WO2016028976A8 - Tissue marker for multimodality radiographic imaging - Google Patents

Tissue marker for multimodality radiographic imaging Download PDF

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Publication number
WO2016028976A8
WO2016028976A8 PCT/US2015/046038 US2015046038W WO2016028976A8 WO 2016028976 A8 WO2016028976 A8 WO 2016028976A8 US 2015046038 W US2015046038 W US 2015046038W WO 2016028976 A8 WO2016028976 A8 WO 2016028976A8
Authority
WO
WIPO (PCT)
Prior art keywords
radiographic marker
gas
imaging modality
multimodality
sensing medium
Prior art date
Application number
PCT/US2015/046038
Other languages
French (fr)
Other versions
WO2016028976A1 (en
Inventor
Patrick J. Bolan
Mark C. GROSS
Daniel A. Halpern
Michael T. Nelson
Original Assignee
Bolan Patrick J
Gross Mark C
Halpern Daniel A
Nelson Michael T
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bolan Patrick J, Gross Mark C, Halpern Daniel A, Nelson Michael T filed Critical Bolan Patrick J
Priority to CN201580057297.8A priority Critical patent/CN107205792B/en
Priority to ES15756323T priority patent/ES2698430T3/en
Priority to CA2958861A priority patent/CA2958861C/en
Priority to EP15756323.0A priority patent/EP3182919B1/en
Publication of WO2016028976A1 publication Critical patent/WO2016028976A1/en
Publication of WO2016028976A8 publication Critical patent/WO2016028976A8/en
Priority to HK18103086.9A priority patent/HK1243615A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00004—(bio)absorbable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3925—Markers, e.g. radio-opaque or breast lesions markers ultrasonic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3933—Liquid markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3954—Markers, e.g. radio-opaque or breast lesions markers magnetic, e.g. NMR or MRI
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3966—Radiopaque markers visible in an X-ray image
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3995—Multi-modality markers

Abstract

A radiographic marker containing a sensing medium that initially includes a gas and liquid mixture for producing increased signal intensity in a first imaging modality. The radiographic marker can have a permeable portion allowing the exchange of the gases or liquids of the sensing medium to be changed or exchanged for at least a second fluid in the surrounding tissue to reduce the bubbles or air pockets created by the gas portion of the sensing medium. The change or exchange of gas for the second liquid in the radiographic marker produces a detectable signal intensity of the radiographic marker in a second imaging modality different from the first imaging modality.
PCT/US2015/046038 2014-08-22 2015-08-20 Tissue marker for multimodality radiographic imaging WO2016028976A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN201580057297.8A CN107205792B (en) 2014-08-22 2015-08-20 Tissue markers for multi-mode radiographic imaging
ES15756323T ES2698430T3 (en) 2014-08-22 2015-08-20 Tissue marker for obtaining multimodality radiographic images
CA2958861A CA2958861C (en) 2014-08-22 2015-08-20 Tissue marker for multimodality radiographic imaging
EP15756323.0A EP3182919B1 (en) 2014-08-22 2015-08-20 Tissue marker for multimodality radiographic imaging
HK18103086.9A HK1243615A1 (en) 2014-08-22 2018-03-02 Tissue marker for multimodality radiographic imaging

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14/466,010 2014-08-22
US14/466,010 US9795455B2 (en) 2014-08-22 2014-08-22 Tissue marker for multimodality radiographic imaging

Publications (2)

Publication Number Publication Date
WO2016028976A1 WO2016028976A1 (en) 2016-02-25
WO2016028976A8 true WO2016028976A8 (en) 2016-05-06

Family

ID=54011129

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2015/046038 WO2016028976A1 (en) 2014-08-22 2015-08-20 Tissue marker for multimodality radiographic imaging

Country Status (7)

Country Link
US (1) US9795455B2 (en)
EP (1) EP3182919B1 (en)
CN (1) CN107205792B (en)
CA (1) CA2958861C (en)
ES (1) ES2698430T3 (en)
HK (1) HK1243615A1 (en)
WO (1) WO2016028976A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11241296B2 (en) 2005-11-17 2022-02-08 Breast-Med, Inc. Imaging fiducial markers and methods
US7702378B2 (en) 2005-11-17 2010-04-20 Breast-Med, Inc. Tissue marker for multimodality radiographic imaging
US9795455B2 (en) 2014-08-22 2017-10-24 Breast-Med, Inc. Tissue marker for multimodality radiographic imaging
US10295487B2 (en) * 2014-10-15 2019-05-21 The Curators Of The University Of Missouri In situ NMR parameter monitoring systems and methods for measuring pH and temperature
EP3685131B1 (en) 2017-09-19 2022-09-07 Beckman Coulter, Inc. Analog light measuring and photon counting in chemiluminescence measurements
US11903767B2 (en) 2019-11-27 2024-02-20 View Point Medical, Inc. Composite tissue markers detectable via multiple detection modalities
US11882992B2 (en) 2019-11-27 2024-01-30 View Point Medical, Inc. Composite tissue markers detectable via multiple detection modalities including radiopaque element
CN113545849A (en) * 2021-08-26 2021-10-26 重庆市妇幼保健院 Operation navigation marking device based on binocular vision and preparation method thereof

