WO2016130385A3 - Tissue ablation by rapid and sustained alteration in membrane potential - Google Patents

Tissue ablation by rapid and sustained alteration in membrane potential Download PDF

Info

Publication number
WO2016130385A3
WO2016130385A3 PCT/US2016/016464 US2016016464W WO2016130385A3 WO 2016130385 A3 WO2016130385 A3 WO 2016130385A3 US 2016016464 W US2016016464 W US 2016016464W WO 2016130385 A3 WO2016130385 A3 WO 2016130385A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
rapid
undesirable tissue
membrane potential
undesirable
Prior art date
Application number
PCT/US2016/016464
Other languages
French (fr)
Other versions
WO2016130385A2 (en
Inventor
George Mbella Ekema
Marjet Danteel HEITZER
Original Assignee
George Mbella Ekema
Heitzer Marjet Danteel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by George Mbella Ekema, Heitzer Marjet Danteel filed Critical George Mbella Ekema
Publication of WO2016130385A2 publication Critical patent/WO2016130385A2/en
Publication of WO2016130385A3 publication Critical patent/WO2016130385A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00333Breast
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00577Ablation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00Ultrasound therapy

Abstract

A method for the ablation of undesirable tissue, such as cells of a cancerous or non-cancerous tumor, infected tissue, adipose tissue, wound, etc., comprising the injection of at least one ion channel or ion pump blocker into said undesirable tissue then applying a low voltage electrical current into said undesirable tissue to trigger a rapid and sustained change in membrane potential (Vm) of the targeted cells, causing said undesirable tissue to die by a process of programmed cell death (apoptosis) followed by immune system action on any surviving cells in the undesirable tissue. Alternatively, depending on the tissue type, a mechanical vibration or an osmotic force may be used instead of a low voltage electrical current.
PCT/US2016/016464 2015-02-10 2016-02-03 Tissue ablation by rapid and sustained alteration in membrane potential WO2016130385A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562114280P 2015-02-10 2015-02-10
US62/114,280 2015-02-10
US201562134680P 2015-03-18 2015-03-18
US62/134,680 2015-03-18

Publications (2)

Publication Number Publication Date
WO2016130385A2 WO2016130385A2 (en) 2016-08-18
WO2016130385A3 true WO2016130385A3 (en) 2017-01-05

Family

ID=56614659

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2016/016464 WO2016130385A2 (en) 2015-02-10 2016-02-03 Tissue ablation by rapid and sustained alteration in membrane potential

Country Status (1)

Country Link
WO (1) WO2016130385A2 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5468223A (en) * 1992-11-30 1995-11-21 C.N.R.S. Paris Electrochemotherapy
US20070118107A1 (en) * 2000-04-27 2007-05-24 Francischelli David E Vibration sensitive ablation device and method
US20120277741A1 (en) * 2003-12-24 2012-11-01 The Regents Of The University Of California Tissue ablation with irreversible electroporation
US20140039489A1 (en) * 2008-04-29 2014-02-06 Virginia Tech Intellectual Properties, Inc. Acute blood-brain barrier disruption using electrical energy based therapy
US20150005767A1 (en) * 2005-07-11 2015-01-01 Medtronic Ablation Frontiers Llc Low power tissue ablation system
WO2015021113A1 (en) * 2013-08-06 2015-02-12 Memorial Sloan Kettering Cancer Center System, method and computer-accessible medium for in-vivo tissue ablation and/or damage

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5468223A (en) * 1992-11-30 1995-11-21 C.N.R.S. Paris Electrochemotherapy
US20070118107A1 (en) * 2000-04-27 2007-05-24 Francischelli David E Vibration sensitive ablation device and method
US20120277741A1 (en) * 2003-12-24 2012-11-01 The Regents Of The University Of California Tissue ablation with irreversible electroporation
US20150005767A1 (en) * 2005-07-11 2015-01-01 Medtronic Ablation Frontiers Llc Low power tissue ablation system
US20140039489A1 (en) * 2008-04-29 2014-02-06 Virginia Tech Intellectual Properties, Inc. Acute blood-brain barrier disruption using electrical energy based therapy
WO2015021113A1 (en) * 2013-08-06 2015-02-12 Memorial Sloan Kettering Cancer Center System, method and computer-accessible medium for in-vivo tissue ablation and/or damage

Also Published As

Publication number Publication date
WO2016130385A2 (en) 2016-08-18

Similar Documents

Publication Publication Date Title
EP3399933A4 (en) Systems, devices, and methods for delivery of pulsed electric field ablative energy to endocardial tissue
EP3449548A4 (en) Fast turn-on power switch
EP3224927B8 (en) Auxiliary system of power supply and energy harvesting for an electric vehicle, and method for operating the auxiliary system of power supply and energy harvesting
EP3444881A4 (en) Conductive adhesive for lithium-ion battery and preparation method therefor, lithium-ion battery electrode plate and preparation method therefor, and lithium-ion battery
MX2016005018A (en) A biopsy collector.
WO2016012544A3 (en) Enhanced reprogramming to ips cells
EP3311894A4 (en) Method for controlling interaction with virtual target, terminal, and storage medium
EP3477746A4 (en) Positive electrode for power storage device, and power storage device
WO2015047484A3 (en) Electrochemical systems and methods for harvesting heat energy
PH12017501218A1 (en) Rpe cell populations and methods of generating same
MX2018003145A (en) Internal wire-triggered pulsed cathodic arc propulsion system.
CL2016001387A1 (en) An assembly comprising an electric vehicle and a charging system and method of operation.
EP3542461A4 (en) High efficiency power amplifier architectures for rf applications
WO2014140546A3 (en) Toroidal trapping geometry pulsed ion source
WO2011035260A3 (en) Distributed ion source acceleration column
EP3521325A4 (en) Polymer, solid polymer electrolyte membrane, and membrane electrode assembly
BR112018071519A2 (en) techniques for benchmarking pairing strategies in a contact center system
BR112017012655A2 (en) use of bioactive molecules
UY36617A (en) IMMUNOGENIC FUSION PROTEINS FOR CANCER TREATMENT
WO2016012088A3 (en) Connection device and electric machine
GB201311410D0 (en) Ejection of Ion Clouds from 3D RF Ion Traps
GB2562580B (en) Electrochemical oxygen pumps utilizing an anion conducting polymer
EP3376570A4 (en) Negative-electrode active material for electrical device, and electrical device in which said material is used
EP3352275A4 (en) High-flexibility electrode assembly and battery cell comprising same
EP3712995A4 (en) Cathode, membrane electrode assembly, and battery

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 16749611

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 16749611

Country of ref document: EP

Kind code of ref document: A2