WO2011035177A3 - High-throughput screening - Google Patents
High-throughput screening Download PDFInfo
- Publication number
- WO2011035177A3 WO2011035177A3 PCT/US2010/049362 US2010049362W WO2011035177A3 WO 2011035177 A3 WO2011035177 A3 WO 2011035177A3 US 2010049362 W US2010049362 W US 2010049362W WO 2011035177 A3 WO2011035177 A3 WO 2011035177A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- throughput screening
- layout
- test compound
- microarray
- provides methods
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
- B01J2219/00315—Microtiter plates
- B01J2219/00317—Microwell devices, i.e. having large numbers of wells
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00504—Pins
- B01J2219/00509—Microcolumns
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00527—Sheets
- B01J2219/00531—Sheets essentially square
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00702—Processes involving means for analysing and characterising the products
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00722—Nucleotides
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00725—Peptides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/0074—Biological products
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/0074—Biological products
- B01J2219/00743—Cells
Abstract
The invention provides a high throughput screening device having a microwell microarray and a printed microarray of test compound deposits. The layout of the test compound deposits matches the layout of the microwells such that each deposit addresses a single microwell when the two arrays are contacted with each other. The invention further provides methods of screening test compounds for biological activity using the device. The invention also provides methods of fabricating the device.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24328309P | 2009-09-17 | 2009-09-17 | |
US61/243,283 | 2009-09-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2011035177A2 WO2011035177A2 (en) | 2011-03-24 |
WO2011035177A3 true WO2011035177A3 (en) | 2011-10-20 |
Family
ID=43759294
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2010/049362 WO2011035177A2 (en) | 2009-09-17 | 2010-09-17 | High-throughput screening |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2011035177A2 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0913258D0 (en) | 2009-07-29 | 2009-09-02 | Dynex Technologies Inc | Reagent dispenser |
US9523701B2 (en) | 2009-07-29 | 2016-12-20 | Dynex Technologies, Inc. | Sample plate systems and methods |
CN102533537B (en) * | 2011-12-29 | 2013-10-23 | 云南师范大学 | Device and method for screening growth and migration behaviors of cells in three-dimensional matrixes at high throughput |
EP2971280B1 (en) * | 2013-03-15 | 2018-08-29 | Arizona Board of Regents on behalf of Arizona State University | Biosensor microarray compositions and methods |
TWI601947B (en) | 2016-04-14 | 2017-10-11 | Ce Biotechnology Inc | Biological particle capture and capture system and method |
WO2017223254A1 (en) * | 2016-06-21 | 2017-12-28 | Massachusetts Institute Of Technology | Methods for cell proliferation and toxicity testing |
CN107843728B (en) * | 2016-09-21 | 2019-10-29 | 曦医生技股份有限公司 | Biological particle captures and acquisition system and method |
US11390836B2 (en) * | 2016-11-17 | 2022-07-19 | Cleveland State University | Chip platforms for microarray 3D bioprinting |
US20220355289A1 (en) * | 2019-04-19 | 2022-11-10 | The Regents Of The University Of Michigan | Systems and methods for multi-target deposition and assays |
US11866685B2 (en) * | 2019-09-27 | 2024-01-09 | University Of South Carolina | Temperature responsive device for mechanobiological manipulation |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6447723B1 (en) * | 2000-03-13 | 2002-09-10 | Packard Instrument Company, Inc. | Microarray spotting instruments incorporating sensors and methods of using sensors for improving performance of microarray spotting instruments |
EP1333286A1 (en) * | 2000-09-18 | 2003-08-06 | I-Card Corporation | Micro well array and method of sealing liquid using the micro well array |
US20080200342A1 (en) * | 2007-02-15 | 2008-08-21 | Rao Rupa S | Device, Array, And Methods For Disease Detection And Analysis |
US7566533B2 (en) * | 2000-11-27 | 2009-07-28 | Intelligent Medical Devices, Inc. | Clinically intelligent diagnostic devices and methods |
-
2010
- 2010-09-17 WO PCT/US2010/049362 patent/WO2011035177A2/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6447723B1 (en) * | 2000-03-13 | 2002-09-10 | Packard Instrument Company, Inc. | Microarray spotting instruments incorporating sensors and methods of using sensors for improving performance of microarray spotting instruments |
EP1333286A1 (en) * | 2000-09-18 | 2003-08-06 | I-Card Corporation | Micro well array and method of sealing liquid using the micro well array |
US7566533B2 (en) * | 2000-11-27 | 2009-07-28 | Intelligent Medical Devices, Inc. | Clinically intelligent diagnostic devices and methods |
US20080200342A1 (en) * | 2007-02-15 | 2008-08-21 | Rao Rupa S | Device, Array, And Methods For Disease Detection And Analysis |
Also Published As
Publication number | Publication date |
---|---|
WO2011035177A2 (en) | 2011-03-24 |
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