WO2011011482A3 - Variable density tissue graft composition and methods of making and using the same - Google Patents

Variable density tissue graft composition and methods of making and using the same Download PDF

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Publication number
WO2011011482A3
WO2011011482A3 PCT/US2010/042698 US2010042698W WO2011011482A3 WO 2011011482 A3 WO2011011482 A3 WO 2011011482A3 US 2010042698 W US2010042698 W US 2010042698W WO 2011011482 A3 WO2011011482 A3 WO 2011011482A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
making
tissue graft
same
variable density
Prior art date
Application number
PCT/US2010/042698
Other languages
French (fr)
Other versions
WO2011011482A4 (en
WO2011011482A2 (en
Inventor
Rodney W. Bosley, Jr.
Clay Fette
Original Assignee
Acell, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acell, Inc. filed Critical Acell, Inc.
Publication of WO2011011482A2 publication Critical patent/WO2011011482A2/en
Publication of WO2011011482A3 publication Critical patent/WO2011011482A3/en
Publication of WO2011011482A4 publication Critical patent/WO2011011482A4/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3633Extracellular matrix [ECM]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0076Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof multilayered, e.g. laminated structures
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/34Materials or treatment for tissue regeneration for soft tissue reconstruction
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10Methods of surface bonding and/or assembly therefor

Abstract

Disclosed are tissue graft compositions made of materials having different densities, methods of making, and methods of treatment for restoring tissues in a patient.
PCT/US2010/042698 2009-07-22 2010-07-21 Variable density tissue graft composition and methods of making and using the same WO2011011482A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/507,338 US8298586B2 (en) 2009-07-22 2009-07-22 Variable density tissue graft composition
US12/507,338 2009-07-22

Publications (3)

Publication Number Publication Date
WO2011011482A2 WO2011011482A2 (en) 2011-01-27
WO2011011482A3 true WO2011011482A3 (en) 2011-04-28
WO2011011482A4 WO2011011482A4 (en) 2011-06-30

Family

ID=42731901

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/042698 WO2011011482A2 (en) 2009-07-22 2010-07-21 Variable density tissue graft composition and methods of making and using the same

Country Status (2)

Country Link
US (6) US8298586B2 (en)
WO (1) WO2011011482A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9480549B2 (en) 2008-04-25 2016-11-01 Allosource Multi-layer tissue patches
US9358320B2 (en) 2008-04-25 2016-06-07 Allosource Multi-layer tissue patches
WO2010099463A2 (en) 2009-02-27 2010-09-02 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Joint bioscaffolds
US8298586B2 (en) 2009-07-22 2012-10-30 Acell Inc Variable density tissue graft composition
US20130317622A1 (en) * 2012-05-25 2013-11-28 Antonio Sambusseti Surgical method for grafting an artificial implant in a bladder and/or in a urethral or ureteral segment
US9526503B2 (en) * 2013-08-12 2016-12-27 W. L. Gore & Associates, Inc. Lumbar ostia occlusion devices and methods of deploying the same
KR102624370B1 (en) 2014-03-21 2024-01-15 유니버시티 오브 피츠버그 - 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 Methods for preparation of a terminally sterilized hydrogel derived from extracellular matrix
CN107405425B (en) * 2014-12-22 2021-03-16 阿罗阿生物外科有限公司 Laminated tissue graft product
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
CN105769381B (en) * 2015-05-26 2018-04-17 南通大学 A kind of biological sticking patch for tissue damage reparation
CN105920669B (en) * 2016-04-25 2019-03-29 上海卓阮医疗科技有限公司 A kind of compound cells epimatrix ingredients Biogenic material
US10270947B2 (en) * 2016-09-15 2019-04-23 Microsoft Technology Licensing, Llc Flat digital image sensor
CA3093611A1 (en) * 2018-03-13 2019-09-19 Institut Quimic De Sarria Cets Fundacio Privada Vascular repair patch
US11826490B1 (en) 2020-12-29 2023-11-28 Acell, Inc. Extracellular matrix sheet devices with improved mechanical properties and method of making
CN116159185B (en) * 2022-12-26 2024-04-09 烟台德胜海洋生物科技有限公司 Composite acellular matrix material and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997037613A1 (en) * 1996-04-05 1997-10-16 Depuy Orthopaedics, Inc. Tissue graft construct for replacement of cartilaginous structures
US5997575A (en) * 1996-04-05 1999-12-07 Purdue Research Foundation Perforated submucosal tissue graft constructs
US20050249772A1 (en) * 2004-05-04 2005-11-10 Prasanna Malaviya Hybrid biologic-synthetic bioabsorbable scaffolds

