WO2011011482A4 - Variable density tissue graft composition and methods of making and using the same - Google Patents

Variable density tissue graft composition and methods of making and using the same Download PDF

Info

Publication number
WO2011011482A4
WO2011011482A4 PCT/US2010/042698 US2010042698W WO2011011482A4 WO 2011011482 A4 WO2011011482 A4 WO 2011011482A4 US 2010042698 W US2010042698 W US 2010042698W WO 2011011482 A4 WO2011011482 A4 WO 2011011482A4
Authority
WO
WIPO (PCT)
Prior art keywords
layer
composition
layers
tissue graft
perforations
Prior art date
Application number
PCT/US2010/042698
Other languages
French (fr)
Other versions
WO2011011482A2 (en
WO2011011482A3 (en
Inventor
Rodney W. Bosley, Jr.
Clay Fette
Original Assignee
Acell, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acell, Inc. filed Critical Acell, Inc.
Publication of WO2011011482A2 publication Critical patent/WO2011011482A2/en
Publication of WO2011011482A3 publication Critical patent/WO2011011482A3/en
Publication of WO2011011482A4 publication Critical patent/WO2011011482A4/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3633—Extracellular matrix [ECM]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0076—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof multilayered, e.g. laminated structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor

Abstract

Disclosed are tissue graft compositions made of materials having different densities, methods of making, and methods of treatment for restoring tissues in a patient.

Claims

AMENDED CLAIMS received by the International Bureau on 5th May 2011 (05.05.11)
1. A tissue graft composition, comprising:
at least two layers, at least one layer comprising an ECM having a density that differs from at least one of the other layers, each of the layers having a first planar surface and a second planar surface and each of the layers at least partially overlapping an adjacent layer.
2. The tissue graft composition of claim 1, wherein a first layer comprises raised elements and a second layer comprises depressions, said raised element of the first layer mated with said depression of the second layer to join said first and said second layers together.
3. The tissue graft composition of claim 1, wherein said at least one layer comprising a density that differs from at least one other layer is in the range of about 400% to 125% more dense than said other layer.
4. The tissue graft composition of claim 1, wherein said at least one of said layers comprises epithelial basement membrane.
5. The tissue graft composition of claim 1, wherein at least one of said two layers comprises aponeurosis.
6. The tissue graft composition of claim 1 , wherein said at least one layer is an intermediate layer positioned between two outer layers, said two outer layers devoid of perforations, said intermediate layer comprising a plurality of perforations that extend from a first planar surface of said intermediate layer to a second planar surface of said intermediate layer thereby forming a lumen in said intermediate layer that is substantially perpendicular to the first and the second planar surface of said intermediate layer.
7. A method for manufacturing a tissue graft composition, comprising:
providing a first layer of planar biological material having a first density;
providing a second layer of planar biological material comprising a second density that is less than the density of the first layer of material; and
joining the first layer to the second layer.
8. The method according to claim 7, further comprising:
introducing perforations into the first layer of material;
introducing columns into the second layer of material and compressing the first layer and the second layer of material together wherein the columns of the second layer of material are introduced into the perforations of the first layer of material to join the first layer to the second layer of material.
9. The method according to claim 8, further comprising a third layer of material, perforating said third layer of material, positioning said third layer of material between said first and said second layers of material, and introducing said columns in said second layer of material through said perforations in said third layer of material to join the first layer, the second layer and the third layers of material.
10. The method according to claim 7, further comprising perforating said first and said second layers.
11. The method according to claim 7, further comprising:
introducing raised members into the first layer of material;
introducing depressed members complementary to the raised members into the second layer of material; and
compressing the first layer and the second layer of material together wherein the raised members of the first layer of material intercalates with the depressed members of the second layer of material thereby joining the first layer to the second layer.
12. The method according to claim 11, further comprising stretching said material over a template to introduce said raised member or said depressed member into the first or the second layer of material.
13. The method according to claim 11, further comprising compressing said first or said second layer of material on a template to introduce said raised member or said depressed member into said material.
14. The method according to claim 11, wherein said first material and said second material are hydratcd materials when said first and said second materials are compressed together.
15. A method for restoring tissue damage of a joint, skin, an abdominal body wall, a thoracic body wall, a tendon, a ligament, or a hernia comprising:
providing a composition comprising a first layer and a second layer of extracellular matrix wherein the second layer has a density at least 125% of the density of the first layer; and
applying said composition to said joint, skin, abdominal body wall, thoracic body wall, tendon, ligament, or hernia.
16. The method of claim 15, wherein said first layer of said composition comprises aponeurosis.
17. The method according to claim 15, wherein said first layer comprises a plurality of perforations, each of said perforations comprising a lumen and said second layer is non- perforated, said lumen of the perforations of said first layer enclosing a portion of said second layer whereby said perforated first layer is joined to said non-perforated second layer.
18. The method of claim 15, wherein said first layer comprises epithelial basement membrane.
19. The method according to claim 18, wherein said composition is implanted in the abdominal wall of a patient and said epithelial basement membrane is positioned on the peritoneal surface of the abdominal wall.
20. A method for restoring an epithelial tissue at an anatomic site of a patient, comprising: providing a composition comprising UBM comprising epithelial basement membrane, and an ECM comprising a devitalized portion of site-specific ECM derived from said anatomic site from a mammal, wherein said epithelial basement membrane is located on a surface of said composition; and
implanting said composition at the anatomic site of the patient wherein said epithelial basement membrane is located on the epithelial side of said anatomic site.
21. The tissue graft composition of claim 1 wherein said first layer comprises a first ECM and said second layer comprises a second ECM.
22. The tissue graft composition of claim 1 wherein said ECM comprises a plurality of naturally associated components of a native ECM.
22
PCT/US2010/042698 2009-07-22 2010-07-21 Variable density tissue graft composition and methods of making and using the same WO2011011482A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/507,338 US8298586B2 (en) 2009-07-22 2009-07-22 Variable density tissue graft composition
US12/507,338 2009-07-22

