WO2013122995A4 - Microfluidic cartridge for processing and detecting nucleic acids - Google Patents
Microfluidic cartridge for processing and detecting nucleic acids Download PDFInfo
- Publication number
- WO2013122995A4 WO2013122995A4 PCT/US2013/025859 US2013025859W WO2013122995A4 WO 2013122995 A4 WO2013122995 A4 WO 2013122995A4 US 2013025859 W US2013025859 W US 2013025859W WO 2013122995 A4 WO2013122995 A4 WO 2013122995A4
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- layer
- cartridge
- fluidic pathway
- port
- detection chamber
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
- C12N15/1013—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by using magnetic beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/52—Containers specially adapted for storing or dispensing a reagent
- B01L3/527—Containers specially adapted for storing or dispensing a reagent for a plurality of reagents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/56—Labware specially adapted for transferring fluids
- B01L3/567—Valves, taps or stop-cocks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
- B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/42—Integrated assemblies, e.g. cassettes or cartridges
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/025—Align devices or objects to ensure defined positions relative to each other
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0605—Metering of fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0615—Loss of fluid by dripping
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0668—Trapping microscopic beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0689—Sealing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/12—Specific details about manufacturing devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/14—Process control and prevention of errors
- B01L2200/142—Preventing evaporation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/02—Identification, exchange or storage of information
- B01L2300/021—Identification, e.g. bar codes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/02—Identification, exchange or storage of information
- B01L2300/021—Identification, e.g. bar codes
- B01L2300/022—Transponder chips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
- B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0609—Holders integrated in container to position an object
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0636—Integrated biosensor, microarrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0672—Integrated piercing tool
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0681—Filter
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/087—Multiple sequential chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0883—Serpentine channels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0893—Geometry, shape and general structure having a very large number of wells, microfabricated wells
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
- B01L2300/123—Flexible; Elastomeric
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/14—Means for pressure control
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0622—Valves, specific forms thereof distribution valves, valves having multiple inlets and/or outlets, e.g. metering valves, multi-way valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/065—Valves, specific forms thereof with moving parts sliding valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0694—Valves, specific forms thereof vents used to stop and induce flow, backpressure valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/084—Passive control of flow resistance
- B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
- B29C65/02—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure
- B29C65/08—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure using ultrasonic vibrations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
- B29C65/48—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding
- B29C65/4805—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding characterised by the type of adhesives
- B29C65/483—Reactive adhesives, e.g. chemically curing adhesives
- B29C65/484—Moisture curing adhesives
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
- B29C65/56—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using mechanical means or mechanical connections, e.g. form-fits
- B29C65/60—Riveting or staking
- B29C65/606—Riveting or staking the rivets being integral with one of the parts to be joined, i.e. staking
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
- B29C66/71—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the composition of the plastics material of the parts to be joined
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/80—General aspects of machine operations or constructions and parts thereof
- B29C66/81—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps
- B29C66/814—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps
- B29C66/8141—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the surface geometry of the part of the pressing elements, e.g. welding jaws or clamps, coming into contact with the parts to be joined
