WO2011002957A3 - Droplet actuator devices and methods - Google Patents

Droplet actuator devices and methods Download PDF

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Publication number
WO2011002957A3
WO2011002957A3 PCT/US2010/040705 US2010040705W WO2011002957A3 WO 2011002957 A3 WO2011002957 A3 WO 2011002957A3 US 2010040705 W US2010040705 W US 2010040705W WO 2011002957 A3 WO2011002957 A3 WO 2011002957A3
Authority
WO
WIPO (PCT)
Prior art keywords
provides
another embodiment
droplet
actuators
actuator devices
Prior art date
Application number
PCT/US2010/040705
Other languages
French (fr)
Other versions
WO2011002957A2 (en
Inventor
Michael G. Pollack
Vijay Srinivasan
Vamsee K. Pamula
George Brackett
Keith R. Brafford
Darius Clark
Zhishan Hua
Scott Norton
Ramakrishna Sista
Gregory F. Smith
Ryan A. Sturmer
Arjun Sudarsan
Prasanna Thwar
Tih-Hong Wang
Theodore Winger
Original Assignee
Advanced Liquid Logic, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Liquid Logic, Inc. filed Critical Advanced Liquid Logic, Inc.
Publication of WO2011002957A2 publication Critical patent/WO2011002957A2/en
Publication of WO2011002957A3 publication Critical patent/WO2011002957A3/en
Priority to US13/238,872 priority Critical patent/US8926065B2/en
Priority to US14/580,407 priority patent/US9545640B2/en
Priority to US14/870,433 priority patent/US9545641B2/en
Priority to US15/099,175 priority patent/US9707579B2/en

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/302—Micromixers the materials to be mixed flowing in the form of droplets
    • B01F33/3021—Micromixers the materials to be mixed flowing in the form of droplets the components to be mixed being combined in a single independent droplet, e.g. these droplets being divided by a non-miscible fluid or consisting of independent droplets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01F33/3031—Micromixers using electro-hydrodynamic [EHD] or electro-kinetic [EKI] phenomena to mix or move the fluids
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    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
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    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
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    • B01L2200/0689—Sealing
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    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
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    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples

Abstract

The invention provides droplet actuator devices for facilitating certain droplet actuated molecular techniques. In one embodiment, the invention provides droplet actuators that facilitate droplet operations in three dimensions. In another embodiment, the invention provides for cost-effective production of droplet actuators. In another embodiment, the invention provides for replacing one or more components of a droplet actuator. In another embodiment, the invention provides droplet actuators using printed conductive inks to form electrodes and/or ground planes. In another embodiment, the invention provides a magnetic clamping fixture for assembling droplet actuators. In another embodiment, the invention provides simple, low cost power sources for use in combination with microfluidic systems. In another embodiment, the invention provides an immunoassay multiplexing platform that uses digital microfluidics and real-time imaging of flash-based chemiluminescent signals. In still another embodiment, the invention provides droplet actuator devices that are fabricated using a plasma treatment process to raise substrate surface energy.
PCT/US2010/040705 2009-07-01 2010-07-01 Droplet actuator devices and methods WO2011002957A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US13/238,872 US8926065B2 (en) 2009-08-14 2011-09-21 Droplet actuator devices and methods
US14/580,407 US9545640B2 (en) 2009-08-14 2014-12-23 Droplet actuator devices comprising removable cartridges and methods
US14/870,433 US9545641B2 (en) 2009-08-14 2015-09-30 Droplet actuator devices and methods
US15/099,175 US9707579B2 (en) 2009-08-14 2016-04-14 Droplet actuator devices comprising removable cartridges and methods

Applications Claiming Priority (22)

Application Number Priority Date Filing Date Title
US22218509P 2009-07-01 2009-07-01
US61/222,185 2009-07-01
US22558209P 2009-07-15 2009-07-15
US61/225,582 2009-07-15
US23411409P 2009-08-14 2009-08-14
US61/234,114 2009-08-14
US23700809P 2009-08-26 2009-08-26
US61/237,008 2009-08-26
US23851209P 2009-08-31 2009-08-31
US61/238,512 2009-08-31
US24154309P 2009-09-11 2009-09-11
US61/241,543 2009-09-11
US25487709P 2009-10-26 2009-10-26
US25484909P 2009-10-26 2009-10-26
US25486509P 2009-10-26 2009-10-26
US61/254,849 2009-10-26
US61/254,877 2009-10-26
US61/254,865 2009-10-26
US28866509P 2009-12-21 2009-12-21
US61/288,665 2009-12-21
US29487410P 2010-01-14 2010-01-14
US61/294,874 2010-01-14

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/238,872 Continuation-In-Part US8926065B2 (en) 2009-08-14 2011-09-21 Droplet actuator devices and methods

Publications (2)

Publication Number Publication Date
WO2011002957A2 WO2011002957A2 (en) 2011-01-06
WO2011002957A3 true WO2011002957A3 (en) 2011-08-04

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Family Applications (1)

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PCT/US2010/040705 WO2011002957A2 (en) 2009-07-01 2010-07-01 Droplet actuator devices and methods

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