WO2014062696A1 - Polymeric treatment compositions - Google Patents
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- WO2014062696A1 WO2014062696A1 PCT/US2013/065078 US2013065078W WO2014062696A1 WO 2014062696 A1 WO2014062696 A1 WO 2014062696A1 US 2013065078 W US2013065078 W US 2013065078W WO 2014062696 A1 WO2014062696 A1 WO 2014062696A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0442—Polymeric X-ray contrast-enhancing agent comprising a halogenated group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/12—Macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/44—Radioisotopes, radionuclides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices
Definitions
- the present invention relates generally to vascular treatment compositions and methods of using these compositions to treat vascular conditions.
- the compositions can comprise a polymer(s) that transitions from a liquid to a solid upon being subject to physiological conditions.
- Embolization is widely used to treat vascular malformations, such as aneurysms, arteriovenous malformations, fistulas, and tumors. These malformations can be treated with a variety of different products, including metallic coils, polymer-metal hybrid coils, microparticles, and foams. However, there remains a need for products that can minimize risks associated with embolization.
- Polymeric compositions which comprise: a biocompatible polymer including a biodegradable linkage to a visualization agent, and a non-physiological solution; wherein the biocompatible polymer is soluble in the non-physiological solution and insoluble at physiological conditions.
- compositions which comprise: a biocompatible polymer including a biodegradable linkage to a visualization agent, and a water-miscible organic solvent; wherein the biocompatible polymer is soluble in the organic solvent and insoluble at physiological conditions.
- Methods are also described for use of the polymeric compositions.
- methods comprising injecting through a delivery device into a physiological environment a liquid embolic composition comprising: a biocompatible polymer including a biodegradable linkage to a visualization agent, and a non-physiological solution, wherein the biocompatible polymer precipitates when it reaches the physiological conditions.
- methods comprising injecting through a delivery device into a vessel with physiological environment a liquid embolic composition comprising: a biocompatible polymer including a biodegradable linkage to a visualization agent, and a water- miscible organic solvent, wherein the biocompatible polymer precipitates when it reaches the physiological conditions and treats the vascular disorder.
- the biodegradable linkage can be cleaved by hydrolysis and/or enzymatic cleavage.
- Biodegradable linkages susceptible to enzymatic cleavage can be esters or amino acids such as Seq. ID 1 , Seq. ID 2, Seq. ID 3, Seq. ID 4, Seq. ID 5, Seq. ID 6, Seq. ID 7, Seq. ID 8, Seq. ID 9, Seq. ID 10, Seq. ID 1 1 , or Seq. ID 12.
- Biodegradable linkages susceptible to hydrolysis can be an ester, a carbonate, or a polyester.
- the biodegradable linked contrast/visualization agent can be an iodinated compound.
- the biocompatible polymer can be a reaction product of two or more different monomers and can have a concentration of about 1 % w/w to about 50% w/w.
- the non-physiological solution can be aqueous and can have a pH of less than about 5 or a pH of greater than about 8.
- a composition for filling a vascular defect comprising: an aqueous solution at non-physiological pH; a biocompatible polymer including a pH sensitive component and a biodegradable linkage to a visualization agent at a concentration of from about 1 % to 50% w/w, that is soluble in the aqueous solution at non-physiological pH and insoluble at physiological conditions.
- methods comprising: providing a liquid embolic composition comprising a biocompatible polymer including a biodegradable linkage to a visualization agent, and a non-physiological pH aqueous solution, wherein the biocompatible polymer is soluble in the non-physiological pH aqueous solution and insoluble in at physiological conditions; inserting a delivery device into a vessel; guiding the delivery device to an area in need of treatment wherein the area has physiological conditions; injecting the liquid embolic polymer composition through the delivery device into the vessel at the area in need of treatment thereby immediately precipitating the polymer and forming a solid polymeric mass; and treating the vascular condition.
- a composition for filling a vascular defect comprising: a water-miscible organic solvent; a biocompatible polymer at a concentration of from about 1 % to 50% w/w including a biodegradable linkage to a visualization agent, which is soluble in the organic solvent and insoluble at physiological conditions.