Publications (3)

Publication Number Publication Date
WO2011011482A2 WO2011011482A2 (en) 2011-01-27
WO2011011482A3 WO2011011482A3 (en) 2011-04-28
WO2011011482A4 true WO2011011482A4 (en) 2011-06-30

Family

ID=42731901

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/042698 WO2011011482A2 (en) 2009-07-22 2010-07-21 Variable density tissue graft composition and methods of making and using the same

Country Status (2)

Country Link
US (6) US8298586B2 (en)
WO (1) WO2011011482A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9480549B2 (en) 2008-04-25 2016-11-01 Allosource Multi-layer tissue patches
US9358320B2 (en) * 2008-04-25 2016-06-07 Allosource Multi-layer tissue patches
US9277999B2 (en) 2009-02-27 2016-03-08 University of Pittsburgh—of the Commonwealth System of Higher Education Joint bioscaffolds
US8298586B2 (en) 2009-07-22 2012-10-30 Acell Inc Variable density tissue graft composition
US20130317622A1 (en) * 2012-05-25 2013-11-28 Antonio Sambusseti Surgical method for grafting an artificial implant in a bladder and/or in a urethral or ureteral segment
US9526503B2 (en) * 2013-08-12 2016-12-27 W. L. Gore & Associates, Inc. Lumbar ostia occlusion devices and methods of deploying the same
JP6681872B2 (en) 2014-03-21 2020-04-15 ユニバーシティ オブ ピッツバーグ −オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション Method for preparing final sterile hydrogel derived from extracellular matrix
EP3237028B1 (en) * 2014-12-22 2021-01-27 Aroa Biosurgery Limited Laminated tissue graft product
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
CN105769381B (en) * 2015-05-26 2018-04-17 南通大学 A kind of biological sticking patch for tissue damage reparation
CN105920669B (en) * 2016-04-25 2019-03-29 上海卓阮医疗科技有限公司 A kind of compound cells epimatrix ingredients Biogenic material
US10270947B2 (en) * 2016-09-15 2019-04-23 Microsoft Technology Licensing, Llc Flat digital image sensor
CA3093611A1 (en) * 2018-03-13 2019-09-19 Institut Quimic De Sarria Cets Fundacio Privada Vascular repair patch
US11826490B1 (en) 2020-12-29 2023-11-28 Acell, Inc. Extracellular matrix sheet devices with improved mechanical properties and method of making

