WO2016029758A1

WO2016029758A1 - Electrically powered needleless injector

Info

Publication number: WO2016029758A1
Application number: PCT/CN2015/084819
Authority: WO
Inventors: 张明
Original assignee: 北京快舒尔医疗技术有限公司
Priority date: 2014-08-27
Filing date: 2015-07-22
Publication date: 2016-03-03
Also published as: EP3187214A4; US20170368261A1; JP6511524B2; JP6864026B2; US11116909B2; EP3187214B1; CN204033941U; JP2017529203A; EP3187214A1; JP2019130380A

Abstract

An electrically powered needleless injector (100), comprising: a needleless injector body (120); and a needless injection end (130) extending from the needleless injector body (120) toward a distal side for administering medicine. The needleless injector body (120) comprises: a housing (3) having an internal portion divided into a pressurized injection chamber (123) and a motor chamber (124); a pressurized injection assembly (170) located in the pressurized injection chamber (123); a needleless injector locking mechanism (180) at least partially located in the pressurized injection chamber (123); and a motor assembly (190) located in the motor chamber (124). The needleless injector (100) is small, reliable in operation, and convenient to use, and utilizes the method of an electrically powered in-built motor (5) serving as the power source for the acquisition and injection of medicine of the needleless injector (100).

Description

Needleless syringe with electric function

Technical field

The utility model relates to the technical field of medicines and medical instruments, and relates to a needle-free injector with electric function.

Background technique

With the development of the pharmaceutical industry, many biologic drugs have been produced. These drugs are characterized by small injection volume and frequent injection. A needled syringe can give the user the fear of a needle and the pain of acupuncture. Needle-free syringes can effectively avoid these problems.

Needle-free syringes currently on the market usually pressurize the liquid medicine through an external power source, and allow the liquid medicine to pass through the fine pores in a high-pressure and high-speed form, penetrate the skin, and enter the body. That is to say, the liquid medicine can penetrate the human or animal skin directly into the body without passing through the needle. At the same time, the needle-free syringe can also make the injected drug more dispersed, which is beneficial to the absorption of the drug and reduce the damage to the subcutaneous tissue and avoid the formation of induration.

However, due to the short development time, the existing needle-free syringes still have many shortcomings. For example, the current needle-free syringe for civilian use is basically manually pressurized by a needle-free syringe, which is very inconvenient for the user to use. The electric needle-free injectors used in large and medium-sized hospitals have a relatively long length and are therefore bulky and inconvenient to operate.

In actual production life, there is an urgent need for a needle-free injector that can be easily operated and has a simple structure.

Utility model content

The purpose of the utility model is to provide a needle-free injector with electric function, which can take medicine and injection into a needle-free injector by a built-in motor, and has reliable operation, convenient use and small volume.

According to the present invention, there is provided a needleless injector having an electric function, comprising: a needleless syringe body; a needleless injection end for administration from a needleless syringe body distally. The needle-free injector body includes: a casing, and the inside of the casing is divided into a pressurized injection chamber And a motor chamber; a pressurized injection assembly located within the pressurized injection chamber; a needle-free injector locking mechanism at least partially within the pressurized injection chamber; and a motor assembly located within the motor chamber.

According to a preferred embodiment, the longitudinal axis of the pressurized injection assembly and the longitudinal axis of the motor assembly are parallel to each other.

According to a preferred embodiment, the pressurized injection assembly includes a push rod, a pressure spring sleeved on the push rod, and a compression body at least partially surrounding the push rod and the compression spring.

According to a preferred embodiment, the push rod is provided on the distal side with a pusher boss, the inside of the compression body is provided with a shoulder, the distal end of the pressure spring abuts against the push rod boss and the pressure spring The proximal end abuts the shoulder and is capable of pressurizing the compression spring when the compression body is driven by the motor assembly.

According to a preferred embodiment, the needle-free injector locking mechanism is capable of locking the compression body and the push rod together by a locking ball that passes through the wall of the compression body and into the groove at the proximal end of the push rod Thereby locking the pressure spring in a pressurized state.