- methods comprising: providing a liquid embolic composition comprising a biocompatible polymer including a biodegradable linkage to a visualization agent, and a water-miscible organic solvent, wherein the biocompatible polymer is soluble in the organic solvent and insoluble in at physiological conditions; inserting a delivery device into a vessel; guiding the delivery device to an area in need of treatment; injecting the liquid embolic polymer composition through the delivery device into the vessel at the area in need of treatment thereby immediately precipitating the polymer and forming a solid polymeric mass; and treating the vascular condition.
- Figure 1 illustrates a pre-treatment angiogram of a rabbit kidney before use of an embodiment of an embolic polymer.
- Figure 2 illustrates a post-treatment angiogram of a rabbit kidney after use of an embodiment of an embolic polymer.
- Figure 3 illustrates a post-treatment CT scan of a rabbit kidney after use of an embodiment of an embolic polymer.
- Figure 4 illustrates a post-treatment angiogram of a rabbit kidney after use of an embodiment of an embolic polymer.
- Figure 5 illustrates a post-treatment MR scan of a rabbit kidney after use of an embodiment of an embolic polymer.
- Described herein generally are polymeric treatment compositions comprising a biocompatible polymer including a visualization species coupled to the polymer by a biodegradable linkage, wherein the biocompatible polymer can be soluble in selected solvent systems and insoluble at physiological conditions or in a physiological solution/fluid in a selected solvent.
- the visualization species can be an opacification agent(s) that can permit visualization in vivo.
- the solution can include a miscible solvent that can dissolve the polymer.
- the solution can include a non- physiological pH solvent.
- compositions and methods described herein can provide polymer treatment solutions to sites that would otherwise not be easily administered to without being soluble prior to exiting a delivery device.
- the compositions can comprise a solution at a non-physiological condition (e.g. non-physiological pH).
- the solution can include a polymer soluble in the solution but insoluble at physiological conditions; the polymer can include a visualization agent biodegradably attached to it.
- the solution can include a polymer soluble in a non- physiological pH aqueous solution but insoluble at physiological conditions.
- the polymer can be soluble in a water-miscible organic solvent but insoluble at physiological conditions (e.g. water).
- a function of the biocompatible polymer can be to precipitate when coming in contact with blood or other physiological fluid.
- the pH of the physiological fluid is the solubility trigger
- the physiological pH can be a pH of about 7.0, about 7.1 , about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7 or about 7.8, between about 7.0 and about 7.8, between about 7.1 and about 7.7, between about 7.2 and about 7.6, or any value in a range bound by or between any of these values.
- the non-physiological pH can be a pH between about 1.0 and about 6.9, or about 2.0 and about 6.0, about 7.9 and about 12.0, about 8.5 and about 10.0.
- the solubility trigger is solubility in a water miscible organic solvent and insolubility at physiological conditions, any physiological environment can initiate the precipitation.
- Precipitation of the polymer at physiological conditions can be used to occlude a biological structure.
- Control of the liquid embolic polymer's solubility can be achieved by selection of the composition of the polymer.
- the polymer can be prepared with monomers having ionizable moieties.
- the polymers can be a reaction product of two different monomers, three different monomers, four different monomers, five different monomers, or more.
- a hydrophobic polymer can be constructed with a minimum amount of ionizable moieties to render the polymer soluble in non-physiological pH solutions.
- the ratio of monomers with ionizable moieties and other monomers can be dependent on the structure of the monomers and can be determined experimentally.
- Polymers sensitive to pH such as amino-containing liquid embolic polymers can be dissolved in a low pH solution, the amines may be substantially protonated and can enhance the solubility of the polymer.
- the resulting solution can be placed in conditions with physiological pH and the amines can deprotonate and render the polymer insoluble.
- carboxylic acid-containing polymers can be dissolved in a high pH solution, the carboxylic acids can be substantially deprotonated and enhance the solubility of the polymer.
- the resulting solution can be placed in conditions with physiological pH and the carboxylic acids can protonate and render the polymer insoluble.
- a monomer or monomers can include at least one visualization species linked to the monomer to impart visibility of the liquid embolic polymer when imaged using a medically relevant imaging technique such as fluoroscopy, computed tomography, or magnetic resonance techniques.
- Characteristic features of the monomers with visualization species can be cores that are visible under medically relevant imaging techniques and a polymerizable moiety attached to the core with a biodegradable linkage.
- a visualization agent can also be linked after polymerization if a reactive pendent group is added to the polymerization mixture before polymerization.
