WO2013148306A1 - Imaging system, method and distal attachment for multidirectional field of view endoscopy - Google Patents
Imaging system, method and distal attachment for multidirectional field of view endoscopy Download PDFInfo
- Publication number
- WO2013148306A1 WO2013148306A1 PCT/US2013/031948 US2013031948W WO2013148306A1 WO 2013148306 A1 WO2013148306 A1 WO 2013148306A1 US 2013031948 W US2013031948 W US 2013031948W WO 2013148306 A1 WO2013148306 A1 WO 2013148306A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- arrangement
- radiation
- exemplary
- endoscopic
- radiations
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00064—Constructional details of the endoscope body
- A61B1/00071—Insertion part of the endoscope body
- A61B1/0008—Insertion part of the endoscope body characterised by distal tip features
- A61B1/00096—Optical elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00002—Operational features of endoscopes
- A61B1/00004—Operational features of endoscopes characterised by electronic signal processing
- A61B1/00009—Operational features of endoscopes characterised by electronic signal processing of image signals during a use of endoscope
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00064—Constructional details of the endoscope body
- A61B1/00071—Insertion part of the endoscope body
- A61B1/0008—Insertion part of the endoscope body characterised by distal tip features
- A61B1/00101—Insertion part of the endoscope body characterised by distal tip features the distal tip features being detachable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00131—Accessories for endoscopes
- A61B1/00137—End pieces at either end of the endoscope, e.g. caps, seals or forceps plugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00163—Optical arrangements
- A61B1/00174—Optical arrangements characterised by the viewing angles
- A61B1/00181—Optical arrangements characterised by the viewing angles for multiple fixed viewing angles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/012—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor characterised by internal passages or accessories therefor
- A61B1/015—Control of fluid supply or evacuation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/012—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor characterised by internal passages or accessories therefor
- A61B1/018—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor characterised by internal passages or accessories therefor for receiving instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
- A61B1/0638—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements providing two or more wavelengths
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
- A61B1/0661—Endoscope light sources
Definitions
- Exemplary embodiments of the present disclosure relate to endoscopic imaging system and methods for multidirectional field of view endoscopy which can be used to improve the field of view, speed and efficiency of diagnostic and therapeutic endoscopic procedures.
- Endoscopes can consist of at least one of the following components, a rigid or flexible tube, a light dehvery system, fluid delivery and recovery system, an. air delivery and recovery system, a lens system, an eyepiece, a high pixel -count color CCD or imaging transmission system, graphical display unit (monitor), and /or accessory channel(s) to allow use of devices for manipulation, sampling or imaging of target lesions.
- the endoscope may be inserted into any natural orifice of the animal or human including the nares, ears, mouth, biliary tract, pancreatic duct, ostomy, urinary tract, vagina, utems, fallopian tubes, anus and/or any opening produced by procedures employing an incision or puncture. into an. internal bod cavit (craniotomy, thoracotomy, mediastinotomy, laparotomy or arthrotomy). While currently available endoscopes are capable of evaluating target structures by the obligatory forward or other directional field of view obtained by current light delivery and lens systems, in some medical applications this design increases the risk for missed detection of important areas of interest. As a result, there is a need for multi-directional visualization.
- Colonoscopy is widely considered the gold standard for detecting mucosal abnormalities in the human colon, and the preferred technique for removal of many non-invasive lesions requires biopsy, polypectomy or endoscopic resection.
- exemplary configurations for the acquisition of multidirectional viewing during endoscopic examination can be provided.
- Exemplary applications can be utilized, in which increasing the field of view while using high resolution endoscopic systems can be improved with the exemplary embodiments of the system and method of continuous and simultaneous forward, and mdtidirectional views during a baroscopfc, laparoscopic, angioseopie, or endoscopic procedure.
- Exemplary embodiments of the present disclosure can relate generally to exemplary configuration of optical elements, and to the app!ication(s) thereof in exemplary endoscopic imaging systems which can be used with medical applications to improve the field of view, speed and efficiency of an endoscopic procedure.
- Exemplary embodiments of the present disclosure can be applied to rigid, flexible, wireless or telescoping endoscope to provide, e.g., continuous multi-directional view of animate and i nanimate holl ow spaces.
- a distal imaging attachment and an imaging system can be used in combination with a rigid, flexible, wireless or telescoping endoscope to create a continuous nmlti-direciional view of animate and inanimate hollow spaces.
- the directions are forward and to the side.
- the directions are forward and backward.
- the directions cover approximately a 4pi solid angle that is only obscured by the device itself.
- This said distal imaging attachment and imaging system may be employed, but not limited to, with endoscopy of animal and human internal anatomical organs and borescopy of inanimate closed spaces.
- the integrated optical element within this imaging system Due to its design, the integrated optical element within this imaging system, allowing both the forward and multidirectional fields of view.
- optica! elements in the exemplary device can be configured to facilitate a multidirectional viewing of target organs or spaces with exemplary endoscopes.
- the exemplary device can be retrofitted to alter the native conventional high definition endoscopes currently used in endoscopic procedures.
- the exemplary device/apparatus can be disposable.
- exemplar ⁇ - embodiments according to the present disclosure as described herein can be provided as exemplary endoscopic lens systemis), and can be termed as “miutidirectiff, “sii ilview” or “retroview”, and utilized as a basis for exemplary embodiments of endoscopic systems for a deployment.
- an exemplary apparatus for imaging at least one anatomical structure can be provided, according to an exemplary embodiment of the present disclosure.
- the apparatu can include an endoscopic first arrangement, radiation source second arrangement which provides at least one electro-magnetic radiation, and a third arrangement attached to at least one portion of the endoscopic arrangement.
- the third arrangement can contain an optical arrangement which, upon impact by the at least one electro-magnetic radiation and based thereon, may transmit a first radiation and reflects a second .radiation.
- the first radiation can impact at least one first portion of the anatomical structure ⁇ ), and the second radiation can impact at least one second portion of the anatomical structare(s).
- Tire first and second portions can be at least partially different from one another. Further, the first and second radiations can have characteristics which are different from one another.
- the characteristics can include or be wavelengths or polarizations
- a detector arrangement can be provided, whereas the endoscopic arrangement can be associated with the radiation source arrangement and the detector arrangement
- the first and second radiations can have spectral regions in red, green and blue band which do not substantially overlap with one another.
- the first radiation can be directed, in a forward direction, and the second radiation can be directed in a backward direction or a side direction.
- the third arrangement can include a cap that can be connected to an. end portion of the endoscopic firs arrangement.
- the second radiation can simultaneously illuminate between 270 and 360 degrees of a field of view.
- the radiation source second arrangement can include a -modulation arrangement whic can be configured to modulate the first and second radiations.
- An electronic arrangement caa which is configured to synchronize the second arrangement and the detector arrangement.
- the electronic arrangement can be configured to (i) synchronize the modulatio arrangement and the detector arrangement, and (ii) control the detector arrangement to detect signals from the anatomical stracture(s) illuminated by the first and second radiation, and separate the signals based the synchronization with the modulation arrangement.
- the anatomical stnicture(s) can be a luminal anatomical structure.
- T he third arrangement can include at least one opening which facilitates a passage of instrumentation, air gasses and/or fl uids therethrough.
- a tube can be provided that is associated with the third arrangement, and whic provide a passage of instrumentation, air gasses and/or fluids therethrough.
- the first and second radiations can have a specific polarization status.
- FIG. 1 is a side cross-sectional block diagram of an imaging system/apparatus and opti cal elements thereof according to an exemplary embodiment of the present disc losure;
- FIG. 2 is a set of view of an exemplary optical element consists a 4-facered pyramid dichroic mirror which can transmit and reflect radiations with different characteristics according to an exemplary embodiment of the present disclosure
- FIG. 3 a block diagram of an endoscopic arrangement, a radiation source arrangement; and a detector arrangement according to exemplary embodiments of the present disc losure;
- FIGS. 4(a) and 4(b) are block diagrams of exemplary modulation arrangements according to an exemplary embodiment of the present disclosure;
- FIG. 5(a) is a diagram of an exemplary electronic switch based on an optical chopper according to an exemplary embodiment, of the present disclosure
- FIG. 5(b) is a diagram of the exemplary electronic switch based on a first switch position according to an exemplary embodiment of the present disclosure
- FIG. 5(c) is a diagram of the exemplar ⁇ ' ' electronic switch based on a second switch position according to an exemplary embodiment of the present disclosure
- FIG, 6(a) a diagram of the exemplary electronic switch of F IG, 6(a) based on the galvo scanner at a second switch position according to another exemplary embodiment of the present disclosure
- FIG. 7 a front view of the optica! elements provided within a distal imaging attachment cap of the exemplary imaging system/apparatus of FIG, I ;
- FIG. 8 a side view of the imaging system/apparatus, optical elements and distal imaging attachment cap, as shown in FIG. 7;
- FIG. 9 is a set of illustrations providing external distal image atfaehm.en.ts and an overlapping field external display Diagram according to exemplary embodiments of the present disclosure.
- FIG. 10 is a set of exemplary images providing exemplary testing results achieved using the exemplary system., method and or computer-accessible medium according to the exemplary embodiments of the present disclosure.
- an optical apparatus/system can be provided which can. be partially reflective and/or may be a polarization or wavelength selective such that certain wavelengths or polarization states are directed to and/or received from different field angles and therefore illuminate and/or receive different fields of view.
- the exemplary states may be altered by changing the characteristics of the optics or the optical characteristics of the light, such as the wavelengths or the polarization, state.
- changes of wavelengths can be different bands of wavelengths in the RGB spectrum.
- the different wavelengths may be comprised of different wavelength bands in the visible and NM spectrum.
- the optical apparatus contains a beam splitter, hi a further exemplary embodiment of the present disclosure, the optical apparatus can be configured and/or structured to be within a cap that can be attached to the distal end of an endoscope, a catheter, a borescope, and/or .laparoscope device.
- the cap can be disposable, and/or can contain one or more apertures or openings to al low the passage of devices, fluids, or tissue to eftect a change in the anatomic structure.
- the arrangement of optica! elements coupled with, or to certain endoscopes, and exemplary signal. processing methods can facilitate an acquisition of continuous raulti- directional views, without the need for additional auxiliary imaging devices deployed through the endoscope accessory channel.
- FIG. 1 shows a side cross-sectional block diagram of an i maging system/apparatns and optical elements thereof according to an exemplary embodiment of the present disclosure.
- a distal imaging attachment cap I of the exemplary imaging system of FIG, 1 can be facilitated in an endoscope 14.
- the attachment cap 1 can contain an optical element/arrangement 4 which cm include certain multiple configurations, such as but not limited to a fiber optic bundle, a tapered fiber optic bundle, a cone mirror, a partial cone mirror, a pentagon mirror., an. inverted pyramid mirror, a prism, and/or multiple mobile optical elements.
- exemplary optical element/arrangement 4 can achieve, e.g., a side and retrograde endoscopic view while maintaining the endoscope's field of view 5, such as the forward field of view.
- the exemplary optical element 4 may also have or applied thereto a customized reflective material to facilitate a detailed and customized manipulation of the field, of vie or wavelengths.
- Such exemplary arrangement can facilitate the user of the exemplary endoscopic system to view both the forward field of view 5 and fields of view located to the side and retrograde 6 to the endoscope's objective lens 2 and endoscope light 3.
- the exemplary optical element 4 can be, e.g.. a 4-faceted pyramid dichroic mirror which can transmit and/or reflect radiations (e.g., electromagnetic .radiations, including light, etc) with different characteristics.
- the exemplary characteristics can include and ' or be wavelengths or polarizations.
- the first and second radiations can have spectral regions ' in red, green, and blue bands which likely do not substantially overlap with one another (at least for the most part), hi addition or alternatively, the first and second radiations can have a specific polarization status.
- the first radiation can be directed in a forward direction 21
- the second radiation can be directed in a backward direction or side directions (e.g., directions 22, 23, 24, 25).
- a manual and/or electronic switch 8 which can include a modulation arrangement
- a manual and/or electronic switch 8 which can include a modulation arrangement
- the distal imaging attachment cap 1 can be placed at the distal tip of the endoscope 1 ,
- a system can be provided ⁇ which cart include but not limited to one or more of, e.g., computer 31 , video capture device and synchronization signal generator 32, and endoscope video processor 33).
- the endoscopic arrangement 14 can be associated with the radiation source arrangement (which can include but not limited to one or more of, e.g., endoscopic Hgnt radiation source 9, an exemplary procedure to filter, polarize, bend and/or exclude predetermined wavelength(s) of the radiations) 7, and manual and/or electronic switch 8) and a detector arrangement.
- the radiation source arrangement can include the modulation arrangement (including, e.g., element 8) which can be configured to modulate the first and second radiations.
- the computer 31 and/or the signal generator 32 can be configured to synchronize the radiatio source arrangement (including, e.g., elements 8, 9) arid/or the entire system (including e.g., elements 31, 32, and 33).
- the computer 31 and or the signal generator 32 can be configured to (i) synchronize the modulation arrangement (including, e.g., element 8 ⁇ and the detector arrangement, and/or (ii) control the system to detect signals from the anatomical structure ⁇ ) illuminated by the first, and second radiation, and separate the signals based the synchronizaiion with the modulation arrangement (e.g., element 8).
- the modulation arrangement including, e.g., element 8 ⁇ and the detector arrangement, and/or (ii) control the system to detect signals from the anatomical structure ⁇ ) illuminated by the first, and second radiation, and separate the signals based the synchronizaiion with the modulation arrangement (e.g., element 8).
- an exemplary modulation arrangement of another exemplary embodiment of the present disclosure ca include a beam, splitter 41 to divide the radiation, (e.g., Sight and/or beam) into two beam paths.
- one beam can pass a filter for predetermined wavelengtfa(s) or polarizations ⁇ 44 to provide the fist radiation 45.
- the other beam can be reflected by a mirror 42, and can pass another filter for another predetermined wavelengih(s) or polarization 43 with different characteristics compared with the wavelength(s) or polarization 44 to provide the second radiation 46.
- another exemplary modulation arrangement can include a beam splitter for predetermined ave!en this) or polarization 47 to provide the first radiation 45 am! the second radiation 46.
- FIGS. 5 ⁇ s)-5(c) illustrate block diagrams of various exemplary electronic switches according to further exemplary' embodiments of the present disclosure.
- the exemplary electronic switches of FIGS. 5(a)-5(c) can include an optical chopper 51 synchronized with the computer 31 and/or the signal generator 32 (shown in FIG. 3).
- the fist radiation 45 and second radiation 46 can be alternatively coupled into the endoscope 14 by exemplary optica! components (e.g., a mirror 52, a beam splitter 53, and a lens 54).
- Such exemplary optical components can be switched by the optical chopper's positions, as shown in. FIG. 5(b) and 5(c).
- FIGS. 5 ⁇ s)-5(c) illustrate block diagrams of various exemplary electronic switches according to further exemplary' embodiments of the present disclosure.
- the exemplary electronic switches of FIGS. 5(a)-5(c) can include an optical chopper 51 synchronized with the computer 31 and/or the signal generator 32 (shown in FIG
- FIGS, 6(a) and 6(b) show another exemplary electronic switch arrangement according to yet another exemplary embodiment of the present disclosure, provided in different switch position.
- the exemplary switch arrangement of FIGS, 6(a) and 6(b) can include a galvo scanner 61 which can be synchronized with the computer 3 and/or the signal generato 32 (shown in FIG. 3).
- the first -radiation 45 and the second radiation 46 can be alternatively- coupled into the endoscope 14 by exemplary optical components (e.g. , lens 62) switched by the galvo scanner's positions as shown in FIGS, 6(a) and.6(b).
- the exemplary distal imaging attachment cap 1 can facilitate a use of a fluid delivery channel 76 and/or an accessory channel 72 to maintain its original use by providing a nonobstructive pathway for an endoscopic manipulation within the endoscope 1 via the accessory channel 72.
- the exerapiary system/appam s/method cao be used for a simultaneous or controlled switching between the above described forward field of view 5 and the side/retrograde field of view 6.
- a exemplary procedure 12 (which can be used to program a processing hardware arrangement, such as, e.g., a computer) can be used to deconstruct a wavelength/polarization "profile" of each field of view 10, 1 1 by electronically splitting native and multidirectional fields of view.
- exemplary selective filtering of, e.g. , white light to facilitate, only the reflectance or transmission phase to- be analyzed can be accomplished by placing applying a filter at the endoscope's connection to its processing arrangement (e.g., the processor). Toggling between the on and off phases, e.g., manually (such as with a manual foot pedal), automatically or via an electronic switch, the reflected or transmitted light/radiation can then be deconstructed via a further procedure which can program or configure the processing arrangement to continuously display the forward and multidirectional fields of view 13 ,
- another procedure can be provided which can program or configure the processing arrangement to deconstruct each ixel, and display the two profiles determined by the reflective transmission wavelengths, polarizations or characteristic properties established by a special arrangement 7, the optical element(s) 4 and angles of observation of each field of view 5, 6.
- the exemplary imaging system of FIG. I can also use of an alternative light source which can be deployed, e.g., via the cap irrigation channel 81 (shown in FIG. 8).
- the use of such light source via the irrigation channel 81 can provide and/or facilitate, e.g., a further selective manipulation of the reflectance and transmission frequencies for an improved discretio between the phases for an exemplary image manipulation via a procedure which can program or configure the processing arrangement to perform such exemplary function,
- a plastic, transparent, serai- flexible disposable cap I can he fitted over the distal tip of the endoscope 14 via a friction fit configuration 82, as shown in FIG. 8.
- the exemplary design and/or configuration of this cap 1 can be provided in various ways, e.g., depending on the indication of the exemplary endoscopic procedure.
- Shapes of the exemplary cap I can include, but are not limited to oblique or perpendicular angled shapes, in respect to the distal aspect of the endoscope 14 and a location of the objective lens 2.
- the distal imaging attachment is designed to be in a specific orientation so as to facilitate the native functions of the endoscope to continue to operate withou an interruption.
- the exemplary cap 1 can include clearance chamber 83 (as shown in FIG. 8), which can seal the distal apparatus away from luminal liquid and contents, while continuing to facilitate the instillation of water for imaging and cleaning.
- This above described exemplary clearance chamber 83 can contain a perforation located above the accessory chamber 86 to facilitate suctioning of contents of the clearance chamber 83.
- a water jet output channel e.g., the fluid deliver 1' chamber
- the distal imaging cap is also structured atid/or designed with an irrigator port 81 which can facilitate the attachment of a lavage device or syringe to aid in a clearance of liquid and/or debri s from the distal attachment cap 1.
- the exemplary cap 1 can be coupled with multiple optical elements 85 in the optical chamber 84.
- a plastic, transparent, semi -flexible and disposable cap which can facilitate a. circular configuration and arrangement of multiple imaging detectors within a small collar 91, as shown in FIG. 9.
- This exemplary collar 91 can facilitate overlapping, multidirectional and circumferential views of the desired target sample (e.g., organ) or space being inspected.
- This exemplary configuration can facilitate the use of multiple light sources and independent optical sensors, e.g., bypassing a preference to alter the conventional endoscopes light source.
- Exemplary image processing of images obtained using the system, apparatus and method accordi ng to the present disclosure can be accompli shed usi ng the exemplary procedures implemented on the exemplary processing arrangement, as described herein.
- an exemplary procedure implemented on the exemplary processing arrangement according to an exemplary embodimeot of the present disclosure can assist i an alignment of the signals to provide, e.g., a 360 degree, multidirectional field of view 92, as shown in FIG. 9.
- FIG. 10 shows a set of exemplary images achieved using the exemplary system, method a»d or computer-accessible medium according to the exemplary embodiments of the present disclosure.
- Such exemplary images were based on exemplary testing result using an exemplary software separation via a simultaneously illumination and utilizing a 442/505/635 nra Yokogawa dichroic beamsplitter installed at the distal to a CCD camera with lens, Massachusetts General Hospital (" GH”) logo and Harvard Medical School (“H. S”) logo were used as the image targets, placed in front of, and at side of the dichroic beamsplitter, respectively.
- the white fight source was not modulated and illuminated on the two image targets simultaneously.
- the separately captured exemplary individual images of the logos are shown in FIG.
- the exemplary procedure 12 described herein above with respect to FIG.. 1 (which may be used to program a processing hardware arrangement, such as, e.g., a computer) can be utilized to deconstruct the wavelength "profile" of each field of view by splitting the native and multidirectional fields of vie with the two logos.
- the exemplary procedure 12 can be one or more programs including, bat not limited to, e.g.. Neural Network and/or Independent Component Analysis, or other procedure/program which can configure the processing hardware arrangement to separate the two views from the captured combined image 101.