According to a preferred embodiment, the needle-free injector locking mechanism comprises a hollow button, the inner end of the button having a platform and a button recess on the proximal side of the platform, the platform abutting through in the locked state The wall of the compression body and the locking ball of the groove at the proximal end of the push rod prevent it from coming off. When the injection is to be unlocked, pressing the button causes the platform to move distally, and the locking ball is pushed into the button The groove thereby allows the push rod to be disengaged from the compression body.

According to a preferred embodiment, the compression body comprises a compression body body of a substantially sleeve-shaped structure and a force transmitting portion projecting upward from the body of the compression body, the force transmission portion being formed with a center hole for receiving the motor assembly.

According to a preferred embodiment, the body of the compression body comprises a thickened portion of the inner wall to form: (a) the shoulder for abutting against the proximal end of the compression spring, and (b) the proximal body from the body of the compression body The end begins a deep groove extending longitudinally for receiving a portion of the needleless syringe locking mechanism.

According to a preferred embodiment, the partition wall extending proximally from the inner side of the distal end wall of the outer casing and the upper side wall of the compression body main body divide the interior of the outer casing into the pressurized injection chamber and the motor chamber.

According to a preferred embodiment, the partition wall supports the motor of the motor assembly above.

According to a preferred embodiment, the motor assembly comprises: a motor, a motor shaft extending from the motor, and a lead screw coupled to the motor shaft, the lead rod extending along the axis of the motor assembly and passing through the central hole of the force transmitting portion .

According to a preferred embodiment, the needle-free injector locking mechanism comprises a hollow button inserted into a deep groove of the proximal end of the compression body, the inner end of the button having a platform and a button located proximal to the platform a groove; a lock post having a proximal end disposed within the button and in contact with the inner wall of the button; a button spring disposed inside the button and located proximal to the lock cylinder; an aperture in the wall of the compression body; a locking ball; a push rod Groove.

The longitudinal axis of the pressurized injection assembly of the present invention and the longitudinal axis of the motor assembly are parallel to each other, and the length of the needle-free injector can be shortened compared to the coaxial structure. It has an internal motor that precisely controls the start and stop of the motor as well as forward and reverse rotation.

The partition wall of the present invention extending proximally from the inner side of the distal end wall of the outer casing and the upper side wall of the compression body main body divide the interior of the outer casing into the pressurized injection chamber and the motor chamber, thereby making the structure more compact And simple.

The utility model has the beneficial effects that the power source of the needle-free injector can be taken by the electric method of the built-in motor, and the power source is reliable, convenient to use and small in volume.

DRAWINGS

1 is a longitudinal cross-sectional view of a needle-free injector in accordance with a preferred embodiment of the present invention showing the needle-free injector in a released state.

Figure 2 is a schematic illustration of the needle-free injector of Figure 1 in a pressurized state.

3 is a schematic view of the needle-free injector of FIG. 1 in a state of taking medicine and adjusting dose.

4 is a schematic view of the appearance of a needle-free injector in accordance with a preferred embodiment of the present invention.

Figure 5 is a partially enlarged schematic view of the rear portion of Figure 3.

detailed description

According to the design concept of the present invention, there are various embodiments for realizing the purpose of the utility model. The structure, configuration and working principle of the needle-free injector of the present invention will be explained below with reference to the preferred embodiments shown in the drawings. Other embodiments that can achieve the objectives of the present invention are contemplated by those skilled in the art in view of the preferred embodiments shown.

In the present specification, the term "distal" refers to the side of the needle-free injector that is close to the patient's skin when in use, and the term "proximal" refers to the side of the needle-free syringe that is remote from the patient's skin when in use, the term "on" The terms "longitudinal" and "right" are relative to the longitudinal axis of the needle-free injector, as indicated with respect to the drawings. Further, the same components are denoted by the same reference numerals.

