WO2014184428A1 - Multichannel pipette - Google Patents

Multichannel pipette Download PDF

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Publication number
WO2014184428A1
WO2014184428A1 PCT/FI2014/050341 FI2014050341W WO2014184428A1 WO 2014184428 A1 WO2014184428 A1 WO 2014184428A1 FI 2014050341 W FI2014050341 W FI 2014050341W WO 2014184428 A1 WO2014184428 A1 WO 2014184428A1
Authority
WO
WIPO (PCT)
Prior art keywords
spacing
pipette
multichannel pipette
multichannel
setting
Prior art date
Application number
PCT/FI2014/050341
Other languages
French (fr)
Inventor
Suvi BERGHÄLL
Vesa Salo
Original Assignee
Thermo Fisher Scientific Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thermo Fisher Scientific Oy filed Critical Thermo Fisher Scientific Oy
Priority to CN201490000672.6U priority Critical patent/CN205868297U/en
Priority to DE212014000126.9U priority patent/DE212014000126U1/en
Publication of WO2014184428A1 publication Critical patent/WO2014184428A1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B01L3/0237—Details of electronic control, e.g. relating to user interface
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/021—Adjust spacings in an array of wells, pipettes or holders, format transfer between arrays of different size or geometry
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/021—Adjust spacings in an array of wells, pipettes or holders, format transfer between arrays of different size or geometry
    • B01L2200/022—Variable spacings

Definitions

  • the present invention relates to a multichannel pipette intended for use in as- pirating and dispensing of liquids and comprising a plurality of cylinders with a piston, each of the cylinders being connected to a lower tip, and where the distance between the lower tips is adjustable.
  • Pipettes used for aspiring and dispensing liquids in laboratories comprise a piston movable in a cylinder for aspiration of liquid into a tip container connected with the cylinder.
  • the volume is usually adjustable.
  • electronic pipettes whose piston is actuated by means of an electric motor and a control system associated with it.
  • electronic pipettes whose pistons are actuated by manual force and which comprise an electronic display only.
  • Electronic pipettes have a user interface for selection of the desired pipette function (e.g. direct or reverse pipetting), setting of the volume and for giving commands for performing operations.
  • the user interface has the necessary switches for input of the necessary settings and performance of the functions.
  • the user interface is connected to a display, by means of which the volume and other necessary data can be displayed.
  • the display can also show menus allowing data input in the control system.
  • Multichannel pipettes having a plurality of lower tips are known, as well as mul- tichannel pipettes with adjustable lower tip spacing.
  • An example of a multichannel pipette with adjustable lower tip spacing is disclosed in publication US 6,235,244, for example. Summary of the invention
  • the present invention now provides a multichannel pipette, which comprises at least one preset spacing setting for the spacing of the lower tips, which spacing setting is identified to the user, or equipped with suitable identification for the user, as application specific setting.
  • the application specific setting or settings in a multichannel pipette of the present invention correspond to the well spacing and sizes of different microtiter plates.
  • Prior art pipettors provide tip spacing on a numerical scale as millimeters. The user thus needs to learn and memorize which spacing corresponds to which application or plate format, for example that a SBS standard compatible 96- well microtiter plate has a 9 mm pitch.
  • Other examples are listed in table 1 . And as can be seen from the below table, some tip spacing values are usable for a plurality of diverse applications.
  • the user can change between preset lower tip spacing settings, which settings inform the user about application(s) suitable for each preset setting more informatively than a pure numeric tip spacing value. This saves a lot of time in pipetting operations, since the users do not need to know or recall the required spacing on a numerical scale or adjust the spacing by visual alignment with the target.
  • the change between settings may be implemented manually.
  • the change between settings may be implemented by the control system or user interface of the pipette, simply by selecting the required application from suitable menu for example.
  • the multichannel pipette according to the invention is advantageously a handheld entity, and in cases of electronic multichannel pipettes the pipette may have a separate charging station, which charging station may also advantageously be used for inputting sequences of pipetting actions forming pipetting operations including the timer and note options, and other data into the control system and/or user interface of the electronic pipette, via data inter- face, for example.
  • This provides for wider implementation of the invention in a multichannel pipette as well as widens the usability of the multichannel pipette.
  • the features of the pipette of the present invention are presented more precisely in the independent claim 1 .
  • the dependent claims define further advantageous features and embodiments of the invention.
  • figure 1 shows schematically an embodiment according to the invention in a first preset setting
  • figure 2 shows schematically the embodiment of figure 1 in a second preset setting.
  • a lower portion of a multichannel pipette comprising a handle portion 1 for holding the pipette (shown only partially in the figures) and an extension portion 2 extending from the lower end of the handle portion. From the bottom of the extension portion 2 extend lower tips 3 of the multichannel pipette, of which there are 8 in this multichannel pipette.
  • the spacing of the lower tips 3 is adjustable, and the spacing of the lower tips is adjusted by moving a slide 4 along the surface of the extension portion 2. In the slide 4 is a small opening 5.
  • the spacing of the lower tips 3 is set to a first preset setting by moving the slide 4 to a place where a text "96 WELL” can be seen through the opening 5.
  • the text "96 WELL” is printed on the surface of the extension portion 2.
  • the changing of preset lower tip spacing can also be carried out through a control system and user interface of an electronic multichannel pipette, whereby an electric motor, for example, changes the spacing of the lower tips, and the user sets the lower tip spacing through the user interface to a required preset value.
  • the used preset lower tip spacing setting can be informed to the user via a display, for example.

