WO2012031342A3 - Polymer system and method for encapsulating human amylin and agonist analogues, and use thereof; released amylin functional evaluation method - Google Patents

Polymer system and method for encapsulating human amylin and agonist analogues, and use thereof; released amylin functional evaluation method Download PDF

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Publication number
WO2012031342A3
WO2012031342A3 PCT/BR2011/000316 BR2011000316W WO2012031342A3 WO 2012031342 A3 WO2012031342 A3 WO 2012031342A3 BR 2011000316 W BR2011000316 W BR 2011000316W WO 2012031342 A3 WO2012031342 A3 WO 2012031342A3
Authority
WO
WIPO (PCT)
Prior art keywords
amylin
released
polymer system
agonist analogues
functional evaluation
Prior art date
Application number
PCT/BR2011/000316
Other languages
French (fr)
Portuguese (pt)
Other versions
WO2012031342A2 (en
Inventor
Luis Mauríco TRAMBAIOLI DA ROCHA E LIMA
Luiz Henrique Guerreiro Rosado
Camile Moreira Mascarenhas
Eduardo RICCI JÚNIOR
Original Assignee
Universidade Federal Do Rio De Janeiro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidade Federal Do Rio De Janeiro filed Critical Universidade Federal Do Rio De Janeiro
Publication of WO2012031342A2 publication Critical patent/WO2012031342A2/en
Publication of WO2012031342A3 publication Critical patent/WO2012031342A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones

Abstract

Diabetes mellitus is a disease which, according to the World Health Organisation, is responsible for a significant proportion of deaths throughout the world. In spite of the large number of glycemic control products aimed at diabetes, there still exist pharmacological and pharmacokinetic gaps to be filled. The present invention aims at describing a method for developing a polymer system for encapsulating amylin and agonist analogues in the form of nanoparticles and microparticles. Another object of the invention is a method of functional in vitro evaluation of amylin released from polymer encapsulation systems. The invention further describes the use of the system for producing a medicament for amylin replenishment therapy in patients, which can be used for treating or preventing metabolic diseases.
PCT/BR2011/000316 2010-09-08 2011-09-08 Polymer system and method for encapsulating human amylin and agonist analogues, and use thereof; released amylin functional evaluation method WO2012031342A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BRPI1003424-2 2010-09-08
BRPI1003424-2A BRPI1003424A2 (en) 2010-09-08 2010-09-08 human amylin containment polymeric system and agonist analogs, process and use; functional assessment process of released amylin

Publications (2)

Publication Number Publication Date
WO2012031342A2 WO2012031342A2 (en) 2012-03-15
WO2012031342A3 true WO2012031342A3 (en) 2012-05-03

Family

ID=45811001

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BR2011/000316 WO2012031342A2 (en) 2010-09-08 2011-09-08 Polymer system and method for encapsulating human amylin and agonist analogues, and use thereof; released amylin functional evaluation method

Country Status (2)

Country Link
BR (1) BRPI1003424A2 (en)
WO (1) WO2012031342A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR102013017626A2 (en) * 2013-06-14 2015-02-10 Univ Rio De Janeiro NON-AGGLOMANTANT BIOCONJUGATES WITH POLYETHYLENEGLYCOL, NON-AGGLOMANTANT BIOCONJUGATES WITH POLYETHYLENEGLYCOL, PHARMACEUTICAL COMPOSITIONS OF LOW TOXICITY, ADJUSTING OR PREVENTION OF THE PREVENTION OF PREVENTION MEASUREMENT
CN103432632B (en) * 2013-09-16 2015-11-25 姚静 A kind of thermosensitive in situ gel compositions and preparation method

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS608382A (en) * 1983-06-28 1985-01-17 Hitachi Chem Co Ltd Preparation of fluorescent particle
EP0467389A2 (en) * 1990-07-19 1992-01-22 University Of Kentucky Research Foundation Drug delivery system involving interaction between protein or polypeptide and hydrophobic biodegradable polymer
WO1994015587A2 (en) * 1993-01-06 1994-07-21 Kinerton Limited Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides
EP1240896A2 (en) * 1998-07-23 2002-09-18 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Encapsulation of water soluble peptides
US20040228833A1 (en) * 2002-10-17 2004-11-18 Costantino Henry R. Microencapsulation and sustained release of biologically active polypeptides
WO2010017215A2 (en) * 2008-08-04 2010-02-11 The Regents Of The University Of California Biodegradable microspheres and methods of use thereof
BRPI0905179A2 (en) * 2009-12-21 2011-08-23 Univ Rio De Janeiro pharmaceutical composition containing amino acids encompassed in a nanoparticulate system and use in tumor electrotherapy

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS608382A (en) * 1983-06-28 1985-01-17 Hitachi Chem Co Ltd Preparation of fluorescent particle
EP0467389A2 (en) * 1990-07-19 1992-01-22 University Of Kentucky Research Foundation Drug delivery system involving interaction between protein or polypeptide and hydrophobic biodegradable polymer
WO1994015587A2 (en) * 1993-01-06 1994-07-21 Kinerton Limited Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides
EP1240896A2 (en) * 1998-07-23 2002-09-18 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Encapsulation of water soluble peptides
US20040228833A1 (en) * 2002-10-17 2004-11-18 Costantino Henry R. Microencapsulation and sustained release of biologically active polypeptides
WO2010017215A2 (en) * 2008-08-04 2010-02-11 The Regents Of The University Of California Biodegradable microspheres and methods of use thereof
BRPI0905179A2 (en) * 2009-12-21 2011-08-23 Univ Rio De Janeiro pharmaceutical composition containing amino acids encompassed in a nanoparticulate system and use in tumor electrotherapy

Also Published As

Publication number Publication date
BRPI1003424A2 (en) 2013-01-08
WO2012031342A2 (en) 2012-03-15

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