4 is a schematic view of the appearance of a needle-free injector 100 in accordance with a preferred embodiment of the present invention. The needle-free injector 100 according to the present invention includes a needle-free injector body 120, a needle-free injection end 130 for administration distally extending from the needle-free injector body 120. Referring to Figures 1 to 3, the needle-free injector body 120 includes a housing 3, the inner portion of which is a pressurized injection chamber 123 and a motor chamber 124; a pressurized injection assembly 170 located within the pressurized injection chamber 123; at least partially A needleless syringe locking mechanism 180 located within the pressurized injection chamber 123; and a motor assembly 190 located within the motor chamber 124.

According to a preferred embodiment of the present invention, the lower end of the distal end of the outer casing 3 is provided with a first hole 121 for the needle-free injection end 130 extending distally from the needle-free injector body 120 (see Figs. 1 to 3), the outer casing The proximal lower side of 3 is provided with a second hole 122 for the needle-free injector locking mechanism 180 to project proximally from the outer casing 3 (see Figs. 1 to 3). Further, a control device 200 is provided outside the outer casing 3. In a preferred embodiment, control device 200 can include at least one control button, such as switch button 19 or the like, for individual or overall control of the release, pressurization, and medication withdrawal of needle-free injector 100.

1 is a longitudinal cross-sectional view of a needle-free injector 100 in accordance with a preferred embodiment of the present invention, showing the needle-free injector 100 in a released state. As shown in FIG. 1, the inner portion of the outer casing 3 of the needleless injector 100 becomes a pressurized injection chamber 123 and a motor chamber 124. The outer casing 3 may be separate or integral. The pressurized injection assembly 170 has a pressurized injection assembly longitudinal axis X-X through the center of the first aperture 121 and the second aperture 122, and a motor assembly longitudinal axis X1-X1 that drives the motor assembly 190 of the needleless injector 100. Figure 1 As shown, the pressurized injection assembly longitudinal axis X-X and the motor assembly longitudinal axis X1-X1 are parallel to each other.

Referring to the drawings: In general, an electric-powered needle-free injector 100 according to the present invention includes a piston 1, a cartridge wall 2, a housing 3, a motor 5, a lead screw 8, a compression body 9, and a steel ball. 10. The button 11, the button spring 12, the lock cylinder 13, the push rod 14, the pressure spring 15, the compression body has a tubular structure, and a thread 16 is vertically protruded from the outer side wall of the compression body 9, and is sleeved on the silk core. a threaded rod 8 having one end connected to the motor shaft 6; the other end of the screw rod is connected to one end of the outer casing 3; the axis of the push rod 14 (ie, the longitudinal axis XX of the pressurized injection assembly) and the axis of the motor shaft 6 (ie the motor assembly longitudinal axis X1-X1) is parallel.

Specifically, as shown in FIG. 1, the needle-free injection end 130 includes a drug tube wall 2 projecting distally from the first hole 121 of the outer casing 3 and a piston 1 located inside the drug tube wall 2. Wherein the drug tube wall 2 is generally cylindrical having a generally closed tapered distal end and an open proximal end having a reduced diameter. The tapered distal end has a micro-hole 131 that passes through the apex of the cone for ejecting the drug solution during use. The smaller diameter portion of the proximal end having a smaller diameter can be accommodated in the first hole 121, and the outer diameter becomes smaller to form a shoulder against the outer side of the distal end wall of the outer casing 3. Of course, those skilled in the art can understand that the connection between the needle-free injection end 130 and the outer casing 3 is not limited thereto, and in addition, the engagement of the reduced diameter portion and the first hole 121 may be in any known manner, including but not limited to Bonding, threaded connection waiting.

As previously mentioned, the needle-free injector 100 further includes a pressurized injection assembly 170 located within the pressurized injection chamber 123, a needle-free injector locking mechanism 180 at least partially within the pressurized injection chamber 123, and located within the motor chamber 124. Motor assembly 190. Wherein, the pressurized injection assembly 170 includes a push rod 14, a pressure spring 15 sleeved on the push rod 14, and a compression body 9 at least partially surrounding the push rod 14 and the pressure spring 15. Wherein the pressure spring 15 can be pressurized, and the needleless syringe locking mechanism 180 can lock it in a pressurized state and unlock it when an injection is required. In particular, the push rod 14 extends along the longitudinal axis X-X of the pressurized injection assembly with a push distal end 141 and a proximal portion 142 that can extend into the cartridge wall 2. A pusher boss 18 is formed between the pusher distal end 141 and the proximal portion 142, and the pusher boss 18 can be pressed against the inner side of the distal end wall of the outer casing 3 when the pusher 14 injects the drug. Pusher 14 The proximal end 143 is provided with a groove 17 disposed around the circumference of the push rod 14. The compression spring 15 is sleeved on the proximal portion 142 of the push rod 14 with the distal end abutting the pusher boss 18.