- An exemplary reactive pendent group can be an acrylate monomer having an epoxide pendent group (e.g., glycidyl acetate) or a hydroxyl ethyl pendent group.
- epoxide pendent group e.g., glycidyl acetate
- hydroxyl ethyl pendent group e.glycidyl acetate
- Visualization of the polymer under fluoroscopy and CT imaging can be imparted by the use of monomers with cores containing iodine, particularly aromatic rings with a plurality of iodine atoms.
- a core containing iodine can be triiodophenol.
- Concentrations of iodine to render the liquid embolic visible using fluoroscopy or CT imaging can range from about 10% to about 60% w/w, about 20% to about 50% w/w, or about 30% to about 40% w/w of the liquid embolic solution.
- Visualization of the polymer under magnetic resonance imaging can be imparted by the incorporation of monomers containing gadolinium.
- a visualization agent for magnetic resonance imaging can be gadolinium diethylenetriaminepentaacetic acid aminoethylmethacrylate. Concentrations of gadolinium to render the liquid embolic visible using magnetic resonance imaging can range from about 0.1 % to about 1 % w/w, about 0.5% to about 1 % w/w, or about 0.1 % to about 0.5% w/w of the liquid embolic solution.
- Some monomers can contain a polymerizable moiety and optionally an ionizable moiety.
- Polymerizable moieties can be those that permit free radical or anionic polymerization, including but not limited to acrylates, methacrylates, acrylamides, methacrylamides, vinyl groups, and derivatives thereof.
- other reactive chemistries can be employed to polymerize the liquid embolic polymer, such as, but not limited to nucleophile/N- hydroxysuccinimde esters, nucleophile/halide, vinyl sulfone/acrylate or maleimide/acrylate.
- Preferred polymerizable moieties can be acrylates and acrylamides.
- Other monomers can contain a polymerizable moiety and can have a structure that is conducive to desired solubility characteristics.
- Polymerizable moities can be those that permit free radical polymerization, including but not limited to acrylates, methacrylates, acrylamides, methacrylamides, vinyl groups, and derivatives thereof.
- other reactive chemistries can be employed to polymerize the liquid embolic polymer, i.e. nucleophile/N- hydroxysuccinimde esters, nucleophile/halide, vinyl sulfone/acrylate or maleimide/acrylate.
- Preferred polymerizable moieties can be acrylates and acrylamides.
- other monomers can compensate for monomers including visualization species.
- a polymer is too hydrophobic for dissolution in a water miscible solvent, more hydrophilic monomers can be introduced to alter the solubility. If a polymer is too hydrophilic and is soluble in water, more hydrophobic monomers can be introduced to alter the solubility.
- Other monomers can include hydroxyethyl methacrylate, t-butyl acrylate, t-butyl acrylamide, n- octyl methacrylate, and methyl methacrylate.
- Such monomers can be present at a concentration of about 1 % w/w to about 50% w/w, about 1 % w/w to about 40% w/w, about 1 % w/w to about 30% w/w, about 1 % w/w to about 20% w/w, about 1 % w/w to about 15% w/w, about 1 % w/w to about 10% w/w, about 2% w/w to about 15% w/w, about 2% w/w to about 20% w/w, about 2% w/w to about 10% w/w, about 1 % w/w, about 2% w/w, about 3% w/w, about 4% w/w, about 5% w/w, about 6%, about 7% w/w, about 8%, about 9% w/w, about 10% w/w, about 1 1 % w/w, about 12% w/w, about 13% w/w, about 14%
- Some monomers can include biodegradable linkages to visualization species.
- Biodegradable linkages can permit separation of the visualization core from the polymer. After separating from the polymer, the core can be removed by diffusion and/or by cells comprising the foreign body response to the polymer.
- Biodegradable linkages can be separated into two types. The two types can include those susceptible to hydrolysis and those susceptible to enzymatic action. Linkages susceptible to hydroylsis can generally include esters, polyesters, or carbonates.
- biodegradable linkages can be introduced into monomers or the polymers after formation.
- One skilled in the art can envision benefits to both methods of introducing biodegradable linkages into the polymers.
- Ester linkages can be introduced by reacting hydroxyl groups with cyclic anhydrides, such as succinic or glutaric anhydride, or cylic esters, such as lactide, glycolide, ⁇ -caprolactone, and trimethylene carbonate.