- B29C66/81411—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the surface geometry of the part of the pressing elements, e.g. welding jaws or clamps, coming into contact with the parts to be joined characterised by its cross-section, e.g. transversal or longitudinal, being non-flat
- B29C66/81421—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the surface geometry of the part of the pressing elements, e.g. welding jaws or clamps, coming into contact with the parts to be joined characterised by its cross-section, e.g. transversal or longitudinal, being non-flat being convex or concave
- B29C66/81423—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the surface geometry of the part of the pressing elements, e.g. welding jaws or clamps, coming into contact with the parts to be joined characterised by its cross-section, e.g. transversal or longitudinal, being non-flat being convex or concave being concave
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/80—General aspects of machine operations or constructions and parts thereof
- B29C66/83—General aspects of machine operations or constructions and parts thereof characterised by the movement of the joining or pressing tools
- B29C66/832—Reciprocating joining or pressing tools
- B29C66/8322—Joining or pressing tools reciprocating along one axis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2031/00—Other particular articles
- B29L2031/756—Microarticles, nanoarticles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
Abstract
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014556810A JP6061313B2 (en) | 2012-02-13 | 2013-02-13 | Microfluidic cartridge for processing and detecting nucleic acids |
EP13748851.6A EP2814942A4 (en) | 2012-02-13 | 2013-02-13 | Microfluidic cartridge for processing and detecting nucleic acids |
CN201380009169.7A CN104254595A (en) | 2012-02-13 | 2013-02-13 | Microfluidic cartridge for processing and detecting nucleic acids |
AU2013221701A AU2013221701B2 (en) | 2012-02-13 | 2013-02-13 | Microfluidic cartridge for processing and detecting nucleic acids |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261598240P | 2012-02-13 | 2012-02-13 | |
US61/598,240 | 2012-02-13 | ||
US201261667606P | 2012-07-03 | 2012-07-03 | |
US61/667,606 | 2012-07-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2013122995A1 WO2013122995A1 (en) | 2013-08-22 |
WO2013122995A4 true WO2013122995A4 (en) | 2013-10-10 |
Family
ID=48945708
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2013/025859 WO2013122995A1 (en) | 2012-02-13 | 2013-02-13 | Microfluidic cartridge for processing and detecting nucleic acids |
PCT/US2013/025918 WO2013123035A1 (en) | 2012-02-13 | 2013-02-13 | System and method for processing and detecting nucleic acids |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2013/025918 WO2013123035A1 (en) | 2012-02-13 | 2013-02-13 | System and method for processing and detecting nucleic acids |
Country Status (6)
Country | Link |
---|---|
US (14) | US9050594B2 (en) |
EP (1) | EP2814942A4 (en) |
JP (1) | JP6061313B2 (en) |
CN (3) | CN104254595A (en) |
AU (1) | AU2013221701B2 (en) |
WO (2) | WO2013122995A1 (en) |
Families Citing this family (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
JP5415253B2 (en) | 2006-03-24 | 2014-02-12 | ハンディラブ・インコーポレーテッド | Integrated system for processing microfluidic samples and methods of use thereof |
US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
WO2009012185A1 (en) * | 2007-07-13 | 2009-01-22 | Handylab, Inc. | Polynucleotide capture materials, and methods of using same |
CN106190806B (en) | 2011-04-15 | 2018-11-06 | 贝克顿·迪金森公司 | Scan real-time microfluid thermal cycler and the method for synchronous thermal cycle and scanning optical detection |
EP2527814A1 (en) * | 2011-04-27 | 2012-11-28 | Koninklijke Philips Electronics N.V. | Sensor system with an exchangeable cartridge and a reader |
EP2739587B1 (en) | 2011-08-01 | 2020-05-27 | Denovo Sciences | Cell capture system |
CN104040238B (en) | 2011-11-04 | 2017-06-27 | 汉迪拉布公司 | Polynucleotides sample preparation apparatus |
US11485968B2 (en) | 2012-02-13 | 2022-11-01 | Neumodx Molecular, Inc. | Microfluidic cartridge for processing and detecting nucleic acids |
US9604213B2 (en) | 2012-02-13 | 2017-03-28 | Neumodx Molecular, Inc. | System and method for processing and detecting nucleic acids |
US11931740B2 (en) | 2012-02-13 | 2024-03-19 | Neumodx Molecular, Inc. | System and method for processing and detecting nucleic acids |
US9637775B2 (en) * | 2012-02-13 | 2017-05-02 | Neumodx Molecular, Inc. | System and method for processing biological samples |
US9050594B2 (en) | 2012-02-13 | 2015-06-09 | Neumodx Molecular, Inc. | System and method for processing and detecting nucleic acids |
US9062342B2 (en) * | 2012-03-16 | 2015-06-23 | Stat-Diagnostica & Innovation, S.L. | Test cartridge with integrated transfer module |
CN107051604B (en) | 2012-08-30 | 2019-07-05 | 生命技术公司 | Vertical grip device |
US20140120544A1 (en) | 2012-10-25 | 2014-05-01 | Neumodx Molecular, Inc. | Method and materials for isolation of nucleic acid materials |
US10391490B2 (en) | 2013-05-31 | 2019-08-27 | Celsee Diagnostics, Inc. | System and method for isolating and analyzing cells |