Further, as still shown in Figs. 1 to 3, the compression body 9 includes a compression body main body 91 having a substantially sleeve-shaped structure and a force transmitting portion projecting upward from the compression body main body 91, that is, a core 16. The force transmitting portion is located substantially at a proximal portion of the sleeve-shaped structure of the compression body main body 91. The inner wall of the proximal portion of the sleeve-shaped structure is thickened inwardly to form an inner wall thickening portion 93 corresponding to the force transmitting portion, and the inner wall is thickened. A shoulder 94 is formed at the junction of the portion 93 and the remainder of the sleeve-like structure. The inner diameter of the inner wall thickened portion 93 and the outer diameter of the push rod 14 are substantially the same. The proximal portion of the inner wall thickened portion 93 is formed with a deep groove 95 extending longitudinally from the proximal end for receiving the needleless syringe locking mechanism 180. And the proximal portion of the compression body main body 91 can protrude from the second hole 122. Further, the force transmitting portion is formed with a center hole 92 through which the screw rod 8 passes. Preferably, the outer side of the distal end of the compression body main body 91 is provided with a flange 96. As shown in Figures 1-3 and 5, the deep groove 95 has a proximal portion of the compression body main body 91 having a first inner side wall 98 and a second outer side wall 99 at respective positions of the first inner side wall 98 (e.g., Small holes 101 are formed in the upper and lower positions.

After assembly, the proximal portion of the compression body main body 91 extends from the second hole 122, and the flange 96 is supported on the lower side of the outer wall of the outer casing 3, and extends on the upper side from the inner side of the outer wall 3 from the inner side of the distal end wall. A portion of the partition wall 31 is in contact with the push rod 14 and the pressure spring 15 sleeved on the push rod 14 in the compression body main body 91, and the other end of the pressure spring 15 abuts against the shoulder 94. Thereby, the pressurized injection chamber 124 is formed by the partition wall 31 and the wall of the compressed body main body 91.

As shown in Fig. 1, the motor 5 is supported above the partition wall 31, and the lead screw 8 connected to the motor shaft 6 of the motor 5 extends along the motor assembly axis X1-X1 and passes through the force transmitting portion, that is, the hole 92 of the nut 16. The shaft 4 at the other end of the screw is rotatably coupled to the outer casing 3 via a bearing 7.

That is to say, the piston 1 is located in the wall 2 of the medicine tube to function as a medicine for taking medicine and injecting it. Connected to the piston 1 is a push rod 14 which is sleeved with a pressure spring 15 on the outside, and a rear end side wall of the push rod 14 is provided with a recess 17 for receiving the steel ball 10 in a locked state (see subsequent description). The front end of the pressure spring 15 is in contact with the pusher boss 18 of the push rod 14, and the rear end of the pressure spring 15 is in contact with the inner table of the compression body 9. The compression body 9 can move axially and The compression spring 15 is compressed and moved. The nut 16 to which the compression body 9 is connected has an internal thread, and the internal thread is screwed to the screw 8. The rotation of the lead screw 8 causes the nut 16 to move axially. The lead screw 8 is connected to the motor 5, and when the motor 5 is rotated, the lead screw 8 is rotated together.

Fig. 5 is a partially enlarged schematic view of the rear portion of Fig. 3, highlighting the needleless syringe locking mechanism 180. The needleless syringe locking mechanism 180 locks the push rod 14 and the compression body 9 together by means of a locking ball, such as a steel ball 10, that engages a hole or slot in the wall of the different members, thereby maintaining the compression spring 15 in a pressurized state.