- the exemplary reconstructed images of each field of view are shown in FIG. 10 as images 104, 105, respectively.
- the exemplary software based separation which splits the two views as described herein., can significantly reduce the complexity of various components/parts of the procedure, system and computer-accessible medium according to the exemplary embodiments of the present disclosure,
- An exemplary integration of such exemplar ⁇ '' configuration thai is associated with a distal imagin cap which is is coupled with various optical elements has been described herein.
- The foregoing merely illustrates the principles of the invention. Various modifications and alterations to the described embodiments will be apparent to those skilled in the art in view of the teachings herein.
- Triadafilopoulos G Watts HD, Higgins J, Van Dam I.
- a novel retrograde- viewing auxiliary imaging device improves the detection of simulated polyps in anatomic models of the colon. Gastrointest Endosc 2007;65:139-44.
Abstract
An exemplary apparatus for imaging at least one anatomical structure can be provided. For example, the apparatus can include an endoscopic first arrangement, a radiation source second arrangement which provides at least one electro-magnetic radiation, and a third arrangement attached to at least one portion of the endoscopic arrangement. The third arrangement can contain an optical arrangement which, upon impact by the at least one electro-magnetic radiation and based thereon, may transmit a first radiation and reflects a second radiation. The first radiation can impact at least one first portion of the anatomical structure(s), and the second radiation can impact at least one second portion of the anatomical structure(s). The first and second portions can be at least partially different from one another. Further, the first and second radiations can have characteristics which are different from one another.
Description
IMAGING SYSTEM, METHOD AND DISTAL ATTACHMENT FOR
MULTIDIRECTIONAL FIELD OF VIEW ENDOSCOPY
CROSS-REFERENCE TO RELATED APFLICATlONf S
[8001] This application based upon and claims the benefit of priority from U.S. Patent Application Serial 'No. 61/618,225, filed March 30, 20.12, the entire disclosure of which is incorporated herein by reference.
FIELD OF THE DISCLOSURE
[8002] Exemplary embodiments of the present disclosure relate to endoscopic imaging system and methods for multidirectional field of view endoscopy which can be used to improve the field of view, speed and efficiency of diagnostic and therapeutic endoscopic procedures.
BACKGROUND OF THE DISCLOSURE
[0003] In. general endoscopic imaging systems allow the evaluation, of animal and human internal organs. Endoscopes can consist of at least one of the following components, a rigid or flexible tube, a light dehvery system, fluid delivery and recovery system, an. air delivery and recovery system, a lens system, an eyepiece, a high pixel -count color CCD or imaging transmission system, graphical display unit (monitor), and /or accessory channel(s) to allow use of devices for manipulation, sampling or imaging of target lesions.
(0004] The endoscope may be inserted into any natural orifice of the animal or human including the nares, ears, mouth, biliary tract, pancreatic duct, ostomy, urinary tract, vagina, utems, fallopian tubes, anus and/or any opening produced by procedures employing an incision or puncture. into an. internal bod cavit (craniotomy, thoracotomy, mediastinotomy, laparotomy or arthrotomy). While currently available endoscopes are capable of evaluating target structures by the obligatory forward or other directional field of view obtained by current light delivery and lens systems, in some medical applications this design increases the risk for missed detection of important areas of interest. As a result, there is a need for multi-directional visualization.
[0005] Colonoscopy is widely considered the gold standard for detecting mucosal abnormalities in the human colon, and the preferred technique for removal of many non-invasive lesions requires biopsy, polypectomy or endoscopic resection. There have been well-documented
limitations related to the practice of colonoscopy with traditional endoscopic instruments. Because most colon cancers are believed to arise from abnormal colon tissue, adenomas, the detection and removal of adenomatous polyps have been recommended tor the prevention of future colon cancers. (See, e.g., ref. 1). Missed polyps or cancers have been one of these unfortunate limitations. (See, e.g., reft. 2-4). Although there are additional factors associated with the risks of missing mucosal lesions such as, a patient's colonic anatomy, patient comfort during an endoscopic procedure and the quality of bowel preparation, it has been well established by other investigators, that the location of mucosal .abnormalities is highly associated with failure of identification. (See, e.g., ref. 4).
(0006] Prior groups have investigated several approaches to attempt, to demonstrate a improvement in the diagnostic yield of a colonoscopic procedure by altering or increasing the conventional forward fields of view. Unfortunately these studies did not demonstrate a significant increase m adenoma detection. (See, e.g. , refs. 5-7). Nevertheless, the uses of a transparen cap that does not change or improve the field of view placed on the distal aspect of colonoscopies have demonstrated great promise in improving the effectiveness of colonoscopy (see, e.g., refs. 8 1) and adenoma detection (see, e.g., ref. 12), however the use of these devices are still associated with a significant adenoma miss rate. (See, e.g., ref. 1 ).
[0007] Other researchers have attempted to improve the adenoma detection rate established with the use of a conventional endoscopic system by increasing the total field of view during a colonoscopy by coupling the traditional endoscope with an auxiliary imaging device, placed within the accessory channel, to provide a continuous retrograde view of the target organ via the accessory channel (See, e.g., ref. 1 ), While this auxiliary imaging device provides a continuous retrograde field of view used in combination with traditional forward viewing endoscopes, it requites the use of an accessory channel of the endoscope. This becomes an important factor during colonoscopy, if used with a standard single channel colonoscopy, due to the necessity to remove the auxiliary imaging device to allow for the use of an appropriate auxiliary sampling or retrieval instrument to biopsy, resect and. retrieve specimens removed from the organ being investigated. This additional equipment has been shown in a prospective, rouSticenter, randomized, controlled trial to decrease the relative risk of missing polyps a d adenomas but was also shown to have a statistically significant increase in the mean total procedure times.1*
Auxiliary endoscopic devices placed within the auxiliary channel of the endoscope have the fiirthef disadvantage that they require an additional endoscope, which increases complexity, ease of lise, and cost of the overall procedure.
[0098] Thus, there is a need to address at least some of the issues and/or deficiencies described herein above,
SU MARY OF EXEMPLARY EMBODIMENTS
10009] In various exemplary embodiments according to the present disclosure, exemplary configurations for the acquisition of multidirectional viewing during endoscopic examination can be provided. Exemplary applications can be utilized, in which increasing the field of view while using high resolution endoscopic systems can be improved with the exemplary embodiments of the system and method of continuous and simultaneous forward, and mdtidirectional views during a baroscopfc, laparoscopic, angioseopie, or endoscopic procedure.
(0010] Exemplary embodiments of the present disclosure can relate generally to exemplary configuration of optical elements, and to the app!ication(s) thereof in exemplary endoscopic imaging systems which can be used with medical applications to improve the field of view, speed and efficiency of an endoscopic procedure. Exemplary embodiments of the present disclosure can be applied to rigid, flexible, wireless or telescoping endoscope to provide, e.g., continuous multi-directional view of animate and i nanimate holl ow spaces.
| 011 f in one further exemplar embodiment of the present disclosure, a distal imaging attachment and an imaging system can be used in combination with a rigid, flexible, wireless or telescoping endoscope to create a continuous nmlti-direciional view of animate and inanimate hollow spaces. According to a further exemplary embodiment of the present disclosure, the directions are forward and to the side. In yet another preferred embodiment of the present disclosure, the directions are forward and backward. In still yet another further embodiment, the directions cover approximately a 4pi solid angle that is only obscured by the device itself. This said distal imaging attachment and imaging system may be employed, but not limited to, with endoscopy of animal and human internal anatomical organs and borescopy of inanimate closed spaces. Due to its design, the integrated optical element within this imaging system, allowing both the forward and multidirectional fields of view.
[001.2] In yet further exemplary embodiment, of the present disclosure, it is also possible to accommodate the simultaneous passage of devices via the accessory channel of video endoscope or applicable device of which the distal imaging attachment is applied, For example, optica! elements in the exemplary device can be configured to facilitate a multidirectional viewing of target organs or spaces with exemplary endoscopes. In another exemplary embodiment of the present disclosure, the exemplary device can be retrofitted to alter the native conventional high definition endoscopes currently used in endoscopic procedures. In still ferther exemplary embodiment of the present disclosure, the exemplary device/apparatus can be disposable.
[0013] Indeed, exemplar}- embodiments according to the present disclosure as described herein, can be provided as exemplary endoscopic lens systemis), and can be termed as "miutidirectionar, "sii ilview" or "retroview", and utilized as a basis for exemplary embodiments of endoscopic systems for a deployment.
[0014] Further, an exemplary apparatus for imaging at least one anatomical structure can be provided, according to an exemplary embodiment of the present disclosure. For example, the apparatu can include an endoscopic first arrangement, radiation source second arrangement which provides at least one electro-magnetic radiation, and a third arrangement attached to at least one portion of the endoscopic arrangement. The third arrangement can contain an optical arrangement which, upon impact by the at least one electro-magnetic radiation and based thereon, may transmit a first radiation and reflects a second .radiation. The first radiation can impact at least one first portion of the anatomical structure^), and the second radiation can impact at least one second portion of the anatomical structare(s). Tire first and second portions can be at least partially different from one another. Further, the first and second radiations can have characteristics which are different from one another.
100.15] For example, the characteristics can include or be wavelengths or polarizations, A detector arrangement can be provided, whereas the endoscopic arrangement can be associated with the radiation source arrangement and the detector arrangement The first and second radiations can have spectral regions in red, green and blue band which do not substantially overlap with one another. The first radiation can be directed, in a forward direction, and the second radiation can be directed in a backward direction or a side direction. The third arrangement can include a cap that can be connected to an. end portion of the endoscopic firs
arrangement. The second radiation can simultaneously illuminate between 270 and 360 degrees of a field of view. Further, the radiation source second arrangement can include a -modulation arrangement whic can be configured to modulate the first and second radiations. An electronic arrangement caa be provided which is configured to synchronize the second arrangement and the detector arrangement. As an alternative or in addition, the electronic arrangement can be configured to (i) synchronize the modulatio arrangement and the detector arrangement, and (ii) control the detector arrangement to detect signals from the anatomical stracture(s) illuminated by the first and second radiation, and separate the signals based the synchronization with the modulation arrangement.
(00161 According to further exemplary embodiments of the present d isclosure, the anatomical stnicture(s) can be a luminal anatomical structure. T he third arrangement can include at least one opening which facilitates a passage of instrumentation, air gasses and/or fl uids therethrough. A tube can be provided that is associated with the third arrangement, and whic provide a passage of instrumentation, air gasses and/or fluids therethrough. Further, the first and second radiations can have a specific polarization status.
[0017] Other features and advantages of the present invention will become apparent upon reading the following detailed description of exemplary embod iments of the present disclosure, when taken in conjunction with the appended claims. BRIEF DESCRIPTION Off THE DRAWINGS
[0018] Further objects, features and advantages of the present disclosure will become apparent from, the following detailed description taken in conjunction with the accompanying Figures showing illustrative embodiments of the present disclosure, in which;
[00.19] FIG. 1 is a side cross-sectional block diagram of an imaging system/apparatus and opti cal elements thereof according to an exemplary embodiment of the present disc losure;
[0020] FIG. 2 is a set of view of an exemplary optical element consists a 4-facered pyramid dichroic mirror which can transmit and reflect radiations with different characteristics according to an exemplary embodiment of the present disclosure;
[002.1] FIG. 3 a block diagram of an endoscopic arrangement, a radiation source arrangement; and a detector arrangement according to exemplary embodiments of the present disc losure;
(0022] FIGS. 4(a) and 4(b) are block diagrams of exemplary modulation arrangements according to an exemplary embodiment of the present disclosure;
0023| FIG. 5(a) is a diagram of an exemplary electronic switch based on an optical chopper according to an exemplary embodiment, of the present disclosure;
(0024] FIG. 5(b) is a diagram of the exemplary electronic switch based on a first switch position according to an exemplary embodiment of the present disclosure;
[0025] FIG. 5(c) is a diagram of the exemplar}'' electronic switch based on a second switch position according to an exemplary embodiment of the present disclosure;
(00 61 G. 6(a) a diagram of a further exemplary electronic switch based on a galvo scanner at a first switch position according to another exemplary embodiment of the present disclosure;
[0027] FIG, 6(a) a diagram of the exemplary electronic switch of F IG, 6(a) based on the galvo scanner at a second switch position according to another exemplary embodiment of the present disclosure;
(0028] FIG. 7 a front view of the optica! elements provided within a distal imaging attachment cap of the exemplary imaging system/apparatus of FIG, I ;
|9029] FIG. 8 a side view of the imaging system/apparatus, optical elements and distal imaging attachment cap, as shown in FIG. 7;
(0030) FIG. 9 is a set of illustrations providing external distal image atfaehm.en.ts and an overlapping field external display Diagram according to exemplary embodiments of the present disclosure; and
0931] FIG. 10 is a set of exemplary images providing exemplary testing results achieved using the exemplary system., method and or computer-accessible medium according to the exemplary embodiments of the present disclosure.
[0932] Throughout, the drawings, the same reference numerals and characters, unless otherwise stated, are used to denote like features, elements, components, or portions of the illustrated embodiments. Moreover, while the present disclosure will now be described in detail with reference to the figures, it is done so in connection with the illustrative embodiments and is not limited by the particular embodiments illustrated in the figures, and/or the appended claims.
DETAILED DESCRIPTION OF EXEMPLARY EMBODIMENTS
0033j Using the exemplary embodiments of the apparatus, system and method of the present disclosure, it is possible to facilitate a visualization of a plurality of fields of view, e.g., at a plurality of angles with respect to the long axis of the endoscope by multiplexing image fields of view using an optical apparatus, in one exemplary embodiment of the present disclosure, an optical apparatus/system can be provided which can. be partially reflective and/or may be a polarization or wavelength selective such that certain wavelengths or polarization states are directed to and/or received from different field angles and therefore illuminate and/or receive different fields of view.
(0034] The exemplary states may be altered by changing the characteristics of the optics or the optical characteristics of the light, such as the wavelengths or the polarization, state. For example, such changes of wavelengths can be different bands of wavelengths in the RGB spectrum. Alternatively, the different wavelengths may be comprised of different wavelength bands in the visible and NM spectrum. Furthermore, e.g., the characteristic^) of the light is not changed by the optical apparatus, but the images are separated using software algorithms, in yet another embodiment, the optical apparatus contains a beam splitter, hi a further exemplary embodiment of the present disclosure, the optical apparatus can be configured and/or structured to be within a cap that can be attached to the distal end of an endoscope, a catheter, a borescope, and/or .laparoscope device. For example, the cap can be disposable, and/or can contain one or more apertures or openings to al low the passage of devices, fluids, or tissue to eftect a change in the anatomic structure.
|0fl35] According to another exemplary embodiment of the present disclosure, the arrangement of optica! elements coupled with, or to certain endoscopes, and exemplary signal. processing methods can facilitate an acquisition of continuous raulti- directional views, without the need for additional auxiliary imaging devices deployed through the endoscope accessory channel.
|0036] FIG. 1. shows a side cross-sectional block diagram of an i maging system/apparatns and optical elements thereof according to an exemplary embodiment of the present disclosure. For example, a distal imaging attachment cap I of the exemplary imaging system of FIG, 1 can be facilitated in an endoscope 14. The attachment cap 1 can contain an optical element/arrangement
4 which cm include certain multiple configurations,, such as but not limited to a fiber optic bundle, a tapered fiber optic bundle, a cone mirror, a partial cone mirror, a pentagon mirror., an. inverted pyramid mirror, a prism, and/or multiple mobile optical elements. The use of such exemplary optical element/arrangement 4 can achieve, e.g., a side and retrograde endoscopic view while maintaining the endoscope's field of view 5, such as the forward field of view. The exemplary optical element 4 may also have or applied thereto a customized reflective material to facilitate a detailed and customized manipulation of the field, of vie or wavelengths. Such exemplary arrangement can facilitate the user of the exemplary endoscopic system to view both the forward field of view 5 and fields of view located to the side and retrograde 6 to the endoscope's objective lens 2 and endoscope light 3.
[0037] According to another exemplary embodiment of the present disclosure, as shown in FIG. 2, the exemplary optical element 4 can be, e.g.. a 4-faceted pyramid dichroic mirror which can transmit and/or reflect radiations (e.g., electromagnetic .radiations, including light, etc) with different characteristics. For example, the exemplary characteristics can include and'or be wavelengths or polarizations. The first and second radiations can have spectral regions 'in red, green, and blue bands which likely do not substantially overlap with one another (at least for the most part), hi addition or alternatively, the first and second radiations can have a specific polarization status. For example, the first radiation can be directed in a forward direction 21 , and the second radiation can be directed in a backward direction or side directions (e.g., directions 22, 23, 24, 25).
|8038] Further, turning to FIG. 1 , according to an exemplary embodiment of the present disclosure, it is possible to facilitate a toggling via a manual and/or electronic switch 8 (which can include a modulation arrangement), e.g., to apply an exemplary procedure to filter, polarize, bend and/or exclude predetenniiied waveiength(s) of one or more radiations (e.g., lights) 7 of an. endoscopic light/radiation source 9. As indicated herein, the distal imaging attachment cap 1 can be placed at the distal tip of the endoscope 1 ,
(0039) According to another exemplary embodiment of the present disclosure, as shown in FIG. 3, a system can be provided {which cart include but not limited to one or more of, e.g., computer 31 , video capture device and synchronization signal generator 32, and endoscope video processor 33). The endoscopic arrangement 14 can be associated with the radiation source arrangement (which can include but not limited to one or more of, e.g., endoscopic
Hgnt radiation source 9, an exemplary procedure to filter, polarize, bend and/or exclude predetermined wavelength(s) of the radiations) 7, and manual and/or electronic switch 8) and a detector arrangement. Further, as indicated herein above, the radiation source arrangement can include the modulation arrangement (including, e.g., element 8) which can be configured to modulate the first and second radiations. The computer 31 and/or the signal generator 32 can be configured to synchronize the radiatio source arrangement (including, e.g., elements 8, 9) arid/or the entire system (including e.g., elements 31, 32, and 33). As an alternative or in addition, the computer 31 and or the signal generator 32 can be configured to (i) synchronize the modulation arrangement (including, e.g., element 8} and the detector arrangement, and/or (ii) control the system to detect signals from the anatomical structure^) illuminated by the first, and second radiation, and separate the signals based the synchronizaiion with the modulation arrangement (e.g., element 8).
[8040] According to yet another exemplary embodiment of the present disclosure, as shown in FIG. 4(a), an exemplary modulation arrangement of another exemplary embodiment of the present disclosure ca include a beam, splitter 41 to divide the radiation, (e.g., Sight and/or beam) into two beam paths. For example, one beam can pass a filter for predetermined wavelengtfa(s) or polarizations} 44 to provide the fist radiation 45. The other beam can be reflected by a mirror 42, and can pass another filter for another predetermined wavelengih(s) or polarization 43 with different characteristics compared with the wavelength(s) or polarization 44 to provide the second radiation 46.
18041] Further, as shown in FIG. 4(b), another exemplary modulation arrangement according to still another exemplary embodiment of the present disclosure can include a beam splitter for predetermined ave!en this) or polarization 47 to provide the first radiation 45 am! the second radiation 46.
[8042] FIGS. 5{s)-5(c) illustrate block diagrams of various exemplary electronic switches according to further exemplary' embodiments of the present disclosure. The exemplary electronic switches of FIGS. 5(a)-5(c) can include an optical chopper 51 synchronized with the computer 31 and/or the signal generator 32 (shown in FIG. 3). The fist radiation 45 and second radiation 46 can be alternatively coupled into the endoscope 14 by exemplary optica! components (e.g., a mirror 52, a beam splitter 53, and a lens 54). Such exemplary optical components can be switched by the optical chopper's positions, as shown in. FIG. 5(b) and 5(c).
(0043] FIGS. 6(a) and 6(b) show another exemplary electronic switch arrangement according to yet another exemplary embodiment of the present disclosure, provided in different switch position. The exemplary switch arrangement of FIGS, 6(a) and 6(b) can include a galvo scanner 61 which can be synchronized with the computer 3 and/or the signal generato 32 (shown in FIG. 3). For example, the first -radiation 45 and the second radiation 46 can be alternatively- coupled into the endoscope 14 by exemplary optical components (e.g. , lens 62) switched by the galvo scanner's positions as shown in FIGS, 6(a) and.6(b).