- cyclic anhydrides such as succinic or glutaric anhydride
- cylic esters such as lactide, glycolide, ⁇ -caprolactone, and trimethylene carbonate.
- the rate of degradation can be controlled by ester selection and the number of esters inserted into biodegradable linkages.
- Linkages susceptible to enzymatic action can include peptides that can be degraded by enzymes, such as but not limited to matrix metalloproteinases, collagenases, elastases, cathepsin, or a combination thereof.
- Peptide sequences degraded by matrix metalloproteinases can include Gly-Pro-Gln-Gly-lle-Ala-Ser-Gln (Seq. ID 1 ), Gly-Pro-Gln-Pro-Ala-Gly-Gln (Seq. ID 2), Gly-Pro-Gln-Gly-Ala-Gly-Gln (Seq.
- Peptide sequences degraded by cathepsin can include Gly-Phe-Gln-Gly-Val-Gln-Phe-Ala-Gly-Phe (Seq. ID 7), Gly-Phe-Gly-Ser-Val-Gln-Phe-Ala-Gly-Phe (Seq.
- Peptide sequences degraded by collagenase can include Gly-Gly- Leu-Gly-Pro-Ala-Gly-Gly-Lys and Ala-Pro-Gly-Leu (Seq. ID 10).
- Peptide sequences degraded by papain can include Gly-Phe-Leu-Gly (Seq. ID 1 1 ).
- Peptide sequences degraded by caspase-3 can include Asp-Glu-Val-Asp-Thr (Seq. ID 12). The rate of degradation can be controlled by the peptide sequence selection.
- liquid embolic polymers can be polymerized from solutions of monomers linked to visualization species and optionally other monomers, or from solutions of monomers whose later polymers are linked to visualization species.
- the solvent used to dissolve the monomers can be any solvent that dissolves the desired monomers. Solvents can include methanol, acetonitrile, dimethyl formamide, and dimethyl sulfoxide.
- Polymerization initiators can be used to start the polymerization of the monomers.
- the polymerization can be initiated by reduction-oxidation, radiation, heat, or any other method known in the art. Radiation cross-linking of the monomer solution can be achieved with ultraviolet light or visible light with suitable initiators or ionizing radiation (e.g. electron beam or gamma ray) without initiators.
- Polymerization can be achieved by application of heat, either by conventionally heating the solution using a heat source such as a heating well, or by application of infrared light to the monomer solution.
- the polymerization initiator can be azobisisobutyronitrile (AIBN) or a water soluble AIBN derivative (2,2'-azobis(2-methylpropionamidine) dihydrochloride).
- AIBN azobisisobutyronitrile
- Other initiators can include ⁇ , ⁇ , ⁇ ', ⁇ '-tetramethylethylenediamine, ammonium persulfate, benzoyl peroxides, azobisisobutyronitriles and combinations thereof.
- Initiator concentrations can be from about 0.1 % w/w to about 5% w/w, about 0.5% w/w to about 3% w/w, about 0.25% w/w, about 0.5% w/w, about 0.75% w/w, about 1 % w/w, about 1 .25% w/w, about 1.50% w/w, about 1.75% w/w, or about 2% w/w, about 3%, about 4%, or about 5% of the mass of the monomers in solution, or any range or value within the listed percentages.
- the polymerization reaction can be performed at elevated temperatures, of about 30°C to about 200°C, about 50°C to about 100°C, about 50°C, about 60°C, about 70°C, about 80°C, about 90°C or about 100°C or can proceed at room temperature without heating.
- the polymer can be recovered by precipitation in a non-solvent and dried under vacuum.
- a water-miscible organic solvent can dissolve the final liquid embolic polymer. Concentrations of the polymer in an organic solvent can be from about 1 % to about 50%, about 2.5% to about 25%, about 5% to about 15%, about 2.5%, about 5%, about 7.5%, about 10%, about 12.5%, about 15%, about 17.5%, about 20%, about 22.5%, about 25%, about 30%, about 35%, about 40%, about 45%, or about 50%, or any percentage or range of percentages bound by the above percentages. Solvents can include methanol, acetonitrile, dimethyl formamide, dimethyl isosorbide, and dimethyl sulfoxide.
- a non-physiological pH aqueous solution can dissolve the liquid embolic polymer.