Abstract

A multichannel pipette comprising a plurality of cylinders with a piston, each of the cylinders being connected to a lower tip (3), and where the distance between the lower tips is adjustable, wherein the multichannel pipette comprises at least one preset spacing setting for the spacing of the lower tips (3), which spacing setting is identified to the user as application specific setting.

Description

Multichannel pipette
Field of technology
The present invention relates to a multichannel pipette intended for use in as- pirating and dispensing of liquids and comprising a plurality of cylinders with a piston, each of the cylinders being connected to a lower tip, and where the distance between the lower tips is adjustable.
Technological background
Pipettes used for aspiring and dispensing liquids in laboratories comprise a piston movable in a cylinder for aspiration of liquid into a tip container connected with the cylinder. The volume is usually adjustable. There are also electronic pipettes whose piston is actuated by means of an electric motor and a control system associated with it. However, there are also electronic pipettes whose pistons are actuated by manual force and which comprise an electronic display only. Electronic pipettes have a user interface for selection of the desired pipette function (e.g. direct or reverse pipetting), setting of the volume and for giving commands for performing operations. The user interface has the necessary switches for input of the necessary settings and performance of the functions. The user interface is connected to a display, by means of which the volume and other necessary data can be displayed. The display can also show menus allowing data input in the control system.
Examples of known electronic pipettes are disclosed in publications WO 2005079989 and WO 2005079987, for example.
Multichannel pipettes having a plurality of lower tips are known, as well as mul- tichannel pipettes with adjustable lower tip spacing. An example of a multichannel pipette with adjustable lower tip spacing is disclosed in publication US 6,235,244, for example. Summary of the invention
In order to enhance the usability of multichannel pipettes with adjustable lower tip spacing, the present invention now provides a multichannel pipette, which comprises at least one preset spacing setting for the spacing of the lower tips, which spacing setting is identified to the user, or equipped with suitable identification for the user, as application specific setting.
Advantageously the application specific setting or settings in a multichannel pipette of the present invention correspond to the well spacing and sizes of different microtiter plates. Prior art pipettors provide tip spacing on a numerical scale as millimeters. The user thus needs to learn and memorize which spacing corresponds to which application or plate format, for example that a SBS standard compatible 96- well microtiter plate has a 9 mm pitch. Other examples are listed in table 1 . And as can be seen from the below table, some tip spacing values are usable for a plurality of diverse applications.
Figure imgf000003_0001
Table 1 .
With the present invention the user can change between preset lower tip spacing settings, which settings inform the user about application(s) suitable for each preset setting more informatively than a pure numeric tip spacing value. This saves a lot of time in pipetting operations, since the users do not need to know or recall the required spacing on a numerical scale or adjust the spacing by visual alignment with the target.
In cases where the multichannel pipette according to the present invention is equipped with a plurality of preset spacing settings of the lower tips, the change between settings may be implemented manually. In the cases where the multichannel pipette of the invention is an electronic pipette comprising a control system and a user interface, the change between settings may be implemented by the control system or user interface of the pipette, simply by selecting the required application from suitable menu for example.
The multichannel pipette according to the invention is advantageously a handheld entity, and in cases of electronic multichannel pipettes the pipette may have a separate charging station, which charging station may also advantageously be used for inputting sequences of pipetting actions forming pipetting operations including the timer and note options, and other data into the control system and/or user interface of the electronic pipette, via data inter- face, for example.
Preferably there are more than two application specifically informed spacing values preset in the multichannel pipette according to the invention. This provides for wider implementation of the invention in a multichannel pipette as well as widens the usability of the multichannel pipette. The features of the pipette of the present invention are presented more precisely in the independent claim 1 . The dependent claims define further advantageous features and embodiments of the invention.
Brief description of the figures Exemplifying embodiments of the invention and its advantages are explained in greater detail below in the sense of an example and with reference to the accompanying drawings, where figure 1 shows schematically an embodiment according to the invention in a first preset setting, and figure 2 shows schematically the embodiment of figure 1 in a second preset setting. Detailed description of the embodiments
In the figures it is shown a lower portion of a multichannel pipette according to the present invention comprising a handle portion 1 for holding the pipette (shown only partially in the figures) and an extension portion 2 extending from the lower end of the handle portion. From the bottom of the extension portion 2 extend lower tips 3 of the multichannel pipette, of which there are 8 in this multichannel pipette.
The spacing of the lower tips 3 is adjustable, and the spacing of the lower tips is adjusted by moving a slide 4 along the surface of the extension portion 2. In the slide 4 is a small opening 5.
In the situation of figure 1 the spacing of the lower tips 3 is set to a first preset setting by moving the slide 4 to a place where a text "96 WELL" can be seen through the opening 5. The text "96 WELL" is printed on the surface of the extension portion 2. When the user sees the text "96 WELL" in the opening 5, he/she knows that the tip spacing now corresponds to the required tip spacing for operating with a standard 96 well microtiter plate, and can now proceed to carrying out pipetting operations with the 96 well microtiter plate and/or corresponding applications.
When the user needs to change the spacing of the lower tips 3 to correspond to different type of application, he/she moves the slide 4 to a new preset spacing, for example to one shown in figure 2. In the situation of figure 2 the slide 4 is moved to a position where the opening 5 displays a text "48 MCT". This text informs that the tip spacing is now increased to a preset value for operating with standard 48 well microtiter plate and/or corresponding applications. The embodiment shown in figures and discussed above relates to manual changing of preset lower tip spacing. The changing of preset lower tip spacing can also be carried out through a control system and user interface of an electronic multichannel pipette, whereby an electric motor, for example, changes the spacing of the lower tips, and the user sets the lower tip spacing through the user interface to a required preset value. The used preset lower tip spacing setting can be informed to the user via a display, for example.