£0044] According t another exempiaiy embodiment of the present disclosure, as shown in FIG. 7, the exemplary distal imaging attachment cap 1 can facilitate a use of a fluid delivery channel 76 and/or an accessory channel 72 to maintain its original use by providing a nonobstructive pathway for an endoscopic manipulation within the endoscope 1 via the accessory channel 72. Other
EXEMPLARY IMAGE PROCESSING
j©04Sj In one exemplary embodiment of the present disclosure, with reference to FIG. I. the exerapiary system/appam s/method cao be used for a simultaneous or controlled switching between the above described forward field of view 5 and the side/retrograde field of view 6. In order to facilitate accurate localization of target lesions obtained with the exemplary imaging system, a exemplary procedure 12 (which can be used to program a processing hardware arrangement, such as, e.g., a computer) can be used to deconstruct a wavelength/polarization "profile" of each field of view 10, 1 1 by electronically splitting native and multidirectional fields of view.
|0<M6] Using an a light/radiation source of the endoscope 14, exemplary selective filtering of, e.g. , white light to facilitate, only the reflectance or transmission phase to- be analyzed can be accomplished by placing applying a filter at the endoscope's connection to its processing arrangement (e.g., the processor). Toggling between the on and off phases, e.g., manually (such as with a manual foot pedal), automatically or via an electronic switch, the reflected or transmitted light/radiation can then be deconstructed via a further procedure which can program or configure the processing arrangement to continuously display the forward and multidirectional fields of view 13 ,
to
(0047] According to yet further exemplary embodiment of the present disclosure, another procedure can be provided which can program or configure the processing arrangement to deconstruct each ixel, and display the two profiles determined by the reflective transmission wavelengths, polarizations or characteristic properties established by a special arrangement 7, the optical element(s) 4 and angles of observation of each field of view 5, 6.
|00 8] The exemplary imaging system of FIG. I can also use of an alternative light source which can be deployed, e.g., via the cap irrigation channel 81 (shown in FIG. 8). The use of such light source via the irrigation channel 81 can provide and/or facilitate, e.g., a further selective manipulation of the reflectance and transmission frequencies for an improved discretio between the phases for an exemplary image manipulation via a procedure which can program or configure the processing arrangement to perform such exemplary function,
EXEMPLAR YAPMJCA ΏΠΝ OF EXEMPLAR ¥EMBi)MMENT
Exemplary Cap Design
| 49| According to one exemplary embodiment of the present disclosure, a plastic, transparent, serai- flexible disposable cap I can he fitted over the distal tip of the endoscope 14 via a friction fit configuration 82, as shown in FIG. 8. The exemplary design and/or configuration of this cap 1 can be provided in various ways, e.g., depending on the indication of the exemplary endoscopic procedure. Shapes of the exemplary cap I can include, but are not limited to oblique or perpendicular angled shapes, in respect to the distal aspect of the endoscope 14 and a location of the objective lens 2.
[9050] In a further exemplary embodiment of the present disclosure, the distal imaging attachment is designed to be in a specific orientation so as to facilitate the native functions of the endoscope to continue to operate withou an interruption. To facilitate the function, of, e.g., cleaning the endoscopes objective lens 71, a light guide 74, an air nozzle 73, and a water nozzle 75 (as shown in FIG. 7), the exemplary cap 1 can include clearance chamber 83 (as shown in FIG. 8), which can seal the distal apparatus away from luminal liquid and contents, while continuing to facilitate the instillation of water for imaging and cleaning. This above described exemplary clearance chamber 83 can contain a perforation located above the accessory chamber 86 to facilitate suctioning of contents of the clearance chamber 83. To facilitate the distai imaging ca to be cleaned, a water jet output channel (e.g., the fluid deliver)1' chamber) 76 can be
1.1
provided which is structured and/or designed to be unobstructed by the exemplary cap 1.
Furthermore, to provide more aggressive cleansing, e.g.., the distal imaging cap is also structured atid/or designed with an irrigator port 81 which can facilitate the attachment of a lavage device or syringe to aid in a clearance of liquid and/or debri s from the distal attachment cap 1.
(0051 ] Further, the exemplary cap 1 can be coupled with multiple optical elements 85 in the optical chamber 84.
Overlapping Field Cap Design
({105 1 According to yet another exemplary embodiment of the present disclosure, it is possible to use a plastic, transparent, semi -flexible and disposable cap, which can facilitate a. circular configuration and arrangement of multiple imaging detectors within a small collar 91, as shown in FIG. 9. This exemplary collar 91 can facilitate overlapping, multidirectional and circumferential views of the desired target sample (e.g., organ) or space being inspected. This exemplary configuration can facilitate the use of multiple light sources and independent optical sensors, e.g., bypassing a preference to alter the conventional endoscopes light source. Exemplary image processing of images obtained using the system, apparatus and method accordi ng to the present disclosure can be accompli shed usi ng the exemplary procedures implemented on the exemplary processing arrangement, as described herein. For example, depending on the number of optical elements placed within the exemplary imaging collar - cap design, an exemplary procedure implemented on the exemplary processing arrangement according to an exemplary embodimeot of the present disclosure can assist i an alignment of the signals to provide, e.g., a 360 degree, multidirectional field of view 92, as shown in FIG. 9.
Exemplary Testing
(0053] Further exemplary testing was performed usin the following: (I ) Polka dot beam splitter, (2) 50:50 beam splitter AQ1 45 degree, (3) long pass dichroic minor, 50% Trans. Reft At 567n.ro, (4) cone mirror or (5) 395/495/610nm Triple-edge dichroic beam splitter installed at multiple distances distal to the endoscopes objective leans. Preliminary testing with both a white light and infrared Sight source was successful in demonstrating that selective observation of the forward and retrograde views could be accomplished if the optical element was oriented at an angle such as a 45 degree. 30 degree, or 60 degree angle to the endoscopes objective lens.
|0Θ54] FIG. 10 shows a set of exemplary images achieved using the exemplary system, method a»d or computer-accessible medium according to the exemplary embodiments of the present disclosure. Such exemplary images were based on exemplary testing result using an exemplary software separation via a simultaneously illumination and utilizing a 442/505/635 nra Yokogawa dichroic beamsplitter installed at the distal to a CCD camera with lens, Massachusetts General Hospital (" GH") logo and Harvard Medical School ("H. S") logo were used as the image targets, placed in front of, and at side of the dichroic beamsplitter, respectively. In this testing, the white fight source was not modulated and illuminated on the two image targets simultaneously. The separately captured exemplary individual images of the logos are shown in FIG. 1.0 as MGH 102, and HMS 1.03. A captured exemplary combined image 101 with the two logos in positions at the same time was the image intended to be processed. The exemplary procedure 12 described herein above with respect to FIG.. 1 (which may be used to program a processing hardware arrangement, such as, e.g., a computer) can be utilized to deconstruct the wavelength "profile" of each field of view by splitting the native and multidirectional fields of vie with the two logos. For example, the exemplary procedure 12 can be one or more programs including, bat not limited to, e.g.. Neural Network and/or Independent Component Analysis, or other procedure/program which can configure the processing hardware arrangement to separate the two views from the captured combined image 101. The exemplary reconstructed images of each field of view are shown in FIG. 10 as images 104, 105, respectively. The exemplary software based separation, which splits the two views as described herein., can significantly reduce the complexity of various components/parts of the procedure, system and computer-accessible medium according to the exemplary embodiments of the present disclosure, |0 55] An exemplary integration of such exemplar}'' configuration thai is associated with a distal imagin cap which is is coupled with various optical elements has been described herein. |1 6| The foregoing merely illustrates the principles of the invention. Various modifications and alterations to the described embodiments will be apparent to those skilled in the art in view of the teachings herein. Indeed, the arrangements, systems and methods according to the exemplary embodiments of the present invention can be used with any OCT system, OFDl system, SD-OCT system or other imaging systems, and for example with those described in. international Patem Application PCT/US2004/029148, filed September 8, 2004, U.S. Patent Application No. 1 1/266,779, filed November 2, 2005, and. U.S. Patent Application No.
10/501 ,276, filed July 9, 2004, the disclosures of which are incorporated by reference herein in their entireties. It will thus be appreciated that those skilled in the art will be able to devise numerous systems, arrangements and methods which, although not explicitly shown or described herein, embody the principles of the invention and are thus within the spirit and scope of the present invention. In addition, to the extent that the prior art knowledge has not been explicitly incorporated by reference herein above, it is explicitly being incorporated herein in its entirety. All publications referenced herein above are incorporated herein by reference in their entireties.
Exemplary References:
1. Winawer SI, Zauber AG, Ho MN, O'Brien MI, Gottlieb LS Sternberg SS, Wave JD,.
Schapi.ro M, Bond JH, Panish Jf, et. al. Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup. N Engl J Med 1 93;329: 1977-8 L
2. Bressler B, Paszai LF> Vinden C5 Li C, He J, Rabeneck L. Colonoscopic miss rates for right- sided, colon cancer: a population-based analysis. Gastroenterology 2004;127:452-6.
3. Rex DK, Cutler CS, Lemmel GT, Rahmani EY, Clark DW, Helper DJ, Lehman. GA, Ma k DG. Colonoscopic miss rates of adenomas determined by back-to-back colonoscopies. Gastroenterology 1 97; 112 :24-8,
4. Haseman JH, Lemmel GT, Rahmani EY. Rex DK, Failure of colonoscopy to detect colorectal cancer: evaluation of 47 cases in 20 hospitals. Gastroiniest Endosc 1997;45:451-5,
5. PelSise , Fernandez-Esparrach G, Cardenas A, Sendino O, Ricart. E, Vaquero E, Gimeno- Garcia AZ, de Miguel CR, Zabalza M, (lines A, Pique JM} Llach J, Castells A. Impact of wide-angle, high-definition endoscopy in the diagnosis of colorectal neoplasia: a randomized controlled trial, Gastroenteroloav 2008;135:1062-8.
6. Rex DK, Chada!awada V, Helper DJ. Wide angle colonoscopy with a prototype instrument: impact on miss rates and efficiency as determined by back-to-back colonoscopies. Am J Gastroenterol 2003;98:2000-5.
7, Deenadayahi VP, Chatlalawada V, Rex DK. 1 70 degrees wide-angle ozonoscope: effect on efficiency and miss rates. Am J Gastroenterol 2004;99:2138-42.
8. Matsushita M, Hajiro , Okazaki ., Takakuwa H, Tommaga M. Efficacy of total colonoscopy with a transparent cap in comparison with colonoscopy without the cap.
Endoscopy '1998;30:444-7.
9. Lee YT, Hui AJ, Wong VW, Hung LC, Sung JJ. Improved colonoscopy success rate with a distally attached mucosectomy cap. Endoscopy 2006;38:739-42.
10, Kondo S, Yamaji Y, Watabe H, Yamada A, Sugimoto T, Ohta M, Ogura K, Okamoto M, Yoshida H, Kawabe T, Omata M. A randomized controlled trial evaluating the usefulness of a transparent hood attached to the tip of the colonoscope. Am J Gastroenterol 2007; 302:75- 81.
11. Harada Y, Hirasawa D, Fujita N, Noda Y, Kobayashi G, Sshida K, Yonechi M, Ito , Suzuki T, Sugawara T, Moraguehi J, Takasawa O, Ghana T, Oohira T, Onochi K. Kanno Y, uroha M, Ivvai W. Impact of a transparent hood on the performance of total colonoscopy: a randomized controlled trial Gastroiniest Endosc 2009;69:637-44.
12. Horiuchi A, akayama Y. Improved colorectal adenoma detection with a transparent retractable extension device. Am J Gastroenterol 2008;103:341-5.
1 . Hewett DG, Rex DK. Cap-fitted colonoscopy: a randomized, tandem colonoscopy study of adenoma miss rates. Gastrointest Endosc 2010:72: 775-8.1.
14. Triadafilopoulos G, Watts HD, Higgins J, Van Dam I. A novel retrograde- viewing auxiliary imaging device (Third Eye etroscope) improves the detection of simulated polyps in anatomic models of the colon. Gastrointest Endosc 2007;65:139-44.
15. Leufkens AM, DeMarco DC, Rastogi A, Akerraan PA, Azzouzi K, Rothstei RI, Vleggaar FP, Repici A, Rando G. Okolo PL Dewit O, Igiijatovic A, Odstrcil E, East J, Deprez PE, Saunders BP, Kal!oo AN, Creel B, Singh V, Leiraon AM, Siersema PD. Effect of a retrograde-viewing device on adenoma detection rate during colonoscopy: the TERRACE study. Gastrointest Endosc 2011;73:480-9.
Claims
1. An apparatus for imaging at least one anatomical structure, comprising:,
an endoscopic first arrangement;
a radiation source second arrangement provides at least one electro-magnetic radiation; and
a third arrangement attached to at least one portion of the endoscopic arrangement, and containing an optical arrangement which, upon impact by the at least one electro-magnetic radiation and based thereon, transmits a first radiation and reflects a second radiation, wherein the first radiation impacts at least one first portion of the at least one anatomical structure, and the second radiation impacts at least one second portion of the at least one anatomical structure, the first and second portions being at least partially different from one another,
wherein the first and second radiations have characteristics which are different from one another,
2. The apparatus according to claim 1 wherein the characteristics are wavelengths or polarizations.
3. The apparatus according to claim 1 , further comprising a detector arrangement, wherein. the endoscopic arrangement is associated with the radiation source arrangement and the detector arrangement,
4. The apparatus according to claim ! . wherein the first and second radiations have spectral regions in red, green and blue band which do not substantially overlap with one another.
5. The apparatus according to claim 1 , wherein the first radiation is directed in a 'forward direction, and wherein the second radiation is directed in a backward direction or a side direction.
6. The apparatus according to claim 1 , wherei the third arrangement includes a cap that is connected to an end portion of the endoscopic first arrangement.
7. The apparatus according to claim 5, wherein the second radiation simultaneously illuminates between 270 and 360 degrees of a field of view,
8. The apparatus according to claim 5, wherein the radiation source second arrangement includes a modulation arrangement which is configured to modulate die first and second radiations.
9. The apparatus according to claim 2, further comprising an electronic arrangement which is configured to synchronize the second arrangement and the detector arrangement.
10. The apparatus according to claim 8, .further comprising an electronic arrangement which is configured (i) synchronize the modulation arrangement and the detector arrangement, and (ii) control the detector arrangement to detect signals from the at least one anatomical structure illuminated by the first and. second, .radiations, and separate the signals based the synchronization, with the modulation arrangement.
11. The apparatus according to claim 1 , wherein the at least one anatomical structure is a. luminal anatomical structure.
12. The apparatus according to claim I , wherein the third arrangement includes at least one opening which facilitates a passage of instrumentation, air gasses and fluids therethrough.
13. The apparatus according to claim I : further comprising a tube associated with the third arrangement, and provides a passage of instrumentation, air gasses and fluids therethrough,
14. The apparatus according to claim 1 , wherein the first and second radiations ha ve a specific polarization status.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/389,631 US9629528B2 (en) | 2012-03-30 | 2013-03-15 | Imaging system, method and distal attachment for multidirectional field of view endoscopy |
EP13768632.5A EP2833776A4 (en) | 2012-03-30 | 2013-03-15 | Imaging system, method and distal attachment for multidirectional field of view endoscopy |
US15/494,021 US20170290499A1 (en) | 2012-03-30 | 2017-04-21 | Imaging system, method and distal attachment for multidirectional field of view endoscopy |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261618225P | 2012-03-30 | 2012-03-30 | |
US61/618,225 | 2012-03-30 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/389,631 A-371-Of-International US9629528B2 (en) | 2012-03-30 | 2013-03-15 | Imaging system, method and distal attachment for multidirectional field of view endoscopy |
US15/494,021 Continuation US20170290499A1 (en) | 2012-03-30 | 2017-04-21 | Imaging system, method and distal attachment for multidirectional field of view endoscopy |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2013148306A1 true WO2013148306A1 (en) | 2013-10-03 |
Family
ID=49261067
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2013/031948 WO2013148306A1 (en) | 2012-03-30 | 2013-03-15 | Imaging system, method and distal attachment for multidirectional field of view endoscopy |
Country Status (3)
Country | Link |
---|---|
US (2) | US9629528B2 (en) |
EP (1) | EP2833776A4 (en) |
WO (1) | WO2013148306A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015164792A1 (en) * | 2014-04-25 | 2015-10-29 | The General Hospital Corporation | Imaging system, method and distal attachment for multidirectional field of view endoscopy |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20170071456A1 (en) * | 2015-06-10 | 2017-03-16 | Nitesh Ratnakar | Novel 360-degree panoramic view formed for endoscope adapted thereto with multiple cameras, and applications thereof to reduce polyp miss rate and facilitate targeted polyp removal |
US10945706B2 (en) | 2017-05-05 | 2021-03-16 | Biim Ultrasound As | Hand held ultrasound probe |