- Polymer concentrations in an aqueous solution can be from about 1 % to about 50%, about 2.5% to about 25%, about 5% to about 15%, about 2.5%, about 5%, about 7.5%, about 10%, about 12.5%, about 15%, about 17.5%, about 20%, about 22.5%, about 25%, about 30%, about 35%, about 40%, about 45%, or about 50%, or any percentage or range of percentages bound by the above percentages.
- the aqueous solution can contain a minimum amount of buffer to maintain a non-physiologic pH after dissolution of the liquid embolic polymer, but not adversely affect the pH of the patient after administration. Alternatively, a buffer may not be needed. Buffer concentrations can range from about 1 mM to about 100 mM, about 20 mM to about 80 mM, about 30mM to about 70 mM, about 40 mM to about 60 mM, about 45 mM to about 55 mM, about 10 mM, about 20 mM, about 30 mM, about 40 mM, about 50 mM, about 60 mM, about 70 mM, about 80 mM, about 90 mM, about 100 mM or any concentration or range of concentrations within the values listed.
- buffers can include citrate and acetate and solution pHs can be from about 3 to about 6, from about 3 to about 5, about 3, about 4, about 5 or about 6.
- buffers can include carbonate, N-cyclohexyl-2-aminoethanesulfonic acid (CHES), N-cyclohexyl-2- hydroxyl-3-aminopropanesulfonic acid (CAMPSO), N-cyclohexyl-3-aminopropanesulfonic acid (CAPS), 3-[4-(2-Hydroxyethyl)-1 -piperazinyl]propanesulfonic acid (HEPPS or EPPS), 3-(N- morpholino)propanesulfonic acid (MOPS), 4-(2-hydroxyethyl)-1 -piperazineethanesulfonic acid (HEPES), 2-(N-morpholino)ethanesulfonic acid
- liquid embolic polymers, solutions, and mixtures described herein can be sterilized without substantially degrading the polymer. After sterilization, at least about 50%, about 60%, about 70%, about 80%, about 90%, about 95% about 99% or about 100% of the polymer can remain intact. In one embodiment, sterilization can be by autoclaving and can be utilized before administration of the polymer.
- the liquid embolic polymer formulation can be removed from a vial using a needle and syringe, and the syringe can be later connected to a delivery device or catheter. Alternatively, the liquid embolic polymer formulation can be prepackaged in a delivery syringe.
- a delivery device or catheter can be primed with a bolus of the same flushing solution or similar water-miscible organic solvent and/or non-physiological pH aqueous solution as used to dissolve the liquid embolic polymer.
- This flushing can prevent clogging of the delivery catheter with the liquid embolic polymer.
- the syringe containing the liquid embolic formulation can then be connected to the proximal end of a delivery catheter, such as a microcatheter, cannula, or the like, and positioned in the desired anatomical site.
- liquid embolic formulation As the liquid embolic formulation is injected, it can push the solvent flushing solution out of the microcatheter. The solubility of the liquid embolic polymer can then rapidly change as it is exposed to physiological conditions. The progress of the liquid embolic formulation inside the delivery catheter can be observed using an imaging technique compatible with the covalently linked visualization agent or agents selected. With continued injection, the liquid embolic formulation can enter a target delivery site as a solid mass.
- the aqueous nature of physiological conditions can reduce the solubility of the liquid embolic polymer and cause it to precipitate from the water-miscible, organic solvent.
- the large buffering capacity of the body's tissues can cause pH of the fluids to change rapidly thus reducing the solubility of the liquid embolic polymer and causing it to precipitate from solution.
- the precipitated liquid embolic polymer can provide occlusion of a target site.
- the biodegradable linkages binding the visualization agents to the liquid embolic polymer can be broken and the visualization of the liquid embolic polymer can be diminished.
- about 40%, about 50%, about 60%, about 70% about 80%, about 90%, about 95%, about 99% or about 100% of the biodegradably linked visualization agents can remain intact after about 5 days, about 2 weeks, about 1 month, about 2 months, about 6 months, about 9 months, about a year, about 2 years, about 5 years, about 10 years or about 20 years.
- Polymers can be fine tuned to degrade faster or slower.
- the precipitated, solidified liquid embolic polymer can provide long-term occlusion of the target site.
- the precipitated liquid embolic polymer can remain substantially stable once implanted.