GB2516669B (en) * | 2013-07-29 | 2015-09-09 | Atlas Genetics Ltd | A method for processing a liquid sample in a fluidic cartridge |
KR102126032B1 (en) * | 2013-07-31 | 2020-07-08 | 삼성전자주식회사 | Multi-channel fluorescence detecting module and nucleic acid analysis system having the same |
EP3055407B1 (en) * | 2013-10-07 | 2022-01-12 | Agdia Inc. | Optical assembly for use in portable testing device for analyzing biological samples |
WO2015073999A1 (en) | 2013-11-18 | 2015-05-21 | Integenx Inc. | Cartridges and instruments for sample analysis |
GB201320542D0 (en) * | 2013-11-21 | 2014-01-01 | Randox Lab Ltd | Assay fluid delivery system |
KR102205900B1 (en) * | 2014-01-29 | 2021-01-21 | 삼성전자주식회사 | Analysis apparatus and method of checking cartridge installation of the analysis apparatus |
KR101653302B1 (en) * | 2014-02-26 | 2016-09-01 | (주)한울티피씨 | device for extracting nucleic acid |
EP3117221B1 (en) * | 2014-03-13 | 2020-09-09 | Genapsys Inc. | Microfluidic devices and methods for sample preparation and analysis |
GB2544198B (en) | 2014-05-21 | 2021-01-13 | Integenx Inc | Fluidic cartridge with valve mechanism |
JP6563927B2 (en) * | 2014-08-26 | 2019-08-21 | ユニバーサル・バイオ・リサーチ株式会社 | Magnetic particle reaction control device using variable pitch dispensing device and reaction control method thereof |
US9625355B2 (en) | 2014-12-01 | 2017-04-18 | General Electric Company | Extraction of materials from regions of interest in a sample |
WO2016130962A1 (en) | 2015-02-13 | 2016-08-18 | Abbott Laboratories | Automated storage modules for diagnostic analyzer liquids and related systems and methods |
CN111413305A (en) | 2015-03-25 | 2020-07-14 | 阿格迪有限责任公司 | Modular testing device for analyzing biological samples |
CN104783810A (en) * | 2015-03-29 | 2015-07-22 | 周二春 | Blood collection tray |
US10233491B2 (en) | 2015-06-19 | 2019-03-19 | IntegenX, Inc. | Valved cartridge and system |
EP3325159B1 (en) * | 2015-07-24 | 2021-06-30 | Novel Microdevices, LLC (dba Novel Devices) | Sample processing device comprising magnetic and mechanical actuating elements using linear or rotational motion |
WO2017027425A1 (en) * | 2015-08-10 | 2017-02-16 | Counsyl, Inc. | Modular liquid handling system |
GB201518993D0 (en) | 2015-10-27 | 2015-12-09 | Randox Lab Ltd | Improvements relating to analysis of biochips |
WO2017081675A1 (en) * | 2015-11-09 | 2017-05-18 | Novamed Ltd. | Body liquids collection and diagnostic device |
US11698332B2 (en) | 2015-11-24 | 2023-07-11 | Hewlett-Packard Development Company, L.P. | Devices having a sample delivery component |
ES2801123T3 (en) * | 2015-12-30 | 2021-01-08 | Tetra Laval Holdings & Finance | Methods and apparatus for guided quality control of a packaging system |
WO2017114665A1 (en) | 2015-12-30 | 2017-07-06 | Tetra Laval Holdings & Finance S.A. | Methods and apparatuses for packaging quality assurance |
JP2017138137A (en) * | 2016-02-02 | 2017-08-10 | 積水化学工業株式会社 | Pcr microchip and nucleic acid amplifier |
JP6953679B2 (en) | 2016-03-30 | 2021-10-27 | ソニーグループ株式会社 | Sample sorting kit, sample sorting device |
US11285478B2 (en) | 2016-04-04 | 2022-03-29 | Combinati Incorporated | Microfluidic siphoning array for nucleic acid quantification |
WO2017181258A1 (en) * | 2016-04-21 | 2017-10-26 | Duane Hewitt | Continuous flow system |
CN105950438B (en) * | 2016-05-17 | 2019-08-16 | 奥然生物科技(上海)有限公司 | A kind of reagent cartridge being provided with push type magnetic bead transfer device |
US10525466B2 (en) * | 2016-09-16 | 2020-01-07 | General Electric Company | Compact valve array with actuation system |
CA3038063A1 (en) * | 2016-09-23 | 2018-03-29 | ArcherDX, Inc. | System for nucleic acid preparation |
CN106318865B (en) * | 2016-10-25 | 2018-03-16 | 西安交通大学 | A kind of nucleic acid extraction and the portable unit of gene magnification |
EP3536775A4 (en) * | 2016-11-01 | 2020-06-03 | Nippon Sheet Glass Company, Limited | Reaction treatment container and reaction treatment device |
DE102016222032A1 (en) * | 2016-11-10 | 2018-05-17 | Robert Bosch Gmbh | Microfluidic device and method for analyzing nucleic acids |
EP3544790B1 (en) * | 2016-11-23 | 2023-12-27 | Siemens Healthineers Nederland B.V. | Ultrasonic welding of a microfluidic device |
CN106520547B (en) * | 2017-01-13 | 2019-04-05 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Nucleic acid extraction instrument |
US11207685B2 (en) * | 2017-02-13 | 2021-12-28 | Bio-Rad Laboratories, Inc. | System, method, and device for forming an array of emulsions |
DE102017204002B4 (en) * | 2017-03-10 | 2019-05-23 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | CENTRIFUGO-PNEUMATIC SWITCHING OF LIQUID |
US11213824B2 (en) | 2017-03-29 | 2022-01-04 | The Research Foundation For The State University Of New York | Microfluidic device and methods |
WO2018212496A2 (en) * | 2017-05-16 | 2018-11-22 | 에스케이텔레콤 주식회사 | Nucleic acid analysis apparatus using catridge |
CN109012768B (en) * | 2017-06-09 | 2021-11-19 | 国家纳米科学中心 | Microfluidic liquid one-way flow control structure, chip and method |
CA3074265A1 (en) * | 2017-06-20 | 2018-12-27 | Redbud Labs | Modular active surface devices for microfluidic systems and methods of making same |
