WO2016130385A3 - Tissue ablation by rapid and sustained alteration in membrane potential - Google Patents
Tissue ablation by rapid and sustained alteration in membrane potential Download PDFInfo
- Publication number
- WO2016130385A3 WO2016130385A3 PCT/US2016/016464 US2016016464W WO2016130385A3 WO 2016130385 A3 WO2016130385 A3 WO 2016130385A3 US 2016016464 W US2016016464 W US 2016016464W WO 2016130385 A3 WO2016130385 A3 WO 2016130385A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tissue
- rapid
- undesirable tissue
- membrane potential
- undesirable
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00333—Breast
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00577—Ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
Abstract
A method for the ablation of undesirable tissue, such as cells of a cancerous or non-cancerous tumor, infected tissue, adipose tissue, wound, etc., comprising the injection of at least one ion channel or ion pump blocker into said undesirable tissue then applying a low voltage electrical current into said undesirable tissue to trigger a rapid and sustained change in membrane potential (Vm) of the targeted cells, causing said undesirable tissue to die by a process of programmed cell death (apoptosis) followed by immune system action on any surviving cells in the undesirable tissue. Alternatively, depending on the tissue type, a mechanical vibration or an osmotic force may be used instead of a low voltage electrical current.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562114280P | 2015-02-10 | 2015-02-10 | |
US62/114,280 | 2015-02-10 | ||
US201562134680P | 2015-03-18 | 2015-03-18 | |
US62/134,680 | 2015-03-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2016130385A2 WO2016130385A2 (en) | 2016-08-18 |
WO2016130385A3 true WO2016130385A3 (en) | 2017-01-05 |
Family
ID=56614659
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2016/016464 WO2016130385A2 (en) | 2015-02-10 | 2016-02-03 | Tissue ablation by rapid and sustained alteration in membrane potential |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2016130385A2 (en) |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5468223A (en) * | 1992-11-30 | 1995-11-21 | C.N.R.S. Paris | Electrochemotherapy |
US20070118107A1 (en) * | 2000-04-27 | 2007-05-24 | Francischelli David E | Vibration sensitive ablation device and method |
US20120277741A1 (en) * | 2003-12-24 | 2012-11-01 | The Regents Of The University Of California | Tissue ablation with irreversible electroporation |
US20140039489A1 (en) * | 2008-04-29 | 2014-02-06 | Virginia Tech Intellectual Properties, Inc. | Acute blood-brain barrier disruption using electrical energy based therapy |
US20150005767A1 (en) * | 2005-07-11 | 2015-01-01 | Medtronic Ablation Frontiers Llc | Low power tissue ablation system |
WO2015021113A1 (en) * | 2013-08-06 | 2015-02-12 | Memorial Sloan Kettering Cancer Center | System, method and computer-accessible medium for in-vivo tissue ablation and/or damage |
-
2016
- 2016-02-03 WO PCT/US2016/016464 patent/WO2016130385A2/en active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5468223A (en) * | 1992-11-30 | 1995-11-21 | C.N.R.S. Paris | Electrochemotherapy |
US20070118107A1 (en) * | 2000-04-27 | 2007-05-24 | Francischelli David E | Vibration sensitive ablation device and method |
US20120277741A1 (en) * | 2003-12-24 | 2012-11-01 | The Regents Of The University Of California | Tissue ablation with irreversible electroporation |
US20150005767A1 (en) * | 2005-07-11 | 2015-01-01 | Medtronic Ablation Frontiers Llc | Low power tissue ablation system |
US20140039489A1 (en) * | 2008-04-29 | 2014-02-06 | Virginia Tech Intellectual Properties, Inc. | Acute blood-brain barrier disruption using electrical energy based therapy |
WO2015021113A1 (en) * | 2013-08-06 | 2015-02-12 | Memorial Sloan Kettering Cancer Center | System, method and computer-accessible medium for in-vivo tissue ablation and/or damage |
Also Published As
Publication number | Publication date |
---|---|
WO2016130385A2 (en) | 2016-08-18 |
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