uses thereof
EP1267708A4 (en) 2000-03-29 2006-04-12 Univ Virginia Method, system, and computer program product for the evaluation of glycemic control in diabetes from self-monitoring data
US6699722B2 (en) 2000-04-14 2004-03-02 A-Fem Medical Corporation Positive detection lateral-flow apparatus and method for small and large analytes
US20040241876A1 (en) 2000-12-22 2004-12-02 France Fannes Flow through assay device, diagnostic kit comprising said assay device and use of said assay device in the detection of an analyte present in a sample
US7043288B2 (en) 2002-04-04 2006-05-09 Inlight Solutions, Inc. Apparatus and method for spectroscopic analysis of tissue to detect diabetes in an individual
US7531362B2 (en) 2001-06-07 2009-05-12 Medmira Inc. Rapid diagnostic assay
CA2487314A1 (en) 2002-06-03 2003-12-11 The Institute For Systems Biology Methods for quantitative proteome analysis of glycoproteins
WO2004089187A2 (en) * 2003-04-01 2004-10-21 University Of Southern California Caries risk test for predicting and assessing the risk of disease
WO2005024429A1 (en) 2003-09-05 2005-03-17 Minomic Pty Ltd Assay for diabetes
DE102004018418A1 (en) 2004-04-15 2005-11-10 Euroimmun Medizinische Labordiagnostika Ag Diagnosis of inflammatory bowel disease, especially ulcerative colitis
EP1828410A2 (en) 2004-12-13 2007-09-05 F. Hoffmann-Roche AG Single nucleotide polymorphism (snp) associated to type ii diabetes
US20090099036A1 (en) 2006-04-18 2009-04-16 The Regents Of The University Of Michigan Methods and compositions for screening glycan structures
JP2010502946A (en) 2006-09-01 2010-01-28 アメリカン タイプ カルチャー コレクション Compositions and methods for diagnosing and treating type 2 diabetes
WO2008030546A2 (en) 2006-09-06 2008-03-13 Ouantrx Biomedical Corporation Lateral flow test strip with migrating label
WO2008055242A2 (en) 2006-11-01 2008-05-08 The Johns Hopkins University Early detection of diabetes
WO2008092214A1 (en) * 2007-02-02 2008-08-07 Minomic International Limited Biomarkers for diabetes
KR100961926B1 (en) 2007-08-30 2010-06-10 서울대학교산학협력단 Biomarker composition for detecting diabetic retinopathy and diagnostic kit therefor

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BUSE, M. G. ET AL.: "Enhanced 0-GlcNAc protein modification is associated with insulin resistance in GLUT1-overexpressing muscles.", AM. J. PHYSIOL. ENDOCRINOL. METAB., vol. 283, 2002, pages E241 - E250 *
CARLSSON, J. ET AL.: "Detection of global glycosylation changes of serum proteins in type 1 diabetes using a lectin panel and multivariate data analysis.", TALANTA, vol. 76, 2008, pages 333 - 337, XP022686063, DOI: doi:10.1016/j.talanta.2008.02.046 *
HIGAI, K. ET AL.: "Altered glycosylation of a I-acid glycoprotein in patients with inflammation and diabetes mellitus.", CLINICA CHIMICA ACTA, vol. 329, 2003, pages 117 - 125, XP002496508, DOI: doi:10.1016/S0009-8981(02)00427-8 *
POLAND, D. C. W. ET AL.: "Increased alpha-fucosylation of a 1-acid glycoprotein in Type I diabetic patients is related to vascular function.", GLYCOCONJUGATE J., vol. 18, 2001, pages 261 - 268 *

Also Published As

Publication number Publication date
US20120208218A1 (en) 2012-08-16
US20100285498A1 (en) 2010-11-11
US20120208217A1 (en) 2012-08-16
US8497076B2 (en) 2013-07-30
US8530175B2 (en) 2013-09-10
WO2010132447A2 (en) 2010-11-18
US8168396B2 (en) 2012-05-01
US8497077B2 (en) 2013-07-30
US20120214179A1 (en) 2012-08-23

Similar Documents

Publication Publication Date Title
WO2010132447A3 (en) Methods for detecting pre-diabetes and diabetes using differential protein glycosylation
WO2006121892A3 (en) Diagnosis of liver pathology through assessment of protein glycosylation
IL177192A0 (en) Analyte test system for determining the concentration of an analyte in a physiological fluid
WO2005114190A3 (en) Methods of identifying biomarkers
WO2008014132A3 (en) Combination analyte measurement device and method of use
WO2008122670A3 (en) Human diabetes susceptibility tnfrsf10b gene
WO2006128192A3 (en) Use of free circulating dna for diagnosis, prognosis, and treatment of cancer
WO2012054555A3 (en) Improved identification of pre-diabetes using a combination of mean glucose and 1,5-anhydroglucitol markers
WO2006117161A3 (en) New labelling strategies for the sensitive detection of analytes
WO2009152607A8 (en) Methods and kits for diagnosing neurodegenerative disease
WO2008131361A3 (en) Biosensors for measuring analytes in the interstitial fluid
WO2007030571A3 (en) Identification of targets and development of reagents for testing and molecular imaging of human disease
WO2005072049A3 (en) Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of endometriosis
WO2007056523A3 (en) Methods for diagnosing and monitoring the progression of cancer
WO2009064901A3 (en) Diagnostic biomarkers of diabetes
WO2007121465A3 (en) Detection of proteins from circulating neoplastic cells
WO2007140185A3 (en) Methods for non-invasive analyte measurement
CN105940300A (en) Device and methods of using device for detection of hyperammonemia
WO2008055242A3 (en) Early detection of diabetes
WO2011008746A3 (en) Serum markers associated with early and other stages of breast cancer
EP1930445A4 (en) Kit and method for detection of urothelial cancer
WO2004000884A3 (en) Compositions and methods for apo-b48 and apo-b100 assay
WO2009126969A3 (en) Biomarkers for endometrial disease
EP1871894A4 (en) The 1, 5-anhydroglucitol (1, 5-ag) assay and a1c/1. 5-ag assay combination for measuring blood glucose excursions in general and postprandial hyperglycemia in diabetic patients
EP2557421A3 (en) Altered mitochondrial activity in diseases resulting from oxidative stress

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 10775402

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 10775402

Country of ref document: EP

Kind code of ref document: A2