WO2015061299A3 - Point-of-care immunosensing device for multi-biomarker detection - Google Patents

Point-of-care immunosensing device for multi-biomarker detection Download PDF

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Publication number
WO2015061299A3
WO2015061299A3 PCT/US2014/061542 US2014061542W WO2015061299A3 WO 2015061299 A3 WO2015061299 A3 WO 2015061299A3 US 2014061542 W US2014061542 W US 2014061542W WO 2015061299 A3 WO2015061299 A3 WO 2015061299A3
Authority
WO
WIPO (PCT)
Prior art keywords
biosensor
fluid
hub
active area
biomarker
Prior art date
Application number
PCT/US2014/061542
Other languages
French (fr)
Other versions
WO2015061299A2 (en
Inventor
Asanterabi Malima
Ahmed Busnaina
Original Assignee
Northeastern University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Northeastern University filed Critical Northeastern University
Priority to US15/027,466 priority Critical patent/US20160258945A1/en
Publication of WO2015061299A2 publication Critical patent/WO2015061299A2/en
Publication of WO2015061299A3 publication Critical patent/WO2015061299A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0896—Nanoscaled
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials

Abstract

An immunosensing device includes a hub mountable to a device for fluid collection, such as a syringe, sample collection container, or vacuum collection container, and a biosensor mounted to the hub. The biosensor includes a biosensor active area in fluid communication with a fluid passage within the hub. The biosensor active area includes nanoelements functionalized with one or more antibodies or antigen binding fragments thereof for contact with a fluid in the fluid passage. The biosensor active area can include multiple regions each including nanoelements functionalized with a different antibody or antigen binding fragment thereof to detect multiple biomarkers. The biosensor, separately or attached to the hub, can be inserted in a biomarker reader for detection of a biomarker in the fluid.
PCT/US2014/061542 2013-10-21 2014-10-21 Point-of-care immunosensing device for multi-biomarker detection WO2015061299A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US15/027,466 US20160258945A1 (en) 2013-10-21 2014-10-21 Point-of-care immunosensing device for multi-biomarker detection

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361893409P 2013-10-21 2013-10-21
US61/893,409 2013-10-21

Publications (2)

Publication Number Publication Date
WO2015061299A2 WO2015061299A2 (en) 2015-04-30
WO2015061299A3 true WO2015061299A3 (en) 2015-10-01

Family

ID=52993739

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/061542 WO2015061299A2 (en) 2013-10-21 2014-10-21 Point-of-care immunosensing device for multi-biomarker detection

Country Status (2)

Country Link
US (1) US20160258945A1 (en)
WO (1) WO2015061299A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106124586A (en) * 2016-06-20 2016-11-16 山东理工大学 A kind of preparation method and application of the sensor of two kinds of hepatitis b virus marker HBs/HBe of detection simultaneously

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10913068B2 (en) 2015-03-13 2021-02-09 Nanyang Technological University Testing device, microfluidic chip and nucleic acid testing method
MX2021006612A (en) * 2018-12-07 2021-07-07 Siemens Healthcare Diagnostics Inc Solution collection device with evaluation element.
DK4048152T3 (en) 2020-07-29 2024-03-11 Biolinq Incorporated SYSTEM FOR CONTINUOUS ANALYTE MONITORING WITH MICRON NEEDLE ARRANGEMENT
EP4153276A4 (en) 2021-05-08 2023-11-08 Biolinq, Inc. Fault detection for microneedle array based continuous analyte monitoring device

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6245296B1 (en) * 1990-02-23 2001-06-12 The United States Of America As Represented By The Secretary Of The Navy Flow immunosensor apparatus
US7006858B2 (en) * 2000-05-15 2006-02-28 Silver James H Implantable, retrievable sensors and immunosensors
US20060240492A1 (en) * 2004-11-12 2006-10-26 Rusling James F Carbon nanotube based immunosensors and methods of making and using
US20060257956A1 (en) * 2003-07-04 2006-11-16 Frederic Basset Method and device for chemical or biological analysis by a sensor with a monolithic chamber in the form of a multi-microtubular sheaf and a lateral integration measuring transducer
US20070099189A1 (en) * 2003-05-30 2007-05-03 Instituto Nacional De Tecnica Aeroespacial "Esteban Terradas" Method and apparatus for detecting substances or analytes from the analysis of one or more samples
US20070281321A1 (en) * 2006-05-31 2007-12-06 Esa Biosciences, Inc. Biosensor for measurement of species in a body fluid
US20100297780A1 (en) * 2007-07-20 2010-11-25 Koninklijke Philips Electronics N.V. Methods and systems for detecting
US20120073969A1 (en) * 2009-03-25 2012-03-29 Abbott Point Of Care Inc. Amelioration of Heterophile Antibody Immunosensor Interference
US20130109997A1 (en) * 2011-11-02 2013-05-02 Peter Linke System for monitoring biological data

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6245296B1 (en) * 1990-02-23 2001-06-12 The United States Of America As Represented By The Secretary Of The Navy Flow immunosensor apparatus
US7006858B2 (en) * 2000-05-15 2006-02-28 Silver James H Implantable, retrievable sensors and immunosensors
US20070099189A1 (en) * 2003-05-30 2007-05-03 Instituto Nacional De Tecnica Aeroespacial "Esteban Terradas" Method and apparatus for detecting substances or analytes from the analysis of one or more samples
US20060257956A1 (en) * 2003-07-04 2006-11-16 Frederic Basset Method and device for chemical or biological analysis by a sensor with a monolithic chamber in the form of a multi-microtubular sheaf and a lateral integration measuring transducer
US20060240492A1 (en) * 2004-11-12 2006-10-26 Rusling James F Carbon nanotube based immunosensors and methods of making and using
US20070281321A1 (en) * 2006-05-31 2007-12-06 Esa Biosciences, Inc. Biosensor for measurement of species in a body fluid
US20100297780A1 (en) * 2007-07-20 2010-11-25 Koninklijke Philips Electronics N.V. Methods and systems for detecting
US20120073969A1 (en) * 2009-03-25 2012-03-29 Abbott Point Of Care Inc. Amelioration of Heterophile Antibody Immunosensor Interference
US20130109997A1 (en) * 2011-11-02 2013-05-02 Peter Linke System for monitoring biological data

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106124586A (en) * 2016-06-20 2016-11-16 山东理工大学 A kind of preparation method and application of the sensor of two kinds of hepatitis b virus marker HBs/HBe of detection simultaneously

Also Published As

Publication number Publication date
WO2015061299A2 (en) 2015-04-30
US20160258945A1 (en) 2016-09-08

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