Family Cites Families (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT261800B (en) 1966-08-22 1968-05-10 Braun Internat Gmbh B Process for the manufacture of tubular, smooth or threaded tissue-blood vessel prostheses
US4439521A (en) 1981-10-21 1984-03-27 Ontario Cancer Institute Method for producing self-reproducing mammalian pancreatic islet-like structures
US4801299A (en) 1983-06-10 1989-01-31 University Patents, Inc. Body implants of extracellular matrix and means and methods of making and using such implants
CA1295796C (en) 1984-03-27 1992-02-18 Conrad Whyne Biodegradable matrix and methods for producing same
US4829000A (en) 1985-08-30 1989-05-09 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Reconstituted basement membrane complex with biological activity
US4780450A (en) 1985-12-20 1988-10-25 The University Of Maryland At Baltimore Physically stable composition and method of use thereof for osseous repair
GB8618374D0 (en) 1986-07-28 1986-09-03 Hsc Res Dev Corp Biological vascular prostheses
US4902508A (en) 1988-07-11 1990-02-20 Purdue Research Foundation Tissue graft composition
US4956178A (en) 1988-07-11 1990-09-11 Purdue Research Foundation Tissue graft composition
US5336616A (en) 1990-09-12 1994-08-09 Lifecell Corporation Method for processing and preserving collagen-based tissues for transplantation
AU2228592A (en) 1991-06-24 1993-01-25 Pacific Biomedical Research, Inc. Hormone-secreting cells maintained in long-term culture
US5281422A (en) 1991-09-24 1994-01-25 Purdue Research Foundation Graft for promoting autogenous tissue growth
US5334719A (en) 1992-06-17 1994-08-02 Merck Frosst Canada, Inc. Bicyclic(azaaromatic)indoles as inhibitors of leukotriene bisynthesis
US5800537A (en) 1992-08-07 1998-09-01 Tissue Engineering, Inc. Method and construct for producing graft tissue from an extracellular matrix
US5275826A (en) 1992-11-13 1994-01-04 Purdue Research Foundation Fluidized intestinal submucosa and its use as an injectable tissue graft
US5641518A (en) 1992-11-13 1997-06-24 Purdue Research Foundation Method of repairing bone tissue
US5352463A (en) 1992-11-13 1994-10-04 Badylak Steven F Tissue graft for surgical reconstruction of a collagenous meniscus and method therefor
US5607590A (en) * 1993-08-06 1997-03-04 Shimizu; Yasuhiko Material for medical use and process for preparing same
DK0871414T3 (en) 1994-03-14 2004-08-30 Cryolife Inc Methods for preparing tissue for implantation
US20020131933A1 (en) * 1996-01-16 2002-09-19 Yves Delmotte Biopolymer membrane and methods for its preparation
US6485723B1 (en) 1995-02-10 2002-11-26 Purdue Research Foundation Enhanced submucosal tissue graft constructs
US5695998A (en) 1995-02-10 1997-12-09 Purdue Research Foundation Submucosa as a growth substrate for islet cells
GB9721585D0 (en) * 1997-10-10 1997-12-10 Geistlich Soehne Ag Chemical product
US5711969A (en) 1995-04-07 1998-01-27 Purdue Research Foundation Large area submucosal tissue graft constructs
US5554389A (en) 1995-04-07 1996-09-10 Purdue Research Foundation Urinary bladder submucosa derived tissue graft
DE69622548T2 (en) 1995-04-07 2003-09-18 Purdue Research Foundation West Lafayette TISSUE TRANSPLANT FOR BUBBLE RECONSTRUCTION
JPH09122225A (en) 1995-10-31 1997-05-13 Bio Eng Lab:Kk Raw membrane material for medical material and manufacture thereof
JPH09122227A (en) 1995-10-31 1997-05-13 Bio Eng Lab:Kk Medical material and manufacture thereof
DE69611025T2 (en) 1995-11-06 2001-03-22 Ford Motor Co Procedure for monitoring and testing the shear strength of riveted joints
WO1997017038A1 (en) 1995-11-09 1997-05-15 University Of Massachusetts Tissue re-surfacing with hydrogel-cell compositions
US5869041A (en) 1996-01-12 1999-02-09 The Miriam Hospital Delivery of bioactive compounds to an organism
US5755791A (en) 1996-04-05 1998-05-26 Purdue Research Foundation Perforated submucosal tissue graft constructs
US5788625A (en) 1996-04-05 1998-08-04 Depuy Orthopaedics, Inc. Method of making reconstructive SIS structure for cartilaginous elements in situ
US6171344B1 (en) 1996-08-16 2001-01-09 Children's Medical Center Corporation Bladder submucosa seeded with cells for tissue reconstruction
DE69725592T2 (en) 1996-08-23 2004-08-05 Cook Biotech, Inc., West Lafayette METHOD FOR OBTAINING A SUITABLE COLLAGEN-BASED MATRIX FROM SUBMUKOSA TISSUE
US6096347A (en) 1996-11-05 2000-08-01 Purdue Research Foundation Myocardial graft constructs
TW510803B (en) 1996-11-20 2002-11-21 Yasuhiko Shimizu Man-made esophagus and its manufacturing method
EP1671604B1 (en) 1996-12-10 2009-07-22 Purdue Research Foundation Synthetic tissue valve
CA2274033C (en) 1996-12-10 2010-05-11 Purdue Research Foundation Biomaterial derived from vertebrate liver tissue