Family Cites Families (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2678195A (en) 1950-06-15 1954-05-11 Hunter Percival George Mechanical vibrator
US4991579A (en) 1987-11-10 1991-02-12 Allen George S Method and apparatus for providing related images over time of a portion of the anatomy using fiducial implants
US6405072B1 (en) 1991-01-28 2002-06-11 Sherwood Services Ag Apparatus and method for determining a location of an anatomical target with reference to a medical apparatus
US5179955A (en) 1991-02-22 1993-01-19 Molecular Biosystems, Inc. Method of abdominal ultrasound imaging
US5344640A (en) 1991-10-22 1994-09-06 Mallinckrodt Medical, Inc. Preparation of apatite particles for medical diagnostic imaging
US5469847A (en) 1992-09-09 1995-11-28 Izi Corporation Radiographic multi-modality skin markers
DE4233978C1 (en) 1992-10-08 1994-04-21 Leibinger Gmbh Body marking device for medical examinations
US5405402A (en) 1993-04-14 1995-04-11 Intermedics Orthopedics, Inc. Implantable prosthesis with radiographic marker
US6419680B1 (en) 1993-06-10 2002-07-16 Sherwood Services Ag CT and MRI visible index markers for stereotactic localization
EP1304085A3 (en) 1994-09-16 2004-01-21 Ethicon Endo-Surgery, Inc. Biodegradable tissue marking device
US6333971B2 (en) 1995-06-07 2001-12-25 George S. Allen Fiducial marker
US5769861A (en) 1995-09-28 1998-06-23 Brainlab Med. Computersysteme Gmbh Method and devices for localizing an instrument
US5782764A (en) 1995-11-07 1998-07-21 Iti Medical Technologies, Inc. Fiber composite invasive medical instruments and methods for use in interventional imaging procedures
US5906599A (en) 1995-11-09 1999-05-25 Intermed, Inc. Device for delivering biological agents
US5702128A (en) 1996-07-18 1997-12-30 Beekley Corporation Radiographic marker system and method of making same
SE511291C2 (en) 1997-03-18 1999-09-06 Anders Widmark Procedure, arrangement and reference organ for radiation therapy
CN1230120C (en) 1997-05-23 2005-12-07 普罗里森姆股份有限公司 MRI-guided therapeutic unit and method
US6270464B1 (en) 1998-06-22 2001-08-07 Artemis Medical, Inc. Biopsy localization method and device
US6181960B1 (en) 1998-01-15 2001-01-30 University Of Virginia Patent Foundation Biopsy marker device
US6161034A (en) 1999-02-02 2000-12-12 Senorx, Inc. Methods and chemical preparations for time-limited marking of biopsy sites
US6347241B2 (en) 1999-02-02 2002-02-12 Senorx, Inc. Ultrasonic and x-ray detectable biopsy site marker and apparatus for applying it
US6363940B1 (en) 1998-05-14 2002-04-02 Calypso Medical Technologies, Inc. System and method for bracketing and removing tissue
US6656192B2 (en) 1998-09-25 2003-12-02 United States Surgical Corporatioin Site marker device
US6402689B1 (en) 1998-09-30 2002-06-11 Sicel Technologies, Inc. Methods, systems, and associated implantable devices for dynamic monitoring of physiological and biological properties of tumors
WO2000024332A1 (en) 1998-10-23 2000-05-04 Cortese Armand F Marker for indicating the location of identified tissue
EP1127355B1 (en) 1998-11-06 2006-03-01 GE Healthcare Limited Products and methods for brachytherapy
US6269148B1 (en) 1998-11-09 2001-07-31 The Suremark Company Radiographic image marking system
US6356782B1 (en) 1998-12-24 2002-03-12 Vivant Medical, Inc. Subcutaneous cavity marking device and method
US6371904B1 (en) 1998-12-24 2002-04-16 Vivant Medical, Inc. Subcutaneous cavity marking device and method
US7983734B2 (en) 2003-05-23 2011-07-19 Senorx, Inc. Fibrous marker and intracorporeal delivery thereof
US6725083B1 (en) 1999-02-02 2004-04-20 Senorx, Inc. Tissue site markers for in VIVO imaging
US6862470B2 (en) 1999-02-02 2005-03-01 Senorx, Inc. Cavity-filling biopsy site markers