- the liquid embolic polymer can remain greater than 60%, 70% 80%, 90%, 95%, or 99%, or nearly 100% intact after at least about 5 days, about 2 weeks, about 1 month, about 2 months, about 6 months, about 9 months, about a year, about 2 years, about 5 years, about 10 years or about 20 years.
- the liquid embolic polymer may be desirable for the entire precipitated liquid embolic polymer to degrade over time.
- the liquid embolic polymer can degrade to less than 40%, 30% 20%, 10%, 5% or 1 % intact after at least about 5 days, about 2 weeks, about 1 month, about 2 months, about 6 months, about 9 months, about a year, about 2 years or about 5 years.
- liquid embolic polymers once precipitated can be cohesive enough to stick to the tissue and/or remain in place through friction with the tissues and forces of circulating blood.
- the precipitated polymer can act as a plug in a vessel held in place by the flow and pressure of the blood.
- the liquid embolic polymer comprises a reaction product of 2-oxo-2-(1-oxo-1-(1-oxo-1-(2,4,6-triiodophenoxy)propan-2-yloxy)propan-2- yloxy)ethoxy)ethyl acrylate, hydroxyethyl methacrylate, and azobisisobutyronitrile.
- the liquid embolic polymer comprises a reaction product of between about 75% and about 98% 2-oxo-2-(1-oxo-1-(1-oxo-1-(2,4,6-triiodophenoxy)propan-2-yloxy)propan-2- yloxy)ethoxy)ethyl acrylate, between about 2% and about 25% hydroxyethyl methacrylate, and less than about 1 % azobisisobutyronitrile.
- the liquid embolic polymer comprises a reaction product of between about 85% and about 98% 2-oxo-2-(1-oxo-1- (1 -oxo-1 -(2,4,6-triiodophenoxy)propan-2-yloxy)propan-2-yloxy)ethoxy)ethyl acrylate, between about 2% and about 15% hydroxyethyl methacrylate, and less than about 1 % azobisisobutyronitrile.
- the liquid embolic polymer comprises a reaction product of 1 -((2-(methacryloyloxy)ethoxy)carbonyloxy) ethyl 3,5-diacetamido-2,4,6- triiodobenzoate, hydroxyethyl methacrylate, and azobisisobutyronitrile.
- the liquid embolic polymer comprises a reaction product of between about 85% and about 98% 1-((2-(methacryloyloxy)ethoxy)carbonyloxy) ethyl 3,5-diacetamido-2,4,6-triiodobenzoate, between about 2% and about 15% hydroxyethyl methacrylate, and less than about 1 % azobisisobutyronitrile.
- the liquid embolic polymer comprises a reaction product of 1 -((2-(methacryloyloxy)ethoxy)carbonyloxy) ethyl 3,5-diacetamido-2,4,6- triiodobenzoate, N-(3-Aminopropyl)methacrylamide hydrochloride, and azobisisobutyronitrile.
- the liquid embolic polymer comprises a reaction product of about 74% 1- ((2-(methacryloyloxy)ethoxy)carbonyloxy) ethyl 3,5-diacetamido-2,4,6-triiodobenzoate, about 26% N-(3-Aminopropyl)methacrylamide hydrochloride, and less than about 1 % azobisisobutyronitrile.
- Example 1 Example 1
- the reddish brown solid residue was suspended in 1000 mL of dry ether and the solids collected on a Buchner funnel. After the solids were dried in vacuo they were suspended in 500 mL distilled water at 2000 rpm and the pH of the mixture adjusted to 8-9 with cesium carbonate. After stirring for 10 min the suspension was filtered and the solids washed 3 X 100 mL of distilled water, dried overnight in vacuo and crushed to a fine powder. Solid residue was again suspended in 1000 mL of dry ether and the solids collected on a Buchner funnel.
- Example 5 To a 10mL vial was added 3 mL of dimethyl sulfoxide, 1.7 g of iodine monomer prepared in Example 1 B, 0.3 g of hydroxyethyl methacrylate, and 10 mg of azobisisobutyronitrile. Upon complete dissolution of all components, the vial was degassed and sparged with argon. The solution was then placed in an 80°C oven for 48 hours to polymerize. After cooling to room temperature, the polymer was recovered by precipitation in ethyl ether and dried under vacuum. It was then dissolved in THF, flashed on a silica column, then redissolved in THF. It was then precipitated in water and then lyophilized to yield the dry polymer product.
