WO2014179627A3 - Compositions and methods for modulating hbv and ttr expression - Google Patents

Compositions and methods for modulating hbv and ttr expression Download PDF

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Publication number
WO2014179627A3
WO2014179627A3 PCT/US2014/036463 US2014036463W WO2014179627A3 WO 2014179627 A3 WO2014179627 A3 WO 2014179627A3 US 2014036463 W US2014036463 W US 2014036463W WO 2014179627 A3 WO2014179627 A3 WO 2014179627A3
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WO
WIPO (PCT)
Prior art keywords
compositions
methods
certain embodiments
ttr expression
modulating hbv
Prior art date
Application number
PCT/US2014/036463
Other languages
French (fr)
Other versions
WO2014179627A9 (en
WO2014179627A2 (en
Inventor
Thazha P. Prakash
Punit P. Seth
Eric E. Swayze
Original Assignee
Isis Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Application filed by Isis Pharmaceuticals, Inc. filed Critical Isis Pharmaceuticals, Inc.
Priority to MA46019A priority Critical patent/MA46019B1/en
Priority to AU2014259757A priority patent/AU2014259757B2/en
Priority to KR1020237024621A priority patent/KR20230113835A/en
Priority to CN201480035618.XA priority patent/CN105378085B/en
Priority to IL296543A priority patent/IL296543A/en
Priority to EP20205948.1A priority patent/EP3828275A1/en
Priority to SI201431207T priority patent/SI2992098T1/en
Priority to MX2015015264A priority patent/MX2015015264A/en
Priority to CA2921167A priority patent/CA2921167A1/en
Priority to KR1020197019617A priority patent/KR102212275B1/en
Priority to PL14791344T priority patent/PL2992098T3/en
Priority to UAA201511840A priority patent/UA121017C2/en
Priority to DK14791344.6T priority patent/DK2992098T3/en
Priority to EP14791344.6A priority patent/EP2992098B1/en
Priority to LTEP14791344.6T priority patent/LT2992098T/en
Priority to CN201910036892.3A priority patent/CN110042098B/en
Priority to KR1020157033025A priority patent/KR102235678B1/en
Priority to MEP-2019-157A priority patent/ME03390B/en
Priority to BR112015027369-6A priority patent/BR112015027369B1/en
Priority to KR1020217003080A priority patent/KR20210014758A/en
Priority to RS20190682A priority patent/RS58981B1/en
Priority to CR20190269A priority patent/CR20190269A/en
Priority to MA38621A priority patent/MA38621B1/en
Priority to RU2015151202A priority patent/RU2670614C9/en
Priority to JP2016512054A priority patent/JP6995478B2/en
Priority to SG11201508870VA priority patent/SG11201508870VA/en
Priority to ES14791344T priority patent/ES2730015T3/en
Priority to KR1020217039866A priority patent/KR102558571B1/en
Priority to NZ631552A priority patent/NZ631552A/en
Priority to EA201592093A priority patent/EA031393B1/en
Priority to IL284593A priority patent/IL284593B2/en
Priority to KR1020217009333A priority patent/KR20210037752A/en
Priority to EP19164959.9A priority patent/EP3524680B1/en
Publication of WO2014179627A2 publication Critical patent/WO2014179627A2/en
Publication of WO2014179627A9 publication Critical patent/WO2014179627A9/en
Priority to US14/633,491 priority patent/US9145558B2/en
Publication of WO2014179627A3 publication Critical patent/WO2014179627A3/en
Priority to US14/822,493 priority patent/US9932580B2/en
Priority to ZA2015/07216A priority patent/ZA201507216B/en
Priority to IL242125A priority patent/IL242125B/en
Priority to PH12015502493A priority patent/PH12015502493A1/en
Priority to CR20150612A priority patent/CR20150612A/en
Priority to HK16109538.2A priority patent/HK1221485A1/en
Priority to AU2017200950A priority patent/AU2017200950B2/en
Priority to US15/687,306 priority patent/US10683499B2/en
Priority to US15/896,379 priority patent/US20190055554A1/en
Priority to PH12018501963A priority patent/PH12018501963A1/en
Priority to IL264241A priority patent/IL264241B/en
Priority to AU2019202598A priority patent/AU2019202598A1/en
Priority to PH12019501191A priority patent/PH12019501191A1/en
Priority to HRP20190987TT priority patent/HRP20190987T1/en
Priority to CY20191100660T priority patent/CY1121879T1/en
Priority to AU2019204784A priority patent/AU2019204784C1/en
Priority to IL270464A priority patent/IL270464B/en
Priority to US16/790,557 priority patent/US20220275365A9/en
Priority to US16/806,941 priority patent/US20200224198A1/en
Priority to IL273184A priority patent/IL273184B/en
Priority to DO2021000095A priority patent/DOP2021000095A/en
Priority to IL284000A priority patent/IL284000A/en
Priority to AU2022202770A priority patent/AU2022202770A1/en
Priority to US17/970,887 priority patent/US20230151365A1/en