US7174201B2 (en) * 1999-03-11 2007-02-06 Biosense, Inc. Position sensing system with integral location pad and position display
US6778850B1 (en) 1999-03-16 2004-08-17 Accuray, Inc. Frameless radiosurgery treatment system and method
US6575991B1 (en) 1999-06-17 2003-06-10 Inrad, Inc. Apparatus for the percutaneous marking of a lesion
US6350244B1 (en) 2000-02-21 2002-02-26 Biopsy Sciences, Llc Bioabsorable markers for use in biopsy procedures
US6450938B1 (en) 2000-03-21 2002-09-17 Promex, Llc Brachytherapy device
US7672712B2 (en) 2000-03-30 2010-03-02 The Regents Of The University Of Michigan Internal marker device for identification of biological substances
US6394965B1 (en) 2000-08-15 2002-05-28 Carbon Medical Technologies, Inc. Tissue marking using biocompatible microparticles
WO2002028472A2 (en) 2000-10-04 2002-04-11 James Peter Amis Non-scatterable, radio-opaque marker for medical imaging applications
EP1339312B1 (en) 2000-10-10 2006-01-04 Microchips, Inc. Microchip reservoir devices using wireless transmission of power and data
DE10050199A1 (en) 2000-10-11 2002-04-25 Ethicon Gmbh Areal implant having a flexible basic structure on a polymer basis, contains ultrasonically detectable elements, which contain or produce gas and set up for detectability for at least four weeks after implantation
US6544185B2 (en) 2000-10-23 2003-04-08 Valentino Montegrande Ultrasound imaging marker and method of use
US6746661B2 (en) 2000-11-16 2004-06-08 Microspherix Llc Brachytherapy seed
EP1255628B1 (en) 2000-12-06 2005-03-02 Koninklijke Philips Electronics N.V. Shaving apparatus
EP1228686A1 (en) 2000-12-27 2002-08-07 Datamars SA Implantable identification marker
US6549802B2 (en) 2001-06-07 2003-04-15 Varian Medical Systems, Inc. Seed localization system and method in ultrasound by fluoroscopy and ultrasound fusion
WO2003005877A2 (en) * 2001-07-12 2003-01-23 Given Imaging Ltd. Device and method for examining a body lumen
US6605047B2 (en) 2001-09-10 2003-08-12 Vivant Medical, Inc. Biopsy marker delivery system
WO2003032837A1 (en) 2001-10-12 2003-04-24 University Of Florida Computer controlled guidance of a biopsy needle
US20030135153A1 (en) 2001-12-17 2003-07-17 Charles Hagemeier Drug implant injection device
US7329414B2 (en) 2002-05-03 2008-02-12 Biopsy Sciences, Llc Biodegradable polymer for marking tissue and sealing tracts
US9682253B2 (en) 2002-06-05 2017-06-20 Varian Medical Systems, Inc. Integrated radiation therapy systems and methods for treating a target in a patient
US6761679B2 (en) 2002-07-02 2004-07-13 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Embedded radiation emitter for the localization and dosimetry of brachytherapy seed implants
US6927406B2 (en) 2002-10-22 2005-08-09 Iso-Science Laboratories, Inc. Multimodal imaging sources
US6889833B2 (en) 2002-12-30 2005-05-10 Calypso Medical Technologies, Inc. Packaged systems for implanting markers in a patient and methods for manufacturing and using such systems
JP2004248956A (en) 2003-02-21 2004-09-09 Fuji Photo Optical Co Ltd Pretest capsule for endoscope
US7792568B2 (en) 2003-03-17 2010-09-07 Boston Scientific Scimed, Inc. MRI-visible medical devices
US7628762B2 (en) 2003-03-19 2009-12-08 Suros Surgical Systems, Inc. Adapter assembly for stereotactic biopsy
US7877133B2 (en) 2003-05-23 2011-01-25 Senorx, Inc. Marker or filler forming fluid
US7783336B2 (en) * 2003-06-06 2010-08-24 Ethicon Endo-Surgery, Inc. Subcutaneous biopsy cavity marker device
US20050033157A1 (en) 2003-07-25 2005-02-10 Klein Dean A. Multi-modality marking material and method
CN1882364A (en) 2003-11-17 2006-12-20 皇家飞利浦电子股份有限公司 Contrast agent for medical imaging techniques and usage thereof
US9408592B2 (en) 2003-12-23 2016-08-09 Senorx, Inc. Biopsy device with aperture orientation and improved tip