AU2018323449B2 (en) | 2017-08-29 | 2020-09-03 | Bio-Rad Laboratories, Inc. | System and method for isolating and analyzing cells |
WO2019133756A1 (en) | 2017-12-29 | 2019-07-04 | Clear Labs, Inc. | Automated priming and library loading device |
KR102066119B1 (en) * | 2018-02-09 | 2020-02-17 | 제노플랜코리아 주식회사 | Dispenser mapping apparatus for multi-analysis and the operation method thereof |
US20210031185A1 (en) * | 2018-03-13 | 2021-02-04 | Hewlett-Packard Development Company, L.P. | Microfluidic devices |
WO2020018074A1 (en) | 2018-07-17 | 2020-01-23 | Hewlett-Packard Development Company, L.P. | Droplet ejectors to provide fluids to droplet ejectors |
US11925932B2 (en) | 2018-04-24 | 2024-03-12 | Hewlett-Packard Development Company, L.P. | Microfluidic devices |
WO2020018073A1 (en) | 2018-07-17 | 2020-01-23 | Hewlett-Packard Development Company, L.P. | Droplet ejectors with target media |
US11931738B2 (en) | 2018-04-24 | 2024-03-19 | Hewlett-Packard Development Company, L.P. | Sequenced droplet ejection to deliver fluids |
WO2020008715A1 (en) | 2018-07-03 | 2020-01-09 | 株式会社島津製作所 | Sample extraction support tool and sample extraction method |
US20210245153A1 (en) | 2018-07-09 | 2021-08-12 | Hewlett-Packard Development Company, L.P. | Analyte capturing devices with fluidic ejection devices |
US11801509B2 (en) | 2018-08-10 | 2023-10-31 | Hewlett-Packard Development Company, L.P. | Serial cellular analytics |
EP3644063B1 (en) * | 2018-10-23 | 2023-07-26 | Roche Diagnostics GmbH | Method of handling laboratory sample containers |
EP3644064B1 (en) * | 2018-10-23 | 2021-08-18 | Roche Diagnostics GmbH | Method of handling laboratory sample containers and apparatus for handling laboratory sample containers |
CN109529961B (en) * | 2019-01-04 | 2020-11-13 | 大连理工大学 | Micro-fluidic device for converging micro-nano biological particles by utilizing oscillatory flow and negative magnetophoresis effect |
US10633693B1 (en) | 2019-04-16 | 2020-04-28 | Celsee Diagnostics, Inc. | System and method for leakage control in a particle capture system |
JP7413408B2 (en) * | 2019-05-07 | 2024-01-15 | バイオ-ラッド ラボラトリーズ インコーポレイテッド | Systems and methods for automated single cell processing |
US11273439B2 (en) | 2019-05-07 | 2022-03-15 | Bio-Rad Laboratories, Inc. | System and method for target material retrieval from microwells |
CN113924494A (en) * | 2019-06-26 | 2022-01-11 | 伯乐实验室有限公司 | System and method for withdrawing target material from a microwell |
US20220143606A1 (en) * | 2019-07-26 | 2022-05-12 | Hewlett-Packard Development Company, L.P. | Microfluidic devices |
USD979092S1 (en) * | 2019-10-02 | 2023-02-21 | Becton, Dickinson And Company | Microfluidic cartridge |
BR112022023052A2 (en) * | 2020-05-11 | 2022-12-20 | Syntr Health Tech Inc | METHOD AND DEVICE FOR PROCESSING TISSUES AND CELLS |
CN111534428A (en) * | 2020-05-22 | 2020-08-14 | 中国科学院上海技术物理研究所 | Integrated nucleic acid extraction and amplification detection system based on PCR amplification |
CN111534429A (en) * | 2020-05-22 | 2020-08-14 | 中国科学院上海技术物理研究所 | Integrated nucleic acid extraction and amplification detection system based on isothermal amplification |
CN111575176A (en) * | 2020-05-22 | 2020-08-25 | 中国科学院上海技术物理研究所 | Closed full-automatic nucleic acid extraction and detection system based on CRISPR technology |
CN111647503B (en) * | 2020-07-09 | 2021-05-25 | 浙江爱津生物技术有限公司 | Magnetic bead method nucleic acid detection kit |
CN111826273B (en) * | 2020-07-22 | 2023-03-21 | 上海逢伙泰企业管理有限公司 | Automatic totally-enclosed micro-fluidic chip for nucleic acid detection |
US20230332998A1 (en) * | 2020-09-29 | 2023-10-19 | Nok Corporation | Particle analysis device and method for producing same |
WO2022231611A1 (en) * | 2021-04-30 | 2022-11-03 | Hewlett-Packard Development Company, L.P. | Microfluidic device |
JP7310874B2 (en) | 2021-12-28 | 2023-07-19 | 凸版印刷株式会社 | Microchannel chip and method for manufacturing microchannel chip |
CN114634853B (en) * | 2022-03-13 | 2023-05-02 | 首玺(广州)医疗科技有限责任公司 | Nucleic acid detection reagent device |
Family Cites Families (151)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US625544A (en) | 1899-05-23 | Fireproof floor and ceiling construction | ||
US778036A (en) | 1904-06-27 | 1904-12-20 | Hoechst Ag | Anthraquinone dye and process of making same. |
US776747A (en) | 1904-07-05 | 1904-12-06 | Dayton Mfg Company | Sliding-door latch. |
US3008066A (en) | 1958-08-25 | 1961-11-07 | Gen Electric | Information storage system |
US3043581A (en) | 1959-05-18 | 1962-07-10 | Thompson Ramo Wooldridge Inc | Shock absorber spring clamp |
US3003329A (en) | 1959-12-21 | 1961-10-10 | Gen Motors Corp | Refrigeration |
US3963151A (en) | 1974-08-05 | 1976-06-15 | Becton, Dickinson And Company | Fluid dispensing system |
GB2125007B (en) * | 1982-08-09 | 1986-09-10 | Kenneth Mortimer | Scissor type jack |
US5750338A (en) | 1986-10-23 | 1998-05-12 | Amoco Corporation | Target and background capture methods with amplification for affinity assays |
CA2143365A1 (en) | 1994-03-14 | 1995-09-15 | Hugh V. Cottingham | Nucleic acid amplification method and apparatus |
US5725831A (en) | 1994-03-14 | 1998-03-10 | Becton Dickinson And Company | Nucleic acid amplification apparatus |