- Example 5 To a 10mL vial was added 3 mL of dimethyl sulfoxide, 1.7 g of iodine monomer prepared in Example 1 B, 0.3 g of hydroxyethyl methacrylate,
- Iodine containing polymers were dissolved in their respective solvents, e.g. aqueous soluble polymers were dissolved in pH 3 buffered solution and organic soluble iodine containing polymers were dissolved in dimethyl sulfoxide. The solutions were dispensed into 0.1 M phosphate buffered saline solution. The precipitate formed was ranked from 1 to 5, with 1 being least cohesive and 5 being most cohesive.
- liquid embolic formulations were delivered through 0.017" I.D. microcatheters.
- the formulations were assessed visually for cohesiveness, injection pressure, plug formation and precipitation speed.
- Precipitation speed was ranked slow, medium and fast. All others were ranked 1 to 5 with 1 being least desired and 5 being most desired.
Abstract
Description
Claims
Priority Applications (7)
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CA2887604A CA2887604C (en) | 2012-10-15 | 2013-10-15 | Liquid embolic compositions and uses thereof for treating vascular conditions |
JP2015537010A JP6385937B2 (en) | 2012-10-15 | 2013-10-15 | Polymeric therapeutic composition |
AU2013331439A AU2013331439B2 (en) | 2012-10-15 | 2013-10-15 | Polymeric treatment compositions |
CN201380053372.4A CN104717983B (en) | 2012-10-15 | 2013-10-15 | It polymerize therapeutic combination |
EP13846860.8A EP2906254B1 (en) | 2012-10-15 | 2013-10-15 | Polymeric treatment compositions |
BR112015008245-9A BR112015008245B1 (en) | 2012-10-15 | 2013-10-15 | POLYMERIC TREATMENT COMPOSITIONS |
KR1020157012402A KR102275634B1 (en) | 2012-10-15 | 2013-10-15 | Polymeric treatment compositions |
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US201261714102P | 2012-10-15 | 2012-10-15 | |
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US11331340B2 (en) | 2012-06-14 | 2022-05-17 | Microvention, Inc. | Polymeric treatment compositions |
US10828388B2 (en) | 2012-10-15 | 2020-11-10 | Microvention, Inc. | Polymeric treatment compositions |
US11801326B2 (en) | 2012-10-15 | 2023-10-31 | Microvention, Inc. | Polymeric treatment compositions |
US11051826B2 (en) | 2016-08-26 | 2021-07-06 | Microvention, Inc. | Embolic compositions |
US11911041B2 (en) | 2016-08-26 | 2024-02-27 | Microvention, Inc. | Embolic compositions |
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EP2906254B1 (en) | 2020-01-08 |
US20240108781A1 (en) | 2024-04-04 |
KR102275634B1 (en) | 2021-07-08 |
AU2013331439A1 (en) | 2015-04-16 |
JP2015536161A (en) | 2015-12-21 |
JP2020127797A (en) | 2020-08-27 |
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JP2018108450A (en) | 2018-07-12 |
US9655989B2 (en) | 2017-05-23 |
CA2887604C (en) | 2021-05-18 |
JP6385937B2 (en) | 2018-09-05 |
BR112015008245B1 (en) | 2022-09-27 |
US20160243273A1 (en) | 2016-08-25 |
CN104717983A (en) | 2015-06-17 |
AU2013331439B2 (en) | 2016-05-12 |
JP6704950B2 (en) | 2020-06-03 |
US20210023261A1 (en) | 2021-01-28 |
KR20150071025A (en) | 2015-06-25 |
US9078950B2 (en) | 2015-07-14 |
US11801326B2 (en) | 2023-10-31 |
EP2906254A1 (en) | 2015-08-19 |
BR112015008245A2 (en) | 2017-07-04 |
JP2022009183A (en) | 2022-01-14 |
CA2887604A1 (en) | 2014-04-24 |
US20170216484A1 (en) | 2017-08-03 |
US20140107251A1 (en) | 2014-04-17 |
US10828388B2 (en) | 2020-11-10 |
CN104717983B (en) | 2018-09-18 |
EP2906254A4 (en) | 2016-10-26 |
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