More specifically, as shown in FIG. 5, the needleless syringe locking mechanism 180 includes: a steel ball 10 capable of freely passing through the small hole 101 in the first inner side wall 98 of the compression body main body 91, a groove 17 of the push rod, and a button 11 A groove 11B and a locking platform 11C are formed in the side wall.

Referring to Fig. 5, the hollow button 11 has a substantially U-shaped longitudinal section, and a shoulder 11A is formed on the outer wall so as to be moved to the nearest side position after being inserted into the deep groove 95 at the proximal end of the compression body main body 91. The inner flange 97 formed by the outer wall of the proximal end of the compression body main body 91 abuts against the button 11 from the needle-free injector. Further, a groove 11B is formed at a distal portion of the inner wall of the button 11. The longitudinal section of the lock cylinder 13 is substantially T-shaped, and the maximum diameter of the proximal end of the T-shape coincides with the inner diameter of the button 11. After assembly, the proximal end of the lock cylinder 13 is placed in the button 11 and is in contact with the inner wall of the button 11, the button spring 12 is located in the button 11 and is located on the proximal side of the lock cylinder 13, one end abuts against the proximal end of the lock cylinder 13, and the other end One end abuts against the proximal end wall of the button 11, and the smaller diameter cylindrical portion of the locking post 13 projects into the proximal portion of the sleeve-like structure of the compression body body 91.

When the syringe needs to work, the switch button 19 of the control device 200 is touched, and the motor 5 rotates to drive the screw 8 to rotate. The rotation of the screw rod 8 causes the compression body 9 to move to the left. Since the distal end of the compression spring 15 abuts against the pusher boss 18, and the proximal end of the compression spring 15 abuts against the shoulder 94 of the compression body 9, the compression spring 15 is pressurized as the compression body 9 moves to the left. At the same time, the right end of the push rod 14 is adjacent to the lock cylinder 13 and pushes the lock cylinder 13 to compress the button spring 12. When moving to a certain position, the steel ball 10 can enter the groove 17 at the right end of the push rod 14, and the button 11 is under the action of the button spring 12. Pop up outward. The platform at the end of the button 11 presses the ball 10 into the groove at the right end of the push rod 14. Thereby, the push rod 14 is locked with the compression body 9, thereby locking the pressure spring 15 in a pressurized state, as shown in FIG.

Then enter the medicine taking and dose adjustment process (Fig. 3 is the medicine taking and dose adjustment state), the motor 5 is reversed, and the compression body 9 is moved to the right side to drive the push rod 14 (the push rod 14 and the compression body 9 at this time) Locked together), the piston 1, the compression spring 15, the lock cylinder 13 and the like are moved to the right side. During the movement, a negative pressure is formed in the wall 2 of the medicine tube, and the medicine enters into the wall 2 of the medicine tube through a small hole at the front end of the medicine tube wall 2. At the same time, the step on the left side of the push rod 14 forms a gap with the outer casing 3. The size of the gap is determined by the dose that needs to be injected.

When the medicine is injected, the button 11 is pressed, the button 11 is moved to the left, and the steel ball enters the groove of the button 11 under the action of the thrust from the push rod 14. The push rod 14 is no longer bound by the steel ball 10, the push rod 14 and the compression body 9 are no longer locked, the pressure spring 15 in a pressurized state acts, and the push rod 14 moves rapidly to the left under the action of the pressure spring 15. . The elastic force of the pressure spring 15 acts on the medicine in the wall 2 of the medicine tube through the push rod 14 and the piston 2, so that the medicine is quickly ejected and injected into the body. A working process is completed and the needle-free injector returns to the state of Figure 1.

The above is a preferred embodiment of the present invention and the technical principles applied thereto, and any technical solution based on the present invention can be made by those skilled in the art without departing from the spirit and scope of the present invention. Obvious changes such as equivalent transformation, simple replacement, etc. are all within the scope of protection of the present invention.

