WO2011047387A3 - Treatment planning for electroporation-based therapies - Google Patents

Treatment planning for electroporation-based therapies Download PDF

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Publication number
WO2011047387A3
WO2011047387A3 PCT/US2010/053077 US2010053077W WO2011047387A3 WO 2011047387 A3 WO2011047387 A3 WO 2011047387A3 US 2010053077 W US2010053077 W US 2010053077W WO 2011047387 A3 WO2011047387 A3 WO 2011047387A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
electroporation
based therapies
methods
devices
Prior art date
Application number
PCT/US2010/053077
Other languages
French (fr)
Other versions
WO2011047387A2 (en
Inventor
Robert E. Neal
Paulo A. Garcia
Rafael V. Davalos
John H. Rossmeisl
John L. Robertson
Original Assignee
Virginia Tech Intellectual Properties, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virginia Tech Intellectual Properties, Inc. filed Critical Virginia Tech Intellectual Properties, Inc.
Priority to EP10824248.8A priority Critical patent/EP2488251A4/en
Publication of WO2011047387A2 publication Critical patent/WO2011047387A2/en
Publication of WO2011047387A3 publication Critical patent/WO2011047387A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

The present invention provides systems, methods, and devices for electroporation- based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
PCT/US2010/053077 2009-10-16 2010-10-18 Treatment planning for electroporation-based therapies WO2011047387A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP10824248.8A EP2488251A4 (en) 2009-10-16 2010-10-18 Treatment planning for electroporation-based therapies

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25244509P 2009-10-16 2009-10-16
US61/252,445 2009-10-16

Publications (2)

Publication Number Publication Date
WO2011047387A2 WO2011047387A2 (en) 2011-04-21
WO2011047387A3 true WO2011047387A3 (en) 2011-09-29

Family

ID=43876931

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/053077 WO2011047387A2 (en) 2009-10-16 2010-10-18 Treatment planning for electroporation-based therapies

Country Status (2)

Country Link
EP (1) EP2488251A4 (en)
WO (1) WO2011047387A2 (en)

