WO2017112000A1 - Storing samples - Google Patents

Storing samples Download PDF

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Publication number
WO2017112000A1
WO2017112000A1 PCT/US2016/039845 US2016039845W WO2017112000A1 WO 2017112000 A1 WO2017112000 A1 WO 2017112000A1 US 2016039845 W US2016039845 W US 2016039845W WO 2017112000 A1 WO2017112000 A1 WO 2017112000A1
Authority
WO
WIPO (PCT)
Prior art keywords
cap
container
transport sleeve
threading
frangible portion
Prior art date
Application number
PCT/US2016/039845
Other languages
French (fr)
Inventor
Frank Cable
James R. Parys
Original Assignee
Coopersurgical, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coopersurgical, Inc. filed Critical Coopersurgical, Inc.
Publication of WO2017112000A1 publication Critical patent/WO2017112000A1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/18—Arrangements of closures with protective outer cap-like covers or of two or more co-operating closures
    • B65D51/20—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0236—Mechanical aspects
    • A01N1/0263—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving, e.g. cool boxes, blood bags or "straws" for cryopreservation
    • A01N1/0268—Carriers for immersion in cryogenic fluid, both for slow-freezing and vitrification, e.g. open or closed "straws" for embryos, oocytes or semen
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/141—Preventing contamination, tampering
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/18—Transport of container or devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0672—Integrated piercing tool
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1894—Cooling means; Cryo cooling