Claims

A needleless injector (100) having an electric function, comprising:

Needle-free injector body (120);

A needle-free injection end (130) for administration distally from the needle-free injector body (120), the needle-free injector body (120) comprising:

a casing (3), the inside of the casing (3) is divided into a pressurized injection chamber (123) and a motor chamber (124);

a pressurized injection assembly (170) located within the pressurized injection chamber (123);

a needle-free injector locking mechanism (180) at least partially within the pressurized injection chamber (123);

A motor assembly (190) located within the motor chamber (124).
The needle-free injector (100) of claim 1 wherein the longitudinal axis (X-X) of the pressurized injection assembly (120) and the longitudinal axis (X1-X1) of the motor assembly (190) are parallel to one another.
The needle-free injector (100) according to claim 1 or 2, wherein the pressurized injection assembly (170) comprises: a push rod (14), a pressure spring sleeved on the push rod (14) ( 15) and a compression body (9) at least partially surrounding the push rod (14) and the compression spring (15).
A needle-free injector (100) according to claim 3, characterized in that the push rod (14) is provided with a pusher boss (18) on the distal side, and the inside of the compression body (9) is provided with a table a shoulder (94), the distal end of the compression spring (15) abuts against the pusher boss (18) and the proximal end of the compression spring (15) abuts the shoulder (94) when the compression body (9) When the motor assembly (190) is driven, the pressure spring (15) can be pressurized.
A needle-free injector (100) according to claim 4, wherein said needle-free injector locking mechanism (180) is capable of passing through a wall of said compression body (9) and into the vicinity of the push rod (14) A locking ball (10) in the groove (17) at the end locks the compression body (9) and the push rod (14) together, thereby locking the pressure spring (15) in a pressurized state.
A needle-free injector (100) according to claim 5, wherein said needle-free injector locking mechanism (180) comprises a hollow button (11), the inner end of said button (11) having a platform (11C) And a button recess (11B) located on the near side of the platform, in the locked state, the platform (11C) abuts against the wall passing through the compression body (9) and enters the proximal end of the push rod (14) The locking ball (10) of the groove (17) prevents it from coming off, and when the injection is to be unlocked, pressing the button (11) causes the platform (11C) to move distally, and the locking ball (10) is pushed into the button. The groove (11B) thereby allows the push rod (14) to be disengaged from the compression body (9).
A needle-free injector (100) according to claim 4, wherein said compression body (9) comprises a compression body body (91) of a substantially sleeve-shaped structure and an upwardly projecting body (91) from the compression body The force transmitting portion (16) is formed with a center hole (92) for receiving the motor assembly (190).
A needle-free injector (100) according to claim 7, wherein said body (91) includes an inner wall thickening portion (93) to form: (a) for abutting against the pressure spring (15) The proximal shoulder (94), and (b) a deep groove (95) extending longitudinally from a proximal end of the compression body (91) for receiving a needleless syringe locking mechanism (180) portion.
A needle-free injector (100) according to claim 7, wherein a partition wall (31) extending proximally from an inner side of the distal end wall of the outer casing (3) and the upper portion of the compression body (91) The side wall divides the interior of the outer casing (3) into the pressurized injection chamber (123) and the motor chamber (124).
A needle-free injector (100) according to claim 9, wherein said partition wall (31) supports a motor (5) of the motor assembly (190) above.
A needle-free injector (100) according to claim 7, wherein said motor assembly (190) comprises: a motor (5), a motor shaft (6) extending from the motor (5), and a motor shaft (6) A connected screw (8) extending along the motor assembly axis (X1-X1) and passing through a central hole (92) of the force transmitting portion.
The needle-free injector (100) according to claim 8, wherein the needle-free injector locking mechanism (180) comprises: inserted into the body of the compression body (91) a hollow button (11) in the deep groove (95) of the end, the inner end of the button (11) has a platform (11C) and a button groove (11B) located on the near side of the platform; the proximal end is placed on the button (11) a lock cylinder (13) inside and in contact with the inner wall of the button (11); a button spring (12) placed inside the button (11) and located on the proximal side of the lock cylinder (13); the compression body (9) A small hole (101) in the wall; a locking ball (10); a groove (17) of the push rod (14).