JP4074666B2 (en) 1996-12-10 2008-04-09 クック バイオテック、インク． Tubular grafts from purified submucosa
AU5520898A (en) 1996-12-10 1998-07-03 Purdue Research Foundation Stent with reduced thrombogenicity
US5866415A (en) 1997-03-25 1999-02-02 Villeneuve; Peter E. Materials for healing cartilage and bone defects
DK0987998T3 (en) 1997-04-11 2005-01-17 Cryolife Inc Decellulation of tissue
EP0989867B1 (en) 1997-06-27 2002-04-24 BADER, Augustinus Biosynthetic transplant and method for the production thereof
US6485969B1 (en) 1997-12-23 2002-11-26 Purdue Research Foundation Biomaterial derived from follicle basement membranes
EP1083843A4 (en) 1998-06-05 2005-06-08 Organogenesis Inc Bioengineered vascular graft support prostheses
AU766719B2 (en) 1998-09-11 2003-10-23 Purdue Research Foundation Enhanced submucosal tissue graft constructs
CA2351396C (en) 1998-11-19 2012-08-14 Organogenesis Inc. Bioengineered tissue constructs and methods for producing and using them
US6322593B1 (en) 1999-04-09 2001-11-27 Sulzer Carbomedics Inc. Method for treating cross-linked biological tissues
DE60017900T2 (en) 1999-04-30 2006-04-06 Massachusetts General Hospital, Boston PREPARATION OF THREE-DIMENSIONAL VASCULARIZED TISSUE BY USING TWO-DIMENSIONAL MICRO-MADE SHAPES
US6454804B1 (en) 1999-10-08 2002-09-24 Bret A. Ferree Engineered tissue annulus fibrosis augmentation methods and apparatus
US6432712B1 (en) 1999-11-22 2002-08-13 Bioscience Consultants, Llc Transplantable recellularized and reendothelialized vascular tissue graft
DE60041611D1 (en) 1999-12-22 2009-04-02 Acell Inc Composition for tissue regeneration
US6579538B1 (en) 1999-12-22 2003-06-17 Acell, Inc. Tissue regenerative compositions for cardiac applications, method of making, and method of use thereof
US6576265B1 (en) 1999-12-22 2003-06-10 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
US20040043006A1 (en) 2002-08-27 2004-03-04 Badylak Stephen F. Tissue regenerative composition
US6376244B1 (en) 1999-12-29 2002-04-23 Children's Medical Center Corporation Methods and compositions for organ decellularization
US6479064B1 (en) 1999-12-29 2002-11-12 Children's Medical Center Corporation Culturing different cell populations on a decellularized natural biostructure for organ reconstruction
DE60018480T2 (en) * 2000-03-09 2006-02-16 Syntacoll Ag MULTILAYER COLLAGEN MATRIX FOR TISSUE CONSTRUCTION
US6638312B2 (en) * 2000-08-04 2003-10-28 Depuy Orthopaedics, Inc. Reinforced small intestinal submucosa (SIS)
WO2002014480A2 (en) 2000-08-16 2002-02-21 Duke University Decellularized tissue engineered constructs and tissues
US20070122388A1 (en) * 2000-12-08 2007-05-31 Kropp Bradley P Tissue graft compositions and methods for producing same
US6827966B2 (en) 2001-05-30 2004-12-07 Novartis Ag Diffusion-controllable coatings on medical device
US6613348B1 (en) 2001-07-31 2003-09-02 Manoj K. Jain Process of controlling absorbency in collagen flakes
BR0214217A (en) 2001-11-16 2004-09-21 Childrens Medical Center Increased Organ Function
US7622299B2 (en) 2002-02-22 2009-11-24 University Of Washington Bioengineered tissue substitutes
US6651637B1 (en) * 2002-10-29 2003-11-25 Transpo Electronics, Inc. Vehicle ignition system using ignition module with reduced heat generation
US20040175366A1 (en) 2003-03-07 2004-09-09 Acell, Inc. Scaffold for cell growth and differentiation
US20050175659A1 (en) 2004-02-09 2005-08-11 Macomber Laurel R. Collagen device and method of preparing the same
US20050283256A1 (en) 2004-02-09 2005-12-22 Codman & Shurtleff, Inc. Collagen device and method of preparing the same
GB2451785B (en) 2004-03-29 2009-03-25 Cook Biotech Inc Medical graft products with differing regions
US20050249772A1 (en) 2004-05-04 2005-11-10 Prasanna Malaviya Hybrid biologic-synthetic bioabsorbable scaffolds
US7569233B2 (en) * 2004-05-04 2009-08-04 Depuy Products, Inc. Hybrid biologic-synthetic bioabsorbable scaffolds
WO2007084278A2 (en) * 2006-01-06 2007-07-26 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Extracellular matrix based gastroesophageal junction reinforcement device
US7771741B2 (en) 2006-05-01 2010-08-10 Warsaw Orthopedic, Inc Demineralized bone matrix devices
US7838022B2 (en) 2006-05-01 2010-11-23 Warsaw Orthopedic, Inc Malleable implants containing demineralized bone matrix
AU2007325460B2 (en) * 2006-10-23 2013-09-05 Cook Biotech Incorporated Processed ECM materials with enhanced component profiles
US20080279833A1 (en) * 2007-05-10 2008-11-13 Matheny Robert G Laminate sheet articles for tissue regeneration
CA2736663C (en) * 2007-09-07 2018-01-02 Surgical Biologics, Llc. Placental tissue grafts and improved methods of preparing and using the same
US8298586B2 (en) 2009-07-22 2012-10-30 Acell Inc Variable density tissue graft composition