CA2156226C (en) | 1994-08-25 | 1999-02-23 | Takayuki Taguchi | Biological fluid analyzing device and method |
US5582988A (en) | 1994-09-15 | 1996-12-10 | Johnson & Johnson Clinical Diagnostics, Inc. | Methods for capture and selective release of nucleic acids using weakly basic polymer and amplification of same |
US6168948B1 (en) | 1995-06-29 | 2001-01-02 | Affymetrix, Inc. | Miniaturized genetic analysis systems and methods |
US5856174A (en) | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
US5863502A (en) | 1996-01-24 | 1999-01-26 | Sarnoff Corporation | Parallel reaction cassette and associated devices |
US5736102A (en) * | 1996-02-21 | 1998-04-07 | Biomerieux Vitek, Inc. | Test sample positioning system |
US7244622B2 (en) * | 1996-04-03 | 2007-07-17 | Applera Corporation | Device and method for multiple analyte detection |
US5824478A (en) | 1996-04-30 | 1998-10-20 | Vysis, Inc. | Diagnostic methods and probes |
US6368871B1 (en) | 1997-08-13 | 2002-04-09 | Cepheid | Non-planar microstructures for manipulation of fluid samples |
US6914137B2 (en) | 1997-12-06 | 2005-07-05 | Dna Research Innovations Limited | Isolation of nucleic acids |
AU758407B2 (en) | 1997-12-24 | 2003-03-20 | Cepheid | Integrated fluid manipulation cartridge |
ATE363339T1 (en) | 1998-05-01 | 2007-06-15 | Gen Probe Inc | STIRRING DEVICE FOR THE FLUID CONTENTS OF A CONTAINER |
US6572830B1 (en) | 1998-10-09 | 2003-06-03 | Motorola, Inc. | Integrated multilayered microfludic devices and methods for making the same |
US7914994B2 (en) | 1998-12-24 | 2011-03-29 | Cepheid | Method for separating an analyte from a sample |
US6431476B1 (en) | 1999-12-21 | 2002-08-13 | Cepheid | Apparatus and method for rapid ultrasonic disruption of cells or viruses |
US6887693B2 (en) | 1998-12-24 | 2005-05-03 | Cepheid | Device and method for lysing cells, spores, or microorganisms |
WO2000058524A2 (en) | 1999-03-31 | 2000-10-05 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Typing of human enteroviruses |
US20040200909A1 (en) | 1999-05-28 | 2004-10-14 | Cepheid | Apparatus and method for cell disruption |
US6818185B1 (en) * | 1999-05-28 | 2004-11-16 | Cepheid | Cartridge for conducting a chemical reaction |
WO2000073413A2 (en) | 1999-05-28 | 2000-12-07 | Cepheid | Apparatus and method for cell disruption |
ATE481499T1 (en) | 1999-09-24 | 2010-10-15 | Ambion Inc | COCKTAIL OF NUCLEASE INHIBITORS |
US6331266B1 (en) | 1999-09-29 | 2001-12-18 | Becton Dickinson And Company | Process of making a molded device |
US6374685B1 (en) | 1999-10-14 | 2002-04-23 | Siemens Automotive, Inc. | Creep enhanced sensor attachment arrangement |
US7867763B2 (en) | 2004-01-25 | 2011-01-11 | Fluidigm Corporation | Integrated chip carriers with thermocycler interfaces and methods of using the same |
DE10029453C2 (en) | 2000-06-21 | 2002-06-13 | Roche Diagnostics Gmbh | Pump for very low flow rates |
US6374684B1 (en) | 2000-08-25 | 2002-04-23 | Cepheid | Fluid control and processing system |
US8048386B2 (en) | 2002-02-25 | 2011-11-01 | Cepheid | Fluid processing and control |
GB2368809B (en) | 2000-09-15 | 2004-09-29 | Norchip As | Microfabricated reaction chamber system |
US6692700B2 (en) | 2001-02-14 | 2004-02-17 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
US7010391B2 (en) | 2001-03-28 | 2006-03-07 | Handylab, Inc. | Methods and systems for control of microfluidic devices |
US7323140B2 (en) | 2001-03-28 | 2008-01-29 | Handylab, Inc. | Moving microdroplets in a microfluidic device |
US6852287B2 (en) | 2001-09-12 | 2005-02-08 | Handylab, Inc. | Microfluidic devices having a reduced number of input and output connections |
US7829025B2 (en) | 2001-03-28 | 2010-11-09 | Venture Lending & Leasing Iv, Inc. | Systems and methods for thermal actuation of microfluidic devices |
US7192557B2 (en) | 2001-03-28 | 2007-03-20 | Handylab, Inc. | Methods and systems for releasing intracellular material from cells within microfluidic samples of fluids |
US7270786B2 (en) | 2001-03-28 | 2007-09-18 | Handylab, Inc. | Methods and systems for processing microfluidic samples of particle containing fluids |
US20020159920A1 (en) * | 2001-04-03 | 2002-10-31 | Weigl Bernhard H. | Multiple redundant microfluidic structures cross reference to related applications |
DE10130512B4 (en) | 2001-06-25 | 2007-08-16 | Bionethos Holding Gmbh | Device for pressure perfusion for growing and / or treating cells |
US20040209331A1 (en) * | 2001-07-16 | 2004-10-21 | Kirk Ririe | Thermal cycling system and method of use |
US7372616B2 (en) | 2001-12-06 | 2008-05-13 | Microfabrica, Inc. | Complex microdevices and apparatus and methods for fabricating such devices |
EP1487969A4 (en) | 2001-12-07 | 2008-07-09 | Dyax Corp | Method and apparatus for washing magnetically responsive particles |
GB0129816D0 (en) * | 2001-12-13 | 2002-01-30 | The Technology Partnership Plc | Testing device for chemical or biochemical analysis |
KR100450818B1 (en) | 2002-03-09 | 2004-10-01 | 삼성전자주식회사 | Multi chamber PCR chip |
US7312085B2 (en) | 2002-04-01 | 2007-12-25 | Fluidigm Corporation | Microfluidic particle-analysis systems |
SE0202074D0 (en) | 2002-06-28 | 2002-07-02 | Amersham Biosciences Ab | Isolation of nucleic acids |
