WO2014179629A8 - Compositions and methods - Google Patents

Compositions and methods Download PDF

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Publication number
WO2014179629A8
WO2014179629A8 PCT/US2014/036466 US2014036466W WO2014179629A8 WO 2014179629 A8 WO2014179629 A8 WO 2014179629A8 US 2014036466 W US2014036466 W US 2014036466W WO 2014179629 A8 WO2014179629 A8 WO 2014179629A8
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
methods
oligomeric compounds
acetylgalactosamine
conjugated
Prior art date
Application number
PCT/US2014/036466
Other languages
French (fr)
Other versions
WO2014179629A3 (en
WO2014179629A2 (en
Inventor
Thazha P. Prakash
Punit P. Seth
Eric E. Swayze
Original Assignee
Isis Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51843959&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2014179629(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to CN201480035633.4A priority Critical patent/CN105378082B/en
Priority to AU2014259759A priority patent/AU2014259759B2/en
Priority to US14/888,318 priority patent/US9714421B2/en
Priority to CA2921518A priority patent/CA2921518A1/en
Priority to JP2016512055A priority patent/JP6456362B2/en
Priority to EP14791863.5A priority patent/EP2992097B1/en
Priority to MX2015015239A priority patent/MX2015015239A/en
Priority to BR112015027321A priority patent/BR112015027321A8/en
Priority to KR1020157033031A priority patent/KR20160002977A/en
Application filed by Isis Pharmaceuticals, Inc. filed Critical Isis Pharmaceuticals, Inc.
Priority to EP19206748.6A priority patent/EP3633039A1/en
Priority to RU2015151204A priority patent/RU2686080C2/en
Publication of WO2014179629A2 publication Critical patent/WO2014179629A2/en
Publication of WO2014179629A3 publication Critical patent/WO2014179629A3/en
Priority to IL242126A priority patent/IL242126B/en
Publication of WO2014179629A8 publication Critical patent/WO2014179629A8/en
Priority to HK16109541.7A priority patent/HK1221486A1/en
Priority to US15/618,365 priority patent/US20180002693A1/en
Priority to IL263843A priority patent/IL263843B/en
Priority to IL273205A priority patent/IL273205A/en
Priority to US16/910,727 priority patent/US20210130823A1/en
Priority to AU2020233603A priority patent/AU2020233603A1/en

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    • A—HUMAN NECESSITIES
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
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    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

Abstract

Provided herein are oligomeric compounds with conjugate groups. In certain embodiments, the oligomeric compounds are conjugated to N-Acetylgalactosamine.
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US14/888,318 US9714421B2 (en) 2013-05-01 2014-05-01 Compositions and methods
IL242126A IL242126B (en) 2013-05-01 2015-10-15 Compounds comprising a modified oligonucleotide and a conjugate group
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US15/618,365 US20180002693A1 (en) 2013-05-01 2017-06-09 Compositions and methods
IL263843A IL263843B (en) 2013-05-01 2018-12-19 Antisense compounds comprising antisense oligonucleotide complementary to a nucleic acid transcript and compositions comprising the same for the treatment of metabolic related diseases
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