US8196589B2 (en) 2003-12-24 2012-06-12 Calypso Medical Technologies, Inc. Implantable marker with wireless signal transmitter
US20050234336A1 (en) 2004-03-26 2005-10-20 Beckman Andrew T Apparatus and method for marking tissue
US20050255045A1 (en) 2004-05-13 2005-11-17 Woltering Eugene A Surgical marking composition and method
US8406845B2 (en) 2004-09-01 2013-03-26 University Of Tennessee Research Foundation Method and apparatus for imaging tracking
US8433391B2 (en) 2004-10-13 2013-04-30 Suros Surgical Systems, Inc. Site marker
US20060079805A1 (en) 2004-10-13 2006-04-13 Miller Michael E Site marker visable under multiple modalities
US8442623B2 (en) 2004-10-13 2013-05-14 Suros Surgical Systems, Inc. Site marker visible under multiple modalities
US8060183B2 (en) 2004-10-13 2011-11-15 Suros Surgical Systems, Inc. Site marker visible under multiple modalities
US8280486B2 (en) 2004-10-13 2012-10-02 Suros Surgical Systems, Inc. Site marker visable under multiple modalities
US20060293581A1 (en) 2005-05-12 2006-12-28 Sunnybrook And Women's College Health Sciences Centre Marker device for X-ray, ultrasound and MR imaging
US8052658B2 (en) 2005-10-07 2011-11-08 Bard Peripheral Vascular, Inc. Drug-eluting tissue marker
US7702378B2 (en) 2005-11-17 2010-04-20 Breast-Med, Inc. Tissue marker for multimodality radiographic imaging
US8688198B2 (en) 2005-11-22 2014-04-01 Suros Surgical Sytems, Inc. Surgical site marker delivery system
US7761137B2 (en) 2005-12-16 2010-07-20 Suros Surgical Systems, Inc. Biopsy site marker deployment device
EP1847845A1 (en) 2006-04-19 2007-10-24 Eidgenössische Technische Hochschule (ETH) Susceptibility-matched magnetic field probe and method for manufacturing the same
US20080033286A1 (en) 2006-08-02 2008-02-07 Civco Medical Instruments Co., Inc. Fiducial marker for imaging localization and method of using the same
EP3542748B1 (en) 2006-12-12 2023-08-16 C. R. Bard, Inc. Multiple imaging mode tissue marker
US20080234572A1 (en) 2007-03-23 2008-09-25 Civco Medical Instruments Co., Inc. Fiducial marker with absorbable connecting sleeve and absorbable spacer for imaging localization
US20090105584A1 (en) 2007-10-18 2009-04-23 Civco Medical Instruments Co., Inc. Fiducial marker deployment system using single stick neeedle and method of use
DE102008011014A1 (en) * 2008-02-25 2009-09-10 Siemens Aktiengesellschaft Medical pillow
WO2009150564A2 (en) * 2008-06-13 2009-12-17 Koninklijke Philips Electronics, N.V. Multimodal imaging fiducial marker
BRPI0917135A2 (en) 2008-08-09 2015-11-10 Massachusetts Inst Technology medical device for extension and retention in a patient's seminal vesicle, ejaculatory duct, prostate or vas deferens, use of a resorbable elastomer, and osmotic pump device.
US8550086B2 (en) * 2010-05-04 2013-10-08 Hologic, Inc. Radiopaque implant
US10806383B2 (en) 2010-05-04 2020-10-20 Massachusetts Institute Of Technology Implantable dissolved oxygen sensor and methods of use
US9918656B2 (en) 2010-06-25 2018-03-20 Massachusetts Institute Of Technology Implantable magnetic relaxation sensors and methods of measuring a sensor's cumulative exposure to a biomarker
US8554309B2 (en) * 2010-09-23 2013-10-08 Hologic, Inc. Localizing obturator with site marking capability
US9795455B2 (en) 2014-08-22 2017-10-24 Breast-Med, Inc. Tissue marker for multimodality radiographic imaging

Also Published As

Publication number Publication date
CA2958861C (en) 2022-05-10
US9795455B2 (en) 2017-10-24
HK1243615A1 (en) 2018-07-20
EP3182919A1 (en) 2017-06-28
US20160051337A1 (en) 2016-02-25
EP3182919B1 (en) 2018-10-17
CA2958861A1 (en) 2016-02-25
CN107205792A (en) 2017-09-26
CN107205792B (en) 2020-06-19
ES2698430T3 (en) 2019-02-04
WO2016028976A1 (en) 2016-02-25

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