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US6994706B2 (en) 2001-08-13 2006-02-07 Minnesota Medical Physics, Llc Apparatus and method for treatment of benign prostatic hyperplasia
US9198733B2 (en) 2008-04-29 2015-12-01 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
US10272178B2 (en) 2008-04-29 2019-04-30 Virginia Tech Intellectual Properties Inc. Methods for blood-brain barrier disruption using electrical energy
US10238447B2 (en) 2008-04-29 2019-03-26 Virginia Tech Intellectual Properties, Inc. System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress
US11272979B2 (en) 2008-04-29 2022-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US8992517B2 (en) 2008-04-29 2015-03-31 Virginia Tech Intellectual Properties Inc. Irreversible electroporation to treat aberrant cell masses
US9867652B2 (en) 2008-04-29 2018-01-16 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
US10245098B2 (en) 2008-04-29 2019-04-02 Virginia Tech Intellectual Properties, Inc. Acute blood-brain barrier disruption using electrical energy based therapy
US11254926B2 (en) 2008-04-29 2022-02-22 Virginia Tech Intellectual Properties, Inc. Devices and methods for high frequency electroporation
US10702326B2 (en) 2011-07-15 2020-07-07 Virginia Tech Intellectual Properties, Inc. Device and method for electroporation based treatment of stenosis of a tubular body part
AU2009243079A1 (en) 2008-04-29 2009-11-05 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation to create tissue scaffolds
US10117707B2 (en) 2008-04-29 2018-11-06 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US9283051B2 (en) 2008-04-29 2016-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating a treatment volume for administering electrical-energy based therapies
US11382681B2 (en) 2009-04-09 2022-07-12 Virginia Tech Intellectual Properties, Inc. Device and methods for delivery of high frequency electrical pulses for non-thermal ablation
US11638603B2 (en) 2009-04-09 2023-05-02 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
WO2010118387A1 (en) 2009-04-09 2010-10-14 Virginia Tech Intellectual Properties, Inc. Integration of very short electric pulses for minimally to noninvasive electroporation
WO2010138919A2 (en) 2009-05-28 2010-12-02 Angiodynamics, Inc. System and method for synchronizing energy delivery to the cardiac rhythm
US9895189B2 (en) 2009-06-19 2018-02-20 Angiodynamics, Inc. Methods of sterilization and treating infection using irreversible electroporation
WO2012051433A2 (en) 2010-10-13 2012-04-19 Angiodynamics, Inc. System and method for electrically ablating tissue of a patient
WO2012088149A2 (en) 2010-12-20 2012-06-28 Virginia Tech Intellectual Properties, Inc. High-frequency electroporation for cancer therapy
US9078665B2 (en) 2011-09-28 2015-07-14 Angiodynamics, Inc. Multiple treatment zone ablation probe
RU2524194C2 (en) * 2012-06-07 2014-07-27 Андрей Леонидович Шпади Method of treating cancer tumours
WO2014149728A1 (en) * 2013-03-15 2014-09-25 Empi, Inc. Personalized image-based guidance for energy-based therapeutic devices
AU2015259303B2 (en) 2014-05-12 2021-10-28 Arena, Christopher B. Selective modulation of intracellular effects of cells using pulsed electric fields
WO2016017045A1 (en) 2014-07-28 2016-02-04 ネッパジーン株式会社 Electric pulse generator for electroporator, and electroporator system provided with electric pulse generator
WO2016100325A1 (en) 2014-12-15 2016-06-23 Virginia Tech Intellectual Properties, Inc. Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment
CN115737104A (en) * 2015-03-31 2023-03-07 昂科赛克医疗公司 Systems and methods for improved tissue sensing-based electroporation
US11337749B2 (en) 2015-10-07 2022-05-24 Mayo Foundation For Medical Education And Research Electroporation for obesity or diabetes treatment
DK3474760T3 (en) 2016-06-27 2023-03-20 Galvanize Therapeutics Inc Generator and a catheter with an electrode for treating a lung passage
US10905492B2 (en) 2016-11-17 2021-02-02 Angiodynamics, Inc. Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode
US11607537B2 (en) 2017-12-05 2023-03-21 Virginia Tech Intellectual Properties, Inc. Method for treating neurological disorders, including tumors, with electroporation
US11311329B2 (en) 2018-03-13 2022-04-26 Virginia Tech Intellectual Properties, Inc. Treatment planning for immunotherapy based treatments using non-thermal ablation techniques
US11925405B2 (en) 2018-03-13 2024-03-12 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
MX2020013431A (en) * 2018-07-18 2021-05-27 Novocure Gmbh Using power loss density and related measures to quantify the dose of tumor treating fields (ttfields).
CN110135073B (en) * 2019-05-17 2023-06-16 沈阳大学 Ultrahigh-strength aluminum alloy pulse current regulation casting and rolling simulation method
US11950835B2 (en) 2019-06-28 2024-04-09 Virginia Tech Intellectual Properties, Inc. Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy
CN114730631A (en) * 2019-12-02 2022-07-08 诺沃库勒有限责任公司 Method and apparatus for optimizing transducer array placement
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WO2023167747A2 (en) * 2021-11-26 2023-09-07 Old Dominion University Research Foundation Enhanced focal stimulation by spatiotemporal summation of nanosecond electric pulses

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US20040009459A1 (en) * 2002-05-06 2004-01-15 Anderson James H. Simulation system for medical procedures
US20060264752A1 (en) * 2005-04-27 2006-11-23 The Regents Of The University Of California Electroporation controlled with real time imaging

Non-Patent Citations (1)

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Also Published As

Publication number Publication date
EP2488251A2 (en) 2012-08-22
EP2488251A4 (en) 2014-02-19
WO2011047387A2 (en) 2011-04-21

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