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    • C12N2310/30—Chemical structure
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    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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Abstract

Provided herein are oligomeric compounds with conjugate groups. In certain embodiments, the oligomeric compounds are conjugated to N-Acetylgalactosamine. In certain embodiments, the present disclosure provides conjugated antisense compounds. In certain embodiments, the present disclosure provides conjugated antisense compounds comprising an antisense oligonucleotide complementary to a nucleic acid transcript of transthyretin (TTR).
PCT/US2014/036463 2013-05-01 2014-05-01 Compositions and methods for modulating hbv and ttr expression WO2014179627A2 (en)

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MA46019A MA46019B1 (en) 2013-05-01 2014-05-01 Compositions and methods for modulating the expression of hbv and ttr
AU2014259757A AU2014259757B2 (en) 2013-05-01 2014-05-01 Compositions and methods for modulating HBV and TTR expression
KR1020237024621A KR20230113835A (en) 2013-05-01 2014-05-01 Compositions and methods for modulating hbv and ttr expression
CN201480035618.XA CN105378085B (en) 2013-05-01 2014-05-01 For adjusting the composition and method of HBV and TTR expression
IL296543A IL296543A (en) 2013-05-01 2014-05-01 Compositions and methods for modulating hbv and ttr expression
EP20205948.1A EP3828275A1 (en) 2013-05-01 2014-05-01 Compositions and methods for modulating ttr expression
SI201431207T SI2992098T1 (en) 2013-05-01 2014-05-01 Compositions and methods for modulating hbv and ttr expression
MX2015015264A MX2015015264A (en) 2013-05-01 2014-05-01 Compositions and methods for modulating hbv and ttr expression.
CA2921167A CA2921167A1 (en) 2013-05-01 2014-05-01 Compositions and methods for modulating hbv and ttr expression
KR1020197019617A KR102212275B1 (en) 2013-05-01 2014-05-01 Compositions and methods for modulating hbv and ttr expression
PL14791344T PL2992098T3 (en) 2013-05-01 2014-05-01 Compositions and methods for modulating hbv and ttr expression
UAA201511840A UA121017C2 (en) 2013-05-01 2014-05-01 Compositions and methods for modulating hbv and ttr expression
DK14791344.6T DK2992098T3 (en) 2013-05-01 2014-05-01 COMPOSITIONS AND METHODS FOR MODULATION OF HBV AND TTR EXPRESSION
EP14791344.6A EP2992098B1 (en) 2013-05-01 2014-05-01 Compositions and methods for modulating hbv and ttr expression
LTEP14791344.6T LT2992098T (en) 2013-05-01 2014-05-01 Compositions and methods for modulating hbv and ttr expression
CN201910036892.3A CN110042098B (en) 2013-05-01 2014-05-01 Compositions and methods for modulating HBV and TTR expression
KR1020157033025A KR102235678B1 (en) 2013-05-01 2014-05-01 Compositions and methods for modulating hbv and ttr expression
MEP-2019-157A ME03390B (en) 2013-05-01 2014-05-01 Compositions and methods for modulating hbv and ttr expression
BR112015027369-6A BR112015027369B1 (en) 2013-05-01 2014-05-01 compounds comprising a modified oligonucleotide and a conjugate group, composition comprising said compounds and uses thereof
KR1020217003080A KR20210014758A (en) 2013-05-01 2014-05-01 Compositions and methods for modulating hbv and ttr expression
RS20190682A RS58981B1 (en) 2013-05-01 2014-05-01 Compositions and methods for modulating hbv and ttr expression
CR20190269A CR20190269A (en) 2013-05-01 2014-05-01 Compositions and methods for modulating hbv and ttr expression
MA38621A MA38621B1 (en) 2013-05-01 2014-05-01 Compositions and methods for modulating the expression of hbv and ttr
RU2015151202A RU2670614C9 (en) 2013-05-01 2014-05-01 Compositions and methods for modulating hbv and ttr expression
JP2016512054A JP6995478B2 (en) 2013-05-01 2014-05-01 Compositions and Methods for Regulating HBV and TTR Expression
SG11201508870VA SG11201508870VA (en) 2013-05-01 2014-05-01 Compositions and methods for modulating hbv and ttr expression