Definitions

  • This disclosure relates to devices and methods for storing samples in cryogenic fluids.
  • Nitrogen as an element of great technical importance, can be produced in a cryogenic nitrogen plant. Air inside a distillation column is separated at cryogenic temperatures (about 100K/-173°C) to produce high purity nitrogen with lppm of impurities. The process is based on the air separation, which was invented by Dr. Carl von Linde in 1895.
  • Liquid nitrogen is widely used in the pharmaceutical, biopharmaceutical, and life sciences industries for lyophilization and quick-freezing of pharmaceutical preparations and storage of cells and microbial cultures.
  • liquid nitrogen can act as a vehicle for transmitting contaminants such as microorganisms.
  • the systems and methods described in this disclosure provide an approach to providing a sterile environment for long term storage of samples (e.g., biological samples) and to sterile retrieval of the samples from storage.
  • Some systems include: a container with an open end; a cap with a frangible portion, the cap sized and configured to be attached to the container closing the open end of the container; and a member with a frangible portion, the member defining an interior cavity, the member sized and configured to be attached to the cap such that the frangible portion of the cap is adjacent the interior cavity of the member.
  • Embodiments of these systems can include one or more of the following features.
  • the container has external threading and the cap has internal threading corresponding to the external threading of the container. In some cases, the cap has external threading and the member has internal threading corresponding to the external threading of the cap.
  • the frangible portion of the cap comprises a metal foil.
  • the metal foil is attached to inner surfaces of an end wall of the cap.
  • the member comprises a hollow cylinder.
  • the frangible portion of the member comprises a metal foil.
  • the member defines a vent hole extending through a wall of the member.
  • systems include a sample vial with a metal end portion.
  • systems include a handling rod with a magnetic end.
  • the handling rod is long enough to extend through the interior cavity of the member.
  • systems include a trocar long enough to extend through the interior cavity of the member.
  • Figure 1 shows components of a sample storage system.
  • Figure 2 shows the sample storage system of Figure 1 assembled for use.
  • Figures 3 A and 3B show the sample storage system of Figure 1 in use.
  • the systems and methods described in this disclosure provide an approach to providing a sterile environment for long term storage of samples (e.g., biological samples) and to sterile retrieval of the samples from storage.
  • Figure 1 shows a storage system 100 that includes a storage container 110, a cap 112, a transport sleeve 114, and a sample vial 116.
  • a trocar 118, a handling rod 120, and tubing 122 are used to retrieve the sample vial 116 from long term storage while limiting the likelihood of contamination of the sample in the sample vial 116.
  • These components of the system are typically provided as pre- sterilized kit.
  • the storage container 110, the cap 112, and the sample vial 116 can be provided as a pre-sterilized storage kit and the transport sleeve 114, the trocar 118, the handling rod 120, and the tubing 122 can be provided as a pre- sterilized retrieval kit.
  • the storage container 110 has an open end with external threading 124.
  • the storage container 110 is sized to receive a sample vial or vials.
  • the storage container 110 is substantially cylindrical in shape. Some storage containers have other dimensions and/or shapes and/or are formed of other materials.
  • the cap 112 is configured to close the storage container for long term storage of the sample.
  • the cap 112 has a body 130 that is a hollow cylinder with openings 132 at each end. Some caps have other dimensions and/or shapes and/or are formed of other materials.
  • One of the openings 132 is covered by a frangible seal 133.
  • the frangible seal 132 provides a frangible portion of the cap.
  • the body 130 of the cap 112 has sidewalls 134 which define one of the openings 132 and an end wall 136 that extends radially inward from the sidewalls 134 to define the other of the openings 132.
  • the sidewalls have both internal threading 126 (see Figures 3 A and 3B) and external threading 128.
  • the internal threading 126 of the cap 112 is sized to engage the external threading 124 of the storage container 110.
  • the frangible seal is a metal foil attached to inner surfaces of the end wall 136 extending across the opening 132 in the end wall 136.
  • the frangible seal is made of other materials and/or is in a different location on the cap 112 (e.g., attached to outer surfaces of the end wall 136).
  • the transport sleeve 114 is a member configured to engage the cap 112 on the storage container 110 when a user is retrieving the sample vial 116 from the storage container 110.
  • the transport sleeve 114 defines an interior cavity and, in the illustrated system, is a hollow cylinder with openings 138 at each end.
  • Some transport sleeves have other dimensions and/or shapes and/or are formed of other materials.
  • the transport sleeve 114 has internal threading 142 on the end closed by the frangible seal 140.
  • the internal threading 142 of the transport sleeve 114 is sized to engage the external threading 128 of the cap 112.
  • the frangible seal 140 of the transport sleeve 114 is a metal foil attached to inner surfaces of the transport sleeve 114 extending across the transport sleeve 114 adjacent the inner threading and spaced from the end of the transport sleeve by the inner threading.
  • the frangible seal is made of other materials and/or is in a different location on the transport sleeve (e.g., attached to outer surfaces of the transport sleeve).
  • the transport sleeve 114 includes a vent hole 143 through the wall of the transport sleeve near the frangible seal 140. As described below, this vent hole limits the trapping of cryogenic fluid between the transport sleeve 114 and the cap 112 when the transport sleeve 115 is being used to being used to retrieve a sample vial 116 from the storage container 110.
  • the frangible seal 140 of the the transport sleeve 114 is disposed on the end of the transport sleeve 114 rather than being inset by the length of the internal threading 142 of the transport sleeve 114. These systems typically do not include a vent hole.
  • the sample vial 116 is similarly to commercially available sample vials. However, in contrast to commercially available vials, the sample vial 116 includes a metal end portion 144.
  • the trocar 118 and the handling rod 120 are metal rods sized to extend through the transport sleeve 114 into the storage container 110.
  • the trocar 118 has a pointed end to pierce the frangible seals 133, 140 and the handling rod 120 has a magnetic end 146.
  • the storage container 110 can be used to provide storage (e.g., long term storage) of samples disposed on or in a sample vial 116 or vials.
  • the sample vial 116 bearing a sample is placed in the storage container 110.
  • the cap 112 is screwed onto the storage container 110 with the internal threading 126 of the cap 112 engaging the external threading 124 of the storage container 110.
  • the storage container 110 is then placed in a container of cryogenic fluid (e.g., liquid nitrogen).
  • cryogenic fluid e.g., liquid nitrogen
  • the end of the transport sleeve 114 with the internal threading 142 and the frangible seal 140 is inserted into the cryogenic fluid.
  • the frangible seal 140 limits (e.g., prevents) flow of the cryogenic fluid into the storage container 110.
  • the transport sleeve 114 is screwed onto the cap 112 with the internal threading 142 of the transport sleeve 114 engaging the external threading 128 of the cap 112.
  • a limited amount of the cryogenic fluid may be trapped within the transport sleeve.
  • Some systems include a vent hole through the wall of the transport sleeve near the frangible seal 140. In these systems, the space between the frangible seal 133 of the cap 112 and the frangible seal 140 of the transport sleeve 114 is reduced as the transport sleeve 114 is screwed onto the cap 112. This reduction in space pushes trapped cryogenic fluid out of the transport sleeve 114 through the vent hole.
  • the frangible seal 140 of the transport sleeve 114 and the frangible seal 133 of the cap 112 are adjacent each other (e.g., with little or no cryogenic fluid between them) when the transport sleeve 114 is pushed down onto the cap 112.
  • the frangible seal 140 of the transport sleeve 114 is broken by the cap 112 while the frangible seal 133 of the cap remains intact.
  • the trocar 118 is inserted through the transport sleeve 114 (as shown in Figure 2) to perforate the frangible seal 133 of the cap 112 and the frangible seal 140 of the transport sleeve.
  • the trocar 118 is removed and the tubing 122 is inserted into the transport sleeve 114 and storage container 110 past the frangible seals as shown in Figure 3 A and 3B.
  • the handling rod 120 is inserted through the tubing 122 to engage the metal end portion 144 of the sample vial 116 with the magnetic end 146 of the handling rod 120.
  • the handling rod 120 is then used to lift the sample vial 116 out of the storage container 110 with the tubing 122 preventing the frangible seals from contacting the sample vial 116.
  • the sample vial can then be immersed in a warming solution.