Also Published As

Publication number Publication date
US8962035B2 (en) 2015-02-24
US20110020420A1 (en) 2011-01-27
US20130035768A1 (en) 2013-02-07
US20150196381A1 (en) 2015-07-16
US10517994B2 (en) 2019-12-31
US20170165401A1 (en) 2017-06-15
US20140018937A1 (en) 2014-01-16
US8298586B2 (en) 2012-10-30
WO2011011482A2 (en) 2011-01-27
US8541032B2 (en) 2013-09-24
WO2011011482A3 (en) 2011-04-28
US20200129666A1 (en) 2020-04-30
US9579183B2 (en) 2017-02-28

Similar Documents

Publication Publication Date Title
WO2011011482A4 (en) Variable density tissue graft composition and methods of making and using the same
US10220114B2 (en) Tissue repair implant
CN105007858B (en) Surgical implant
US9750594B2 (en) Soft tissue implants and methods for making same
EP2448497B1 (en) Device for treatment of incision or hernia
DE69635241T2 (en) LARGE-SIZED TRANSPLANTS FROM SUBMUCOSAL FABRIC AND METHOD FOR THEIR PRODUCTION
US10285795B2 (en) Method and apparatus for creating a reconstructive graft
JP5567124B2 (en) Incision closure device and method
US10478168B2 (en) Device and method for treatment of incision or hernia
WO2005034763A8 (en) Devices, systems, and methods for suturing tissue
EP1306061A3 (en) Absorbable mesh implant
WO2008021921B1 (en) Medical implant sheets useful for tissue regeneration
US20170239051A1 (en) Surgical membrane
WO2003099230A3 (en) Electroprocessed collagen and tissue engineering
RU2400160C1 (en) Technique for prosthetic inguinal hernioplasty
CA2575007A1 (en) Implant for treating rotator cuff injuries
CN206714851U (en) Compound cross linked porous breast sticking patch
US11877921B2 (en) Method and apparatus for creating a modified tissue graft
WO2022146730A1 (en) Implantable pouch device and methods of making thereof
WO2002007584A3 (en) Method for recellularization of a decellularized heart valve and heart valve produced thereby

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 10737709

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase in:

Ref country code: DE

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC (EPO FORM 1205N DATED 30.03.2012)

122 Ep: pct application non-entry in european phase

Ref document number: 10737709

Country of ref document: EP

Kind code of ref document: A2