EP3820386A4 (en) * | 2018-07-09 | 2022-04-20 | Previvo Genetics, Inc. | Uterine lavage devices, systems, and methods |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0029555A2 (en) * | 1979-11-22 | 1981-06-03 | Olympus Optical Co., Ltd. | Endoscope light source device |
US20070238955A1 (en) * | 2006-01-18 | 2007-10-11 | The General Hospital Corporation | Systems and methods for generating data using one or more endoscopic microscopy techniques |
WO2008134449A1 (en) * | 2007-04-24 | 2008-11-06 | Tomophase Corporation | Delivering light via optical waveguide and multi-view optical probe head |
Family Cites Families (660)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2339754A (en) | 1941-03-04 | 1944-01-25 | Westinghouse Electric & Mfg Co | Supervisory apparatus |
US3090753A (en) | 1960-08-02 | 1963-05-21 | Exxon Research Engineering Co | Ester oil compositions containing acid anhydride |
GB1257778A (en) | 1967-12-07 | 1971-12-22 | ||
US3601480A (en) | 1968-07-10 | 1971-08-24 | Physics Int Co | Optical tunnel high-speed camera system |
JPS4932484U (en) | 1972-06-19 | 1974-03-20 | ||
US3872407A (en) | 1972-09-01 | 1975-03-18 | Us Navy | Rapidly tunable laser |
JPS584481Y2 (en) | 1973-06-23 | 1983-01-26 | オリンパス光学工業株式会社 | Naishikiyoushiyahenkankogakkei |
FR2253410A5 (en) | 1973-12-03 | 1975-06-27 | Inst Nat Sante Rech Med | |
US3941121A (en) | 1974-12-20 | 1976-03-02 | The University Of Cincinnati | Focusing fiber-optic needle endoscope |
US3983507A (en) | 1975-01-06 | 1976-09-28 | Research Corporation | Tunable laser systems and method |
US3973219A (en) | 1975-04-24 | 1976-08-03 | Cornell Research Foundation, Inc. | Very rapidly tuned cw dye laser |
US4030831A (en) | 1976-03-22 | 1977-06-21 | The United States Of America As Represented By The Secretary Of The Navy | Phase detector for optical figure sensing |
US4141362A (en) | 1977-05-23 | 1979-02-27 | Richard Wolf Gmbh | Laser endoscope |
US4224929A (en) | 1977-11-08 | 1980-09-30 | Olympus Optical Co., Ltd. | Endoscope with expansible cuff member and operation section |
GB2047894B (en) | 1978-03-09 | 1982-11-03 | Nat Res Dev | Speckle interferometric measurement of small oscillatory movements |
GB2030313A (en) | 1978-06-29 | 1980-04-02 | Wolf Gmbh Richard | Endoscopes |
FR2448728A1 (en) | 1979-02-07 | 1980-09-05 | Thomson Csf | ROTATING JOINT DEVICE FOR OPTICAL CONDUCTOR CONNECTION AND SYSTEM COMPRISING SUCH A DEVICE |
US4295738A (en) | 1979-08-30 | 1981-10-20 | United Technologies Corporation | Fiber optic strain sensor |
US4300816A (en) | 1979-08-30 | 1981-11-17 | United Technologies Corporation | Wide band multicore optical fiber |
US4428643A (en) | 1981-04-08 | 1984-01-31 | Xerox Corporation | Optical scanning system with wavelength shift correction |
US5065331A (en) | 1981-05-18 | 1991-11-12 | Vachon Reginald I | Apparatus and method for determining the stress and strain in pipes, pressure vessels, structural members and other deformable bodies |
GB2106736B (en) | 1981-09-03 | 1985-06-12 | Standard Telephones Cables Ltd | Optical transmission system |
US4479499A (en) | 1982-01-29 | 1984-10-30 | Alfano Robert R | Method and apparatus for detecting the presence of caries in teeth using visible light |
US5302025A (en) | 1982-08-06 | 1994-04-12 | Kleinerman Marcos Y | Optical systems for sensing temperature and other physical parameters |
US4601036A (en) | 1982-09-30 | 1986-07-15 | Honeywell Inc. | Rapidly tunable laser |
HU187188B (en) | 1982-11-25 | 1985-11-28 | Koezponti Elelmiszeripari | Device for generating radiation of controllable spectral structure |
CH663466A5 (en) | 1983-09-12 | 1987-12-15 | Battelle Memorial Institute | METHOD AND DEVICE FOR DETERMINING THE POSITION OF AN OBJECT IN RELATION TO A REFERENCE. |
JPS6140633A (en) | 1984-08-02 | 1986-02-26 | Nec Corp | Tablet device |
US4639999A (en) | 1984-11-02 | 1987-02-03 | Xerox Corporation | High resolution, high efficiency I.R. LED printing array fabrication method |
US4763977A (en) | 1985-01-09 | 1988-08-16 | Canadian Patents And Development Limited-Societe | Optical fiber coupler with tunable coupling ratio and method of making |
EP0590268B1 (en) | 1985-03-22 | 1998-07-01 | Massachusetts Institute Of Technology | Fiber Optic Probe System for Spectrally Diagnosing Tissue |
US5318024A (en) | 1985-03-22 | 1994-06-07 | Massachusetts Institute Of Technology | Laser endoscope for spectroscopic imaging |
DE3610165A1 (en) | 1985-03-27 | 1986-10-02 | Olympus Optical Co., Ltd., Tokio/Tokyo | OPTICAL SCAN MICROSCOPE |
US4607622A (en) | 1985-04-11 | 1986-08-26 | Charles D. Fritch | Fiber optic ocular endoscope |
US4631498A (en) | 1985-04-26 | 1986-12-23 | Hewlett-Packard Company | CW Laser wavemeter/frequency locking technique |
US4650327A (en) | 1985-10-28 | 1987-03-17 | Oximetrix, Inc. | Optical catheter calibrating assembly |
JPH0664683B2 (en) | 1986-02-13 | 1994-08-22 | 松下電器産業株式会社 | Rotating magnetic head recorder |
US5040889A (en) | 1986-05-30 | 1991-08-20 | Pacific Scientific Company | Spectrometer with combined visible and ultraviolet sample illumination |
CA1290019C (en) | 1986-06-20 | 1991-10-01 | Hideo Kuwahara | Dual balanced optical signal receiver |
US4770492A (en) | 1986-10-28 | 1988-09-13 | Spectran Corporation | Pressure or strain sensitive optical fiber |
JPH0824665B2 (en) | 1986-11-28 | 1996-03-13 | オリンパス光学工業株式会社 | Endoscope device |
US4744656A (en) | 1986-12-08 | 1988-05-17 | Spectramed, Inc. | Disposable calibration boot for optical-type cardiovascular catheter |
US4751706A (en) | 1986-12-31 | 1988-06-14 | The United States Of America As Represented By The Secretary Of The Army | Laser for providing rapid sequence of different wavelengths |
US4834111A (en) | 1987-01-12 | 1989-05-30 | The Trustees Of Columbia University In The City Of New York | Heterodyne interferometer |
CA1339426C (en) | 1987-09-01 | 1997-09-02 | Michael R. Layton | Hydrophone demodulator circuit and method |
US5202931A (en) | 1987-10-06 | 1993-04-13 | Cell Analysis Systems, Inc. | Methods and apparatus for the quantitation of nuclear protein |
US4909631A (en) | 1987-12-18 | 1990-03-20 | Tan Raul Y | Method for film thickness and refractive index determination |
US4890901A (en) | 1987-12-22 | 1990-01-02 | Hughes Aircraft Company | Color corrector for embedded prisms |
US4892406A (en) | 1988-01-11 | 1990-01-09 | United Technologies Corporation | Method of and arrangement for measuring vibrations |
FR2626367B1 (en) | 1988-01-25 | 1990-05-11 | Thomson Csf | MULTI-POINT FIBER OPTIC TEMPERATURE SENSOR |
FR2626383B1 (en) | 1988-01-27 | 1991-10-25 | Commissariat Energie Atomique | EXTENDED FIELD SCAN AND DEPTH CONFOCAL OPTICAL MICROSCOPY AND DEVICES FOR CARRYING OUT THE METHOD |
US4925302A (en) | 1988-04-13 | 1990-05-15 | Hewlett-Packard Company | Frequency locking device |
US4998972A (en) | 1988-04-28 | 1991-03-12 | Thomas J. Fogarty | Real time angioscopy imaging system |
US5730731A (en) | 1988-04-28 | 1998-03-24 | Thomas J. Fogarty | Pressure-based irrigation accumulator |
US4905169A (en) | 1988-06-02 | 1990-02-27 | The United States Of America As Represented By The United States Department Of Energy | Method and apparatus for simultaneously measuring a plurality of spectral wavelengths present in electromagnetic radiation |
US5242437A (en) | 1988-06-10 | 1993-09-07 | Trimedyne Laser Systems, Inc. | Medical device applying localized high intensity light and heat, particularly for destruction of the endometrium |
ATE158659T1 (en) | 1988-07-13 | 1997-10-15 | Optiscan Pty Ltd | CONFOCAL SCANNING ENDOSCOPE |
GB8817672D0 (en) | 1988-07-25 | 1988-09-01 | Sira Ltd | Optical apparatus |
US5214538A (en) | 1988-07-25 | 1993-05-25 | Keymed (Medical And Industrial Equipment) Limited | Optical apparatus |
US4868834A (en) | 1988-09-14 | 1989-09-19 | The United States Of America As Represented By The Secretary Of The Army | System for rapidly tuning a low pressure pulsed laser |
DE3833602A1 (en) | 1988-10-03 | 1990-02-15 | Krupp Gmbh | SPECTROMETER FOR SIMULTANEOUS INTENSITY MEASUREMENT IN DIFFERENT SPECTRAL AREAS |
US4940328A (en) | 1988-11-04 | 1990-07-10 | Georgia Tech Research Corporation | Optical sensing apparatus and method |
US4966589A (en) | 1988-11-14 | 1990-10-30 | Hemedix International, Inc. | Intravenous catheter placement device |
WO1990006718A1 (en) | 1988-12-21 | 1990-06-28 | Massachusetts Institute Of Technology | A method for laser induced fluorescence of tissue |
US5046501A (en) | 1989-01-18 | 1991-09-10 | Wayne State University | Atherosclerotic identification |
US5085496A (en) | 1989-03-31 | 1992-02-04 | Sharp Kabushiki Kaisha | Optical element and optical pickup device comprising it |
US5317389A (en) | 1989-06-12 | 1994-05-31 | California Institute Of Technology | Method and apparatus for white-light dispersed-fringe interferometric measurement of corneal topography |
US4965599A (en) | 1989-11-13 | 1990-10-23 | Eastman Kodak Company | Scanning apparatus for halftone image screen writing |
US5133035A (en) | 1989-11-14 | 1992-07-21 | Hicks John W | Multifiber endoscope with multiple scanning modes to produce an image free of fixed pattern noise |
US4984888A (en) | 1989-12-13 | 1991-01-15 | Imo Industries, Inc. | Two-dimensional spectrometer |
KR930003307B1 (en) | 1989-12-14 | 1993-04-24 | 주식회사 금성사 | Three dimensional projector |
US5257617A (en) * | 1989-12-25 | 1993-11-02 | Asahi Kogaku Kogyo Kabushiki Kaisha | Sheathed endoscope and sheath therefor |
US5251009A (en) | 1990-01-22 | 1993-10-05 | Ciba-Geigy Corporation | Interferometric measuring arrangement for refractive index measurements in capillary tubes |
DD293205B5 (en) | 1990-03-05 | 1995-06-29 | Zeiss Carl Jena Gmbh | Optical fiber guide for a medical observation device |
US5039193A (en) | 1990-04-03 | 1991-08-13 | Focal Technologies Incorporated | Fibre optic single mode rotary joint |
JPH0456907A (en) | 1990-06-26 | 1992-02-24 | Fujikura Ltd | Optical fiber coupler |
US5262644A (en) | 1990-06-29 | 1993-11-16 | Southwest Research Institute | Remote spectroscopy for raman and brillouin scattering |
US5197470A (en) | 1990-07-16 | 1993-03-30 | Eastman Kodak Company | Near infrared diagnostic method and instrument |
GB9015793D0 (en) | 1990-07-18 | 1990-09-05 | Medical Res Council | Confocal scanning optical microscope |
US5845639A (en) | 1990-08-10 | 1998-12-08 | Board Of Regents Of The University Of Washington | Optical imaging methods |
US5127730A (en) | 1990-08-10 | 1992-07-07 | Regents Of The University Of Minnesota | Multi-color laser scanning confocal imaging system |
JP3104984B2 (en) | 1990-09-27 | 2000-10-30 | オリンパス光学工業株式会社 | Optical scanning device for tomographic image observation |
US5305759A (en) | 1990-09-26 | 1994-04-26 | Olympus Optical Co., Ltd. | Examined body interior information observing apparatus by using photo-pulses controlling gains for depths |
JPH04135551A (en) | 1990-09-27 | 1992-05-11 | Olympus Optical Co Ltd | Optical three-dimensional image observing device |
US5241364A (en) | 1990-10-19 | 1993-08-31 | Fuji Photo Film Co., Ltd. | Confocal scanning type of phase contrast microscope and scanning microscope |
US5250186A (en) | 1990-10-23 | 1993-10-05 | Cetus Corporation | HPLC light scattering detector for biopolymers |
US5202745A (en) | 1990-11-07 | 1993-04-13 | Hewlett-Packard Company | Polarization independent optical coherence-domain reflectometry |
US5275594A (en) | 1990-11-09 | 1994-01-04 | C. R. Bard, Inc. | Angioplasty system having means for identification of atherosclerotic plaque |
JP3035336B2 (en) | 1990-11-27 | 2000-04-24 | 興和株式会社 | Blood flow measurement device |
US5228001A (en) | 1991-01-23 | 1993-07-13 | Syracuse University | Optical random access memory |
US5784162A (en) | 1993-08-18 | 1998-07-21 | Applied Spectral Imaging Ltd. | Spectral bio-imaging methods for biological research, medical diagnostics and therapy |
US6198532B1 (en) | 1991-02-22 | 2001-03-06 | Applied Spectral Imaging Ltd. | Spectral bio-imaging of the eye |
US5293872A (en) | 1991-04-03 | 1994-03-15 | Alfano Robert R | Method for distinguishing between calcified atherosclerotic tissue and fibrous atherosclerotic tissue or normal cardiovascular tissue using Raman spectroscopy |
US5465147A (en) | 1991-04-29 | 1995-11-07 | Massachusetts Institute Of Technology | Method and apparatus for acquiring images using a ccd detector array and no transverse scanner |
US5748598A (en) | 1995-12-22 | 1998-05-05 | Massachusetts Institute Of Technology | Apparatus and methods for reading multilayer storage media using short coherence length sources |
DE69227902T3 (en) | 1991-04-29 | 2010-04-22 | Massachusetts Institute Of Technology, Cambridge | DEVICE FOR OPTICAL IMAGING AND MEASUREMENT |
US6501551B1 (en) | 1991-04-29 | 2002-12-31 | Massachusetts Institute Of Technology | Fiber optic imaging endoscope interferometer with at least one faraday rotator |
US6111645A (en) | 1991-04-29 | 2000-08-29 | Massachusetts Institute Of Technology | Grating based phase control optical delay line |
US6485413B1 (en) | 1991-04-29 | 2002-11-26 | The General Hospital Corporation | Methods and apparatus for forward-directed optical scanning instruments |
US6134003A (en) | 1991-04-29 | 2000-10-17 | Massachusetts Institute Of Technology | Method and apparatus for performing optical measurements using a fiber optic imaging guidewire, catheter or endoscope |
US6564087B1 (en) | 1991-04-29 | 2003-05-13 | Massachusetts Institute Of Technology | Fiber optic needle probes for optical coherence tomography imaging |
US5956355A (en) | 1991-04-29 | 1999-09-21 | Massachusetts Institute Of Technology | Method and apparatus for performing optical measurements using a rapidly frequency-tuned laser |
US5441053A (en) | 1991-05-03 | 1995-08-15 | University Of Kentucky Research Foundation | Apparatus and method for multiple wavelength of tissue |
US5281811A (en) | 1991-06-17 | 1994-01-25 | Litton Systems, Inc. | Digital wavelength division multiplex optical transducer having an improved decoder |
US5208651A (en) | 1991-07-16 | 1993-05-04 | The Regents Of The University Of California | Apparatus and method for measuring fluorescence intensities at a plurality of wavelengths and lifetimes |
WO1993003672A1 (en) | 1991-08-20 | 1993-03-04 | Redd Douglas C B | Optical histochemical analysis, in vivo detection and real-time guidance for ablation of abnormal tissues using a raman spectroscopic detection system |
DE4128744C1 (en) | 1991-08-29 | 1993-04-22 | Siemens Ag, 8000 Muenchen, De | |
US5177488A (en) | 1991-10-08 | 1993-01-05 | Hughes Aircraft Company | Programmable fiber optic delay line, and radar target simulation system incorporating the same |
DE69218386T2 (en) | 1991-12-30 | 1997-09-04 | Philips Electronics Nv | Optical device and device provided with such an optical device for scanning an information level |
US5353790A (en) | 1992-01-17 | 1994-10-11 | Board Of Regents, The University Of Texas System | Method and apparatus for optical measurement of bilirubin in tissue |
US5212667A (en) | 1992-02-03 | 1993-05-18 | General Electric Company | Light imaging in a scattering medium, using ultrasonic probing and speckle image differencing |
US5217456A (en) | 1992-02-24 | 1993-06-08 | Pdt Cardiovascular, Inc. | Device and method for intra-vascular optical radial imaging |
US5248876A (en) | 1992-04-21 | 1993-09-28 | International Business Machines Corporation | Tandem linear scanning confocal imaging system with focal volumes at different heights |
US5283795A (en) | 1992-04-21 | 1994-02-01 | Hughes Aircraft Company | Diffraction grating driven linear frequency chirped laser |
US5486701A (en) | 1992-06-16 | 1996-01-23 | Prometrix Corporation | Method and apparatus for measuring reflectance in two wavelength bands to enable determination of thin film thickness |
US5411025A (en) | 1992-06-30 | 1995-05-02 | Cordis Webster, Inc. | Cardiovascular catheter with laterally stable basket-shaped electrode array |
US5716324A (en) | 1992-08-25 | 1998-02-10 | Fuji Photo Film Co., Ltd. | Endoscope with surface and deep portion imaging systems |
US5348003A (en) | 1992-09-03 | 1994-09-20 | Sirraya, Inc. | Method and apparatus for chemical analysis |
EP0587514A1 (en) | 1992-09-11 | 1994-03-16 | Welch Allyn, Inc. | Processor module for video inspection probe |
US5772597A (en) | 1992-09-14 | 1998-06-30 | Sextant Medical Corporation | Surgical tool end effector |
US5698397A (en) | 1995-06-07 | 1997-12-16 | Sri International | Up-converting reporters for biological and other assays using laser excitation techniques |
EP0595666B1 (en) | 1992-09-21 | 1999-12-01 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Probe and procedure for a precise determination of velocity or flow of a liquid |
US5439000A (en) | 1992-11-18 | 1995-08-08 | Spectrascience, Inc. | Method of diagnosing tissue with guidewire |
US5383467A (en) | 1992-11-18 | 1995-01-24 | Spectrascience, Inc. | Guidewire catheter and apparatus for diagnostic imaging |
US5785663A (en) | 1992-12-21 | 1998-07-28 | Artann Corporation | Method and device for mechanical imaging of prostate |
US5400771A (en) | 1993-01-21 | 1995-03-28 | Pirak; Leon | Endotracheal intubation assembly and related method |
JPH06222242A (en) | 1993-01-27 | 1994-08-12 | Shin Etsu Chem Co Ltd | Optical fiber coupler and its manufacture |
US5987346A (en) | 1993-02-26 | 1999-11-16 | Benaron; David A. | Device and method for classification of tissue |
US5414509A (en) | 1993-03-08 | 1995-05-09 | Associated Universities, Inc. | Optical pressure/density measuring means |
JP3112595B2 (en) | 1993-03-17 | 2000-11-27 | 安藤電気株式会社 | Optical fiber strain position measuring device using optical frequency shifter |
FI93781C (en) | 1993-03-18 | 1995-05-26 | Wallac Oy | Biospecific multiparametric assay method |
DE4309056B4 (en) | 1993-03-20 | 2006-05-24 | Häusler, Gerd, Prof. Dr. | Method and device for determining the distance and scattering intensity of scattering points |
DE4310209C2 (en) | 1993-03-29 | 1996-05-30 | Bruker Medizintech | Optical stationary imaging in strongly scattering media |
US5485079A (en) | 1993-03-29 | 1996-01-16 | Matsushita Electric Industrial Co., Ltd. | Magneto-optical element and optical magnetic field sensor |
US5424827A (en) | 1993-04-30 | 1995-06-13 | Litton Systems, Inc. | Optical system and method for eliminating overlap of diffraction spectra |
SE501932C2 (en) | 1993-04-30 | 1995-06-26 | Ericsson Telefon Ab L M | Apparatus and method for dispersion compensation in a fiber optic transmission system |
DE4314189C1 (en) | 1993-04-30 | 1994-11-03 | Bodenseewerk Geraetetech | Device for the examination of optical fibres made of glass by means of heterodyne Brillouin spectroscopy |
US5454807A (en) | 1993-05-14 | 1995-10-03 | Boston Scientific Corporation | Medical treatment of deeply seated tissue using optical radiation |
EP0627643B1 (en) | 1993-06-03 | 1999-05-06 | Hamamatsu Photonics K.K. | Laser scanning optical system using axicon |
JP3234353B2 (en) | 1993-06-15 | 2001-12-04 | 富士写真フイルム株式会社 | Tomographic information reader |