Abstract

A system including: a container with an open end; a cap with a frangible portion, the cap sized and configured to be attached to the container closing the open end of the container; and a member with a frangible portion, the member defining an interior cavity, the member sized and configured to be attached to the cap such that the frangible portion of the cap is adjacent the interior cavity of the member.

Description

Storing Samples
CROSS-REFERENCE TO RELATED APPLICATIONS
This application claims priority to U. S. Provisional Patent Application No. 62/270,965, filed on December 22, 2015, the entire contents of which is incorporated herein by reference.
FIELD
This disclosure relates to devices and methods for storing samples in cryogenic fluids.
BACKGROUND
Nitrogen, as an element of great technical importance, can be produced in a cryogenic nitrogen plant. Air inside a distillation column is separated at cryogenic temperatures (about 100K/-173°C) to produce high purity nitrogen with lppm of impurities. The process is based on the air separation, which was invented by Dr. Carl von Linde in 1895.
Liquid nitrogen is widely used in the pharmaceutical, biopharmaceutical, and life sciences industries for lyophilization and quick-freezing of pharmaceutical preparations and storage of cells and microbial cultures. However, liquid nitrogen can act as a vehicle for transmitting contaminants such as microorganisms.
SUMMARY
The systems and methods described in this disclosure provide an approach to providing a sterile environment for long term storage of samples (e.g., biological samples) and to sterile retrieval of the samples from storage.
Some systems include: a container with an open end; a cap with a frangible portion, the cap sized and configured to be attached to the container closing the open end of the container; and a member with a frangible portion, the member defining an interior cavity, the member sized and configured to be attached to the cap such that the frangible portion of the cap is adjacent the interior cavity of the member.
Embodiments of these systems can include one or more of the following features.
In some embodiments, the container has external threading and the cap has internal threading corresponding to the external threading of the container. In some cases, the cap has external threading and the member has internal threading corresponding to the external threading of the cap.
In some embodiments, the frangible portion of the cap comprises a metal foil. In some cases, the metal foil is attached to inner surfaces of an end wall of the cap.
In some embodiments, the member comprises a hollow cylinder.
In some embodiments, the frangible portion of the member comprises a metal foil.
In some embodiments, the member defines a vent hole extending through a wall of the member.
In some embodiments, systems include a sample vial with a metal end portion. In some cases, systems include a handling rod with a magnetic end. In some cases, the handling rod is long enough to extend through the interior cavity of the member.
In some embodiments, systems include a trocar long enough to extend through the interior cavity of the member.
The details of one or more embodiments of the invention are set forth in the accompanying drawings and the description below. Other features, objects, and advantages of the invention will be apparent from the description and drawings, and from the claims.
DESCRIPTION OF DRAWINGS
Figure 1 shows components of a sample storage system.
Figure 2 shows the sample storage system of Figure 1 assembled for use. Figures 3 A and 3B show the sample storage system of Figure 1 in use.
Like reference symbols in the various drawings indicate like elements.
DETAILED DESCRIPTION
The systems and methods described in this disclosure provide an approach to providing a sterile environment for long term storage of samples (e.g., biological samples) and to sterile retrieval of the samples from storage.
Figure 1 shows a storage system 100 that includes a storage container 110, a cap 112, a transport sleeve 114, and a sample vial 116. A trocar 118, a handling rod 120, and tubing 122 (see Figures 3A and 3B) are used to retrieve the sample vial 116 from long term storage while limiting the likelihood of contamination of the sample in the sample vial 116. These components of the system are typically provided as pre- sterilized kit. Alternatively, the storage container 110, the cap 112, and the sample vial 116 can be provided as a pre-sterilized storage kit and the transport sleeve 114, the trocar 118, the handling rod 120, and the tubing 122 can be provided as a pre- sterilized retrieval kit.
The storage container 110 has an open end with external threading 124. The storage container 110 is sized to receive a sample vial or vials. The storage container 110 is substantially cylindrical in shape. Some storage containers have other dimensions and/or shapes and/or are formed of other materials.
The cap 112 is configured to close the storage container for long term storage of the sample. The cap 112 has a body 130 that is a hollow cylinder with openings 132 at each end. Some caps have other dimensions and/or shapes and/or are formed of other materials. One of the openings 132 is covered by a frangible seal 133. The frangible seal 132 provides a frangible portion of the cap. The body 130 of the cap 112 has sidewalls 134 which define one of the openings 132 and an end wall 136 that extends radially inward from the sidewalls 134 to define the other of the openings 132. The sidewalls have both internal threading 126 (see Figures 3 A and 3B) and external threading 128. The internal threading 126 of the cap 112 is sized to engage the external threading 124 of the storage container 110. In the cap 112, the frangible seal is a metal foil attached to inner surfaces of the end wall 136 extending across the opening 132 in the end wall 136. In some caps, the frangible seal is made of other materials and/or is in a different location on the cap 112 (e.g., attached to outer surfaces of the end wall 136).