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT261800B (en) * 1966-08-22 1968-05-10 Braun Internat Gmbh B Process for the manufacture of tubular, smooth or threaded tissue-blood vessel prostheses
US4439521A (en) * 1981-10-21 1984-03-27 Ontario Cancer Institute Method for producing self-reproducing mammalian pancreatic islet-like structures
US4801299A (en) * 1983-06-10 1989-01-31 University Patents, Inc. Body implants of extracellular matrix and means and methods of making and using such implants
CA1295796C (en) * 1984-03-27 1992-02-18 Conrad Whyne Biodegradable matrix and methods for producing same
US4829000A (en) * 1985-08-30 1989-05-09 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Reconstituted basement membrane complex with biological activity
US4780450A (en) * 1985-12-20 1988-10-25 The University Of Maryland At Baltimore Physically stable composition and method of use thereof for osseous repair
GB8618374D0 (en) * 1986-07-28 1986-09-03 Hsc Res Dev Corp Biological vascular prostheses
US4902508A (en) * 1988-07-11 1990-02-20 Purdue Research Foundation Tissue graft composition
US4956178A (en) * 1988-07-11 1990-09-11 Purdue Research Foundation Tissue graft composition
US5336616A (en) * 1990-09-12 1994-08-09 Lifecell Corporation Method for processing and preserving collagen-based tissues for transplantation
DK0605428T5 (en) 1991-06-24 2003-01-06 Hcell Technology Inc Hormone-secreting pancreatic cells maintained in long-term culture
US5281422A (en) * 1991-09-24 1994-01-25 Purdue Research Foundation Graft for promoting autogenous tissue growth
US5334719A (en) 1992-06-17 1994-08-02 Merck Frosst Canada, Inc. Bicyclic(azaaromatic)indoles as inhibitors of leukotriene bisynthesis
US5800537A (en) * 1992-08-07 1998-09-01 Tissue Engineering, Inc. Method and construct for producing graft tissue from an extracellular matrix
US5352463A (en) * 1992-11-13 1994-10-04 Badylak Steven F Tissue graft for surgical reconstruction of a collagenous meniscus and method therefor
US5641518A (en) * 1992-11-13 1997-06-24 Purdue Research Foundation Method of repairing bone tissue
US5275826A (en) * 1992-11-13 1994-01-04 Purdue Research Foundation Fluidized intestinal submucosa and its use as an injectable tissue graft
US5607590A (en) * 1993-08-06 1997-03-04 Shimizu; Yasuhiko Material for medical use and process for preparing same
DK0871414T3 (en) 1994-03-14 2004-08-30 Cryolife Inc Methods for preparing tissue for implantation
US20020131933A1 (en) * 1996-01-16 2002-09-19 Yves Delmotte Biopolymer membrane and methods for its preparation
US6485723B1 (en) * 1995-02-10 2002-11-26 Purdue Research Foundation Enhanced submucosal tissue graft constructs
US5695998A (en) * 1995-02-10 1997-12-09 Purdue Research Foundation Submucosa as a growth substrate for islet cells
GB9721585D0 (en) * 1997-10-10 1997-12-10 Geistlich Soehne Ag Chemical product
DE69622548T2 (en) * 1995-04-07 2003-09-18 Purdue Research Foundation West Lafayette TISSUE TRANSPLANT FOR BUBBLE RECONSTRUCTION
US5711969A (en) * 1995-04-07 1998-01-27 Purdue Research Foundation Large area submucosal tissue graft constructs
US5554389A (en) * 1995-04-07 1996-09-10 Purdue Research Foundation Urinary bladder submucosa derived tissue graft
JPH09122225A (en) * 1995-10-31 1997-05-13 Bio Eng Lab:Kk Raw membrane material for medical material and manufacture thereof