US7235988B2 (en) | 2002-07-09 | 2007-06-26 | Caesar A. Saloma | Method for generating high-contrast images of semiconductor sites via one-photon optical beam-induced current imaging and confocal reflectance microscopy |
US6899838B2 (en) | 2002-07-12 | 2005-05-31 | Becton, Dickinson And Company | Method of forming a mold and molding a micro-device |
US20040018611A1 (en) | 2002-07-23 | 2004-01-29 | Ward Michael Dennis | Microfluidic devices for high gradient magnetic separation |
US6787421B2 (en) | 2002-08-15 | 2004-09-07 | Freescale Semiconductor, Inc. | Method for forming a dual gate oxide device using a metal oxide and resulting device |
TW590982B (en) * | 2002-09-27 | 2004-06-11 | Agnitio Science & Technology I | Micro-fluid driving device |
US7186383B2 (en) * | 2002-09-27 | 2007-03-06 | Ast Management Inc. | Miniaturized fluid delivery and analysis system |
US7582635B2 (en) | 2002-12-24 | 2009-09-01 | Purdue Pharma, L.P. | Therapeutic agents useful for treating pain |
US20040138154A1 (en) | 2003-01-13 | 2004-07-15 | Lei Yu | Solid surface for biomolecule delivery and high-throughput assay |
US6893524B2 (en) | 2003-01-24 | 2005-05-17 | Glastic Corporation | Method and apparatus for manufacturing a reinforcement |
US7820030B2 (en) | 2003-04-16 | 2010-10-26 | Handylab, Inc. | System and method for electrochemical detection of biological compounds |
US7425700B2 (en) | 2003-05-22 | 2008-09-16 | Stults John T | Systems and methods for discovery and analysis of markers |
US7731906B2 (en) | 2003-07-31 | 2010-06-08 | Handylab, Inc. | Processing particle-containing samples |
CA2479452C (en) | 2003-08-30 | 2008-11-04 | F.Hoffmann-La Roche Ag | Method and device for determining analytes in a liquid |
US7943388B2 (en) | 2003-11-14 | 2011-05-17 | 3M Innovative Properties Company | Acoustic sensors and methods |
WO2005070546A1 (en) | 2004-01-12 | 2005-08-04 | Applera Corporation | Method and device for detection of nucleic acid sequences |
US7763209B2 (en) | 2004-03-11 | 2010-07-27 | Handylab, Inc. | Sample preparation device and method |
US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
AU2005241080B2 (en) | 2004-05-03 | 2011-08-11 | Handylab, Inc. | Processing polynucleotide-containing samples |
CA2569601C (en) | 2004-06-07 | 2014-10-21 | Iquum, Inc. | Sample multiprocessing |
US7164749B2 (en) | 2004-06-28 | 2007-01-16 | Smiths Detection, Inc. | Method and apparatus for meat scanning |
CA2513340A1 (en) | 2004-08-25 | 2006-02-25 | F. Hoffmann-La Roche Ag | Reusable substrate for dna microarray production |
US7556858B2 (en) | 2004-09-30 | 2009-07-07 | 3M Innovative Properties Company | Substrate with attached dendrimers |
WO2006037160A1 (en) | 2004-10-05 | 2006-04-13 | The University Of Melbourne | Porous polyelectrolyte materials |
ATE520029T1 (en) | 2004-11-05 | 2011-08-15 | Hoffmann La Roche | BIOCHEMICAL DEVICE AND DETECTION METHOD |
CN1773190B (en) | 2004-11-12 | 2010-05-05 | 中国科学院电工研究所 | Solar energy thermoelectric co-supply system |
US8738106B2 (en) * | 2005-01-31 | 2014-05-27 | Given Imaging, Ltd | Device, system and method for in vivo analysis |
US7252501B2 (en) | 2005-02-16 | 2007-08-07 | D-M-E Company | Nozzle and apparatus for injection molding |
US7580533B2 (en) | 2005-02-16 | 2009-08-25 | Schwartz David M | Particulate flow detection microphone |
US7932081B2 (en) | 2005-03-10 | 2011-04-26 | Gen-Probe Incorporated | Signal measuring system for conducting real-time amplification assays |
JP5638752B2 (en) | 2005-04-26 | 2014-12-10 | コーニンクレッカ フィリップス エヌ ヴェ | MRI contrast agent containing CEST active paramagnetic complex |
EP1885883A4 (en) | 2005-04-30 | 2009-09-23 | Jae Chern Yoo | Bio-disc, bio-driver apparatus, and assay method using the same |
WO2006122311A2 (en) * | 2005-05-11 | 2006-11-16 | The Trustees Of The University Of Pennsylvania | Microfluidic chip |
US7340083B2 (en) | 2005-06-29 | 2008-03-04 | University Of Washington | Method and system for atherosclerosis risk scoring |
FR2888050A1 (en) | 2005-06-30 | 2007-01-05 | Pierrette Wehrlen | PASSIVE ANTENNA SYSTEM FOR BIOLOGICAL PROTECTION |
US20070031282A1 (en) | 2005-08-04 | 2007-02-08 | Piero Zucchelli | Devices and methods for interfacing microfluidic devices with fluid handling devices |
WO2007024778A2 (en) | 2005-08-22 | 2007-03-01 | Applera Corporation | Device, system and method for depositing processed immiscible-fluid-discrete-volumes |
US9957569B2 (en) | 2005-09-12 | 2018-05-01 | The Regents Of The University Of Michigan | Recurrent gene fusions in prostate cancer |
WO2007041619A2 (en) | 2005-09-30 | 2007-04-12 | Caliper Life Sciences, Inc. | Microfluidic device for purifying a biological component using magnetic beads |
US7763453B2 (en) | 2005-11-30 | 2010-07-27 | Micronics, Inc. | Microfluidic mixing and analytic apparatus |
US7998708B2 (en) * | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US8088616B2 (en) | 2006-03-24 | 2012-01-03 | Handylab, Inc. | Heater unit for microfluidic diagnostic system |
JP5415253B2 (en) | 2006-03-24 | 2014-02-12 | ハンディラブ・インコーポレーテッド | Integrated system for processing microfluidic samples and methods of use thereof |
US8741230B2 (en) | 2006-03-24 | 2014-06-03 | Theranos, Inc. | Systems and methods of sample processing and fluid control in a fluidic system |