The transport sleeve 114 is a member configured to engage the cap 112 on the storage container 110 when a user is retrieving the sample vial 116 from the storage container 110. The transport sleeve 114 defines an interior cavity and, in the illustrated system, is a hollow cylinder with openings 138 at each end. Some transport sleeves have other dimensions and/or shapes and/or are formed of other materials.
One of the openings 138 is covered by a frangible seal 140. The transport sleeve 114 has internal threading 142 on the end closed by the frangible seal 140. The internal threading 142 of the transport sleeve 114 is sized to engage the external threading 128 of the cap 112. The frangible seal 140 of the transport sleeve 114 is a metal foil attached to inner surfaces of the transport sleeve 114 extending across the transport sleeve 114 adjacent the inner threading and spaced from the end of the transport sleeve by the inner threading. In some transport sleeves, the frangible seal is made of other materials and/or is in a different location on the transport sleeve (e.g., attached to outer surfaces of the transport sleeve).
The transport sleeve 114 includes a vent hole 143 through the wall of the transport sleeve near the frangible seal 140. As described below, this vent hole limits the trapping of cryogenic fluid between the transport sleeve 114 and the cap 112 when the transport sleeve 115 is being used to being used to retrieve a sample vial 116 from the storage container 110. In some systems, the frangible seal 140 of the the transport sleeve 114 is disposed on the end of the transport sleeve 114 rather than being inset by the length of the internal threading 142 of the transport sleeve 114. These systems typically do not include a vent hole.
The sample vial 116 is similarly to commercially available sample vials. However, in contrast to commercially available vials, the sample vial 116 includes a metal end portion 144.
The trocar 118 and the handling rod 120 are metal rods sized to extend through the transport sleeve 114 into the storage container 110. The trocar 118 has a pointed end to pierce the frangible seals 133, 140 and the handling rod 120 has a magnetic end 146.
The storage container 110 can be used to provide storage (e.g., long term storage) of samples disposed on or in a sample vial 116 or vials. The sample vial 116 bearing a sample is placed in the storage container 110. The cap 112 is screwed onto the storage container 110 with the internal threading 126 of the cap 112 engaging the external threading 124 of the storage container 110. The storage container 110 is then placed in a container of cryogenic fluid (e.g., liquid nitrogen). The frangible seal 133 of the storage container 110 and the engagement between the internal threading 126 of the cap 112 and the external threading 124 of the storage container 110 limits (e.g., prevents) flow of the cryogenic fluid into the storage container 110.
To retrieve the sample from the cryogenic fluid, the end of the transport sleeve 114 with the internal threading 142 and the frangible seal 140 is inserted into the cryogenic fluid. The frangible seal 140 limits (e.g., prevents) flow of the cryogenic fluid into the storage container 110. The transport sleeve 114 is screwed onto the cap 112 with the internal threading 142 of the transport sleeve 114 engaging the external threading 128 of the cap 112.
A limited amount of the cryogenic fluid may be trapped within the transport sleeve. Some systems include a vent hole through the wall of the transport sleeve near the frangible seal 140. In these systems, the space between the frangible seal 133 of the cap 112 and the frangible seal 140 of the transport sleeve 114 is reduced as the transport sleeve 114 is screwed onto the cap 112. This reduction in space pushes trapped cryogenic fluid out of the transport sleeve 114 through the vent hole. In systems with the frangible seal 140 of the transport sleeve 114 disposed on the end of the transport sleeve 114 rather than being inset by the length of the internal threading 142 of the transport sleeve 114, the frangible seal 140 of the transport sleeve 114 and the frangible seal 133 of the cap 112 are adjacent each other (e.g., with little or no cryogenic fluid between them) when the transport sleeve 114 is pushed down onto the cap 112. As the transport sleeve 114 is screwed onto the cap 112, the frangible seal 140 of the transport sleeve 114 is broken by the cap 112 while the frangible seal 133 of the cap remains intact.
Once the transport sleeve 114 is firmly attached to the cap 112, the trocar 118 is inserted through the transport sleeve 114 (as shown in Figure 2) to perforate the frangible seal 133 of the cap 112 and the frangible seal 140 of the transport sleeve. The trocar 118 is removed and the tubing 122 is inserted into the transport sleeve 114 and storage container 110 past the frangible seals as shown in Figure 3 A and 3B. The handling rod 120 is inserted through the tubing 122 to engage the metal end portion 144 of the sample vial 116 with the magnetic end 146 of the handling rod 120. The handling rod 120 is then used to lift the sample vial 116 out of the storage container 110 with the tubing 122 preventing the frangible seals from contacting the sample vial 116. The sample vial can then be immersed in a warming solution.
A number of embodiments of the invention have been described.
Nevertheless, it will be understood that various modifications may be made without departing from the spirit and scope of the invention. Accordingly, other embodiments are within the scope of the following claims.