US5840031A (en) | 1993-07-01 | 1998-11-24 | Boston Scientific Corporation | Catheters for imaging, sensing electrical potentials and ablating tissue |
US5995645A (en) | 1993-08-18 | 1999-11-30 | Applied Spectral Imaging Ltd. | Method of cancer cell detection |
US5803082A (en) | 1993-11-09 | 1998-09-08 | Staplevision Inc. | Omnispectramammography |
US5983125A (en) | 1993-12-13 | 1999-11-09 | The Research Foundation Of City College Of New York | Method and apparatus for in vivo examination of subcutaneous tissues inside an organ of a body using optical spectroscopy |
US5450203A (en) | 1993-12-22 | 1995-09-12 | Electroglas, Inc. | Method and apparatus for determining an objects position, topography and for imaging |
US5411016A (en) | 1994-02-22 | 1995-05-02 | Scimed Life Systems, Inc. | Intravascular balloon catheter for use in combination with an angioscope |
US5590660A (en) | 1994-03-28 | 1997-01-07 | Xillix Technologies Corp. | Apparatus and method for imaging diseased tissue using integrated autofluorescence |
DE4411017C2 (en) | 1994-03-30 | 1995-06-08 | Alexander Dr Knuettel | Optical stationary spectroscopic imaging in strongly scattering objects through special light focusing and signal detection of light of different wavelengths |
TW275570B (en) | 1994-05-05 | 1996-05-11 | Boehringer Mannheim Gmbh | |
DE69531118D1 (en) | 1994-07-14 | 2003-07-24 | Washington Res Foundation Seat | DEVICE FOR DETECTING THE BARRETT METAPLASIA IN THE EYES |
US5459325A (en) | 1994-07-19 | 1995-10-17 | Molecular Dynamics, Inc. | High-speed fluorescence scanner |
US6159445A (en) | 1994-07-20 | 2000-12-12 | Nycomed Imaging As | Light imaging contrast agents |
CA2172284C (en) | 1994-08-08 | 1999-09-28 | Richard J. Mammone | Processing of keratoscopic images using local spatial phase |
DE69528024T2 (en) | 1994-08-18 | 2003-10-09 | Zeiss Carl | Surgical apparatus controlled with optical coherence tomography |
US5491524A (en) | 1994-10-05 | 1996-02-13 | Carl Zeiss, Inc. | Optical coherence tomography corneal mapping apparatus |
US5740808A (en) | 1996-10-28 | 1998-04-21 | Ep Technologies, Inc | Systems and methods for guilding diagnostic or therapeutic devices in interior tissue regions |
US5817144A (en) | 1994-10-25 | 1998-10-06 | Latis, Inc. | Method for contemporaneous application OF laser energy and localized pharmacologic therapy |
US6033721A (en) | 1994-10-26 | 2000-03-07 | Revise, Inc. | Image-based three-axis positioner for laser direct write microchemical reaction |
JPH08136345A (en) | 1994-11-10 | 1996-05-31 | Anritsu Corp | Double monochromator |
JPH08160129A (en) | 1994-12-05 | 1996-06-21 | Uniden Corp | Speed detector |
US5566267A (en) | 1994-12-15 | 1996-10-15 | Ceram Optec Industries Inc. | Flat surfaced optical fibers and diode laser medical delivery devices |
US5600486A (en) | 1995-01-30 | 1997-02-04 | Lockheed Missiles And Space Company, Inc. | Color separation microlens |
US5648848A (en) | 1995-02-01 | 1997-07-15 | Nikon Precision, Inc. | Beam delivery apparatus and method for interferometry using rotatable polarization chucks |
DE19506484C2 (en) | 1995-02-24 | 1999-09-16 | Stiftung Fuer Lasertechnologie | Method and device for selective non-invasive laser myography (LMG) |
RU2100787C1 (en) | 1995-03-01 | 1997-12-27 | Геликонов Валентин Михайлович | Fibre-optical interferometer and fiber-optical piezoelectric transducer |
WO1996028212A1 (en) | 1995-03-09 | 1996-09-19 | Innotech Usa, Inc. | Laser surgical device and method of its use |
US5868731A (en) | 1996-03-04 | 1999-02-09 | Innotech Usa, Inc. | Laser surgical device and method of its use |
US5526338A (en) | 1995-03-10 | 1996-06-11 | Yeda Research & Development Co. Ltd. | Method and apparatus for storage and retrieval with multilayer optical disks |
US5697373A (en) | 1995-03-14 | 1997-12-16 | Board Of Regents, The University Of Texas System | Optical method and apparatus for the diagnosis of cervical precancers using raman and fluorescence spectroscopies |
US5735276A (en) | 1995-03-21 | 1998-04-07 | Lemelson; Jerome | Method and apparatus for scanning and evaluating matter |
JP3945820B2 (en) | 1995-03-24 | 2007-07-18 | オプティスキャン ピーティーワイ リミテッド | Optical fiber confocal image forming apparatus with variable near-confocal control means |
US5565983A (en) | 1995-05-26 | 1996-10-15 | The Perkin-Elmer Corporation | Optical spectrometer for detecting spectra in separate ranges |
US5785651A (en) | 1995-06-07 | 1998-07-28 | Keravision, Inc. | Distance measuring confocal microscope |
US5621830A (en) | 1995-06-07 | 1997-04-15 | Smith & Nephew Dyonics Inc. | Rotatable fiber optic joint |
WO1997001167A1 (en) | 1995-06-21 | 1997-01-09 | Massachusetts Institute Of Technology | Apparatus and method for accessing data on multilayered optical media |
ATA107495A (en) | 1995-06-23 | 1996-06-15 | Fercher Adolf Friedrich Dr | COHERENCE BIOMETRY AND TOMOGRAPHY WITH DYNAMIC COHERENT FOCUS |
JP3654309B2 (en) | 1995-06-28 | 2005-06-02 | 株式会社日立メディコ | Acicular ultrasonic probe |
US5829439A (en) | 1995-06-28 | 1998-11-03 | Hitachi Medical Corporation | Needle-like ultrasonic probe for ultrasonic diagnosis apparatus, method of producing same, and ultrasonic diagnosis apparatus using same |
US6104945A (en) | 1995-08-01 | 2000-08-15 | Medispectra, Inc. | Spectral volume microprobe arrays |
AU1130797A (en) | 1995-08-24 | 1997-03-19 | Purdue Research Foundation | Fluorescence lifetime-based imaging and spectroscopy in tissues and other random media |
US6016197A (en) | 1995-08-25 | 2000-01-18 | Ceramoptec Industries Inc. | Compact, all-optical spectrum analyzer for chemical and biological fiber optic sensors |
FR2738343B1 (en) | 1995-08-30 | 1997-10-24 | Cohen Sabban Joseph | OPTICAL MICROSTRATIGRAPHY DEVICE |
US6615071B1 (en) | 1995-09-20 | 2003-09-02 | Board Of Regents, The University Of Texas System | Method and apparatus for detecting vulnerable atherosclerotic plaque |
AU709432B2 (en) | 1995-09-20 | 1999-08-26 | California Institute Of Technology | Detecting thermal discrepancies in vessel walls |
US6763261B2 (en) | 1995-09-20 | 2004-07-13 | Board Of Regents, The University Of Texas System | Method and apparatus for detecting vulnerable atherosclerotic plaque |
US5742419A (en) | 1995-11-07 | 1998-04-21 | The Board Of Trustees Of The Leland Stanford Junior Universtiy | Miniature scanning confocal microscope |
DE19542955C2 (en) | 1995-11-17 | 1999-02-18 | Schwind Gmbh & Co Kg Herbert | endoscope |
US5719399A (en) | 1995-12-18 | 1998-02-17 | The Research Foundation Of City College Of New York | Imaging and characterization of tissue based upon the preservation of polarized light transmitted therethrough |
JP3699761B2 (en) | 1995-12-26 | 2005-09-28 | オリンパス株式会社 | Epifluorescence microscope |
US5748318A (en) | 1996-01-23 | 1998-05-05 | Brown University Research Foundation | Optical stress generator and detector |
US5840023A (en) | 1996-01-31 | 1998-11-24 | Oraevsky; Alexander A. | Optoacoustic imaging for medical diagnosis |
US5642194A (en) | 1996-02-05 | 1997-06-24 | The Regents Of The University Of California | White light velocity interferometer |
US5862273A (en) | 1996-02-23 | 1999-01-19 | Kaiser Optical Systems, Inc. | Fiber optic probe with integral optical filtering |
US5843000A (en) | 1996-05-07 | 1998-12-01 | The General Hospital Corporation | Optical biopsy forceps and method of diagnosing tissue |
ATA84696A (en) | 1996-05-14 | 1998-03-15 | Adolf Friedrich Dr Fercher | METHOD AND ARRANGEMENTS FOR INCREASING CONTRAST IN OPTICAL COHERENCE TOMOGRAPHY |
US6020963A (en) | 1996-06-04 | 2000-02-01 | Northeastern University | Optical quadrature Interferometer |
US5795295A (en) | 1996-06-25 | 1998-08-18 | Carl Zeiss, Inc. | OCT-assisted surgical microscope with multi-coordinate manipulator |
US5842995A (en) | 1996-06-28 | 1998-12-01 | Board Of Regents, The Univerisity Of Texas System | Spectroscopic probe for in vivo measurement of raman signals |
US6296608B1 (en) | 1996-07-08 | 2001-10-02 | Boston Scientific Corporation | Diagnosing and performing interventional procedures on tissue in vivo |
US6245026B1 (en) | 1996-07-29 | 2001-06-12 | Farallon Medsystems, Inc. | Thermography catheter |
US6396941B1 (en) | 1996-08-23 | 2002-05-28 | Bacus Research Laboratories, Inc. | Method and apparatus for internet, intranet, and local viewing of virtual microscope slides |
US5840075A (en) | 1996-08-23 | 1998-11-24 | Eclipse Surgical Technologies, Inc. | Dual laser device for transmyocardial revascularization procedures |
US6544193B2 (en) | 1996-09-04 | 2003-04-08 | Marcio Marc Abreu | Noninvasive measurement of chemical substances |
JPH1090603A (en) | 1996-09-18 | 1998-04-10 | Olympus Optical Co Ltd | Endscopic optical system |
US5801831A (en) | 1996-09-20 | 1998-09-01 | Institute For Space And Terrestrial Science | Fabry-Perot spectrometer for detecting a spatially varying spectral signature of an extended source |
RU2108122C1 (en) | 1996-09-24 | 1998-04-10 | Владимир Павлович Жаров | Method and device for physiotherapeutic irradiation with light |
US6249349B1 (en) | 1996-09-27 | 2001-06-19 | Vincent Lauer | Microscope generating a three-dimensional representation of an object |
DE19640495C2 (en) | 1996-10-01 | 1999-12-16 | Leica Microsystems | Device for confocal surface measurement |
US5843052A (en) | 1996-10-04 | 1998-12-01 | Benja-Athon; Anuthep | Irrigation kit for application of fluids and chemicals for cleansing and sterilizing wounds |
TW365001B (en) | 1996-10-17 | 1999-07-21 | Hitachi Ltd | Non-volatile semiconductor memory apparatus and the operation method |
US5904651A (en) | 1996-10-28 | 1999-05-18 | Ep Technologies, Inc. | Systems and methods for visualizing tissue during diagnostic or therapeutic procedures |
US5752518A (en) | 1996-10-28 | 1998-05-19 | Ep Technologies, Inc. | Systems and methods for visualizing interior regions of the body |
US6044288A (en) | 1996-11-08 | 2000-03-28 | Imaging Diagnostics Systems, Inc. | Apparatus and method for determining the perimeter of the surface of an object being scanned |
US5872879A (en) | 1996-11-25 | 1999-02-16 | Boston Scientific Corporation | Rotatable connecting optical fibers |
US6517532B1 (en) | 1997-05-15 | 2003-02-11 | Palomar Medical Technologies, Inc. | Light energy delivery head |
US6437867B2 (en) | 1996-12-04 | 2002-08-20 | The Research Foundation Of The City University Of New York | Performing selected optical measurements with optical coherence domain reflectometry |
US6249630B1 (en) | 1996-12-13 | 2001-06-19 | Imra America, Inc. | Apparatus and method for delivery of dispersion-compensated ultrashort optical pulses with high peak power |
US5906759A (en) | 1996-12-26 | 1999-05-25 | Medinol Ltd. | Stent forming apparatus with stent deforming blades |
US5871449A (en) | 1996-12-27 | 1999-02-16 | Brown; David Lloyd | Device and method for locating inflamed plaque in an artery |
US5991697A (en) | 1996-12-31 | 1999-11-23 | The Regents Of The University Of California | Method and apparatus for optical Doppler tomographic imaging of fluid flow velocity in highly scattering media |
EP1018045A4 (en) | 1996-12-31 | 2001-01-31 | Corning Inc | Optical couplers with multilayer fibers |
US5760901A (en) | 1997-01-28 | 1998-06-02 | Zetetic Institute | Method and apparatus for confocal interference microscopy with background amplitude reduction and compensation |
JP3213250B2 (en) | 1997-01-29 | 2001-10-02 | 株式会社生体光情報研究所 | Optical measurement device |
US5801826A (en) | 1997-02-18 | 1998-09-01 | Williams Family Trust B | Spectrometric device and method for recognizing atomic and molecular signatures |
US5836877A (en) | 1997-02-24 | 1998-11-17 | Lucid Inc | System for facilitating pathological examination of a lesion in tissue |
US6010449A (en) | 1997-02-28 | 2000-01-04 | Lumend, Inc. | Intravascular catheter system for treating a vascular occlusion |
US6120516A (en) | 1997-02-28 | 2000-09-19 | Lumend, Inc. | Method for treating vascular occlusion |
US5968064A (en) | 1997-02-28 | 1999-10-19 | Lumend, Inc. | Catheter system for treating a vascular occlusion |
WO1998038907A1 (en) | 1997-03-06 | 1998-09-11 | Massachusetts Institute Of Technology | Instrument for optically scanning of living tissue |
AU6604998A (en) | 1997-03-13 | 1998-09-29 | Biomax Technologies, Inc. | Methods and apparatus for detecting the rejection of transplanted tissue |
US6078047A (en) | 1997-03-14 | 2000-06-20 | Lucent Technologies Inc. | Method and apparatus for terahertz tomographic imaging |
US5994690A (en) | 1997-03-17 | 1999-11-30 | Kulkarni; Manish D. | Image enhancement in optical coherence tomography using deconvolution |
JPH10267830A (en) | 1997-03-26 | 1998-10-09 | Kowa Co | Optical measuring device |
JPH10267631A (en) | 1997-03-26 | 1998-10-09 | Kowa Co | Optical measuring instrument |
JP2001526650A (en) | 1997-04-29 | 2001-12-18 | ニユコメド・イメージング・アクシエセルカペト | Optical contrast agent |
WO1998048845A1 (en) | 1997-04-29 | 1998-11-05 | Nycomed Imaging As | Method of demarcating tissue |
SE511285C2 (en) | 1997-04-29 | 1999-09-06 | Foersvarets Forskningsanstalt | Melt-cast charges |
US6117128A (en) | 1997-04-30 | 2000-09-12 | Kenton W. Gregory | Energy delivery catheter and method for the use thereof |
US5887009A (en) | 1997-05-22 | 1999-03-23 | Optical Biopsy Technologies, Inc. | Confocal optical scanning system employing a fiber laser |
US6002480A (en) | 1997-06-02 | 1999-12-14 | Izatt; Joseph A. | Depth-resolved spectroscopic optical coherence tomography |
US6006128A (en) | 1997-06-02 | 1999-12-21 | Izatt; Joseph A. | Doppler flow imaging using optical coherence tomography |
US6208415B1 (en) | 1997-06-12 | 2001-03-27 | The Regents Of The University Of California | Birefringence imaging in biological tissue using polarization sensitive optical coherent tomography |
WO1998058588A1 (en) | 1997-06-23 | 1998-12-30 | Focus Surgery, Inc. | Methods and devices for providing acoustic hemostasis |
US5920390A (en) | 1997-06-26 | 1999-07-06 | University Of North Carolina | Fiberoptic interferometer and associated method for analyzing tissue |
US6048349A (en) | 1997-07-09 | 2000-04-11 | Intraluminal Therapeutics, Inc. | Systems and methods for guiding a medical instrument through a body |
US6058352A (en) | 1997-07-25 | 2000-05-02 | Physical Optics Corporation | Accurate tissue injury assessment using hybrid neural network analysis |
US5921926A (en) | 1997-07-28 | 1999-07-13 | University Of Central Florida | Three dimensional optical imaging colposcopy |
US6014214A (en) | 1997-08-21 | 2000-01-11 | Li; Ming-Chiang | High speed inspection of a sample using coherence processing of scattered superbroad radiation |
US5892583A (en) | 1997-08-21 | 1999-04-06 | Li; Ming-Chiang | High speed inspection of a sample using superbroad radiation coherent interferometer |
US6069698A (en) | 1997-08-28 | 2000-05-30 | Olympus Optical Co., Ltd. | Optical imaging apparatus which radiates a low coherence light beam onto a test object, receives optical information from light scattered by the object, and constructs therefrom a cross-sectional image of the object |
US6297018B1 (en) | 1998-04-17 | 2001-10-02 | Ljl Biosystems, Inc. | Methods and apparatus for detecting nucleic acid polymorphisms |
US5920373A (en) | 1997-09-24 | 1999-07-06 | Heidelberg Engineering Optische Messysteme Gmbh | Method and apparatus for determining optical characteristics of a cornea |
US6193676B1 (en) | 1997-10-03 | 2001-02-27 | Intraluminal Therapeutics, Inc. | Guide wire assembly |
US5951482A (en) | 1997-10-03 | 1999-09-14 | Intraluminal Therapeutics, Inc. | Assemblies and methods for advancing a guide wire through body tissue |
US6091984A (en) | 1997-10-10 | 2000-07-18 | Massachusetts Institute Of Technology | Measuring tissue morphology |
US5955737A (en) | 1997-10-27 | 1999-09-21 | Systems & Processes Engineering Corporation | Chemometric analysis for extraction of individual fluorescence spectrum and lifetimes from a target mixture |
US6052186A (en) | 1997-11-05 | 2000-04-18 | Excel Precision, Inc. | Dual laser system for extended heterodyne interferometry |
US6134010A (en) | 1997-11-07 | 2000-10-17 | Lucid, Inc. | Imaging system using polarization effects to enhance image quality |
US6037579A (en) | 1997-11-13 | 2000-03-14 | Biophotonics Information Laboratories, Ltd. | Optical interferometer employing multiple detectors to detect spatially distorted wavefront in imaging of scattering media |
US6107048A (en) | 1997-11-20 | 2000-08-22 | Medical College Of Georgia Research Institute, Inc. | Method of detecting and grading dysplasia in epithelial tissue |
EP1103041B1 (en) | 1998-01-28 | 2016-03-23 | Immersion Medical, Inc. | Interface device and method for interfacing instruments to medical procedure simulation system |
US6165170A (en) | 1998-01-29 | 2000-12-26 | International Business Machines Corporation | Laser dermablator and dermablation |
US6134033A (en) | 1998-02-26 | 2000-10-17 | Tyco Submarine Systems Ltd. | Method and apparatus for improving spectral efficiency in wavelength division multiplexed transmission systems |
US6831781B2 (en) | 1998-02-26 | 2004-12-14 | The General Hospital Corporation | Confocal microscopy with multi-spectral encoding and system and apparatus for spectroscopically encoded confocal microscopy |
US6341036B1 (en) | 1998-02-26 | 2002-01-22 | The General Hospital Corporation | Confocal microscopy with multi-spectral encoding |
US6048742A (en) | 1998-02-26 | 2000-04-11 | The United States Of America As Represented By The Secretary Of The Air Force | Process for measuring the thickness and composition of thin semiconductor films deposited on semiconductor wafers |
RU2148378C1 (en) | 1998-03-06 | 2000-05-10 | Геликонов Валентин Михайлович | Device for performing optic coherent tomography, optic fiber scanning device and method for diagnosing biological tissue in vivo |
US6066102A (en) | 1998-03-09 | 2000-05-23 | Spectrascience, Inc. | Optical biopsy forceps system and method of diagnosing tissue |
US6174291B1 (en) | 1998-03-09 | 2001-01-16 | Spectrascience, Inc. | Optical biopsy system and methods for tissue diagnosis |
US6151522A (en) | 1998-03-16 | 2000-11-21 | The Research Foundation Of Cuny | Method and system for examining biological materials using low power CW excitation raman spectroscopy |
US6384915B1 (en) | 1998-03-30 | 2002-05-07 | The Regents Of The University Of California | Catheter guided by optical coherence domain reflectometry |
US6175669B1 (en) | 1998-03-30 | 2001-01-16 | The Regents Of The Universtiy Of California | Optical coherence domain reflectometry guidewire |
DE19814057B4 (en) | 1998-03-30 | 2009-01-02 | Carl Zeiss Meditec Ag | Arrangement for optical coherence tomography and coherence topography |
US6996549B2 (en) | 1998-05-01 | 2006-02-07 | Health Discovery Corporation | Computer-aided image analysis |
AU3781799A (en) | 1998-05-01 | 1999-11-23 | Board Of Regents, The University Of Texas System | Method and apparatus for subsurface imaging |
JPH11326826A (en) | 1998-05-13 | 1999-11-26 | Sony Corp | Illuminating method and illuminator |