JPH09122227A (en) * 1995-10-31 1997-05-13 Bio Eng Lab:Kk Medical material and manufacture thereof
DE69611025T2 (en) 1995-11-06 2001-03-22 Ford Motor Co Procedure for monitoring and testing the shear strength of riveted joints
WO1997017038A1 (en) 1995-11-09 1997-05-15 University Of Massachusetts Tissue re-surfacing with hydrogel-cell compositions
US5869041A (en) * 1996-01-12 1999-02-09 The Miriam Hospital Delivery of bioactive compounds to an organism
US6171344B1 (en) * 1996-08-16 2001-01-09 Children's Medical Center Corporation Bladder submucosa seeded with cells for tissue reconstruction
ES2208974T3 (en) * 1996-08-23 2004-06-16 Cook Biotech, Inc. PROTESIS OF GRAFT, MATERIALS AND METHODS.
JP4676580B2 (en) * 1996-11-05 2011-04-27 パーデュー・リサーチ・ファウンデーション Myocardial graft composition
TW510803B (en) 1996-11-20 2002-11-21 Yasuhiko Shimizu Man-made esophagus and its manufacturing method
EP0942739B1 (en) 1996-12-10 2006-04-12 Purdue Research Foundation Biomaterial derived from vertebrate liver tissue
CA2273250C (en) 1996-12-10 2008-01-29 Cook Biotech, Inc. Stent grafts containing purified submucosa
JP4084420B2 (en) 1996-12-10 2008-04-30 パーデュー・リサーチ・ファウンデーション Tubular submucosa graft composition
AU736572B2 (en) * 1996-12-10 2001-08-02 Purdue Research Foundation Artificial vascular valves
US5866415A (en) * 1997-03-25 1999-02-02 Villeneuve; Peter E. Materials for healing cartilage and bone defects
DE69827001T2 (en) 1997-04-11 2005-09-08 Cryolife, Inc. GEWEBEDEZELLULARIZATION
ES2175753T3 (en) 1997-06-27 2002-11-16 Augustinus Bader BIOSYNTHETIC GRAFT AND METHOD FOR PRODUCTION.
EP1042453A4 (en) * 1997-12-23 2003-05-21 Purdue Research Foundation Biomaterial derived from follicle basement membranes
MXPA00012063A (en) * 1998-06-05 2003-04-22 Organogenesis Inc Bioengineered vascular graft support prostheses.
JP2002525043A (en) 1998-09-11 2002-08-13 パーデュー・リサーチ・ファウンデーション Improved submucosal tissue graft composition
AU769637B2 (en) * 1998-11-19 2004-01-29 Organogenesis Inc. Bioengineered tissue constructs and methods for producing and using them
US6322593B1 (en) * 1999-04-09 2001-11-27 Sulzer Carbomedics Inc. Method for treating cross-linked biological tissues
EP1187909B1 (en) * 1999-04-30 2005-02-02 Massachusetts General Hospital Fabrication of threedimensional vascularized tissue using microfabricated two-dimensional molds
US6454804B1 (en) * 1999-10-08 2002-09-24 Bret A. Ferree Engineered tissue annulus fibrosis augmentation methods and apparatus
US6432712B1 (en) * 1999-11-22 2002-08-13 Bioscience Consultants, Llc Transplantable recellularized and reendothelialized vascular tissue graft
US6579538B1 (en) * 1999-12-22 2003-06-17 Acell, Inc. Tissue regenerative compositions for cardiac applications, method of making, and method of use thereof
US6576265B1 (en) * 1999-12-22 2003-06-10 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
DK2055325T3 (en) 1999-12-22 2019-09-30 Acell Inc Tissue regeneration composition
US20040043006A1 (en) * 2002-08-27 2004-03-04 Badylak Stephen F. Tissue regenerative composition
US6479064B1 (en) * 1999-12-29 2002-11-12 Children's Medical Center Corporation Culturing different cell populations on a decellularized natural biostructure for organ reconstruction
US6376244B1 (en) * 1999-12-29 2002-04-23 Children's Medical Center Corporation Methods and compositions for organ decellularization