Claims

WHAT IS CLAIMED IS:
1. A system comprising:
a container with an open end;
a cap with a frangible portion, the cap sized and configured to be attached to the container closing the open end of the container; and
a member with a frangible portion, the member defining an interior cavity, the member sized and configured to be attached to the cap such that the frangible portion of the cap is adjacent the interior cavity of the member.
2. The system of claim 1, wherein the container has external threading and the cap has internal threading corresponding to the external threading of the container.
3. The system of claim 2, wherein the cap has external threading and the member has intemal threading corresponding to the external threading of the cap.
4. The system of claim 1, wherein the frangible portion of the cap comprises a metal foil.
5. The system of claim 4, wherein the metal foil is attached to inner surfaces of an end wall of the cap.
6. The system of claim 1, wherein the member comprises a hollow cylinder.
7. The system of claim 1, wherein the frangible portion of the member comprises a metal foil.
8. The system of claim 1, wherein the member defines a vent hole extending through a wall of the member.
9. The system of claim 1, comprising a sample vial with a metal end portion.
10. The system of claim 9, comprising a handling rod with a magnetic end.
11. The system of claim 10, wherein the handling rod is long enough to extend through the interior cavity of the member.
12. The system of claim 1, comprising a trocar long enough to extend through the interior cavity of the member.
PCT/US2016/039845 2015-12-22 2016-06-28 Storing samples WO2017112000A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562270965P 2015-12-22 2015-12-22
US62/270,965 2015-12-22

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WO2017112000A1 true WO2017112000A1 (en) 2017-06-29

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IT201800007334A1 (en) * 2018-07-19 2020-01-19 CONTAINMENT DEVICE AND METHOD FOR FIXATION, STORAGE AND TRANSPORT OF BIOPTIC SAMPLES
CN117342130A (en) * 2023-12-04 2024-01-05 四川省医学科学院·四川省人民医院 Department of neurology tissue sample local preservation device

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US20080135512A1 (en) * 2006-12-11 2008-06-12 International Plastics And Equipment Corp. Closure
US20080251489A1 (en) * 2007-04-16 2008-10-16 Becton, Dickinson And Company Pierceable cap
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Publication number Priority date Publication date Assignee Title
US20020130100A1 (en) * 1996-07-17 2002-09-19 Smith James C. Closure device for containers
US6537263B1 (en) * 1998-09-24 2003-03-25 Biodome Device for connecting a receptacle and a container and ready-for-use set comprising same
US20090273121A1 (en) * 2005-08-10 2009-11-05 Abbott Laboratories Closure for container for holding biological samples
US20080135512A1 (en) * 2006-12-11 2008-06-12 International Plastics And Equipment Corp. Closure
US20080251489A1 (en) * 2007-04-16 2008-10-16 Becton, Dickinson And Company Pierceable cap

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201800007334A1 (en) * 2018-07-19 2020-01-19 CONTAINMENT DEVICE AND METHOD FOR FIXATION, STORAGE AND TRANSPORT OF BIOPTIC SAMPLES
CN117342130A (en) * 2023-12-04 2024-01-05 四川省医学科学院·四川省人民医院 Department of neurology tissue sample local preservation device
CN117342130B (en) * 2023-12-04 2024-02-23 四川省医学科学院·四川省人民医院 Department of neurology tissue sample local preservation device

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