WO2011153122A3 - Apparatus and methods for preparation and analysis of dried samples of a biological fluid - Google Patents

Apparatus and methods for preparation and analysis of dried samples of a biological fluid Download PDF

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Publication number
WO2011153122A3
WO2011153122A3 PCT/US2011/038494 US2011038494W WO2011153122A3 WO 2011153122 A3 WO2011153122 A3 WO 2011153122A3 US 2011038494 W US2011038494 W US 2011038494W WO 2011153122 A3 WO2011153122 A3 WO 2011153122A3
Authority
WO
WIPO (PCT)
Prior art keywords
impermeable
region
sample
planar
fluid sample
Prior art date
Application number
PCT/US2011/038494
Other languages
French (fr)
Other versions
WO2011153122A2 (en
Inventor
Moon Chul Jung
Edouard S. P. Bouvier
Geoff C. Gerhardt
Original Assignee
Waters Technologies Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Waters Technologies Corporation filed Critical Waters Technologies Corporation
Priority to US13/698,164 priority Critical patent/US20130068043A1/en
Publication of WO2011153122A2 publication Critical patent/WO2011153122A2/en
Publication of WO2011153122A3 publication Critical patent/WO2011153122A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/405—Concentrating samples by adsorption or absorption
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • G01N2001/2873—Cutting or cleaving
    • G01N2001/288—Filter punches
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
    • G01N2001/4088—Concentrating samples by other techniques involving separation of suspended solids filtration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N2030/009—Extraction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G01N2030/062—Preparation extracting sample from raw material

Abstract

Described is a device for collecting a fluid sample, such as a biological fluid sample. The device includes a planar collection substrate having an absorbent material. The planar collection substrate includes an impermeable region and a sample collection region. The impermeable region is impermeable to the fluid sample and is embedded in the planar collection substrate in a spatial pattern. The sample collection region is in an area excluded from the spatial pattern and has a shape and a size defined by the spatial pattern. The sample collection region is configured to receive a known volume of the fluid sample. In an alternative form, the device includes a sample collection element disposed in an impermeable planar holder and, in another alternative form, the device includes an absorbent material disposed inside an impermeable tube wall.
PCT/US2011/038494 2010-06-01 2011-05-31 Apparatus and methods for preparation and analysis of dried samples of a biological fluid WO2011153122A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US13/698,164 US20130068043A1 (en) 2010-06-01 2011-05-31 Apparatus and methods for preparation and analysis of dried samples of a biological fluid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35017610P 2010-06-01 2010-06-01
US61/350,176 2010-06-01

Publications (2)

Publication Number Publication Date
WO2011153122A2 WO2011153122A2 (en) 2011-12-08
WO2011153122A3 true WO2011153122A3 (en) 2012-02-09

Family

ID=45067251

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/038494 WO2011153122A2 (en) 2010-06-01 2011-05-31 Apparatus and methods for preparation and analysis of dried samples of a biological fluid

Country Status (1)

Country Link
WO (1) WO2011153122A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013122754A1 (en) 2012-02-14 2013-08-22 Waters Technologies Corporation Dried sample carrier having dissolvable sample collection regions
WO2014058615A2 (en) 2012-10-09 2014-04-17 Waters Technologies Corporation Apparatus and method for analyte extraction

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4994238A (en) * 1988-06-09 1991-02-19 Daffern George M Constant volume chemical analysis test device
US5935520A (en) * 1993-04-20 1999-08-10 Fuji Photo Film Co., Ltd. Dry analytical element
US20030104510A1 (en) * 2001-12-05 2003-06-05 Yu Yeung Siu Test strips having a plurality of reaction zones and methods for using and manufacturing the same
US20090075390A1 (en) * 2007-09-19 2009-03-19 Claros Diagnostics, Inc. Liquid containment for integrated assays

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4994238A (en) * 1988-06-09 1991-02-19 Daffern George M Constant volume chemical analysis test device
US5935520A (en) * 1993-04-20 1999-08-10 Fuji Photo Film Co., Ltd. Dry analytical element
US20030104510A1 (en) * 2001-12-05 2003-06-05 Yu Yeung Siu Test strips having a plurality of reaction zones and methods for using and manufacturing the same
US20090075390A1 (en) * 2007-09-19 2009-03-19 Claros Diagnostics, Inc. Liquid containment for integrated assays

Also Published As

Publication number Publication date
WO2011153122A2 (en) 2011-12-08

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