GB2436616A (en) | 2006-03-29 | 2007-10-03 | Inverness Medical Switzerland | Assay device and method |
US8232091B2 (en) * | 2006-05-17 | 2012-07-31 | California Institute Of Technology | Thermal cycling system |
US8163535B2 (en) * | 2006-06-26 | 2012-04-24 | Blood Cell Storage, Inc. | Devices and processes for nucleic acid extraction |
US20100029544A1 (en) | 2006-07-12 | 2010-02-04 | Woei Ping Cheng | Composition |
US8187557B2 (en) | 2006-07-13 | 2012-05-29 | Cepheid | Reagent reservoir system for analytical instruments |
WO2008097342A2 (en) | 2006-07-31 | 2008-08-14 | Sigma-Aldrich Co. | Compositions and methods for isolation of biological molecules |
GB0618966D0 (en) * | 2006-09-26 | 2006-11-08 | Iti Scotland Ltd | Cartridge system |
EP1916524A1 (en) | 2006-09-27 | 2008-04-30 | Roche Diagnostics GmbH | Rotatable test element |
EP2078756A4 (en) | 2006-10-03 | 2010-09-08 | Univ Gifu | Detection of bacterium by utilizing dnaj gene and use thereof |
WO2008061165A2 (en) | 2006-11-14 | 2008-05-22 | Handylab, Inc. | Microfluidic cartridge and method of making same |
US7738094B2 (en) | 2007-01-26 | 2010-06-15 | Becton, Dickinson And Company | Method, system, and compositions for cell counting and analysis |
US8323899B2 (en) | 2007-02-01 | 2012-12-04 | Siemens Healthcare Diagnostics Inc. | Silica magnetic particles with a high nucleic acid binding capacity |
CN101715483A (en) * | 2007-02-05 | 2010-05-26 | 微芯片生物工艺学股份有限公司 | microfluidic and nanofluidic devices, systems, and applications |
US7863035B2 (en) | 2007-02-15 | 2011-01-04 | Osmetech Technology Inc. | Fluidics devices |
US8183359B2 (en) | 2007-03-01 | 2012-05-22 | Gen-Probe Incorporated | Kits for amplifying DNA |
US8506908B2 (en) * | 2007-03-09 | 2013-08-13 | Vantix Holdings Limited | Electrochemical detection system |
EP2149610B1 (en) | 2007-03-26 | 2018-05-16 | Fundacion Gaiker | Device for detecting genetic material by means of polymerase chain reaction |
US20080241569A1 (en) | 2007-03-30 | 2008-10-02 | Haoyu Qin | Encapsulation of raman active nanoparticles |
CN101801311A (en) * | 2007-05-01 | 2010-08-11 | 布赖汉姆妇女医院有限公司 | Wound healing device |
AU2008265610B2 (en) | 2007-06-21 | 2012-08-23 | Gen-Probe Incorporated | Instrument and receptacles for performing processes |
GB0713140D0 (en) | 2007-07-06 | 2007-08-15 | Illingworth Paul | Fluid flow control systems |
US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
WO2009012185A1 (en) | 2007-07-13 | 2009-01-22 | Handylab, Inc. | Polynucleotide capture materials, and methods of using same |
US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
US8133671B2 (en) | 2007-07-13 | 2012-03-13 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
WO2009022994A1 (en) | 2007-08-13 | 2009-02-19 | Agency For Science, Technology And Research | Microfluidic separation system |
US20100300978A1 (en) * | 2007-09-19 | 2010-12-02 | Agency For Science, Technology And Research | Device, system and method for washing and isolating magnetic particles in a continous fluid flow |
US7995798B2 (en) | 2007-10-15 | 2011-08-09 | Given Imaging Ltd. | Device, system and method for estimating the size of an object in a body lumen |
JP2011501183A (en) | 2007-10-29 | 2011-01-06 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | Leaky total reflection biosensor cartridge |
US8961902B2 (en) | 2008-04-23 | 2015-02-24 | Bioscale, Inc. | Method and apparatus for analyte processing |
US20100009351A1 (en) | 2008-07-11 | 2010-01-14 | Handylab, Inc. | Polynucleotide Capture Materials, and Method of Using Same |
CN102203605B (en) | 2008-08-27 | 2014-07-23 | 生命技术公司 | Apparatus for and method of processing biological samples |
CA2738317C (en) | 2008-09-24 | 2020-01-14 | Straus Holdings Inc. | Imaging analyzer for testing analytes |
US8288520B2 (en) | 2008-10-27 | 2012-10-16 | Qiagen Gaithersburg, Inc. | Fast results hybrid capture assay and system |
DE102008063003A1 (en) | 2008-12-23 | 2010-06-24 | Qiagen Gmbh | Nucleic acid purification method |
US8168134B2 (en) | 2008-12-24 | 2012-05-01 | Life Technologies Corporation | Biological analysis systems, devices and methods |
US8672532B2 (en) | 2008-12-31 | 2014-03-18 | Integenx Inc. | Microfluidic methods |
EP2393941A2 (en) | 2009-02-09 | 2011-12-14 | Frederic Zenhausern | Improvements in and relating to microfluidic devices for processing a sample |
NZ595982A (en) * | 2009-04-22 | 2013-10-25 | Clinical Genomics Pty Ltd | Method and apparatus for isolating a target bioentity from a biological sample |
US8003329B2 (en) | 2009-05-12 | 2011-08-23 | Becton Dickinson & Company | Molecular counting by color-coded micelles |
US20100300563A1 (en) | 2009-05-27 | 2010-12-02 | John Ramunas | Modular device and method for moving fluids to and from a sample delivery element |
CN102459565A (en) | 2009-06-02 | 2012-05-16 | 尹特根埃克斯有限公司 | Fluidic devices with diaphragm valves |
US8533202B2 (en) | 2009-07-07 | 2013-09-10 | Yahoo! Inc. | Entropy-based mixing and personalization |
JP4457180B1 (en) | 2009-08-07 | 2010-04-28 | 株式会社アドバンテスト | Wafer tray and test equipment |
CA2773186A1 (en) | 2009-09-24 | 2011-03-31 | Qiagen Gaithersburg, Inc. | Compositions, methods, and kits for isolating and analyzing nucleic acids using an anion exchange material |