US6053613A (en) | 1998-05-15 | 2000-04-25 | Carl Zeiss, Inc. | Optical coherence tomography with new interferometer |
FR2778838A1 (en) | 1998-05-19 | 1999-11-26 | Koninkl Philips Electronics Nv | METHOD FOR DETECTING VARIATIONS IN ELASTICITY AND ECHOGRAPHIC APPARATUS FOR CARRYING OUT THIS METHOD |
US5995223A (en) | 1998-06-01 | 1999-11-30 | Power; Joan Fleurette | Apparatus for rapid phase imaging interferometry and method therefor |
JPH11352409A (en) | 1998-06-05 | 1999-12-24 | Olympus Optical Co Ltd | Fluorescence detector |
US6549801B1 (en) | 1998-06-11 | 2003-04-15 | The Regents Of The University Of California | Phase-resolved optical coherence tomography and optical doppler tomography for imaging fluid flow in tissue with fast scanning speed and high velocity sensitivity |
WO2000003651A1 (en) | 1998-07-15 | 2000-01-27 | Corazon Technologies, Inc. | Methods and devices for reducing the mineral content of vascular calcified lesions |
US6166373A (en) | 1998-07-21 | 2000-12-26 | The Institute For Technology Development | Focal plane scanner with reciprocating spatial window |
JP2000046729A (en) | 1998-07-31 | 2000-02-18 | Takahisa Mitsui | Apparatus and method for high-speed measurement of optical topographic image by using wavelength dispersion |
US20040140130A1 (en) | 1998-08-31 | 2004-07-22 | Halliburton Energy Services, Inc., A Delaware Corporation | Roller-cone bits, systems, drilling methods, and design methods with optimization of tooth orientation |
US6741884B1 (en) | 1998-09-03 | 2004-05-25 | Hypermed, Inc. | Infrared endoscopic balloon probes |
US8024027B2 (en) | 1998-09-03 | 2011-09-20 | Hyperspectral Imaging, Inc. | Infrared endoscopic balloon probes |
AU6139199A (en) | 1998-09-11 | 2000-04-03 | Spectrx, Inc. | Multi-modal optical tissue diagnostic system |
JP2000131222A (en) | 1998-10-22 | 2000-05-12 | Olympus Optical Co Ltd | Optical tomographic image device |
AU6417599A (en) | 1998-10-08 | 2000-04-26 | University Of Kentucky Research Foundation, The | Methods and apparatus for (in vivo) identification and characterization of vulnerable atherosclerotic plaques |
JP2000121961A (en) | 1998-10-13 | 2000-04-28 | Olympus Optical Co Ltd | Confocal optical scanning probe system |
US6274871B1 (en) | 1998-10-22 | 2001-08-14 | Vysis, Inc. | Method and system for performing infrared study on a biological sample |
US6324419B1 (en) | 1998-10-27 | 2001-11-27 | Nejat Guzelsu | Apparatus and method for non-invasive measurement of stretch |
JP2000126116A (en) | 1998-10-28 | 2000-05-09 | Olympus Optical Co Ltd | Photo-diagnosis system |
US6524249B2 (en) | 1998-11-11 | 2003-02-25 | Spentech, Inc. | Doppler ultrasound method and apparatus for monitoring blood flow and detecting emboli |
US6516014B1 (en) | 1998-11-13 | 2003-02-04 | The Research And Development Institute, Inc. | Programmable frequency reference for laser frequency stabilization, and arbitrary optical clock generator, using persistent spectral hole burning |
EP1002497B1 (en) | 1998-11-20 | 2006-07-26 | Fuji Photo Film Co., Ltd. | Blood vessel imaging system |
US5975697A (en) | 1998-11-25 | 1999-11-02 | Oti Ophthalmic Technologies, Inc. | Optical mapping apparatus with adjustable depth resolution |
US6352502B1 (en) | 1998-12-03 | 2002-03-05 | Lightouch Medical, Inc. | Methods for obtaining enhanced spectroscopic information from living tissue, noninvasive assessment of skin condition and detection of skin abnormalities |
RU2149464C1 (en) | 1999-01-19 | 2000-05-20 | Таганрогский государственный радиотехнический университет | Dynamic memory unit for storage of radio signals |
US6191862B1 (en) | 1999-01-20 | 2001-02-20 | Lightlab Imaging, Llc | Methods and apparatus for high speed longitudinal scanning in imaging systems |
US6272376B1 (en) | 1999-01-22 | 2001-08-07 | Cedars-Sinai Medical Center | Time-resolved, laser-induced fluorescence for the characterization of organic material |
US6445944B1 (en) | 1999-02-01 | 2002-09-03 | Scimed Life Systems | Medical scanning system and related method of scanning |
US6615072B1 (en) | 1999-02-04 | 2003-09-02 | Olympus Optical Co., Ltd. | Optical imaging device |
US6185271B1 (en) | 1999-02-16 | 2001-02-06 | Richard Estyn Kinsinger | Helical computed tomography with feedback scan control |
DE19908883A1 (en) | 1999-03-02 | 2000-09-07 | Rainer Heintzmann | Process for increasing the resolution of optical imaging |
US20070048818A1 (en) | 1999-03-12 | 2007-03-01 | Human Genome Sciences, Inc. | Human secreted proteins |
EP1181598A4 (en) | 1999-03-29 | 2004-05-12 | Scimed Life Systems Inc | Single mode optical fiber coupling systems |
US6859275B2 (en) | 1999-04-09 | 2005-02-22 | Plain Sight Systems, Inc. | System and method for encoded spatio-spectral information processing |
US6264610B1 (en) | 1999-05-05 | 2001-07-24 | The University Of Connecticut | Combined ultrasound and near infrared diffused light imaging system |
US6353693B1 (en) | 1999-05-31 | 2002-03-05 | Sanyo Electric Co., Ltd. | Optical communication device and slip ring unit for an electronic component-mounting apparatus |
US6611833B1 (en) | 1999-06-23 | 2003-08-26 | Tissueinformatics, Inc. | Methods for profiling and classifying tissue using a database that includes indices representative of a tissue population |
JP2001004447A (en) | 1999-06-23 | 2001-01-12 | Yokogawa Electric Corp | Spectrometer |
US6993170B2 (en) | 1999-06-23 | 2006-01-31 | Icoria, Inc. | Method for quantitative analysis of blood vessel structure |
US6208887B1 (en) | 1999-06-24 | 2001-03-27 | Richard H. Clarke | Catheter-delivered low resolution Raman scattering analyzing system for detecting lesions |
US7426409B2 (en) | 1999-06-25 | 2008-09-16 | Board Of Regents, The University Of Texas System | Method and apparatus for detecting vulnerable atherosclerotic plaque |
GB9915082D0 (en) | 1999-06-28 | 1999-08-25 | Univ London | Optical fibre probe |
US6359692B1 (en) | 1999-07-09 | 2002-03-19 | Zygo Corporation | Method and system for profiling objects having multiple reflective surfaces using wavelength-tuning phase-shifting interferometry |
AU6093400A (en) | 1999-07-13 | 2001-01-30 | Chromavision Medical Systems, Inc. | Automated detection of objects in a biological sample |
DE60032637T2 (en) | 1999-07-30 | 2007-11-15 | Ceramoptec Gmbh | MEDICAL DIODE LASER SYSTEM WITH TWO WAVE LENGTHS |
WO2001008561A1 (en) | 1999-07-30 | 2001-02-08 | Boston Scientific Limited | Rotational and translational drive coupling for catheter assembly |
JP2001046321A (en) | 1999-08-09 | 2001-02-20 | Asahi Optical Co Ltd | Endoscope device |
US6445939B1 (en) | 1999-08-09 | 2002-09-03 | Lightlab Imaging, Llc | Ultra-small optical probes, imaging optics, and methods for using same |
US6725073B1 (en) | 1999-08-17 | 2004-04-20 | Board Of Regents, The University Of Texas System | Methods for noninvasive analyte sensing |
JP3869589B2 (en) | 1999-09-02 | 2007-01-17 | ペンタックス株式会社 | Fiber bundle and endoscope apparatus |
JP4464519B2 (en) | 2000-03-21 | 2010-05-19 | オリンパス株式会社 | Optical imaging device |
US6687010B1 (en) | 1999-09-09 | 2004-02-03 | Olympus Corporation | Rapid depth scanning optical imaging device |
US6198956B1 (en) | 1999-09-30 | 2001-03-06 | Oti Ophthalmic Technologies Inc. | High speed sector scanning apparatus having digital electronic control |
JP2001174744A (en) | 1999-10-06 | 2001-06-29 | Olympus Optical Co Ltd | Optical scanning probe device |
JP4363719B2 (en) | 1999-10-08 | 2009-11-11 | オリンパス株式会社 | Ultrasound-guided puncture system device |
US6393312B1 (en) | 1999-10-13 | 2002-05-21 | C. R. Bard, Inc. | Connector for coupling an optical fiber tissue localization device to a light source |
US6308092B1 (en) | 1999-10-13 | 2001-10-23 | C. R. Bard Inc. | Optical fiber tissue localization device |
AU1182401A (en) | 1999-10-15 | 2001-04-23 | Cellavision Ab | Microscope and method for manufacturing a composite image with a high resolution |
US6538817B1 (en) | 1999-10-25 | 2003-03-25 | Aculight Corporation | Method and apparatus for optical coherence tomography with a multispectral laser source |
JP2001125009A (en) | 1999-10-28 | 2001-05-11 | Asahi Optical Co Ltd | Endoscope |
IL132687A0 (en) | 1999-11-01 | 2001-03-19 | Keren Mechkarim Ichilov Pnimit | System and method for evaluating body fluid samples |
CA2392228A1 (en) | 1999-11-19 | 2001-05-25 | Ming Xiao | Compact spectrofluorometer |
US7236637B2 (en) | 1999-11-24 | 2007-06-26 | Ge Medical Systems Information Technologies, Inc. | Method and apparatus for transmission and display of a compressed digitized image |
EP1232377B1 (en) | 1999-11-24 | 2004-03-31 | Haag-Streit Ag | Method and device for measuring the optical properties of at least two regions located at a distance from one another in a transparent and/or diffuse object |
EP1240476A1 (en) | 1999-12-09 | 2002-09-18 | Oti Ophthalmic Technologies Inc. | Optical mapping apparatus with adjustable depth resolution |
JP2001174404A (en) | 1999-12-15 | 2001-06-29 | Takahisa Mitsui | Apparatus and method for measuring optical tomographic image |
US6738144B1 (en) | 1999-12-17 | 2004-05-18 | University Of Central Florida | Non-invasive method and low-coherence apparatus system analysis and process control |
US6680780B1 (en) | 1999-12-23 | 2004-01-20 | Agere Systems, Inc. | Interferometric probe stabilization relative to subject movement |
US6445485B1 (en) | 2000-01-21 | 2002-09-03 | At&T Corp. | Micro-machine polarization-state controller |
EP1251779A1 (en) | 2000-01-27 | 2002-10-30 | National Research Council of Canada | Visible-near infrared spectroscopy in burn injury assessment |
JP3660185B2 (en) | 2000-02-07 | 2005-06-15 | 独立行政法人科学技術振興機構 | Tomographic image forming method and apparatus therefor |
US6475210B1 (en) | 2000-02-11 | 2002-11-05 | Medventure Technology Corp | Light treatment of vulnerable atherosclerosis plaque |
US6556305B1 (en) | 2000-02-17 | 2003-04-29 | Veeco Instruments, Inc. | Pulsed source scanning interferometer |
US6618143B2 (en) | 2000-02-18 | 2003-09-09 | Idexx Laboratories, Inc. | High numerical aperture flow cytometer and method of using same |
US6751490B2 (en) | 2000-03-01 | 2004-06-15 | The Board Of Regents Of The University Of Texas System | Continuous optoacoustic monitoring of hemoglobin concentration and hematocrit |
US6687013B2 (en) | 2000-03-28 | 2004-02-03 | Hitachi, Ltd. | Laser interferometer displacement measuring system, exposure apparatus, and electron beam lithography apparatus |
WO2001072215A1 (en) | 2000-03-28 | 2001-10-04 | Board Of Regents, The University Of Texas System | Enhancing contrast in biological imaging |
US6567585B2 (en) | 2000-04-04 | 2003-05-20 | Optiscan Pty Ltd | Z sharpening for fibre confocal microscopes |
US6692430B2 (en) | 2000-04-10 | 2004-02-17 | C2Cure Inc. | Intra vascular imaging apparatus |
EP1299057A2 (en) | 2000-04-27 | 2003-04-09 | Iridex Corporation | Method and apparatus for real-time detection, control and recording of sub-clinical therapeutic laser lesions during ocular laser photocoagulation |
AU2001259435A1 (en) | 2000-05-03 | 2001-11-12 | Stephen T Flock | Optical imaging of subsurface anatomical structures and biomolecules |
US6711283B1 (en) | 2000-05-03 | 2004-03-23 | Aperio Technologies, Inc. | Fully automatic rapid microscope slide scanner |
US6441959B1 (en) | 2000-05-19 | 2002-08-27 | Avanex Corporation | Method and system for testing a tunable chromatic dispersion, dispersion slope, and polarization mode dispersion compensator utilizing a virtually imaged phased array |
US6301048B1 (en) | 2000-05-19 | 2001-10-09 | Avanex Corporation | Tunable chromatic dispersion and dispersion slope compensator utilizing a virtually imaged phased array |
US6560259B1 (en) | 2000-05-31 | 2003-05-06 | Applied Optoelectronics, Inc. | Spatially coherent surface-emitting, grating coupled quantum cascade laser with unstable resonance cavity |
US6975898B2 (en) | 2000-06-19 | 2005-12-13 | University Of Washington | Medical imaging, diagnosis, and therapy using a scanning single optical fiber system |
JP4460117B2 (en) | 2000-06-29 | 2010-05-12 | 独立行政法人理化学研究所 | Grism |
JP2002035005A (en) | 2000-07-21 | 2002-02-05 | Olympus Optical Co Ltd | Therapeutic device |
US6757467B1 (en) | 2000-07-25 | 2004-06-29 | Optical Air Data Systems, Lp | Optical fiber system |
US6441356B1 (en) | 2000-07-28 | 2002-08-27 | Optical Biopsy Technologies | Fiber-coupled, high-speed, angled-dual-axis optical coherence scanning microscopes |
US6882432B2 (en) | 2000-08-08 | 2005-04-19 | Zygo Corporation | Frequency transform phase shifting interferometry |
WO2002014944A1 (en) | 2000-08-11 | 2002-02-21 | Crystal Fibre A/S | Optical wavelength converter |
US7625335B2 (en) | 2000-08-25 | 2009-12-01 | 3Shape Aps | Method and apparatus for three-dimensional optical scanning of interior surfaces |
DE10042840A1 (en) | 2000-08-30 | 2002-03-14 | Leica Microsystems | Device and method for exciting fluorescence microscope markers in multiphoton scanning microscopy |
WO2002021170A1 (en) | 2000-09-05 | 2002-03-14 | Arroyo Optics, Inc. | System and method for fabricating components of precise optical path length |
JP2002095663A (en) | 2000-09-26 | 2002-04-02 | Fuji Photo Film Co Ltd | Method of acquiring optical tomographic image of sentinel lymph node and its device |
JP2002113017A (en) | 2000-10-05 | 2002-04-16 | Fuji Photo Film Co Ltd | Laser treatment device |
AU2002230842A1 (en) | 2000-10-30 | 2002-05-15 | The General Hospital Corporation | Optical methods and systems for tissue analysis |
AU1210502A (en) | 2000-10-31 | 2002-05-15 | Forskningsct Riso | Optical amplification in coherent optical frequency modulated continuous wave reflectometry |
JP3842101B2 (en) | 2000-10-31 | 2006-11-08 | 富士写真フイルム株式会社 | Endoscope device |
US6687036B2 (en) | 2000-11-03 | 2004-02-03 | Nuonics, Inc. | Multiplexed optical scanner technology |
JP2002148185A (en) | 2000-11-08 | 2002-05-22 | Fuji Photo Film Co Ltd | Oct apparatus |
US9295391B1 (en) | 2000-11-10 | 2016-03-29 | The General Hospital Corporation | Spectrally encoded miniature endoscopic imaging probe |
AU2002216035A1 (en) | 2000-11-13 | 2002-05-21 | Gnothis Holding Sa | Detection of nucleic acid polymorphisms |
US6665075B2 (en) | 2000-11-14 | 2003-12-16 | Wm. Marshurice University | Interferometric imaging system and method |
DE10057539B4 (en) | 2000-11-20 | 2008-06-12 | Robert Bosch Gmbh | Interferometric measuring device |
US6558324B1 (en) | 2000-11-22 | 2003-05-06 | Siemens Medical Solutions, Inc., Usa | System and method for strain image display |
US6856712B2 (en) | 2000-11-27 | 2005-02-15 | University Of Washington | Micro-fabricated optical waveguide for use in scanning fiber displays and scanned fiber image acquisition |
US7027633B2 (en) | 2000-11-30 | 2006-04-11 | Foran David J | Collaborative diagnostic systems |
JP4786027B2 (en) | 2000-12-08 | 2011-10-05 | オリンパス株式会社 | Optical system and optical apparatus |
US6501878B2 (en) | 2000-12-14 | 2002-12-31 | Nortel Networks Limited | Optical fiber termination |
US6687007B1 (en) | 2000-12-14 | 2004-02-03 | Kestrel Corporation | Common path interferometer for spectral image generation |
US6515752B2 (en) | 2000-12-28 | 2003-02-04 | Coretek, Inc. | Wavelength monitoring system |
CN101194856A (en) | 2000-12-28 | 2008-06-11 | 帕洛玛医疗技术有限公司 | Methods and products for producing lattices of EMR-treated islets in tissues, and uses therefor |
WO2002054046A1 (en) | 2000-12-28 | 2002-07-11 | Dmitri Olegovich Lapotko | Method and device for photothermal examination of microinhomogeneities |
EP1221581A1 (en) | 2001-01-04 | 2002-07-10 | Universität Stuttgart | Interferometer |
JP2002205434A (en) | 2001-01-10 | 2002-07-23 | Seiko Epson Corp | Image output unit and printing system |
WO2002054948A1 (en) | 2001-01-11 | 2002-07-18 | The Johns Hopkins University | Assessment of tooth structure using laser based ultrasonics |
US7177491B2 (en) | 2001-01-12 | 2007-02-13 | Board Of Regents The University Of Texas System | Fiber-based optical low coherence tomography |
JP3628615B2 (en) | 2001-01-16 | 2005-03-16 | 独立行政法人科学技術振興機構 | Heterodyne beat image synchronous measurement device |
US6697652B2 (en) | 2001-01-19 | 2004-02-24 | Massachusetts Institute Of Technology | Fluorescence, reflectance and light scattering spectroscopy for measuring tissue |
EP1358443A2 (en) | 2001-01-22 | 2003-11-05 | Jonathan E. Roth | Method and apparatus for polarization-sensitive optical coherence tomography |
US7973936B2 (en) | 2001-01-30 | 2011-07-05 | Board Of Trustees Of Michigan State University | Control system and apparatus for use with ultra-fast laser |
US20020140942A1 (en) | 2001-02-17 | 2002-10-03 | Fee Michale Sean | Acousto-optic monitoring and imaging in a depth sensitive manner |
GB0104378D0 (en) | 2001-02-22 | 2001-04-11 | Expro North Sea Ltd | Improved tubing coupling |
US6654127B2 (en) | 2001-03-01 | 2003-11-25 | Carl Zeiss Ophthalmic Systems, Inc. | Optical delay line |
US6721094B1 (en) | 2001-03-05 | 2004-04-13 | Sandia Corporation | Long working distance interference microscope |
US7244232B2 (en) | 2001-03-07 | 2007-07-17 | Biomed Solutions, Llc | Process for identifying cancerous and/or metastatic cells of a living organism |
IL142773A (en) | 2001-03-08 | 2007-10-31 | Xtellus Inc | Fiber optical attenuator |
JP2002263055A (en) | 2001-03-12 | 2002-09-17 | Olympus Optical Co Ltd | Tip hood for endoscope |
US6563995B2 (en) | 2001-04-02 | 2003-05-13 | Lightwave Electronics | Optical wavelength filtering apparatus with depressed-index claddings |
US6552796B2 (en) | 2001-04-06 | 2003-04-22 | Lightlab Imaging, Llc | Apparatus and method for selective data collection and signal to noise ratio enhancement using optical coherence tomography |
US8046057B2 (en) | 2001-04-11 | 2011-10-25 | Clarke Dana S | Tissue structure identification in advance of instrument |
US7139598B2 (en) | 2002-04-04 | 2006-11-21 | Veralight, Inc. | Determination of a measure of a glycation end-product or disease state using tissue fluorescence |
US20020158211A1 (en) | 2001-04-16 | 2002-10-31 | Dakota Technologies, Inc. | Multi-dimensional fluorescence apparatus and method for rapid and highly sensitive quantitative analysis of mixtures |
DE10118760A1 (en) | 2001-04-17 | 2002-10-31 | Med Laserzentrum Luebeck Gmbh | Procedure for determining the runtime distribution and arrangement |
EP2333523B1 (en) | 2001-04-30 | 2020-04-08 | The General Hospital Corporation | Method and apparatus for improving image clarity and sensitivity in optical coherence tomography using dynamic feedback to control focal properties and coherence gating |
US7616986B2 (en) | 2001-05-07 | 2009-11-10 | University Of Washington | Optical fiber scanner for performing multimodal optical imaging |
US6701181B2 (en) | 2001-05-31 | 2004-03-02 | Infraredx, Inc. | Multi-path optical catheter |
US6615062B2 (en) | 2001-05-31 | 2003-09-02 | Infraredx, Inc. | Referencing optical catheters |
US20030103995A1 (en) | 2001-06-04 | 2003-06-05 | Hamblin Michael R. | Detection and therapy of vulnerable plaque with photodynamic compounds |