ES2238992T3 (en) * 2000-03-09 2005-09-16 Syntacoll Ag COLLAR MATRIX OF MULTIPLE LAYERS FOR THE RECONSTRUCTION OF FABRIC.
US6638312B2 (en) * 2000-08-04 2003-10-28 Depuy Orthopaedics, Inc. Reinforced small intestinal submucosa (SIS)
US6962814B2 (en) * 2000-08-16 2005-11-08 Duke University Decellularized tissue engineered constructs and tissues
US20070122388A1 (en) * 2000-12-08 2007-05-31 Kropp Bradley P Tissue graft compositions and methods for producing same
US6827966B2 (en) * 2001-05-30 2004-12-07 Novartis Ag Diffusion-controllable coatings on medical device
US6613348B1 (en) * 2001-07-31 2003-09-02 Manoj K. Jain Process of controlling absorbency in collagen flakes
BR0214217A (en) 2001-11-16 2004-09-21 Childrens Medical Center Increased Organ Function
US7622299B2 (en) * 2002-02-22 2009-11-24 University Of Washington Bioengineered tissue substitutes
US6651637B1 (en) * 2002-10-29 2003-11-25 Transpo Electronics, Inc. Vehicle ignition system using ignition module with reduced heat generation
US20040175366A1 (en) * 2003-03-07 2004-09-09 Acell, Inc. Scaffold for cell growth and differentiation
US20050283256A1 (en) * 2004-02-09 2005-12-22 Codman & Shurtleff, Inc. Collagen device and method of preparing the same
US20050175659A1 (en) * 2004-02-09 2005-08-11 Macomber Laurel R. Collagen device and method of preparing the same
CA2560876A1 (en) 2004-03-29 2005-10-13 Cook Biotech Incorporated Medical graft products with differing regions and methods and systems for producing the same
US7569233B2 (en) * 2004-05-04 2009-08-04 Depuy Products, Inc. Hybrid biologic-synthetic bioabsorbable scaffolds
US20070166396A1 (en) * 2006-01-06 2007-07-19 University Of Pittsburgh Extracellular matrix based gastroesophageal junction reinforcement device
US7771741B2 (en) * 2006-05-01 2010-08-10 Warsaw Orthopedic, Inc Demineralized bone matrix devices
US7838022B2 (en) * 2006-05-01 2010-11-23 Warsaw Orthopedic, Inc Malleable implants containing demineralized bone matrix
CA2667214C (en) * 2006-10-23 2015-12-01 Cook Biotech Incorporated Processed ecm materials with enhanced component profiles
US20080279833A1 (en) * 2007-05-10 2008-11-13 Matheny Robert G Laminate sheet articles for tissue regeneration
CA2736663C (en) * 2007-09-07 2018-01-02 Surgical Biologics, Llc. Placental tissue grafts and improved methods of preparing and using the same
US8298586B2 (en) 2009-07-22 2012-10-30 Acell Inc Variable density tissue graft composition

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997037613A1 (en) * 1996-04-05 1997-10-16 Depuy Orthopaedics, Inc. Tissue graft construct for replacement of cartilaginous structures
US5997575A (en) * 1996-04-05 1999-12-07 Purdue Research Foundation Perforated submucosal tissue graft constructs
US20050249772A1 (en) * 2004-05-04 2005-11-10 Prasanna Malaviya Hybrid biologic-synthetic bioabsorbable scaffolds

Also Published As

Publication number Publication date
US20140018937A1 (en) 2014-01-16
WO2011011482A4 (en) 2011-06-30
US8298586B2 (en) 2012-10-30
WO2011011482A2 (en) 2011-01-27
US20150196381A1 (en) 2015-07-16
US10517994B2 (en) 2019-12-31
US20130035768A1 (en) 2013-02-07
US8962035B2 (en) 2015-02-24
US8541032B2 (en) 2013-09-24
US20170165401A1 (en) 2017-06-15
US9579183B2 (en) 2017-02-28
US20110020420A1 (en) 2011-01-27
US20200129666A1 (en) 2020-04-30

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