CA3157087A1 (en) | 2009-12-07 | 2011-06-16 | Meso Scale Technologies, Llc | Assay cartridges and methods of using the same |
US8226985B2 (en) | 2010-01-28 | 2012-07-24 | International Business Machines Corporation | Surface modified nanoparticles, methods of their preparation, and uses thereof for gene and drug delivery |
US20110193017A1 (en) * | 2010-02-09 | 2011-08-11 | Conocophillips Company | Autoclave reactor heating assembly and methods |
US9180451B2 (en) | 2010-06-28 | 2015-11-10 | Stmicroelectronics S.R.L. | Fluidic cartridge for detecting chemicals in samples, in particular for performing biochemical analyses |
FR2962131B1 (en) | 2010-06-30 | 2013-10-18 | Centre Nat Rech Scient | PROCESS FOR FUNCTIONALIZING FAT BODIES OF NATURAL ORIGIN |
US9050594B2 (en) | 2012-02-13 | 2015-06-09 | Neumodx Molecular, Inc. | System and method for processing and detecting nucleic acids |
US20140120544A1 (en) | 2012-10-25 | 2014-05-01 | Neumodx Molecular, Inc. | Method and materials for isolation of nucleic acid materials |
-
2013
- 2013-02-13 US US13/766,359 patent/US9050594B2/en active Active
- 2013-02-13 CN CN201380009169.7A patent/CN104254595A/en active Pending
- 2013-02-13 AU AU2013221701A patent/AU2013221701B2/en active Active
- 2013-02-13 US US13/766,009 patent/US9101930B2/en active Active
- 2013-02-13 EP EP13748851.6A patent/EP2814942A4/en active Pending
- 2013-02-13 US US13/766,000 patent/US9433940B2/en active Active
- 2013-02-13 JP JP2014556810A patent/JP6061313B2/en active Active
- 2013-02-13 WO PCT/US2013/025859 patent/WO2013122995A1/en active Application Filing
- 2013-02-13 US US13/766,377 patent/US9339812B2/en active Active
- 2013-02-13 CN CN201380009286.3A patent/CN104271765B/en active Active
- 2013-02-13 WO PCT/US2013/025918 patent/WO2013123035A1/en active Application Filing
- 2013-02-13 CN CN202111328908.1A patent/CN114134029A/en active Pending
- 2013-02-13 US US13/765,996 patent/US9738887B2/en active Active
-
2015
- 2015-05-05 US US14/704,215 patent/US9441219B2/en active Active
- 2015-06-30 US US14/755,821 patent/US9403165B2/en active Active
-
2016
- 2016-04-21 US US15/134,765 patent/US10041062B2/en active Active
- 2016-06-14 US US15/182,187 patent/US9452430B1/en active Active
- 2016-08-29 US US15/249,771 patent/US11655467B2/en active Active
-
2017
- 2017-01-16 US US15/407,160 patent/US10557132B2/en active Active
- 2017-12-01 US US15/828,721 patent/US11142757B2/en active Active
-
2021
- 2021-10-11 US US17/450,529 patent/US20220023862A1/en active Pending
-
2023
- 2023-05-22 US US18/321,681 patent/US20230287387A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2013122995A4 (en) | Microfluidic cartridge for processing and detecting nucleic acids | |
US10875019B2 (en) | Multi-flux microfluidic chip for nucleic acid detection and capable of actively controlling flow path, and use method thereof | |
US9459186B2 (en) | Sample preparation and loading module | |
US9044755B2 (en) | Gene analysis apparatus and gene analysis method using the same | |
US9623407B2 (en) | Microfluidic device with longitudinal and transverse liquid barriers for transverse flow mixing | |
CN111989157B (en) | Micro-fluidic chip | |
JP4964955B2 (en) | Disposable device for liquid sample analysis by nucleic acid amplification | |
CN103180047A (en) | Microfluidic device with auxiliary and bypass channels | |
CN101520034A (en) | Integrated normal-closed PDMS micro-valve, preparation process thereof and micro-pump containing micro-valve | |
US20220186172A1 (en) | Cell separation apparatus for bioreactor | |
CN205435775U (en) | Micro -fluidic chip | |
US9238225B2 (en) | Fluid controlling apparatus and method of controlling fluid by using the same | |
JP6366226B2 (en) | Microchip reactor | |
CN111212688B (en) | Microfluidic device with bubble transfer | |
Kobayashi et al. | Microfluidic chip with serially connected filters for improvement of collection efficiency in blood plasma separation | |
Cho et al. | An assembly disposable degassing microfluidic device using a gas-permeable hydrophobic membrane and a reusable microsupport array | |
CN204448036U (en) | A kind of micro-fluidic chip | |
CN111389474B (en) | Micro-fluidic chip for sample dispersion and preparation method and application thereof | |
US7748410B2 (en) | Fluid handling apparatus | |
US20200276581A1 (en) | Micro-fluid chip | |
JP4836272B2 (en) | Liquid introduction device | |
WO2023102900A1 (en) | Microfluidic device and microfluidic detection device | |
JP2019163949A (en) | Micro fluid device and reaction system | |
CN217830067U (en) | Microfluidic chip suitable for bonding PSA (pressure sensitive adhesive) tape | |
KR102346313B1 (en) | Modular micro-fluidic chip |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 13748851 Country of ref document: EP Kind code of ref document: A1 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2013748851 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: 2014556810 Country of ref document: JP Kind code of ref document: A |
|
ENP | Entry into the national phase |
Ref document number: 2013221701 Country of ref document: AU Date of ref document: 20130213 Kind code of ref document: A |
|
NENP | Non-entry into the national phase |
Ref country code: DE |