US6879851B2 (en) | 2001-06-07 | 2005-04-12 | Lightlab Imaging, Llc | Fiber optic endoscopic gastrointestinal probe |
DE60100064T2 (en) | 2001-06-07 | 2003-04-17 | Agilent Technologies Inc | Determination of the properties of an optical device |
DE10129651B4 (en) | 2001-06-15 | 2010-07-08 | Carl Zeiss Jena Gmbh | Method for compensation of the dispersion in signals of short-coherence and / or OCT interferometers |
US6702744B2 (en) | 2001-06-20 | 2004-03-09 | Advanced Cardiovascular Systems, Inc. | Agents that stimulate therapeutic angiogenesis and techniques and devices that enable their delivery |
US6685885B2 (en) | 2001-06-22 | 2004-02-03 | Purdue Research Foundation | Bio-optical compact dist system |
US20040166593A1 (en) | 2001-06-22 | 2004-08-26 | Nolte David D. | Adaptive interferometric multi-analyte high-speed biosensor |
WO2003003903A2 (en) | 2001-07-02 | 2003-01-16 | Palomar Medical Technologies, Inc. | Laser device for medical/cosmetic procedures |
US6795199B2 (en) | 2001-07-18 | 2004-09-21 | Avraham Suhami | Method and apparatus for dispersion compensated reflected time-of-flight tomography |
DE10137530A1 (en) | 2001-08-01 | 2003-02-13 | Presens Prec Sensing Gmbh | Arrangement and method for multiple fluorescence measurement |
WO2003011764A2 (en) | 2001-08-03 | 2003-02-13 | Volker Westphal | Real-time imaging system and method |
WO2003012405A2 (en) | 2001-08-03 | 2003-02-13 | Rollins Andrew M | Aspects of basic oct engine technologies for high speed optical coherence tomography and light source and other improvements in oct |
US20030030816A1 (en) | 2001-08-11 | 2003-02-13 | Eom Tae Bong | Nonlinearity error correcting method and phase angle measuring method for displacement measurement in two-freqency laser interferometer and displacement measurement system using the same |
US6900899B2 (en) | 2001-08-20 | 2005-05-31 | Agilent Technologies, Inc. | Interferometers with coated polarizing beam splitters that are rotated to optimize extinction ratios |
US20030045798A1 (en) | 2001-09-04 | 2003-03-06 | Richard Hular | Multisensor probe for tissue identification |
EP1293925A1 (en) | 2001-09-18 | 2003-03-19 | Agfa-Gevaert | Radiographic scoring method |
US6961123B1 (en) | 2001-09-28 | 2005-11-01 | The Texas A&M University System | Method and apparatus for obtaining information from polarization-sensitive optical coherence tomography |
JP2003102672A (en) | 2001-10-01 | 2003-04-08 | Japan Science & Technology Corp | Method and device for automatically detecting, treating, and collecting objective site of lesion or the like |
DE10150934A1 (en) | 2001-10-09 | 2003-04-10 | Zeiss Carl Jena Gmbh | Depth resolved measurement and imaging of biological samples using laser scanning microscopy, whereby heterodyne detection and optical modulation is used to allow imaging of deep sample regions |
US7822470B2 (en) | 2001-10-11 | 2010-10-26 | Osypka Medical Gmbh | Method for determining the left-ventricular ejection time TLVE of a heart of a subject |
US6980299B1 (en) | 2001-10-16 | 2005-12-27 | General Hospital Corporation | Systems and methods for imaging a sample |
US6658278B2 (en) | 2001-10-17 | 2003-12-02 | Terumo Cardiovascular Systems Corporation | Steerable infrared imaging catheter having steering fins |
US7006231B2 (en) | 2001-10-18 | 2006-02-28 | Scimed Life Systems, Inc. | Diffraction grating based interferometric systems and methods |
US6749344B2 (en) | 2001-10-24 | 2004-06-15 | Scimed Life Systems, Inc. | Connection apparatus for optical coherence tomography catheters |
EP1441215B1 (en) * | 2001-10-31 | 2012-08-01 | Olympus Corporation | Optical scanning type observation device |
US6661513B1 (en) | 2001-11-21 | 2003-12-09 | Roygbiv, Llc | Refractive-diffractive spectrometer |
AU2002360198A1 (en) | 2001-12-11 | 2003-07-09 | C2Cure Inc. | Apparatus, method and system for intravascular photographic imaging |
US20030216719A1 (en) | 2001-12-12 | 2003-11-20 | Len Debenedictis | Method and apparatus for treating skin using patterns of optical energy |
WO2003052883A2 (en) | 2001-12-14 | 2003-06-26 | Agilent Technologies, Inc. | Retro-reflecting device in particular for tunable lasers |
US7736301B1 (en) | 2001-12-18 | 2010-06-15 | Advanced Cardiovascular Systems, Inc. | Rotatable ferrules and interfaces for use with an optical guidewire |
US7365858B2 (en) | 2001-12-18 | 2008-04-29 | Massachusetts Institute Of Technology | Systems and methods for phase measurements |
US6975891B2 (en) | 2001-12-21 | 2005-12-13 | Nir Diagnostics Inc. | Raman spectroscopic system with integrating cavity |
US6947787B2 (en) | 2001-12-21 | 2005-09-20 | Advanced Cardiovascular Systems, Inc. | System and methods for imaging within a body lumen |
EP1324051A1 (en) | 2001-12-26 | 2003-07-02 | Kevin R. Forrester | Motion measuring device |
US20080154090A1 (en) | 2005-01-04 | 2008-06-26 | Dune Medical Devices Ltd. | Endoscopic System for In-Vivo Procedures |
ATE503982T1 (en) | 2002-01-11 | 2011-04-15 | Gen Hospital Corp | DEVICE FOR OCT IMAGE ACQUISITION WITH AXIAL LINE FOCUS FOR IMPROVED RESOLUTION AND DEPTH OF FIELD |
US7072045B2 (en) | 2002-01-16 | 2006-07-04 | The Regents Of The University Of California | High resolution optical coherence tomography with an improved depth range using an axicon lens |
JP2005516187A (en) | 2002-01-24 | 2005-06-02 | ザ ジェネラル ホスピタル コーポレーション | Apparatus and method for ranging with parallel detection of spectral bands and noise reduction of low coherence interferometry (LCI) and optical coherence tomography (OCT) signals |
US7355716B2 (en) | 2002-01-24 | 2008-04-08 | The General Hospital Corporation | Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands |
WO2003069272A1 (en) | 2002-02-14 | 2003-08-21 | Imalux Corporation | Method for studying an object and an optical interferometer for carrying out said method |
US20030165263A1 (en) | 2002-02-19 | 2003-09-04 | Hamer Michael J. | Histological assessment |
US7116887B2 (en) | 2002-03-19 | 2006-10-03 | Nufern | Optical fiber |
US6704590B2 (en) | 2002-04-05 | 2004-03-09 | Cardiac Pacemakers, Inc. | Doppler guiding catheter using sensed blood turbulence levels |
US7006232B2 (en) | 2002-04-05 | 2006-02-28 | Case Western Reserve University | Phase-referenced doppler optical coherence tomography |
US7113818B2 (en) | 2002-04-08 | 2006-09-26 | Oti Ophthalmic Technologies Inc. | Apparatus for high resolution imaging of moving organs |
US7016048B2 (en) | 2002-04-09 | 2006-03-21 | The Regents Of The University Of California | Phase-resolved functional optical coherence tomography: simultaneous imaging of the stokes vectors, structure, blood flow velocity, standard deviation and birefringence in biological samples |
US20030236443A1 (en) | 2002-04-19 | 2003-12-25 | Cespedes Eduardo Ignacio | Methods and apparatus for the identification and stabilization of vulnerable plaque |
US7503904B2 (en) | 2002-04-25 | 2009-03-17 | Cardiac Pacemakers, Inc. | Dual balloon telescoping guiding catheter |
JP4135551B2 (en) | 2002-05-07 | 2008-08-20 | 松下電工株式会社 | Position sensor |
JP3834789B2 (en) | 2002-05-17 | 2006-10-18 | 独立行政法人科学技術振興機構 | Autonomous ultra-short optical pulse compression, phase compensation, waveform shaping device |
RU2242710C2 (en) | 2002-06-07 | 2004-12-20 | Геликонов Григорий Валентинович | Method and device for building object image and device for delivering low coherence optical radiation |
US7272252B2 (en) | 2002-06-12 | 2007-09-18 | Clarient, Inc. | Automated system for combining bright field and fluorescent microscopy |
US7364296B2 (en) | 2002-06-12 | 2008-04-29 | University Of Rochester | Method and apparatus for improving both lateral and axial resolution in ophthalmoscopy |
RU2213421C1 (en) | 2002-06-21 | 2003-09-27 | Южно-Российский государственный университет экономики и сервиса | Dynamic radio-signal memory device |
JP4045140B2 (en) | 2002-06-21 | 2008-02-13 | 国立大学法人 筑波大学 | Polarization-sensitive optical spectral interference coherence tomography apparatus and method for measuring polarization information inside a sample using the apparatus |
US20040039252A1 (en) | 2002-06-27 | 2004-02-26 | Koch Kenneth Elmon | Self-navigating endotracheal tube |
JP3621693B2 (en) | 2002-07-01 | 2005-02-16 | フジノン株式会社 | Interferometer device |
US7072047B2 (en) | 2002-07-12 | 2006-07-04 | Case Western Reserve University | Method and system for quantitative image correction for optical coherence tomography |
JP3950378B2 (en) | 2002-07-19 | 2007-08-01 | 新日本製鐵株式会社 | Synchronous machine |
JP4258015B2 (en) | 2002-07-31 | 2009-04-30 | 毅 椎名 | Ultrasonic diagnostic system, strain distribution display method, and elastic modulus distribution display method |
JP4373651B2 (en) | 2002-09-03 | 2009-11-25 | Hoya株式会社 | Diagnostic light irradiation device |
JP2004113780A (en) | 2002-09-06 | 2004-04-15 | Pentax Corp | Endoscope and optical tomographic endoscope system |
US7283247B2 (en) | 2002-09-25 | 2007-10-16 | Olympus Corporation | Optical probe system |
WO2004029566A1 (en) | 2002-09-26 | 2004-04-08 | Bio Techplex Corporation | Method and apparatus for screening using a waveform modulated led |
US6842254B2 (en) | 2002-10-16 | 2005-01-11 | Fiso Technologies Inc. | System and method for measuring an optical path difference in a sensing interferometer |
WO2004034869A2 (en) | 2002-10-18 | 2004-04-29 | Arieh Sher | Atherectomy system with imaging guidewire |
US20040092829A1 (en) | 2002-11-07 | 2004-05-13 | Simon Furnish | Spectroscope with modified field-of-view |
JP4246986B2 (en) | 2002-11-18 | 2009-04-02 | 株式会社町田製作所 | Vibration object observation system and vocal cord observation processing apparatus |
US6847449B2 (en) | 2002-11-27 | 2005-01-25 | The United States Of America As Represented By The Secretary Of The Navy | Method and apparatus for reducing speckle in optical coherence tomography images |
EP1426799A3 (en) | 2002-11-29 | 2005-05-18 | Matsushita Electric Industrial Co., Ltd. | Optical demultiplexer, optical multi-/demultiplexer, and optical device |
DE10260256B9 (en) | 2002-12-20 | 2007-03-01 | Carl Zeiss | Interferometer system and measuring / machining tool |
GB0229734D0 (en) | 2002-12-23 | 2003-01-29 | Qinetiq Ltd | Grading oestrogen and progesterone receptors expression |
JP4148771B2 (en) | 2002-12-27 | 2008-09-10 | 株式会社トプコン | Laser device for medical machine |
US7123363B2 (en) | 2003-01-03 | 2006-10-17 | Rose-Hulman Institute Of Technology | Speckle pattern analysis method and system |
US7567349B2 (en) | 2003-03-31 | 2009-07-28 | The General Hospital Corporation | Speckle reduction in optical coherence tomography by path length encoded angular compounding |
US7075658B2 (en) | 2003-01-24 | 2006-07-11 | Duke University | Method for optical coherence tomography imaging with molecular contrast |
JP2006516739A (en) | 2003-01-24 | 2006-07-06 | ザ・ジェネラル・ホスピタル・コーポレイション | System and method for identifying tissue using a low coherence interferometer |
US8054468B2 (en) | 2003-01-24 | 2011-11-08 | The General Hospital Corporation | Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands |
US6943892B2 (en) | 2003-01-29 | 2005-09-13 | Sarnoff Corporation | Instrument having a multi-mode optical element and method |
WO2004073501A2 (en) | 2003-02-20 | 2004-09-02 | Gutin Mikhail | Optical coherence tomography with 3d coherence scanning |
JP4338412B2 (en) | 2003-02-24 | 2009-10-07 | Hoya株式会社 | Confocal probe and confocal microscope |
US7271918B2 (en) | 2003-03-06 | 2007-09-18 | Zygo Corporation | Profiling complex surface structures using scanning interferometry |
JP4135550B2 (en) | 2003-04-18 | 2008-08-20 | 日立電線株式会社 | Semiconductor light emitting device |
JP2004317437A (en) | 2003-04-18 | 2004-11-11 | Olympus Corp | Optical imaging apparatus |
US7110109B2 (en) | 2003-04-18 | 2006-09-19 | Ahura Corporation | Raman spectroscopy system and method and specimen holder therefor |
US7347548B2 (en) | 2003-05-01 | 2008-03-25 | The Cleveland Clinic Foundation | Method and apparatus for measuring a retinal sublayer characteristic |
JP4571625B2 (en) | 2003-05-05 | 2010-10-27 | ディーフォーディー テクノロジーズ エルエルシー | Imaging by optical tomography |
CN101785656B (en) | 2003-05-12 | 2012-08-15 | 富士胶片株式会社 | Balloon controller for a balloon type endoscope |
SE527164C2 (en) | 2003-05-14 | 2006-01-10 | Spectracure Ab | Interactive therapy/diagnosis system for tumor, has operation mode selector to optically direct non-ionizing electromagnetic therapeutic and/or diagnostic radiation to tumor site, through radiation conductor |
US7376455B2 (en) | 2003-05-22 | 2008-05-20 | Scimed Life Systems, Inc. | Systems and methods for dynamic optical imaging |
WO2004111929A2 (en) | 2003-05-28 | 2004-12-23 | Duke University | Improved system for fourier domain optical coherence tomography |
EP1627248A4 (en) | 2003-05-29 | 2008-06-04 | Univ Michigan | Double-clad fiber scanning microscope |
EP1644697A4 (en) | 2003-05-30 | 2006-11-29 | Univ Duke | System and method for low coherence broadband quadrature interferometry |
US7263394B2 (en) | 2003-06-04 | 2007-08-28 | Tomophase Corporation | Coherence-gated optical glucose monitor |
US6943881B2 (en) | 2003-06-04 | 2005-09-13 | Tomophase Corporation | Measurements of optical inhomogeneity and other properties in substances using propagation modes of light |
KR101546024B1 (en) | 2003-06-06 | 2015-08-20 | 더 제너럴 하스피탈 코포레이션 | Process and apparatus for a wavelength tunning source |
US7458683B2 (en) | 2003-06-16 | 2008-12-02 | Amo Manufacturing Usa, Llc | Methods and devices for registering optical measurement datasets of an optical system |
US7170913B2 (en) | 2003-06-19 | 2007-01-30 | Multiwave Photonics, Sa | Laser source with configurable output beam characteristics |
US20040260182A1 (en) | 2003-06-23 | 2004-12-23 | Zuluaga Andres F. | Intraluminal spectroscope with wall contacting probe |
JP4677208B2 (en) | 2003-07-29 | 2011-04-27 | オリンパス株式会社 | Confocal microscope |
US20050038322A1 (en) | 2003-08-11 | 2005-02-17 | Scimed Life Systems | Imaging endoscope |
WO2005017495A2 (en) | 2003-08-14 | 2005-02-24 | University Of Central Florida | Interferometric sensor for characterizing materials |
US7539530B2 (en) | 2003-08-22 | 2009-05-26 | Infraredx, Inc. | Method and system for spectral examination of vascular walls through blood during cardiac motion |
US20050083534A1 (en) | 2003-08-28 | 2005-04-21 | Riza Nabeel A. | Agile high sensitivity optical sensor |
JP4590171B2 (en) | 2003-08-29 | 2010-12-01 | オリンパス株式会社 | Capsule type medical device and medical device equipped with the capsule type medical device |
JP2005077964A (en) | 2003-09-03 | 2005-03-24 | Fujitsu Ltd | Spectroscope apparatus |
US20050057680A1 (en) | 2003-09-16 | 2005-03-17 | Agan Martin J. | Method and apparatus for controlling integration time in imagers |
US20050059894A1 (en) | 2003-09-16 | 2005-03-17 | Haishan Zeng | Automated endoscopy device, diagnostic method, and uses |
US7935055B2 (en) | 2003-09-19 | 2011-05-03 | Siemens Medical Solutions Usa, Inc. | System and method of measuring disease severity of a patient before, during and after treatment |
US6949072B2 (en) | 2003-09-22 | 2005-09-27 | Infraredx, Inc. | Devices for vulnerable plaque detection |
US8172747B2 (en) | 2003-09-25 | 2012-05-08 | Hansen Medical, Inc. | Balloon visualization for traversing a tissue wall |
EP1677095A1 (en) | 2003-09-26 | 2006-07-05 | The Kitasato Gakuen Foundation | Variable-wavelength light generator and light interference tomograph |
JP3796550B2 (en) | 2003-09-26 | 2006-07-12 | 日本電信電話株式会社 | Optical interference tomography device |
US7142835B2 (en) | 2003-09-29 | 2006-11-28 | Silicon Laboratories, Inc. | Apparatus and method for digital image correction in a receiver |
US7292792B2 (en) | 2003-09-30 | 2007-11-06 | Lucent Technologies Inc. | High speed modulation of optical subcarriers |
DE10349230A1 (en) | 2003-10-23 | 2005-07-07 | Carl Zeiss Meditec Ag | Apparatus for interferometric eye length measurement with increased sensitivity |
KR101384553B1 (en) | 2003-10-27 | 2014-04-11 | 더 제너럴 하스피탈 코포레이션 | Method and apparatus for performing optical imaging using frequency-domain interferometry |
DE10351319B4 (en) | 2003-10-31 | 2005-10-20 | Med Laserzentrum Luebeck Gmbh | Interferometer for optical coherence tomography |
US7130320B2 (en) | 2003-11-13 | 2006-10-31 | Mitutoyo Corporation | External cavity laser with rotary tuning element |
WO2005054780A1 (en) | 2003-11-28 | 2005-06-16 | The General Hospital Corporation | Method and apparatus for three-dimensional spectrally encoded imaging |
US7359062B2 (en) | 2003-12-09 | 2008-04-15 | The Regents Of The University Of California | High speed spectral domain functional optical coherence tomography and optical doppler tomography for in vivo blood flow dynamics and tissue structure |
DE10358735B4 (en) | 2003-12-15 | 2011-04-21 | Siemens Ag | Catheter device comprising a catheter, in particular an intravascular catheter |
US7145661B2 (en) | 2003-12-31 | 2006-12-05 | Carl Zeiss Meditec, Inc. | Efficient optical coherence tomography (OCT) system and method for rapid imaging in three dimensions |
JP4414771B2 (en) | 2004-01-08 | 2010-02-10 | オリンパス株式会社 | Confocal microspectroscope |
RU2255426C1 (en) | 2004-02-19 | 2005-06-27 | Южно-Российский государственный университет экономики и сервиса | Radio-signal dynamic memory device having series binary fiber- optic system |
JP4462959B2 (en) | 2004-02-25 | 2010-05-12 | 富士通株式会社 | Microscope image photographing system and method |
US20110178409A1 (en) | 2004-02-27 | 2011-07-21 | Optiscan Pty Ltd | Optical Element |
US7242480B2 (en) | 2004-05-14 | 2007-07-10 | Medeikon Corporation | Low coherence interferometry for detecting and characterizing plaques |
US20050254059A1 (en) | 2004-05-14 | 2005-11-17 | Alphonse Gerard A | Low coherence interferometric system for optical metrology |
US7190464B2 (en) | 2004-05-14 | 2007-03-13 | Medeikon Corporation | Low coherence interferometry for detecting and characterizing plaques |
EP1754016B1 (en) | 2004-05-29 | 2016-05-18 | The General Hospital Corporation | Process, system and software arrangement for a chromatic dispersion compensation using reflective layers in optical coherence tomography (oct) imaging |
US7447408B2 (en) | 2004-07-02 | 2008-11-04 | The General Hospital Corproation | Imaging system and related techniques |
DE102004035269A1 (en) | 2004-07-21 | 2006-02-16 | Rowiak Gmbh | Laryngoscope with OCT |
KR101332222B1 (en) | 2004-08-06 | 2013-11-22 | 더 제너럴 하스피탈 코포레이션 | Process, system and software arrangement for determining at least one location in a sample using an optical coherence tomography |
WO2006020605A2 (en) | 2004-08-10 | 2006-02-23 | The Regents Of The University Of California | Device and method for the delivery and/or elimination of compounds in tissue |
US7218822B2 (en) | 2004-09-03 | 2007-05-15 | Chemimage Corporation | Method and apparatus for fiberscope |
US7365859B2 (en) | 2004-09-10 | 2008-04-29 | The General Hospital Corporation | System and method for optical coherence imaging |
US7366376B2 (en) | 2004-09-29 | 2008-04-29 | The General Hospital Corporation | System and method for optical coherence imaging |
