WO2013102810A3 - Biologically active graft for skin replacement therapy - Google Patents

Biologically active graft for skin replacement therapy Download PDF

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Publication number
WO2013102810A3
WO2013102810A3 PCT/IB2012/057150 IB2012057150W WO2013102810A3 WO 2013102810 A3 WO2013102810 A3 WO 2013102810A3 IB 2012057150 W IB2012057150 W IB 2012057150W WO 2013102810 A3 WO2013102810 A3 WO 2013102810A3
Authority
WO
WIPO (PCT)
Prior art keywords
biologically active
composition
replacement therapy
skin replacement
warm
Prior art date
Application number
PCT/IB2012/057150
Other languages
French (fr)
Other versions
WO2013102810A4 (en
WO2013102810A2 (en
Inventor
Carlos A ALVARADO
Original Assignee
Alvarado Carlos A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alvarado Carlos A filed Critical Alvarado Carlos A
Publication of WO2013102810A2 publication Critical patent/WO2013102810A2/en
Publication of WO2013102810A3 publication Critical patent/WO2013102810A3/en
Publication of WO2013102810A4 publication Critical patent/WO2013102810A4/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/24—Mucus; Mucous glands; Bursa; Synovial fluid; Arthral fluid; Excreta; Spinal fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3629—Intestinal tissue, e.g. small intestinal submucosa

Abstract

The present invention relates to a biologically active graft (BAG) composition and methods for its preparation and use. More particularly, it details a method for preparing a non-immunogenic tissue graft composition comprising esophagus mucosa, basement membrane and tunica submucosa as intact natural sheet forms (Ad integrum), delaminated from the tunica muscularis and adventitia of an esophagus of a warm-blooded vertebrate. The composition is capable of serving as a substitute for skin autograft for skin replacement therapy and induces stromal cells regeneration when implanted in warm-blooded vertebrate including human subjects.
PCT/IB2012/057150 2012-01-04 2012-12-10 Biologically active graft for skin replacement therapy WO2013102810A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261583138P 2012-01-04 2012-01-04
US61/583,138 2012-01-04

Publications (3)

Publication Number Publication Date
WO2013102810A2 WO2013102810A2 (en) 2013-07-11
WO2013102810A3 true WO2013102810A3 (en) 2013-11-07
WO2013102810A4 WO2013102810A4 (en) 2014-02-27

Family

ID=48745497

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2012/057150 WO2013102810A2 (en) 2012-01-04 2012-12-10 Biologically active graft for skin replacement therapy

Country Status (1)

Country Link
WO (1) WO2013102810A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6893666B2 (en) * 1999-12-22 2005-05-17 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
US20100028396A1 (en) * 2008-07-30 2010-02-04 Ward Brian Roderick Tissue scaffolds derived from forestomach extracellular matrix

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6893666B2 (en) * 1999-12-22 2005-05-17 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
US20100028396A1 (en) * 2008-07-30 2010-02-04 Ward Brian Roderick Tissue scaffolds derived from forestomach extracellular matrix

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BADYLAK S F ET AL.: "Extracellular matrix as a biological scaffold material: Structure and function.", ACTA BIOMATERIALIA, vol. 5, no. 1, January 2009 (2009-01-01), pages 1 - 13, XP025804515, DOI: doi:10.1016/j.actbio.2008.09.013 *
BHRANY AMIT D ET AL.: "Development of an esophagus acellular matrix tissue scaffold.", TISSUE ENGINEERING., vol. 12, no. 2, February 2006 (2006-02-01), pages 319 - 330 *
OZEKI M ET AL.: "Evaluation of decellularized esophagus as a scaffold for cultured esophageal epithelial cells.", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH - PART A, vol. 79, no. 4, 15 December 2006 (2006-12-15), pages 771 - 778 *

Also Published As

Publication number Publication date
WO2013102810A4 (en) 2014-02-27
WO2013102810A2 (en) 2013-07-11

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