Claims

Claims
1 . A multichannel pipette comprising
- a plurality of cylinders with a piston, each of the cylinders being connected to a lower tip (3), and - where the distance between the lower tips is adjustable, characterized in that the multichannel pipette comprises at least one preset spacing setting for the spacing of the lower tips (3), which spacing setting is identified to the user by the pipette as an application specific setting.
2. A multichannel pipette according to claims 1 , wherein the application specific settings corresponds to the well spacing and sizes of different micro- titer plates.
3. A multichannel pipette according to claim 1 or 2, wherein the change between a plurality of spacing settings is implemented manually.
4. A multichannel pipette according to claim 1 or 2, wherein the pipette is an electronic pipette and the change between settings is implemented by a control system or a user interface of the electronic pipette.
PCT/FI2014/050341 2013-05-13 2014-05-09 Multichannel pipette WO2014184428A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201490000672.6U CN205868297U (en) 2013-05-13 2014-05-09 Multichannel pipette
DE212014000126.9U DE212014000126U1 (en) 2013-05-13 2014-05-09 Multichannel pipette

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20135498 2013-05-13
FI20135498A FI20135498A (en) 2013-05-13 2013-05-13 a multichannel pipette,

Publications (1)

Publication Number Publication Date
WO2014184428A1 true WO2014184428A1 (en) 2014-11-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FI2014/050341 WO2014184428A1 (en) 2013-05-13 2014-05-09 Multichannel pipette

Country Status (4)

Country Link
CN (1) CN205868297U (en)
DE (1) DE212014000126U1 (en)
FI (1) FI20135498A (en)
WO (1) WO2014184428A1 (en)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5061449A (en) * 1989-07-25 1991-10-29 Matrix Technologies, Corp. Expandable multi-channel pipetter
US6235244B1 (en) 1998-12-14 2001-05-22 Matrix Technologies Corp. Uniformly expandable multi-channel pipettor
WO2005079987A1 (en) 2004-02-25 2005-09-01 Thermo Electron Oy Controllable pipette
WO2005079989A1 (en) 2004-02-25 2005-09-01 Thermo Electron Oy Electronic pipette
US20070092410A1 (en) * 2005-10-26 2007-04-26 Ricker Robert D Device for pipetting solution from one plate format to a different plate platform using movable position pipette tips
US20090104079A1 (en) * 2007-10-17 2009-04-23 Rainin Instrument, Llc Liquid end assembly for a handheld multichannel pipette with adjustable nozzle spacing
US20090274587A1 (en) * 2008-05-05 2009-11-05 Viaflo Corporation Multi-channel pipettor with repositionable tips

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5061449A (en) * 1989-07-25 1991-10-29 Matrix Technologies, Corp. Expandable multi-channel pipetter
US6235244B1 (en) 1998-12-14 2001-05-22 Matrix Technologies Corp. Uniformly expandable multi-channel pipettor
WO2005079987A1 (en) 2004-02-25 2005-09-01 Thermo Electron Oy Controllable pipette
WO2005079989A1 (en) 2004-02-25 2005-09-01 Thermo Electron Oy Electronic pipette
US20070092410A1 (en) * 2005-10-26 2007-04-26 Ricker Robert D Device for pipetting solution from one plate format to a different plate platform using movable position pipette tips
US20090104079A1 (en) * 2007-10-17 2009-04-23 Rainin Instrument, Llc Liquid end assembly for a handheld multichannel pipette with adjustable nozzle spacing
US20090274587A1 (en) * 2008-05-05 2009-11-05 Viaflo Corporation Multi-channel pipettor with repositionable tips

Also Published As

Publication number Publication date
CN205868297U (en) 2017-01-11
FI20135498A (en) 2014-11-14
DE212014000126U1 (en) 2016-01-13

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