US7113625B2 (en) | 2004-10-01 | 2006-09-26 | U.S. Pathology Labs, Inc. | System and method for image analysis of slides |
SE0402435L (en) | 2004-10-08 | 2006-04-09 | Trajan Badju | Process and system for generating three-dimensional images |
JP2008517281A (en) | 2004-10-22 | 2008-05-22 | ファーミスカン・オーストラリア・ピーティーワイ・リミテッド | Analysis method and apparatus |
JP5175101B2 (en) | 2004-10-29 | 2013-04-03 | ザ ジェネラル ホスピタル コーポレイション | System and method for performing Jones matrix based analysis to measure unpolarized polarization parameters using polarization sensitive optical coherence tomography |
EP1807722B1 (en) | 2004-11-02 | 2022-08-10 | The General Hospital Corporation | Fiber-optic rotational device, optical system for imaging a sample |
US7417740B2 (en) | 2004-11-12 | 2008-08-26 | Medeikon Corporation | Single trace multi-channel low coherence interferometric sensor |
DE102005045071A1 (en) | 2005-09-21 | 2007-04-12 | Siemens Ag | Catheter device with a position sensor system for the treatment of a partial and / or complete vascular occlusion under image monitoring |
US8617152B2 (en) | 2004-11-15 | 2013-12-31 | Medtronic Ablation Frontiers Llc | Ablation system with feedback |
GB0425419D0 (en) | 2004-11-18 | 2004-12-22 | Sira Ltd | Interference apparatus and method and probe |
WO2006058187A2 (en) | 2004-11-23 | 2006-06-01 | Robert Eric Betzig | Optical lattice microscopy |
GB0426609D0 (en) | 2004-12-03 | 2005-01-05 | Ic Innovations Ltd | Analysis |
JP2006162366A (en) | 2004-12-06 | 2006-06-22 | Fujinon Corp | Optical tomographic imaging system |
US7450242B2 (en) | 2004-12-10 | 2008-11-11 | Fujifilm Corporation | Optical tomography apparatus |
US7336366B2 (en) | 2005-01-20 | 2008-02-26 | Duke University | Methods and systems for reducing complex conjugate ambiguity in interferometric data |
US8315282B2 (en) | 2005-01-20 | 2012-11-20 | Massachusetts Institute Of Technology | Fourier domain mode locking: method and apparatus for control and improved performance |
US7330270B2 (en) | 2005-01-21 | 2008-02-12 | Carl Zeiss Meditec, Inc. | Method to suppress artifacts in frequency-domain optical coherence tomography |
US7342659B2 (en) | 2005-01-21 | 2008-03-11 | Carl Zeiss Meditec, Inc. | Cross-dispersed spectrometer in a spectral domain optical coherence tomography system |
HU227859B1 (en) | 2005-01-27 | 2012-05-02 | E Szilveszter Vizi | Real-time 3d nonlinear microscope measuring system and its application |
US7267494B2 (en) | 2005-02-01 | 2007-09-11 | Finisar Corporation | Fiber stub for cladding mode coupling reduction |
US7860555B2 (en) | 2005-02-02 | 2010-12-28 | Voyage Medical, Inc. | Tissue visualization and manipulation system |
US7664300B2 (en) | 2005-02-03 | 2010-02-16 | Sti Medical Systems, Llc | Uterine cervical cancer computer-aided-diagnosis (CAD) |
DE102005007574B3 (en) | 2005-02-18 | 2006-08-31 | Siemens Ag | catheter device |
EP1910996A1 (en) | 2005-02-23 | 2008-04-16 | Lyncee Tec S.A. | Wave front sensing method and apparatus |
JP4628820B2 (en) | 2005-02-25 | 2011-02-09 | サンテック株式会社 | Wavelength scanning fiber laser light source |
US7530948B2 (en) | 2005-02-28 | 2009-05-12 | University Of Washington | Tethered capsule endoscope for Barrett's Esophagus screening |
DE102005010790A1 (en) | 2005-03-09 | 2006-09-14 | Basf Ag | Photovoltaic cell with a photovoltaically active semiconductor material contained therein |
US20060224053A1 (en) | 2005-03-30 | 2006-10-05 | Skyline Biomedical, Inc. | Apparatus and method for non-invasive and minimally-invasive sensing of venous oxygen saturation and pH levels |
JP2008538612A (en) | 2005-04-22 | 2008-10-30 | ザ ジェネラル ホスピタル コーポレイション | Configuration, system, and method capable of providing spectral domain polarization sensitive optical coherence tomography |
WO2006116362A2 (en) | 2005-04-25 | 2006-11-02 | The Trustees Of Boston University | Structured substrates for optical surface profiling |
US20070009935A1 (en) | 2005-05-13 | 2007-01-11 | The General Hospital Corporation | Arrangements, systems and methods capable of providing spectral-domain optical coherence reflectometry for a sensitive detection of chemical and biological sample |
WO2006127692A2 (en) | 2005-05-23 | 2006-11-30 | Hess Harald F | Optical microscopy with phototransformable optical labels |
JP2008542758A (en) | 2005-05-31 | 2008-11-27 | ザ ジェネラル ホスピタル コーポレイション | System, method and apparatus capable of using spectrally encoded heterodyne interferometry for imaging |
EP1889037A2 (en) | 2005-06-01 | 2008-02-20 | The General Hospital Corporation | Apparatus, method and system for performing phase-resolved optical frequency domain imaging |
JP2008545500A (en) | 2005-06-07 | 2008-12-18 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | Laser optical feedback tomography sensor and method |
US7391520B2 (en) | 2005-07-01 | 2008-06-24 | Carl Zeiss Meditec, Inc. | Fourier domain optical coherence tomography employing a swept multi-wavelength laser and a multi-channel receiver |
WO2007005913A2 (en) | 2005-07-01 | 2007-01-11 | Infotonics Technology Center, Inc. | Non-invasive monitoring system |
DE102005034443A1 (en) | 2005-07-22 | 2007-02-22 | Carl Zeiss Jena Gmbh | Sample e.g. cell particle, luminescence microscopy method, involves prevailing one of sample regions for image of sample, so that image has local resolution which is enhanced in relation to excitation radiation distribution |
US7292347B2 (en) | 2005-08-01 | 2007-11-06 | Mitutoyo Corporation | Dual laser high precision interferometer |
JP4376837B2 (en) | 2005-08-05 | 2009-12-02 | サンテック株式会社 | Wavelength scanning laser light source |
DE602006017558D1 (en) | 2005-08-09 | 2010-11-25 | Gen Hospital Corp | DEVICE AND METHOD FOR CARRYING OUT POLARIZATION-BASED QUADRATURE DEMODULATION IN OPTICAL COHERENCE TOMOGRAPHY |
US7668342B2 (en) | 2005-09-09 | 2010-02-23 | Carl Zeiss Meditec, Inc. | Method of bioimage data processing for revealing more meaningful anatomic features of diseased tissues |
US8357917B2 (en) | 2005-09-10 | 2013-01-22 | Baer Stephen C | High resolution microscopy using an optically switchable fluorophore |
US8114581B2 (en) | 2005-09-15 | 2012-02-14 | The Regents Of The University Of California | Methods and compositions for detecting neoplastic cells |
JP4708937B2 (en) | 2005-09-15 | 2011-06-22 | Hoya株式会社 | OCT observation instrument, fixing instrument, and OCT system |
KR100743591B1 (en) | 2005-09-23 | 2007-07-27 | 한국과학기술원 | Confocal Self-Interference Microscopy Which Excluding Side Lobes |
EP1937137B1 (en) | 2005-09-29 | 2022-06-15 | General Hospital Corporation | Method and apparatus for optical imaging via spectral encoding |
US7450241B2 (en) | 2005-09-30 | 2008-11-11 | Infraredx, Inc. | Detecting vulnerable plaque |
US7400410B2 (en) | 2005-10-05 | 2008-07-15 | Carl Zeiss Meditec, Inc. | Optical coherence tomography for eye-length measurement |
WO2007044612A2 (en) | 2005-10-07 | 2007-04-19 | Bioptigen, Inc. | Imaging systems using unpolarized light and related methods and controllers |
CA2626116C (en) | 2005-10-11 | 2012-08-21 | Duke University | Systems and method for endoscopic angle-resolved low coherence interferometry |
WO2007044786A2 (en) | 2005-10-11 | 2007-04-19 | Zygo Corporation | Interferometry method and system including spectral decomposition |
US7408649B2 (en) | 2005-10-26 | 2008-08-05 | Kla-Tencor Technologies Corporation | Method and apparatus for optically analyzing a surface |
US8145018B2 (en) | 2006-01-19 | 2012-03-27 | The General Hospital Corporation | Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and methods for producing one or more optical arrangements |
US20070223006A1 (en) | 2006-01-19 | 2007-09-27 | The General Hospital Corporation | Systems and methods for performing rapid fluorescence lifetime, excitation and emission spectral measurements |
US9087368B2 (en) | 2006-01-19 | 2015-07-21 | The General Hospital Corporation | Methods and systems for optical imaging or epithelial luminal organs by beam scanning thereof |
GB0601183D0 (en) | 2006-01-20 | 2006-03-01 | Perkinelmer Ltd | Improvements in and relating to imaging |
WO2007090147A2 (en) | 2006-01-31 | 2007-08-09 | The Board Of Trustees Of The University Of Illinois | Method and apparatus for measurement of optical properties in tissue |
WO2007092911A2 (en) | 2006-02-08 | 2007-08-16 | The General Hospital Corporation | Methods, arrangements and systems for obtaining information associated with an anatomical sample using optical microscopy |
US8184367B2 (en) | 2006-02-15 | 2012-05-22 | University Of Central Florida Research Foundation | Dynamically focused optical instrument |
DE102006008990B4 (en) | 2006-02-23 | 2008-05-21 | Atmos Medizintechnik Gmbh & Co. Kg | Method and arrangement for generating a signal corresponding to the opening state of the vocal folds of the larynx |
TWI414543B (en) | 2006-02-24 | 2013-11-11 | Toray Industries | Fiber reinforced thermoplastic resin molded body, molding material, and process for manufacturing the same |
JP2007271761A (en) | 2006-03-30 | 2007-10-18 | Fujitsu Ltd | Spectrometer and wavelength dispersion controller |
US7742173B2 (en) | 2006-04-05 | 2010-06-22 | The General Hospital Corporation | Methods, arrangements and systems for polarization-sensitive optical frequency domain imaging of a sample |
US20070253901A1 (en) | 2006-04-27 | 2007-11-01 | David Deng | Atherosclerosis genes and related reagents and methods of use thereof |
WO2007127395A2 (en) | 2006-04-28 | 2007-11-08 | Bioptigen, Inc. | Methods, systems and computer program products for optical coherence tomography (oct) using automatic dispersion compensation |
WO2007133964A2 (en) | 2006-05-12 | 2007-11-22 | The General Hospital Corporation | Processes, arrangements and systems for providing a fiber layer thickness map based on optical coherence tomography images |
US7460248B2 (en) | 2006-05-15 | 2008-12-02 | Carestream Health, Inc. | Tissue imaging system |
EP1859727A1 (en) | 2006-05-26 | 2007-11-28 | Stichting voor de Technische Wetenschappen | optical triggering system for stroboscopy and a stroboscopic system |
US7599074B2 (en) | 2006-06-19 | 2009-10-06 | The Board Of Trustees Of The Leland Stanford Junior University | Grating angle magnification enhanced angular sensor and scanner |
US20070291277A1 (en) | 2006-06-20 | 2007-12-20 | Everett Matthew J | Spectral domain optical coherence tomography system |
JP5507247B2 (en) | 2006-08-28 | 2014-05-28 | サーモ エレクトロン サイエンティフィック インストルメンツ リミテッド ライアビリティ カンパニー | Spectroscopic microscopy with image-driven analysis |
WO2008049118A2 (en) | 2006-10-19 | 2008-04-24 | The General Hospital Corporation | Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample and effecting such portion(s) |
US7817354B2 (en) * | 2006-10-25 | 2010-10-19 | Capsovision Inc. | Panoramic imaging system |
WO2008052155A2 (en) | 2006-10-26 | 2008-05-02 | Cornell Research Foundation, Inc. | System for producing optical pulses of a desired wavelength using cherenkov radiation |
JP2010508056A (en) | 2006-10-30 | 2010-03-18 | エルフィ−テック リミテッド | System and method for in vivo measurement of biological parameters |
DE102006054556A1 (en) | 2006-11-20 | 2008-05-21 | Zimmer Medizinsysteme Gmbh | Apparatus and method for non-invasive, optical detection of chemical and physical blood values and body constituents |
JP5226533B2 (en) * | 2006-11-28 | 2013-07-03 | オリンパス株式会社 | Endoscope device |
US20080204762A1 (en) | 2007-01-17 | 2008-08-28 | Duke University | Methods, systems, and computer program products for removing undesired artifacts in fourier domain optical coherence tomography (FDOCT) systems using integrating buckets |
EP2102583A2 (en) | 2007-01-19 | 2009-09-23 | The General Hospital Corporation | Apparatus and method for controlling ranging depth in optical frequency domain imaging |
US20080226029A1 (en) | 2007-03-12 | 2008-09-18 | Weir Michael P | Medical device including scanned beam unit for imaging and therapy |
JP5227525B2 (en) | 2007-03-23 | 2013-07-03 | 株式会社日立製作所 | Biological light measurement device |
US8222385B2 (en) | 2007-03-26 | 2012-07-17 | National University Corporation Tokyo University of Marine Science Technology | Germ cell marker using fish vasa gene |
WO2008124845A2 (en) | 2007-04-10 | 2008-10-16 | University Of Southern California | Methods and systems for blood flow measurement using doppler optical coherence tomography |
US8115919B2 (en) | 2007-05-04 | 2012-02-14 | The General Hospital Corporation | Methods, arrangements and systems for obtaining information associated with a sample using optical microscopy |
US7799558B1 (en) | 2007-05-22 | 2010-09-21 | Dultz Shane C | Ligand binding assays on microarrays in closed multiwell plates |
US7835074B2 (en) * | 2007-06-05 | 2010-11-16 | Sterling Lc | Mini-scope for multi-directional imaging |
US8166967B2 (en) | 2007-08-15 | 2012-05-01 | Chunyuan Qiu | Systems and methods for intubation |
WO2009033064A2 (en) | 2007-09-05 | 2009-03-12 | The General Hospital Corporation | Systems, methods and computer-accessible medium for providing spectral-domain optical coherence phase microscopy for cell and deep tissue imaging |
WO2009049296A2 (en) | 2007-10-12 | 2009-04-16 | The General Hospital Corporation | Systems and processes for optical imaging of luminal anatomic structures |
US9332942B2 (en) | 2008-01-28 | 2016-05-10 | The General Hospital Corporation | Systems, processes and computer-accessible medium for providing hybrid flourescence and optical coherence tomography imaging |
JP5192247B2 (en) | 2008-01-29 | 2013-05-08 | 並木精密宝石株式会社 | OCT probe |
US7898656B2 (en) | 2008-04-30 | 2011-03-01 | The General Hospital Corporation | Apparatus and method for cross axis parallel spectroscopy |
US8184298B2 (en) | 2008-05-21 | 2012-05-22 | The Board Of Trustees Of The University Of Illinois | Spatial light interference microscopy and fourier transform light scattering for cell and tissue characterization |
CN102046071B (en) | 2008-06-02 | 2013-11-06 | 光学实验室成像公司 | Quantitative methods for obtaining tissue characteristics from optical coherence tomography images |
JP5324839B2 (en) | 2008-06-19 | 2013-10-23 | 株式会社トプコン | Optical image measuring device |
JP5546112B2 (en) | 2008-07-07 | 2014-07-09 | キヤノン株式会社 | Ophthalmic imaging apparatus and ophthalmic imaging method |
US8133127B1 (en) | 2008-07-21 | 2012-03-13 | Synder Terrance W | Sports training device and methods of use |
JP5371315B2 (en) | 2008-07-30 | 2013-12-18 | キヤノン株式会社 | Optical coherence tomography method and optical coherence tomography apparatus |
US20100081873A1 (en) * | 2008-09-30 | 2010-04-01 | AiHeart Medical Technologies, Inc. | Systems and methods for optical viewing and therapeutic intervention in blood vessels |
US20110160681A1 (en) | 2008-12-04 | 2011-06-30 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems, devices, and methods including catheters having light removable coatings based on a sensed condition |
CN101744601B (en) | 2008-12-05 | 2013-04-24 | 德昌电机(深圳)有限公司 | Capsule type imaging device and internal image capturing system |
US8864669B2 (en) | 2008-12-29 | 2014-10-21 | Perseus-Biomed Inc. | Method and system for tissue imaging and analysis |
US8457715B2 (en) | 2009-04-08 | 2013-06-04 | Covidien Lp | System and method for determining placement of a tracheal tube |
US9089331B2 (en) | 2009-07-31 | 2015-07-28 | Case Western Reserve University | Characterizing ablation lesions using optical coherence tomography (OCT) |
WO2011055376A1 (en) | 2009-11-09 | 2011-05-12 | Tata Institute Of Fundamental Research | Biological laser plasma x-ray point source |
KR101522850B1 (en) | 2010-01-14 | 2015-05-26 | 삼성전자주식회사 | Method and apparatus for encoding/decoding motion vector |
EP2542145B1 (en) | 2010-03-05 | 2020-08-12 | The General Hospital Corporation | Systems which provide microscopic images of at least one anatomical structure at a particular resolution |
-
2013
- 2013-03-15 WO PCT/US2013/031948 patent/WO2013148306A1/en active Application Filing
- 2013-03-15 EP EP13768632.5A patent/EP2833776A4/en not_active Withdrawn
- 2013-03-15 US US14/389,631 patent/US9629528B2/en active Active
-
2017
- 2017-04-21 US US15/494,021 patent/US20170290499A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0029555A2 (en) * | 1979-11-22 | 1981-06-03 | Olympus Optical Co., Ltd. | Endoscope light source device |
US20070238955A1 (en) * | 2006-01-18 | 2007-10-11 | The General Hospital Corporation | Systems and methods for generating data using one or more endoscopic microscopy techniques |
WO2008134449A1 (en) * | 2007-04-24 | 2008-11-06 | Tomophase Corporation | Delivering light via optical waveguide and multi-view optical probe head |
Non-Patent Citations (1)
Title |
---|
See also references of EP2833776A4 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015164792A1 (en) * | 2014-04-25 | 2015-10-29 | The General Hospital Corporation | Imaging system, method and distal attachment for multidirectional field of view endoscopy |
EP3133976A4 (en) * | 2014-04-25 | 2017-12-27 | The General Hospital Corporation | Imaging system, method and distal attachment for multidirectional field of view endoscopy |
Also Published As
Publication number | Publication date |
---|---|
EP2833776A1 (en) | 2015-02-11 |
US20170290499A1 (en) | 2017-10-12 |
US20150073210A1 (en) | 2015-03-12 |
US9629528B2 (en) | 2017-04-25 |
EP2833776A4 (en) | 2015-12-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20200221941A1 (en) | Multi-camera endoscope | |
US10905320B2 (en) | Multi-camera endoscope | |
US11653816B2 (en) | Next generation endoscope | |
CN107713968B (en) | Secondary imaging endoscopic device | |
US10799095B2 (en) | Multi-viewing element endoscope | |
JP6599317B2 (en) | Imaging probe | |
US8734334B2 (en) | Method and device for imaging an interior surface of a corporeal cavity | |
US5419309A (en) | Tip cleaning accessory for rigid endoscopic instrument | |
US7621869B2 (en) | Next generation colonoscope | |
US20140187859A1 (en) | Endoluminal introducer | |
US20170290499A1 (en) | Imaging system, method and distal attachment for multidirectional field of view endoscopy | |
US20080108869A1 (en) | Optical surgical device and methods of use | |
Kurniawan et al. | Flexible gastro-intestinal endoscopy—clinical challenges and technical achievements | |
JP2001521806A (en) | Video rectoscope | |
JP2015533300A (en) | Multi-camera endoscope | |
KR20220124833A (en) | Optical coupler for an endoscope | |
Kohli et al. | How endoscopes work | |
US20170055815A1 (en) | Imaging system, method and distal attachment for multidirectional field of view endoscopy | |
US20220160216A1 (en) | Multi-viewing element endoscope | |
WO2015164792A1 (en) | Imaging system, method and distal attachment for multidirectional field of view endoscopy |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 13768632 Country of ref document: EP Kind code of ref document: A1 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 14389631 Country of ref document: US |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2013768632 Country of ref document: EP |