ES14791344T ES2730015T3 (en) 2013-05-01 2014-05-01 Compositions and methods to modulate HBV and TTR expression
KR1020217039866A KR102558571B1 (en) 2013-05-01 2014-05-01 Compositions and methods for modulating hbv and ttr expression
NZ631552A NZ631552A (en) 2013-05-01 2014-05-01 Compositions and methods for modulating hbv expression
EA201592093A EA031393B1 (en) 2013-05-01 2014-05-01 Compositions and methods for modulating hbv and ttr expression
IL284593A IL284593B2 (en) 2013-05-01 2014-05-01 Compositions and methods for modulating hbv and ttr expression
KR1020217009333A KR20210037752A (en) 2013-05-01 2014-05-01 Compositions and methods for modulating hbv and ttr expression
EP19164959.9A EP3524680B1 (en) 2013-05-01 2014-05-01 Compositions and methods for modulating ttr expression
US14/633,491 US9145558B2 (en) 2013-05-01 2015-02-27 Compositions and methods for modulating HBV expression
US14/822,493 US9932580B2 (en) 2013-05-01 2015-08-10 Compositions and methods for modulating HBV expression
ZA2015/07216A ZA201507216B (en) 2013-05-01 2015-09-29 Compositions and methods for modulating hbv and ttr expression
IL242125A IL242125B (en) 2013-05-01 2015-10-15 Compound comprising conjugate group and modified oligonucleotide consisting of 12 to 30 linked nucleosides and use thereof for treating a hbv-related disease
PH12015502493A PH12015502493A1 (en) 2013-05-01 2015-10-29 Compositions and methods for modulating hbv and ttr expression
CR20150612A CR20150612A (en) 2013-05-01 2015-11-12 COMPOSITIONS AND METHODS TO MODULATE THE EXPRESSION OF TTR AND VHB
HK16109538.2A HK1221485A1 (en) 2013-05-01 2016-08-10 Compositions and methods for modulating hbv and ttr expression hbv ttr
AU2017200950A AU2017200950B2 (en) 2013-05-01 2017-02-13 Compositions and methods for modulating hbv and ttr expression
US15/687,306 US10683499B2 (en) 2013-05-01 2017-08-25 Compositions and methods for modulating TTR expression
US15/896,379 US20190055554A1 (en) 2013-05-01 2018-02-14 Compositions and methods for modulating hbv expression
PH12018501963A PH12018501963A1 (en) 2013-05-01 2018-09-12 Compositions and methods for modulating hbv and ttr expression
IL264241A IL264241B (en) 2013-05-01 2019-01-14 Compositions and methods for modulating hbv and ttr expression
AU2019202598A AU2019202598A1 (en) 2013-05-01 2019-04-15 Compositions and methods for modulating hbv and ttr expression
PH12019501191A PH12019501191A1 (en) 2013-05-01 2019-05-29 Compositions and methods for modulating hbv and ttr expression
HRP20190987TT HRP20190987T1 (en) 2013-05-01 2019-05-30 Compositions and methods for modulating hbv and ttr expression
CY20191100660T CY1121879T1 (en) 2013-05-01 2019-06-26 COMPOSITIONS AND METHODS FOR MODULATION OF HBV AND TTR EXPRESSION
AU2019204784A AU2019204784C1 (en) 2013-05-01 2019-07-03 Compositions and methods for modulating hbv and ttr expression
IL270464A IL270464B (en) 2013-05-01 2019-11-06 Compositions and methods for modulating hbv and ttr expression
US16/790,557 US20220275365A9 (en) 2013-05-01 2020-02-13 Compositions and methods for modulating ttr expression
US16/806,941 US20200224198A1 (en) 2013-05-01 2020-03-02 Compositions and methods for modulating hbv expression
IL273184A IL273184B (en) 2013-05-01 2020-03-09 Compositions and methods for modulating hbv and ttr expression
DO2021000095A DOP2021000095A (en) 2013-05-01 2021-05-17 COMPOSITIONS AND METHODS TO MODULATE THE EXPRESSION OF TTR
IL284000A IL284000A (en) 2013-05-01 2021-06-14 Compositions and methods for modulating hbv and ttr expression
AU2022202770A AU2022202770A1 (en) 2013-05-01 2022-04-27 Compositions and methods for modulating hbv and ttr expression
US17/970,887 US20230151365A1 (en) 2013-05-01 2022-10-21 Compositions and methods for modulating ttr expression

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US61/871,673 2013-08-29
US201361880790P 2013-09-20 2013-09-20
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US201461976991P 2014-04-08 2014-04-08
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